5a93 - Revision history

OCA at 11:05, 10 January 2024

OCA — Wed, 10 Jan 2024 11:05:58 GMT

←Older revision		Revision as of 11:05, 10 January 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5a93]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A93 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5a93]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A93 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CEF:CEFOTAXIME,+C3+CLEAVED,+OPEN,+BOUND+FORM'>CEF</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Hybrid , Neutron Diffraction , X-ray diffraction, [[Resolution\|Resolution]] 1.598Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CEF:CEFOTAXIME,+C3+CLEAVED,+OPEN,+BOUND+FORM'>CEF</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a93 OCA], [https://pdbe.org/5a93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a93 RCSB], [https://www.ebi.ac.uk/pdbsum/5a93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a93 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a93 OCA], [https://pdbe.org/5a93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a93 RCSB], [https://www.ebi.ac.uk/pdbsum/5a93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a93 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 04:46, 25 May 2023

OCA — Thu, 25 May 2023 04:46:07 GMT

←Older revision		Revision as of 04:46, 25 May 2023
Line 3:		Line 3:
	<StructureSection load='5a93' size='340' side='right'caption='[[5a93]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='5a93' size='340' side='right'caption='[[5a93]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5a93]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A93 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5A93 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5a93]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A93 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CEF:CEFOTAXIME,+C3+CLEAVED,+OPEN,+BOUND+FORM'>CEF</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CEF:CEFOTAXIME,+C3+CLEAVED,+OPEN,+BOUND+FORM'>CEF</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a90\|5a90]], [[5a91\|5a91]], [[5a92\|5a92]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a93 OCA], [https://pdbe.org/5a93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a93 RCSB], [https://www.ebi.ac.uk/pdbsum/5a93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a93 ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5a93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a93 OCA], [~~http~~://pdbe.org/5a93 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5a93 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5a93 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5a93 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/BLC97_ECOLX BLC97_ECOLX]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895]]~~	+	[[Category: Escherichia coli]]
-	~~[[Category: Beta-lactamase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Coates, L]]	+	[[Category: Coates L]]
-	[[Category: Cooper~~, J B~~]]	+	[[Category: Cooper JB]]
-	[[Category: Erskine~~, P T~~]]	+	[[Category: Erskine PT]]
-	[[Category: Ginell~~, S L~~]]	+	[[Category: Ginell SL]]
-	[[Category: Ostermann, A]]	+	[[Category: Ostermann A]]
-	[[Category: Schrader~~, T E~~]]	+	[[Category: Schrader TE]]
-	[[Category: Tomanicek~~, S J~~]]	+	[[Category: Tomanicek SJ]]
-	[[Category: Vandavasi~~, V G~~]]	+	[[Category: Vandavasi VG]]
-	[[Category: Weiss~~, K L]]~~	+	[[Category: Weiss KL]]
-	~~[[Category: Beta lactamase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Joint neutron x-ray~~]]	+

OCA at 07:06, 19 August 2020

OCA — Wed, 19 Aug 2020 07:06:09 GMT

←Older revision		Revision as of 07:06, 19 August 2020
Line 1:		Line 1:

	==293K Joint X-ray Neutron with Cefotaxime: EXPLORING THE MECHANISM OF BETA-LACTAM RING PROTONATION IN THE CLASS A BETA-LACTAMASE ACYLATION MECHANISM USING NEUTRON AND X-RAY CRYSTALLOGRAPHY==		==293K Joint X-ray Neutron with Cefotaxime: EXPLORING THE MECHANISM OF BETA-LACTAM RING PROTONATION IN THE CLASS A BETA-LACTAMASE ACYLATION MECHANISM USING NEUTRON AND X-RAY CRYSTALLOGRAPHY==
-	<StructureSection load='5a93' size='340' side='right' caption='[[5a93]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='5a93' size='340' side='right'caption='[[5a93]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5a93]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A93 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5A93 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5a93]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A93 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5A93 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CEF:CEFOTAXIME,+C3+CLEAVED,+OPEN,+BOUND+FORM'>CEF</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CEF:CEFOTAXIME,+C3+CLEAVED,+OPEN,+BOUND+FORM'>CEF</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a90\|5a90]], [[5a91\|5a91]], [[5a92\|5a92]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a90\|5a90]], [[5a91\|5a91]], [[5a92\|5a92]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5a93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a93 OCA], [http://pdbe.org/5a93 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a93 RCSB], [http://www.ebi.ac.uk/pdbsum/5a93 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a93 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5a93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a93 OCA], [http://pdbe.org/5a93 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a93 RCSB], [http://www.ebi.ac.uk/pdbsum/5a93 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a93 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Beta-lactamase\|Beta-lactamase]]	+	*[[Beta-lactamase 3D structures\|Beta-lactamase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
		+	[[Category: Large Structures]]
	[[Category: Coates, L]]		[[Category: Coates, L]]
	[[Category: Cooper, J B]]		[[Category: Cooper, J B]]

OCA at 08:20, 3 October 2018

OCA — Wed, 03 Oct 2018 08:20:47 GMT

←Older revision		Revision as of 08:20, 3 October 2018
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5a93]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A93 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5a93]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A93 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~PCZ~~:~~(2R)-2-[(1R)-1-{[(2Z)-2-(2-AMINO-1~~,~~3-THIAZOL-4-YL)-2-(METHOXYIMINO)ACETYL]AMINO}-2-OXOETHYL]-5-METHYLIDENE-5~~,~~6-DIHYDRO-2H-1~~,~~3-THIAZINE-4-CARBOXYLIC~~+~~ACID~~'>~~PCZ~~</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CEF:CEFOTAXIME,+C3+CLEAVED,+OPEN,+BOUND+FORM'>CEF</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a90\|5a90]], [[5a91\|5a91]], [[5a92\|5a92]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a90\|5a90]], [[5a91\|5a91]], [[5a92\|5a92]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>

OCA at 06:08, 6 June 2018

OCA — Wed, 06 Jun 2018 06:08:56 GMT

←Older revision		Revision as of 06:08, 6 June 2018
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 5a93" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5a93" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-lactamase\|Beta-lactamase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:53, 15 February 2018

OCA — Thu, 15 Feb 2018 06:53:12 GMT

←Older revision		Revision as of 06:53, 15 February 2018
Line 3:		Line 3:
	<StructureSection load='5a93' size='340' side='right' caption='[[5a93]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='5a93' size='340' side='right' caption='[[5a93]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5a93]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A93 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5a93]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A93 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCZ:(2R)-2-[(1R)-1-{[(2Z)-2-(2-AMINO-1,3-THIAZOL-4-YL)-2-(METHOXYIMINO)ACETYL]AMINO}-2-OXOETHYL]-5-METHYLIDENE-5,6-DIHYDRO-2H-1,3-THIAZINE-4-CARBOXYLIC+ACID'>PCZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCZ:(2R)-2-[(1R)-1-{[(2Z)-2-(2-AMINO-1,3-THIAZOL-4-YL)-2-(METHOXYIMINO)ACETYL]AMINO}-2-OXOETHYL]-5-METHYLIDENE-5,6-DIHYDRO-2H-1,3-THIAZINE-4-CARBOXYLIC+ACID'>PCZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a90\|5a90]], [[5a91\|5a91]], [[5a92\|5a92]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a90\|5a90]], [[5a91\|5a91]], [[5a92\|5a92]]</td></tr>
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus coli migula 1895]]
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
	[[Category: Coates, L]]		[[Category: Coates, L]]

OCA at 16:12, 25 January 2017

OCA — Wed, 25 Jan 2017 16:12:33 GMT

←Older revision		Revision as of 16:12, 25 January 2017
Line 1:		Line 1:
		+
	==293K Joint X-ray Neutron with Cefotaxime: EXPLORING THE MECHANISM OF BETA-LACTAM RING PROTONATION IN THE CLASS A BETA-LACTAMASE ACYLATION MECHANISM USING NEUTRON AND X-RAY CRYSTALLOGRAPHY==		==293K Joint X-ray Neutron with Cefotaxime: EXPLORING THE MECHANISM OF BETA-LACTAM RING PROTONATION IN THE CLASS A BETA-LACTAMASE ACYLATION MECHANISM USING NEUTRON AND X-RAY CRYSTALLOGRAPHY==
	<StructureSection load='5a93' size='340' side='right' caption='[[5a93]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='5a93' size='340' side='right' caption='[[5a93]], [[Resolution\|resolution]] 1.60Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a90\|5a90]], [[5a91\|5a91]], [[5a92\|5a92]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a90\|5a90]], [[5a91\|5a91]], [[5a92\|5a92]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a93 OCA], [http://pdbe.org/5a93 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a93 RCSB], [http://www.ebi.ac.uk/pdbsum/5a93 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a93 OCA], [http://pdbe.org/5a93 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a93 RCSB], [http://www.ebi.ac.uk/pdbsum/5a93 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a93 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:46, 16 December 2015

OCA — Wed, 16 Dec 2015 13:46:50 GMT

←Older revision		Revision as of 13:46, 16 December 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==293K Joint X-ray Neutron with Cefotaxime: EXPLORING THE MECHANISM OF BETA-LACTAM RING PROTONATION IN THE CLASS A BETA-LACTAMASE ACYLATION MECHANISM USING NEUTRON AND X-RAY CRYSTALLOGRAPHY==
		+	<StructureSection load='5a93' size='340' side='right' caption='[[5a93]], [[Resolution\|resolution]] 1.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5a93]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A93 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCZ:(2R)-2-[(1R)-1-{[(2Z)-2-(2-AMINO-1,3-THIAZOL-4-YL)-2-(METHOXYIMINO)ACETYL]AMINO}-2-OXOETHYL]-5-METHYLIDENE-5,6-DIHYDRO-2H-1,3-THIAZINE-4-CARBOXYLIC+ACID'>PCZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a90\|5a90]], [[5a91\|5a91]], [[5a92\|5a92]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a93 OCA], [http://pdbe.org/5a93 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a93 RCSB], [http://www.ebi.ac.uk/pdbsum/5a93 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The catalytic mechanism of class A beta-lactamases is often debated due in part to the large number of amino acids that interact with bound beta-lactam substrates. The role and function of the conserved residue Lys 73 in the catalytic mechanism of class A type beta-lactamase enzymes is still not well understood after decades of scientific research. To better elucidate the functions of this vital residue, we used both neutron and high-resolution X-ray diffraction to examine both the structures of the ligand free protein and the acyl-enzyme complex of perdeuterated E166A Toho-1 beta-lactamase with the antibiotic cefotaxime. The E166A mutant lacks a critical glutamate residue that has a key role in the deacylation step of the catalytic mechanism, allowing the acyl-enzyme adduct to be captured for study. In our ligand free structures, Lys 73 is present in a single conformation, however in all of our acyl-enzyme structures, Lys 73 is present in two different conformations, in which one conformer is closer to Ser 70 while the other conformer is positioned closer to Ser 130, which supports the existence of a possible pathway by which proton transfer from Lys 73 to Ser 130 can occur. This and further clarifications of the role of Lys 73 in the acylation mechanism may facilitate the design of inhibitors that capitalize on the enzyme's native machinery.

-	~~The entry 5a93 is ON HOLD~~	+	Exploring the Mechanism of beta-Lactam Ring Protonation in the Class A beta-lactamase Acylation Mechanism Using Neutron and X-ray Crystallography.,Vandavasi VG, Weiss KL, Cooper JB, Erskine PT, Tomanicek SJ, Ostermann A, Schrader TE, Ginell SL, Coates L J Med Chem. 2015 Dec 2. PMID:26630115<ref>PMID:26630115</ref>

-	~~Authors: VANDAVASI~~, V.~~G., WEISS, K.L., COOPER, J.B., ERSKINE, P.T., TOMANICEK,~~ S.~~J., OSTERMANN, A., SCHRADER, T.E., GINELL, S.L., COATES, L~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: 293K Joint X~~-~~ray Neutron with Cefotaxime: EXPLORING THE MECHANISM OF BETA~~-~~LACTAM RING PROTONATION IN THE CLASS A BETA-LACTAMASE ACYLATION MECHANISM USING NEUTRON AND X-RAY CRYSTALLOGRAPHY~~	+	<div class="pdbe-citations 5a93" style="background-color:#fffaf0;"></div>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	== References ==
-	~~[[Category: Vandavasi, V.G]]~~	+	<references/>
-	~~[[Category: Weiss, K.L]]~~	+	__TOC__
-	~~[[Category: Schrader, T.E]]~~	+	</StructureSection>
-	~~[[Category: Ginell, S.L]]~~	+	[[Category: Beta-lactamase]]
-	[[Category: ~~Erskine, P.T~~]]	+
	[[Category: Coates, L]]		[[Category: Coates, L]]
		+	[[Category: Cooper, J B]]
		+	[[Category: Erskine, P T]]
		+	[[Category: Ginell, S L]]
	[[Category: Ostermann, A]]		[[Category: Ostermann, A]]
-	[[Category: ~~Cooper~~, ~~J.B~~]]	+	[[Category: Schrader, T E]]
-	[[Category: Tomanicek, S.J]]	+	[[Category: Tomanicek, S J]]
		+	[[Category: Vandavasi, V G]]
		+	[[Category: Weiss, K L]]
		+	[[Category: Beta lactamase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Joint neutron x-ray]]

OCA at 12:15, 2 December 2015

OCA — Wed, 02 Dec 2015 12:15:45 GMT

←Older revision		Revision as of 12:15, 2 December 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5a93 is ON HOLD ~~until sometime in the future~~	+	The entry 5a93 is ON HOLD

	Authors: VANDAVASI, V.G., WEISS, K.L., COOPER, J.B., ERSKINE, P.T., TOMANICEK, S.J., OSTERMANN, A., SCHRADER, T.E., GINELL, S.L., COATES, L.		Authors: VANDAVASI, V.G., WEISS, K.L., COOPER, J.B., ERSKINE, P.T., TOMANICEK, S.J., OSTERMANN, A., SCHRADER, T.E., GINELL, S.L., COATES, L.

OCA at 00:24, 1 December 2015

OCA — Tue, 01 Dec 2015 00:24:20 GMT

←Older revision		Revision as of 00:24, 1 December 2015
Line 7:		Line 7:
	Description: 293K Joint X-ray Neutron with Cefotaxime: EXPLORING THE MECHANISM OF BETA-LACTAM RING PROTONATION IN THE CLASS A BETA-LACTAMASE ACYLATION MECHANISM USING NEUTRON AND X-RAY CRYSTALLOGRAPHY		Description: 293K Joint X-ray Neutron with Cefotaxime: EXPLORING THE MECHANISM OF BETA-LACTAM RING PROTONATION IN THE CLASS A BETA-LACTAMASE ACYLATION MECHANISM USING NEUTRON AND X-RAY CRYSTALLOGRAPHY
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Vandavasi, V.G]]
		+	[[Category: Weiss, K.L]]
	[[Category: Schrader, T.E]]		[[Category: Schrader, T.E]]
		+	[[Category: Ginell, S.L]]
	[[Category: Erskine, P.T]]		[[Category: Erskine, P.T]]
	[[Category: Coates, L]]		[[Category: Coates, L]]
	[[Category: Ostermann, A]]		[[Category: Ostermann, A]]
	[[Category: Cooper, J.B]]		[[Category: Cooper, J.B]]
-	[[Category: Vandavasi, V.G]]
-	[[Category: Weiss, K.L]]
-	[[Category: Ginell, S.L]]
	[[Category: Tomanicek, S.J]]		[[Category: Tomanicek, S.J]]