5a2f - Revision history

OCA at 11:03, 10 January 2024

OCA — Wed, 10 Jan 2024 11:03:02 GMT

←Older revision		Revision as of 11:03, 10 January 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5a2f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A2F FirstGlance]. <br>		<table><tr><td colspan='2'>[[5a2f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A2F FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.86Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a2f OCA], [https://pdbe.org/5a2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a2f RCSB], [https://www.ebi.ac.uk/pdbsum/5a2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a2f ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a2f OCA], [https://pdbe.org/5a2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a2f RCSB], [https://www.ebi.ac.uk/pdbsum/5a2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a2f ProSAT]</span></td></tr>
	</table>		</table>

OCA at 04:35, 25 May 2023

OCA — Thu, 25 May 2023 04:35:19 GMT

←Older revision		Revision as of 04:35, 25 May 2023
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	<StructureSection load='5a2f' size='340' side='right'caption='[[5a2f]], [[Resolution\|resolution]] 1.86Å' scene=''>		<StructureSection load='5a2f' size='340' side='right'caption='[[5a2f]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5a2f]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A2F OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5A2F FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5a2f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A2F FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a2e\|5a2e]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a2f OCA], [https://pdbe.org/5a2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a2f RCSB], [https://www.ebi.ac.uk/pdbsum/5a2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a2f ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5a2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a2f OCA], [~~http~~://pdbe.org/5a2f PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5a2f RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5a2f PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5a2f ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CD166_HUMAN CD166_HUMAN]] Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system.	+	[https://www.uniprot.org/uniprot/CD166_HUMAN CD166_HUMAN] Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Brown~~, M H~~]]	+	[[Category: Brown MH]]
-	[[Category: Chappell~~, P E~~]]	+	[[Category: Chappell PE]]
-	[[Category: Johnson, S]]	+	[[Category: Johnson S]]
-	[[Category: Lea~~, S M]]~~	+	[[Category: Lea SM]]
-	~~[[Category: Activated leukocyte cell adhesion protein]]~~	+
-	~~[[Category: Alcam]]~~	+
-	~~[[Category: Cell adhesion~~]]	+

OCA at 08:54, 26 June 2019

OCA — Wed, 26 Jun 2019 08:54:45 GMT

←Older revision		Revision as of 08:54, 26 June 2019
Line 1:		Line 1:

	==Two membrane distal IgSF domains of CD166==		==Two membrane distal IgSF domains of CD166==
-	<StructureSection load='5a2f' size='340' side='right' caption='[[5a2f]], [[Resolution\|resolution]] 1.86Å' scene=''>	+	<StructureSection load='5a2f' size='340' side='right'caption='[[5a2f]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5a2f]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A2F FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5a2f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A2F FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a2e\|5a2e]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a2e\|5a2e]]</td></tr>
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Brown, M H]]		[[Category: Brown, M H]]
	[[Category: Chappell, P E]]		[[Category: Chappell, P E]]
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	[[Category: Alcam]]		[[Category: Alcam]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
-	[[Category: Human]]

OCA at 14:16, 24 May 2017

OCA — Wed, 24 May 2017 14:16:57 GMT

←Older revision		Revision as of 14:16, 24 May 2017
Line 1:		Line 1:
		+
	==Two membrane distal IgSF domains of CD166==		==Two membrane distal IgSF domains of CD166==
	<StructureSection load='5a2f' size='340' side='right' caption='[[5a2f]], [[Resolution\|resolution]] 1.86Å' scene=''>		<StructureSection load='5a2f' size='340' side='right' caption='[[5a2f]], [[Resolution\|resolution]] 1.86Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a2e\|5a2e]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a2e\|5a2e]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a2f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5a2f RCSB], [http://www.ebi.ac.uk/pdbsum/5a2f PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a2f OCA], [http://pdbe.org/5a2f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a2f RCSB], [http://www.ebi.ac.uk/pdbsum/5a2f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a2f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 5a2f" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:11, 22 July 2015

OCA — Wed, 22 Jul 2015 14:11:27 GMT

←Older revision		Revision as of 14:11, 22 July 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Two membrane distal IgSF domains of CD166==
		+	<StructureSection load='5a2f' size='340' side='right' caption='[[5a2f]], [[Resolution\|resolution]] 1.86Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5a2f]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A2F FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a2e\|5a2e]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a2f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5a2f RCSB], [http://www.ebi.ac.uk/pdbsum/5a2f PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CD166_HUMAN CD166_HUMAN]] Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	CD6 is a transmembrane protein with an extracellular region containing three scavenger receptor cysteine rich (SRCR) domains. The membrane proximal domain of CD6 binds the N-terminal immunoglobulin superfamily (IgSF) domain of another cell surface receptor, CD166, which also engages in homophilic interactions. CD6 expression is mainly restricted to T cells, and the interaction between CD6 and CD166 regulates T-cell activation. We have solved the X-ray crystal structures of the three SRCR domains of CD6 and two N-terminal domains of CD166. This first structure of consecutive SRCR domains reveals a nonlinear organization. We characterized the binding sites on CD6 and CD166 and showed that a SNP in CD6 causes glycosylation that hinders the CD6/CD166 interaction. Native mass spectrometry analysis showed that there is competition between the heterophilic and homophilic interactions. These data give insight into how interactions of consecutive SRCR domains are perturbed by SNPs and potential therapeutic reagents.

-	~~The entry 5a2f is ON HOLD until Paper Publication~~	+	Structures of CD6 and Its Ligand CD166 Give Insight into Their Interaction.,Chappell PE, Garner LI, Yan J, Metcalfe C, Hatherley D, Johnson S, Robinson CV, Lea SM, Brown MH Structure. 2015 Jun 22. pii: S0969-2126(15)00222-1. doi:, 10.1016/j.str.2015.05.019. PMID:26146185<ref>PMID:26146185</ref>

-	~~Authors: Chappell~~, P.~~E., Johnson,~~ S.~~, Lea, S~~.~~M.,~~ Brown, M.H.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: Two membrane distal IgSF domains of CD166~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Brown, M H]]
		+	[[Category: Chappell, P E]]
	[[Category: Johnson, S]]		[[Category: Johnson, S]]
-	[[Category: Lea, S.M]]	+	[[Category: Lea, S M]]
-	[[Category: ~~Brown, M.H~~]]	+	[[Category: Activated leukocyte cell adhesion protein]]
-	[[Category: ~~Chappell, P.E~~]]	+	[[Category: Alcam]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Human]]

OCA at 11:26, 3 June 2015

OCA — Wed, 03 Jun 2015 11:26:39 GMT

←Older revision		Revision as of 11:26, 3 June 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5a2f is ON HOLD	+	The entry 5a2f is ON HOLD until Paper Publication

	Authors: Chappell, P.E., Johnson, S., Lea, S.M., Brown, M.H.		Authors: Chappell, P.E., Johnson, S., Lea, S.M., Brown, M.H.

OCA: Protected "5a2f" [edit=sysop:move=sysop]

OCA — Wed, 27 May 2015 15:02:45 GMT

Protected "5a2f" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:02, 27 May 2015

OCA: New page: '''Unreleased structure''' The entry 5a2f is ON HOLD Authors: Chappell, P.E., Johnson, S., Lea, S.M., Brown, M.H. Description: Two membrane distal IgSF domains of CD166 [[Category: Unr...

OCA — Wed, 27 May 2015 15:02:44 GMT

New page: '''Unreleased structure''' The entry 5a2f is ON HOLD Authors: Chappell, P.E., Johnson, S., Lea, S.M., Brown, M.H. Description: Two membrane distal IgSF domains of CD166 [[Category: Unr...

New page

'''Unreleased structure'''

The entry 5a2f is ON HOLD

Authors: Chappell, P.E., Johnson, S., Lea, S.M., Brown, M.H.

Description: Two membrane distal IgSF domains of CD166
[[Category: Unreleased Structures]]
[[Category: Johnson, S]]
[[Category: Lea, S.M]]
[[Category: Brown, M.H]]
[[Category: Chappell, P.E]]