5a3v - Revision history

OCA at 11:36, 9 May 2024

OCA — Thu, 09 May 2024 11:36:44 GMT

←Older revision		Revision as of 11:36, 9 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5a3v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A3V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A3V FirstGlance]. <br>		<table><tr><td colspan='2'>[[5a3v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A3V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A3V FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a3v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a3v OCA], [https://pdbe.org/5a3v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a3v RCSB], [https://www.ebi.ac.uk/pdbsum/5a3v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a3v ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.34Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a3v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a3v OCA], [https://pdbe.org/5a3v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a3v RCSB], [https://www.ebi.ac.uk/pdbsum/5a3v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a3v ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 04:38, 25 May 2023

OCA — Thu, 25 May 2023 04:38:03 GMT

←Older revision		Revision as of 04:38, 25 May 2023
Line 3:		Line 3:
	<StructureSection load='5a3v' size='340' side='right'caption='[[5a3v]], [[Resolution\|resolution]] 2.34Å' scene=''>		<StructureSection load='5a3v' size='340' side='right'caption='[[5a3v]], [[Resolution\|resolution]] 2.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5a3v]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A3V OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5A3V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5a3v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A3V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A3V FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a3j\|5a3j]], [[5a4d\|5a4d]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a3v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a3v OCA], [https://pdbe.org/5a3v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a3v RCSB], [https://www.ebi.ac.uk/pdbsum/5a3v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a3v ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5a3v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a3v OCA], [~~http~~://pdbe.org/5a3v PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5a3v RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5a3v PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5a3v ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/QORH_ARATH QORH_ARATH]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Large Structures]]
-	[[Category: Cobessi, D]]
-	[[Category: Curien, G]]
-	[[Category: Ferrer, J L]]
-	[[Category: Giustini, C]]
-	[[Category: Mas-y-mas, S]]
-	[[Category: Rolland, N]]
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
-	[[Category: ~~Chloroplast~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Gamma-ketol reductase~~]]	+	[[Category: Cobessi D]]
-	[[Category: ~~Oxidoreductase~~]]	+	[[Category: Curien G]]
-	[[Category: ~~Oxydoreductase~~]]	+	[[Category: Ferrer JL]]
		+	[[Category: Giustini C]]
		+	[[Category: Mas-y-mas S]]
		+	[[Category: Rolland N]]

OCA at 07:06, 10 July 2019

OCA — Wed, 10 Jul 2019 07:06:51 GMT

←Older revision		Revision as of 07:06, 10 July 2019
Line 1:		Line 1:

	==Crystal structure of the chloroplastic gamma-ketol reductase from Arabidopsis thaliana==		==Crystal structure of the chloroplastic gamma-ketol reductase from Arabidopsis thaliana==
-	<StructureSection load='5a3v' size='340' side='right' caption='[[5a3v]], [[Resolution\|resolution]] 2.34Å' scene=''>	+	<StructureSection load='5a3v' size='340' side='right'caption='[[5a3v]], [[Resolution\|resolution]] 2.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5a3v]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A3V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A3V FirstGlance]. <br>		<table><tr><td colspan='2'>[[5a3v]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A3V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A3V FirstGlance]. <br>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Cobessi, D]]		[[Category: Cobessi, D]]
	[[Category: Curien, G]]		[[Category: Curien, G]]

OCA at 07:01, 5 April 2017

OCA — Wed, 05 Apr 2017 07:01:03 GMT

←Older revision		Revision as of 07:01, 5 April 2017
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a3v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a3v OCA], [http://pdbe.org/5a3v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a3v RCSB], [http://www.ebi.ac.uk/pdbsum/5a3v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a3v ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a3v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a3v OCA], [http://pdbe.org/5a3v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a3v RCSB], [http://www.ebi.ac.uk/pdbsum/5a3v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a3v ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Enzymatic and non-enzymatic peroxidation of polyunsaturated fatty acids give rise to accumulation of aldehydes, ketones, and alpha,beta-unsaturated carbonyls of various lengths, known as oxylipins. Oxylipins with alpha,beta-unsaturated carbonyls are reactive electrophile species and are toxic. Cells have evolved several mechanisms to scavenge reactive electrophile oxylipins and decrease their reactivity such as by coupling with glutathione, or by reduction using NAD(P)H-dependent reductases and dehydrogenases of various substrate specificities. Plant cell chloroplasts produce reactive electrophile oxylipins named gamma-ketols downstream of enzymatic lipid peroxidation. The chloroplast envelope quinone oxidoreductase homolog (ceQORH) from Arabidopsis thaliana was previously shown to reduce the reactive double bond of gamma-ketols. In marked difference with its cytosolic homolog alkenal reductase (AtAER) that displays a high activity toward the ketodiene 13-oxo-9(Z),11(E)-octadecadienoic acid (13-KODE) and the ketotriene 13-oxo-9(Z), 11(E), 15(Z)-octadecatrienoic acid (13-KOTE), ceQORH binds, but does not reduce, 13-KODE and 13-KOTE. Crystal structures of apo-ceQORH and ceQORH bound to 13-KOTE or to NADP+ and 13-KOTE have been solved showing a large ligand binding site, also observed in the structure of the cytosolic alkenal/one reductase. Positioning of the alpha,beta-unsaturated carbonyl of 13-KOTE in ceQORH-NADP+-13-KOTE, far away from the NADP+ nicotinamide ring, provides a rational for the absence of activity with the ketodienes and ketotrienes. ceQORH is a monomeric enzyme in solution whereas other enzymes from the quinone oxidoreductase family are stable dimers and a structural explanation of this difference is proposed. A possible in vivo role of ketodienes and ketotrienes binding to ceQORH is also discussed.
		+
		+	Crystal Structure of the Chloroplastic Oxoene Reductase ceQORH from Arabidopsis thaliana.,Mas Y Mas S, Curien G, Giustini C, Rolland N, Ferrer JL, Cobessi D Front Plant Sci. 2017 Mar 9;8:329. doi: 10.3389/fpls.2017.00329. eCollection, 2017. PMID:28337214<ref>PMID:28337214</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5a3v" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 16:59, 3 October 2016

OCA — Mon, 03 Oct 2016 16:59:41 GMT

←Older revision		Revision as of 16:59, 3 October 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5a3v ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of the chloroplastic gamma-ketol reductase from Arabidopsis thaliana==
-		+	<StructureSection load='5a3v' size='340' side='right' caption='[[5a3v]], [[Resolution\|resolution]] 2.34Å' scene=''>
-	~~Authors~~: ~~Mas~~-y-~~mas~~, S., ~~Curien, G~~., ~~Giustini, C~~., ~~Rolland, N~~., ~~Ferrer, J~~.L., Cobessi, D.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5a3v]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A3V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A3V FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of the chloroplastic gamma-ketol reductase from Arabidopsis thaliana~~	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a3j\|5a3j]], [[5a4d\|5a4d]]</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a3v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a3v OCA], [http://pdbe.org/5a3v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a3v RCSB], [http://www.ebi.ac.uk/pdbsum/5a3v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a3v ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Cobessi, D]]
		+	[[Category: Curien, G]]
		+	[[Category: Ferrer, J L]]
	[[Category: Giustini, C]]		[[Category: Giustini, C]]
-	~~[[Category: Curien, G]]~~	+	[[Category: Mas-y-mas, S]]
-	[[Category: Mas-Y-~~Mas~~, S]]	+
	[[Category: Rolland, N]]		[[Category: Rolland, N]]
-	[[Category: ~~Cobessi, D~~]]	+	[[Category: Arabidopsis thaliana]]
-	[[Category: ~~Ferrer, J.L~~]]	+	[[Category: Chloroplast]]
		+	[[Category: Gamma-ketol reductase]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Oxydoreductase]]

OCA at 00:19, 1 December 2015

OCA — Tue, 01 Dec 2015 00:19:24 GMT

←Older revision		Revision as of 00:19, 1 December 2015
Line 8:		Line 8:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Giustini, C]]		[[Category: Giustini, C]]
		+	[[Category: Curien, G]]
	[[Category: Mas-Y-Mas, S]]		[[Category: Mas-Y-Mas, S]]
		+	[[Category: Rolland, N]]
	[[Category: Cobessi, D]]		[[Category: Cobessi, D]]
	[[Category: Ferrer, J.L]]		[[Category: Ferrer, J.L]]
-	[[Category: Curien, G]]
-	[[Category: Rolland, N]]

OCA at 00:25, 16 October 2015

OCA — Fri, 16 Oct 2015 00:25:58 GMT

←Older revision		Revision as of 00:25, 16 October 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5a3v is ON HOLD	+	The entry 5a3v is ON HOLD until Paper Publication

	Authors: Mas-y-mas, S., Curien, G., Giustini, C., Rolland, N., Ferrer, J.L., Cobessi, D.		Authors: Mas-y-mas, S., Curien, G., Giustini, C., Rolland, N., Ferrer, J.L., Cobessi, D.

OCA: Protected "5a3v" [edit=sysop:move=sysop]

OCA — Wed, 10 Jun 2015 12:37:50 GMT

Protected "5a3v" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:37, 10 June 2015

OCA: New page: '''Unreleased structure''' The entry 5a3v is ON HOLD Authors: Mas-y-mas, S., Curien, G., Giustini, C., Rolland, N., Ferrer, J.L., Cobessi, D. Description: Crystal structure of the chlo...

OCA — Wed, 10 Jun 2015 12:37:49 GMT

New page: '''Unreleased structure''' The entry 5a3v is ON HOLD Authors: Mas-y-mas, S., Curien, G., Giustini, C., Rolland, N., Ferrer, J.L., Cobessi, D. Description: Crystal structure of the chlo...

New page

'''Unreleased structure'''

The entry 5a3v is ON HOLD

Authors: Mas-y-mas, S., Curien, G., Giustini, C., Rolland, N., Ferrer, J.L., Cobessi, D.

Description: Crystal structure of the chloroplastic gamma-ketol reductase from Arabidopsis thaliana
[[Category: Unreleased Structures]]
[[Category: Giustini, C]]
[[Category: Mas-Y-Mas, S]]
[[Category: Cobessi, D]]
[[Category: Ferrer, J.L]]
[[Category: Curien, G]]
[[Category: Rolland, N]]