5a59 - Revision history

OCA at 11:37, 9 May 2024

OCA — Thu, 09 May 2024 11:37:32 GMT

←Older revision		Revision as of 11:37, 9 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5a59]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A59 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A59 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5a59]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A59 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A59 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PRD_900084:Thomsen-Friedenreich+antigen'>PRD_900084</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PRD_900084:Thomsen-Friedenreich+antigen'>PRD_900084</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a59 OCA], [https://pdbe.org/5a59 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a59 RCSB], [https://www.ebi.ac.uk/pdbsum/5a59 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a59 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a59 OCA], [https://pdbe.org/5a59 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a59 RCSB], [https://www.ebi.ac.uk/pdbsum/5a59 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a59 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 04:39, 25 May 2023

OCA — Thu, 25 May 2023 04:39:50 GMT

←Older revision		Revision as of 04:39, 25 May 2023
Line 3:		Line 3:
	<StructureSection load='5a59' size='340' side='right'caption='[[5a59]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='5a59' size='340' side='right'caption='[[5a59]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5a59]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Strpn Strpn~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A59 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5A59 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5a59]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A59 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A59 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><~~/td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PRD_900084:Thomsen-Friedenreich+antigen'>PRD_900084</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td>~~<td class="sblockDat">[[5a55\|5a55]], [[5a56\|5a56]], [[5a57\|5a57]], [[5a58\|5a58]], [[5a5a\|5a5a]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a59 OCA], [https://pdbe.org/5a59 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a59 RCSB], [https://www.ebi.ac.uk/pdbsum/5a59 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a59 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5a59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a59 OCA], [~~http~~://pdbe.org/5a59 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5a59 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5a59 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5a59 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GH101_STRPN GH101_STRPN]] Is involved in the breakdown of mucin-type O-linked glycans. Specifically removes the T-antigen disaccharide (Gal-beta-1,3-GalNAc-alpha) from extracellular host glycoproteins. Is representative of a broadly important class of virulence factors (By similarity).	+	[https://www.uniprot.org/uniprot/GH101_STRPN GH101_STRPN] Is involved in the breakdown of mucin-type O-linked glycans. Specifically removes the T-antigen disaccharide (Gal-beta-1,3-GalNAc-alpha) from extracellular host glycoproteins. Is representative of a broadly important class of virulence factors (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Strpn~~]]	+	[[Category: Streptococcus pneumoniae TIGR4]]
-	[[Category: Boraston~~, A B~~]]	+	[[Category: Boraston AB]]
-	[[Category: Deng, L]]	+	[[Category: Deng L]]
-	[[Category: Gregg~~, K J~~]]	+	[[Category: Gregg KJ]]
-	[[Category: Suits~~, M D.L~~]]	+	[[Category: Suits MDL]]
-	[[Category: Vocadlo~~, D J]]~~	+	[[Category: Vocadlo DJ]]
-	~~[[Category: Gh101]]~~	+
-	~~[[Category: Glycoside hydrolase family 101]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Mucin degradation]]~~	+
-	~~[[Category: T-antigen~~]]	+

OCA at 08:42, 26 June 2019

OCA — Wed, 26 Jun 2019 08:42:01 GMT

←Older revision		Revision as of 08:42, 26 June 2019
Line 1:		Line 1:
		+
	==The structure of GH101 E796Q mutant from Streptococcus pneumoniae TIGR4 in complex with T-antigen==		==The structure of GH101 E796Q mutant from Streptococcus pneumoniae TIGR4 in complex with T-antigen==
-	<StructureSection load='5a59' size='340' side='right' caption='[[5a59]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='5a59' size='340' side='right'caption='[[5a59]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5a59]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A59 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5a59]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strpn Strpn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A59 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:~~MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=A2G:N~~-~~ACETYL-2-DEOXY-2-AMINO~~-GALACTOSE'>~~A2G~~</scene>, <scene name='pdbligand=~~GAL~~:~~BETA-D-GALACTOSE~~'>~~GAL~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a55\|5a55]], [[5a56\|5a56]], [[5a57\|5a57]], [[5a58\|5a58]], [[5a5a\|5a5a]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a55\|5a55]], [[5a56\|5a56]], [[5a57\|5a57]], [[5a58\|5a58]], [[5a5a\|5a5a]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a59 OCA], [http://pdbe.org/5a59 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a59 RCSB], [http://www.ebi.ac.uk/pdbsum/5a59 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a59 OCA], [http://pdbe.org/5a59 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a59 RCSB], [http://www.ebi.ac.uk/pdbsum/5a59 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a59 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Strpn]]
	[[Category: Boraston, A B]]		[[Category: Boraston, A B]]
	[[Category: Deng, L]]		[[Category: Deng, L]]

OCA at 21:21, 30 November 2015

OCA — Mon, 30 Nov 2015 21:21:33 GMT

←Older revision		Revision as of 21:21, 30 November 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a55\|5a55]], [[5a56\|5a56]], [[5a57\|5a57]], [[5a58\|5a58]], [[5a5a\|5a5a]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a55\|5a55]], [[5a56\|5a56]], [[5a57\|5a57]], [[5a58\|5a58]], [[5a5a\|5a5a]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a59 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5a59 RCSB], [http://www.ebi.ac.uk/pdbsum/5a59 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a59 OCA], [http://pdbe.org/5a59 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a59 RCSB], [http://www.ebi.ac.uk/pdbsum/5a59 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 5a59" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:51, 9 September 2015

OCA — Wed, 09 Sep 2015 04:51:41 GMT

←Older revision		Revision as of 04:51, 9 September 2015
Line 9:		Line 9:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/GH101_STRPN GH101_STRPN]] Is involved in the breakdown of mucin-type O-linked glycans. Specifically removes the T-antigen disaccharide (Gal-beta-1,3-GalNAc-alpha) from extracellular host glycoproteins. Is representative of a broadly important class of virulence factors (By similarity).		[[http://www.uniprot.org/uniprot/GH101_STRPN GH101_STRPN]] Is involved in the breakdown of mucin-type O-linked glycans. Specifically removes the T-antigen disaccharide (Gal-beta-1,3-GalNAc-alpha) from extracellular host glycoproteins. Is representative of a broadly important class of virulence factors (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	O-linked glycosylation is one of the most abundant post-translational modifications of proteins. Within the secretory pathway of higher eukaryotes, the core of these glycans is frequently an N-acetylgalactosamine residue that is alpha-linked to serine or threonine residues. Glycoside hydrolases in family 101 are presently the only known enzymes to be able to hydrolyze this glycosidic linkage. Here we determine the high-resolution structures of the catalytic domain comprising a fragment of GH101 from Streptococcus pneumoniae TIGR4, SpGH101, in the absence of carbohydrate, and in complex with reaction products, inhibitor, and substrate analogues. Upon substrate binding, a tryptophan lid (residues 724-WNW-726) closes on the substrate. The closing of this lid fully engages the substrate in the active site with D764 positioned directly beneath C1 of the sugar residue bound within the -1 subsite, consistent with its proposed role as the catalytic nucleophile. In all of the bound forms of the enzyme, however, the proposed catalytic acid/base residue was found to be too distant from the glycosidic oxygen (>4.3 A) to serve directly as a general catalytic acid/base residue and thereby facilitate cleavage of the glycosidic bond. These same complexes, however, revealed a structurally conserved water molecule positioned between the catalytic acid/base and the glycosidic oxygen. On the basis of these structural observations we propose a new variation of the retaining glycoside hydrolase mechanism wherein the intervening water molecule enables a Grotthuss proton shuttle between E796 and the glycosidic oxygen, permitting this residue to serve as the general acid/base catalytic residue.
		+
		+	Structural analysis of a family 101 glycoside hydrolase in complex with carbohydrates reveals insights into its mechanism.,Gregg KJ, Suits MD, Deng L, Vocadlo DJ, Boraston AB J Biol Chem. 2015 Aug 24. pii: jbc.M115.680470. PMID:26304114<ref>PMID:26304114</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 12:32, 2 September 2015

OCA — Wed, 02 Sep 2015 12:32:58 GMT

←Older revision		Revision as of 12:32, 2 September 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==The structure of GH101 E796Q mutant from Streptococcus pneumoniae TIGR4 in complex with T-antigen==
-		+	<StructureSection load='5a59' size='340' side='right' caption='[[5a59]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~The entry~~ 5a59 is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5a59]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A59 FirstGlance]. <br>
-	~~Authors~~: ~~Gregg, K~~.J.~~, Suits, M~~.D.L., ~~Deng~~, L., ~~Vocadlo~~, ~~D.J.~~, ~~Boraston~~, ~~A.B.~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a55\|5a55]], [[5a56\|5a56]], [[5a57\|5a57]], [[5a58\|5a58]], [[5a5a\|5a5a]]</td></tr>
-	~~Description~~: ~~The structure of GH101 E796Q mutant from Streptococcus pneumoniae TIGR4 in complex with T~~-~~antigen~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a59 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5a59 RCSB], [http://www.ebi.ac.uk/pdbsum/5a59 PDBsum]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Suits~~, M.D.L]]	+	== Function ==
-	[[~~Category~~: ~~Gregg, K~~.J]]	+	[[http://www.uniprot.org/uniprot/GH101_STRPN GH101_STRPN]] Is involved in the breakdown of mucin-type O-linked glycans. Specifically removes the T-antigen disaccharide (Gal-beta-1,3-GalNAc-alpha) from extracellular host glycoproteins. Is representative of a broadly important class of virulence factors (By similarity).
-	[[Category: Boraston, A.B]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Boraston, A B]]
	[[Category: Deng, L]]		[[Category: Deng, L]]
-	[[Category: ~~Vocadlo~~, D.J]]	+	[[Category: Gregg, K J]]
		+	[[Category: Suits, M D.L]]
		+	[[Category: Vocadlo, D J]]
		+	[[Category: Gh101]]
		+	[[Category: Glycoside hydrolase family 101]]
		+	[[Category: Hydrolase]]
		+	[[Category: Mucin degradation]]
		+	[[Category: T-antigen]]

OCA: Protected "5a59" [edit=sysop:move=sysop]

OCA — Wed, 24 Jun 2015 11:19:05 GMT

Protected "5a59" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:19, 24 June 2015

OCA: New page: '''Unreleased structure''' The entry 5a59 is ON HOLD Authors: Gregg, K.J., Suits, M.D.L., Deng, L., Vocadlo, D.J., Boraston, A.B. Description: The structure of GH101 E796Q mutant from ...

OCA — Wed, 24 Jun 2015 11:19:03 GMT

New page: '''Unreleased structure''' The entry 5a59 is ON HOLD Authors: Gregg, K.J., Suits, M.D.L., Deng, L., Vocadlo, D.J., Boraston, A.B. Description: The structure of GH101 E796Q mutant from ...

New page

'''Unreleased structure'''

The entry 5a59 is ON HOLD

Authors: Gregg, K.J., Suits, M.D.L., Deng, L., Vocadlo, D.J., Boraston, A.B.

Description: The structure of GH101 E796Q mutant from Streptococcus pneumoniae TIGR4 in complex with T-antigen
[[Category: Unreleased Structures]]
[[Category: Suits, M.D.L]]
[[Category: Gregg, K.J]]
[[Category: Boraston, A.B]]
[[Category: Deng, L]]
[[Category: Vocadlo, D.J]]