5abj - Revision history

OCA at 11:39, 9 May 2024

OCA — Thu, 09 May 2024 11:39:15 GMT

←Older revision		Revision as of 11:39, 9 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5abj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Coxsackievirus_A16 Coxsackievirus A16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ABJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ABJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[5abj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Coxsackievirus_A16 Coxsackievirus A16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ABJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ABJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=YM2:1-[(3S)-5-[4-[(E)-ETHOXYIMINOMETHYL]PHENOXY]-3-METHYL-PENTYL]-3-PYRIDIN-4-YL-IMIDAZOLIDIN-2-ONE'>YM2</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.75Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=YM2:1-[(3S)-5-[4-[(E)-ETHOXYIMINOMETHYL]PHENOXY]-3-METHYL-PENTYL]-3-PYRIDIN-4-YL-IMIDAZOLIDIN-2-ONE'>YM2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5abj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5abj OCA], [https://pdbe.org/5abj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5abj RCSB], [https://www.ebi.ac.uk/pdbsum/5abj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5abj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5abj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5abj OCA], [https://pdbe.org/5abj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5abj RCSB], [https://www.ebi.ac.uk/pdbsum/5abj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5abj ProSAT]</span></td></tr>
	</table>		</table>

OCA at 04:49, 25 May 2023

OCA — Thu, 25 May 2023 04:49:51 GMT

←Older revision		Revision as of 04:49, 25 May 2023
Line 3:		Line 3:
	<StructureSection load='5abj' size='340' side='right'caption='[[5abj]], [[Resolution\|resolution]] 2.75Å' scene=''>		<StructureSection load='5abj' size='340' side='right'caption='[[5abj]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5abj]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Cv-a16 Cv-a16~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ABJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ABJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5abj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Coxsackievirus_A16 Coxsackievirus A16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ABJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ABJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=YM2:1-[(3S)-5-[4-[(E)-ETHOXYIMINOMETHYL]PHENOXY]-3-METHYL-PENTYL]-3-PYRIDIN-4-YL-IMIDAZOLIDIN-2-ONE'>YM2</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=YM2:1-[(3S)-5-[4-[(E)-ETHOXYIMINOMETHYL]PHENOXY]-3-METHYL-PENTYL]-3-PYRIDIN-4-YL-IMIDAZOLIDIN-2-ONE'>YM2</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5abj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5abj OCA], [~~http~~://pdbe.org/5abj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5abj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5abj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5abj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5abj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5abj OCA], [https://pdbe.org/5abj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5abj RCSB], [https://www.ebi.ac.uk/pdbsum/5abj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5abj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/I3W9E1_9ENTO I3W9E1_9ENTO]] Protein 2C associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).[SAAS:SAAS000199_004_016611] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266] RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047]	+	[https://www.uniprot.org/uniprot/I3W9E1_9ENTO I3W9E1_9ENTO] Protein 2C associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).[SAAS:SAAS000199_004_016611] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266] RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 5abj" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5abj" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cv-a16~~]]	+	[[Category: Coxsackievirus A16]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Colibus, L De]]	+	[[Category: De Colibus L]]
-	[[Category: Fry~~, E E~~]]	+	[[Category: Fry EE]]
-	[[Category: Grimes~~, J M~~]]	+	[[Category: Grimes JM]]
-	[[Category: Leyssen, P]]	+	[[Category: Leyssen P]]
-	[[Category: Neyts, J]]	+	[[Category: Neyts J]]
-	[[Category: Puerstinger, G]]	+	[[Category: Puerstinger G]]
-	[[Category: Rao, Z]]	+	[[Category: Rao Z]]
-	[[Category: Ren, J]]	+	[[Category: Ren J]]
-	[[Category: Spyrou~~, J A.B~~]]	+	[[Category: Spyrou JAB]]
-	[[Category: Stuart~~, D I~~]]	+	[[Category: Stuart DI]]
-	[[Category: Tijsma, A]]	+	[[Category: Tijsma A]]
-	[[Category: Wang, X]]	+	[[Category: Wang X]]
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Virus~~]]	+

OCA at 07:51, 3 July 2019

OCA — Wed, 03 Jul 2019 07:51:56 GMT

←Older revision		Revision as of 07:51, 3 July 2019
Line 1:		Line 1:
		+
	==Structure of Coxsackievirus A16 in complex with GPP3==		==Structure of Coxsackievirus A16 in complex with GPP3==
-	<StructureSection load='5abj' size='340' side='right' caption='[[5abj]], [[Resolution\|resolution]] 2.75Å' scene=''>	+	<StructureSection load='5abj' size='340' side='right'caption='[[5abj]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5abj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Coxsackievirus_a16 Coxsackievirus~~ a16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ABJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ABJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5abj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cv-a16 Cv-a16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ABJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ABJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=YM2:1-[(3S)-5-[4-[(E)-ETHOXYIMINOMETHYL]PHENOXY]-3-METHYL-PENTYL]-3-PYRIDIN-4-YL-IMIDAZOLIDIN-2-ONE'>YM2</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=YM2:1-[(3S)-5-[4-[(E)-ETHOXYIMINOMETHYL]PHENOXY]-3-METHYL-PENTYL]-3-PYRIDIN-4-YL-IMIDAZOLIDIN-2-ONE'>YM2</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5abj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5abj OCA], [http://pdbe.org/5abj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5abj RCSB], [http://www.ebi.ac.uk/pdbsum/5abj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5abj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5abj OCA], [http://pdbe.org/5abj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5abj RCSB], [http://www.ebi.ac.uk/pdbsum/5abj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5abj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Coxsackievirus~~ a16]]	+	[[Category: Cv-a16]]
		+	[[Category: Large Structures]]
	[[Category: Colibus, L De]]		[[Category: Colibus, L De]]
	[[Category: Fry, E E]]		[[Category: Fry, E E]]

OCA at 21:40, 30 November 2015

OCA — Mon, 30 Nov 2015 21:40:35 GMT

←Older revision		Revision as of 21:40, 30 November 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[5abj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Coxsackievirus_a16 Coxsackievirus a16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ABJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ABJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[5abj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Coxsackievirus_a16 Coxsackievirus a16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ABJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ABJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=YM2:1-[(3S)-5-[4-[(E)-ETHOXYIMINOMETHYL]PHENOXY]-3-METHYL-PENTYL]-3-PYRIDIN-4-YL-IMIDAZOLIDIN-2-ONE'>YM2</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=YM2:1-[(3S)-5-[4-[(E)-ETHOXYIMINOMETHYL]PHENOXY]-3-METHYL-PENTYL]-3-PYRIDIN-4-YL-IMIDAZOLIDIN-2-ONE'>YM2</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5abj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5abj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5abj RCSB], [http://www.ebi.ac.uk/pdbsum/5abj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5abj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5abj OCA], [http://pdbe.org/5abj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5abj RCSB], [http://www.ebi.ac.uk/pdbsum/5abj PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/I3W9E1_9ENTO I3W9E1_9ENTO]] Protein 2C associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).[SAAS:SAAS000199_004_016611] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266] RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047]		[[http://www.uniprot.org/uniprot/I3W9E1_9ENTO I3W9E1_9ENTO]] Protein 2C associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).[SAAS:SAAS000199_004_016611] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266] RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The replication of enterovirus 71 (EV71) and coxsackievirus A16 (CVA16), which are the major cause of hand, foot and mouth disease (HFMD) in children, can be inhibited by the capsid binder GPP3. Here, we present the crystal structure of CVA16 in complex with GPP3, which clarifies the role of the key residues involved in interactions with the inhibitor. Based on this model, in silico docking was performed to investigate the interactions with the two next-generation capsid binders NLD and ALD, which we show to be potent inhibitors of a panel of enteroviruses with potentially interesting pharmacological properties. A meta-analysis was performed using the available structural information to obtain a deeper insight into those structural features required for capsid binders to interact effectively and also those that confer broad-spectrum anti-enterovirus activity.
		+
		+	Structure Elucidation of Coxsackievirus A16 in Complex with GPP3 Informs a Systematic Review of Highly Potent Capsid Binders to Enteroviruses.,De Colibus L, Wang X, Tijsma A, Neyts J, Spyrou JA, Ren J, Grimes JM, Puerstinger G, Leyssen P, Fry EE, Rao Z, Stuart DI PLoS Pathog. 2015 Oct 20;11(10):e1005165. doi: 10.1371/journal.ppat.1005165., eCollection 2015 Oct. PMID:26485389<ref>PMID:26485389</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5abj" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:22, 9 September 2015

OCA — Wed, 09 Sep 2015 11:22:31 GMT

←Older revision		Revision as of 11:22, 9 September 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Structure of Coxsackievirus A16 in complex with GPP3==
-		+	<StructureSection load='5abj' size='340' side='right' caption='[[5abj]], [[Resolution\|resolution]] 2.75Å' scene=''>
-	~~The entry~~ 5abj is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5abj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Coxsackievirus_a16 Coxsackievirus a16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ABJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ABJ FirstGlance]. <br>
-	~~Authors~~: ~~De Colibus, L~~.~~, Wang, X~~.~~, Tijsma, A~~.~~, Neyts, J~~.~~, Spyrou, J~~.A.B.~~, Ren, J~~.~~, Grimes, J~~.M.~~, Puerstinger, G~~.~~, Leyssen, P~~., ~~Fry~~, E.E., ~~Rao~~, Z., ~~Stuart, D~~.I.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=YM2:1-[(3S)-5-[4-[(E)-ETHOXYIMINOMETHYL]PHENOXY]-3-METHYL-PENTYL]-3-PYRIDIN-4-YL-IMIDAZOLIDIN-2-ONE'>YM2</scene></td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5abj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5abj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5abj RCSB], [http://www.ebi.ac.uk/pdbsum/5abj PDBsum]</span></td></tr>
-	~~Description: Structure of Coxsackievirus A16 in complex with GPP3~~	+	</table>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	== Function ==
-	[~~[Category~~: ~~Spyrou~~, J.A.B]]	+	[[http://www.uniprot.org/uniprot/I3W9E1_9ENTO I3W9E1_9ENTO]] Protein 2C associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).[SAAS:SAAS000199_004_016611] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266] RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047]
-	[[~~Category~~: ~~Rao, Z]~~]	+	__TOC__
-	[[Category: ~~Tijsma, A~~]]	+	</StructureSection>
-	[[Category: De Colibus, L]]	+	[[Category: Coxsackievirus a16]]
-	[[Category: Fry, E.E]]	+	[[Category: Colibus, L De]]
-	[[Category: ~~Wang~~, X]]	+	[[Category: Fry, E E]]
		+	[[Category: Grimes, J M]]
	[[Category: Leyssen, P]]		[[Category: Leyssen, P]]
-	[[Category: Grimes, J.M]]
-	[[Category: Ren, J]]
	[[Category: Neyts, J]]		[[Category: Neyts, J]]
	[[Category: Puerstinger, G]]		[[Category: Puerstinger, G]]
-	[[Category: Stuart, D.I]]	+	[[Category: Rao, Z]]
		+	[[Category: Ren, J]]
		+	[[Category: Spyrou, J A.B]]
		+	[[Category: Stuart, D I]]
		+	[[Category: Tijsma, A]]
		+	[[Category: Wang, X]]
		+	[[Category: Inhibitor]]
		+	[[Category: Virus]]

OCA at 09:52, 20 August 2015

OCA — Thu, 20 Aug 2015 09:52:36 GMT

←Older revision		Revision as of 09:52, 20 August 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5abj is ON HOLD	+	The entry 5abj is ON HOLD until Paper Publication

	Authors: De Colibus, L., Wang, X., Tijsma, A., Neyts, J., Spyrou, J.A.B., Ren, J., Grimes, J.M., Puerstinger, G., Leyssen, P., Fry, E.E., Rao, Z., Stuart, D.I.		Authors: De Colibus, L., Wang, X., Tijsma, A., Neyts, J., Spyrou, J.A.B., Ren, J., Grimes, J.M., Puerstinger, G., Leyssen, P., Fry, E.E., Rao, Z., Stuart, D.I.

OCA: Protected "5abj" [edit=sysop:move=sysop]

OCA — Wed, 12 Aug 2015 12:15:04 GMT

Protected "5abj" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:15, 12 August 2015

OCA: New page: '''Unreleased structure''' The entry 5abj is ON HOLD Authors: De Colibus, L., Wang, X., Tijsma, A., Neyts, J., Spyrou, J.A.B., Ren, J., Grimes, J.M., Puerstinger, G., Leyssen, P., Fry, ...

OCA — Wed, 12 Aug 2015 12:15:03 GMT

New page: '''Unreleased structure''' The entry 5abj is ON HOLD Authors: De Colibus, L., Wang, X., Tijsma, A., Neyts, J., Spyrou, J.A.B., Ren, J., Grimes, J.M., Puerstinger, G., Leyssen, P., Fry, ...

New page

'''Unreleased structure'''

The entry 5abj is ON HOLD

Authors: De Colibus, L., Wang, X., Tijsma, A., Neyts, J., Spyrou, J.A.B., Ren, J., Grimes, J.M., Puerstinger, G., Leyssen, P., Fry, E.E., Rao, Z., Stuart, D.I.

Description: Structure of Coxsackievirus A16 in complex with GPP3
[[Category: Unreleased Structures]]
[[Category: Spyrou, J.A.B]]
[[Category: Rao, Z]]
[[Category: Tijsma, A]]
[[Category: De Colibus, L]]
[[Category: Fry, E.E]]
[[Category: Wang, X]]
[[Category: Leyssen, P]]
[[Category: Grimes, J.M]]
[[Category: Ren, J]]
[[Category: Neyts, J]]
[[Category: Puerstinger, G]]
[[Category: Stuart, D.I]]