5ad3 - Revision history

OCA at 11:07, 10 January 2024

OCA — Wed, 10 Jan 2024 11:07:43 GMT

←Older revision		Revision as of 11:07, 10 January 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5ad3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AD3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AD3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5ad3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AD3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AD3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K6K:3-METHOXY-N-[2-[4-[1-(3-METHOXY-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)-4-PIPERIDYL]PHENOXY]ETHYL]-N-METHYL-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-AMINE'>K6K</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.49Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K6K:3-METHOXY-N-[2-[4-[1-(3-METHOXY-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)-4-PIPERIDYL]PHENOXY]ETHYL]-N-METHYL-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-AMINE'>K6K</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ad3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ad3 OCA], [https://pdbe.org/5ad3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ad3 RCSB], [https://www.ebi.ac.uk/pdbsum/5ad3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ad3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ad3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ad3 OCA], [https://pdbe.org/5ad3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ad3 RCSB], [https://www.ebi.ac.uk/pdbsum/5ad3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ad3 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 04:51, 25 May 2023

OCA — Thu, 25 May 2023 04:51:57 GMT

←Older revision		Revision as of 04:51, 25 May 2023
Line 3:		Line 3:
	<StructureSection load='5ad3' size='340' side='right'caption='[[5ad3]], [[Resolution\|resolution]] 1.49Å' scene=''>		<StructureSection load='5ad3' size='340' side='right'caption='[[5ad3]], [[Resolution\|resolution]] 1.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ad3]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AD3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5AD3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ad3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AD3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AD3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K6K:3-METHOXY-N-[2-[4-[1-(3-METHOXY-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)-4-PIPERIDYL]PHENOXY]ETHYL]-N-METHYL-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-AMINE'>K6K</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K6K:3-METHOXY-N-[2-[4-[1-(3-METHOXY-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)-4-PIPERIDYL]PHENOXY]ETHYL]-N-METHYL-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-AMINE'>K6K</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ad2\|5ad2]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ad3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ad3 OCA], [https://pdbe.org/5ad3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ad3 RCSB], [https://www.ebi.ac.uk/pdbsum/5ad3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ad3 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ad3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ad3 OCA], [~~http~~://pdbe.org/5ad3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ad3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ad3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ad3 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>	+	[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).	+	[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bobby, R]]	+	[[Category: Bobby R]]
-	[[Category: Boiko, S]]	+	[[Category: Boiko S]]
-	[[Category: Bradbury~~, R H~~]]	+	[[Category: Bradbury RH]]
-	[[Category: Callis, R]]	+	[[Category: Callis R]]
-	[[Category: Chen, H]]	+	[[Category: Chen H]]
-	[[Category: Dale, I]]	+	[[Category: Dale I]]
-	[[Category: Daniels, D]]	+	[[Category: Daniels D]]
-	[[Category: Flavell, L]]	+	[[Category: Flavell L]]
-	[[Category: Holdgate, G]]	+	[[Category: Holdgate G]]
-	[[Category: Jowitt~~, T A~~]]	+	[[Category: Jowitt TA]]
-	[[Category: Kikhney, A]]	+	[[Category: Kikhney A]]
-	[[Category: McAlister, M]]	+	[[Category: McAlister M]]
-	[[Category: Ogg, D]]	+	[[Category: Ogg D]]
-	[[Category: Patel, J]]	+	[[Category: Patel J]]
-	[[Category: Petteruti, P]]	+	[[Category: Petteruti P]]
-	[[Category: Rabow~~, A A~~]]	+	[[Category: Rabow AA]]
-	[[Category: Robb~~, G R~~]]	+	[[Category: Robb GR]]
-	[[Category: Robers, M]]	+	[[Category: Robers M]]
-	[[Category: Stratton, N]]	+	[[Category: Stratton N]]
-	[[Category: Svergun~~, D I~~]]	+	[[Category: Svergun DI]]
-	[[Category: Walker, G]]	+	[[Category: Walker G]]
-	[[Category: Wang, W]]	+	[[Category: Wang W]]
-	[[Category: Waring~~, M J~~]]	+	[[Category: Waring MJ]]
-	[[Category: Whittaker, D]]	+	[[Category: Whittaker D]]
-	~~[[Category: Transcription~~]]	+

OCA at 07:22, 3 July 2019

OCA — Wed, 03 Jul 2019 07:22:17 GMT

←Older revision		Revision as of 07:22, 3 July 2019
Line 1:		Line 1:

	==Bivalent binding to BET bromodomains==		==Bivalent binding to BET bromodomains==
-	<StructureSection load='5ad3' size='340' side='right' caption='[[5ad3]], [[Resolution\|resolution]] 1.49Å' scene=''>	+	<StructureSection load='5ad3' size='340' side='right'caption='[[5ad3]], [[Resolution\|resolution]] 1.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ad3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AD3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AD3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ad3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AD3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AD3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K6K:3-METHOXY-N-[2-[4-[1-(3-METHOXY-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)-4-PIPERIDYL]PHENOXY]ETHYL]-N-METHYL-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-AMINE'>K6K</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K6K:3-METHOXY-N-[2-[4-[1-(3-METHOXY-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)-4-PIPERIDYL]PHENOXY]ETHYL]-N-METHYL-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-AMINE'>K6K</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ad2\|5ad2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ad2\|5ad2]]</td></tr>
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 5ad3" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5ad3" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Bromodomain-containing protein 3D structures\|Bromodomain-containing protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bobby, R]]		[[Category: Bobby, R]]
	[[Category: Boiko, S]]		[[Category: Boiko, S]]

OCA at 20:03, 9 December 2016

OCA — Fri, 09 Dec 2016 20:03:40 GMT

←Older revision		Revision as of 20:03, 9 December 2016
Line 12:		Line 12:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).		[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Proteins of the bromodomain and extraterminal (BET) family, in particular bromodomain-containing protein 4 (BRD4), are of great interest as biological targets. BET proteins contain two separate bromodomains, and existing inhibitors bind to them monovalently. Here we describe the discovery and characterization of probe compound biBET, capable of engaging both bromodomains simultaneously in a bivalent, in cis binding mode. The evidence provided here was obtained in a variety of biophysical and cellular experiments. The bivalent binding results in very high cellular potency for BRD4 binding and pharmacological responses such as disruption of BRD4-mediator complex subunit 1 foci with an EC50 of 100 pM. These compounds will be of considerable utility as BET/BRD4 chemical probes. This work illustrates a novel concept in ligand design-simultaneous targeting of two separate domains with a drug-like small molecule-providing precedent for a potentially more effective paradigm for developing ligands for other multi-domain proteins.
		+
		+	Potent and selective bivalent inhibitors of BET bromodomains.,Waring MJ, Chen H, Rabow AA, Walker G, Bobby R, Boiko S, Bradbury RH, Callis R, Clark E, Dale I, Daniels DL, Dulak A, Flavell L, Holdgate G, Jowitt TA, Kikhney A, McAlister M, Mendez J, Ogg D, Patel J, Petteruti P, Robb GR, Robers MB, Saif S, Stratton N, Svergun DI, Wang W, Whittaker D, Wilson DM, Yao Y Nat Chem Biol. 2016 Dec;12(12):1097-1104. doi: 10.1038/nchembio.2210. Epub 2016, Oct 24. PMID:27775716<ref>PMID:27775716</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5ad3" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:00, 3 October 2016

OCA — Mon, 03 Oct 2016 17:00:31 GMT

←Older revision		Revision as of 17:00, 3 October 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5ad3 ~~is ON HOLD until Paper Publication~~	+	==Bivalent binding to BET bromodomains==
-		+	<StructureSection load='5ad3' size='340' side='right' caption='[[5ad3]], [[Resolution\|resolution]] 1.49Å' scene=''>
-	~~Authors~~: ~~Waring, M~~.J.~~, Chen, H~~.~~, Rabow, A~~.A.~~, Walker, G~~., ~~Bobby~~, R., ~~Boiko~~, S., ~~Bradbury~~, R.H.~~, Callis, R~~.~~, Dale, I~~., ~~Daniels, D~~.~~, Flavell, L~~., ~~Holdgate, G~~., ~~Jowitt, T~~.A.~~, Kikhney, A~~., ~~McAlister, M~~.~~, Ogg, D~~.~~, Patel, J~~., ~~Petteruti, P~~., ~~Robb~~, G.R., ~~Robers~~, M., ~~Stratton~~, N., ~~Svergun~~, D.I., ~~Wang~~, W., ~~Whittaker~~, D.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5ad3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AD3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AD3 FirstGlance]. <br>
-	~~Description~~: ~~Bivalent binding to BET bromodomains~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K6K:3-METHOXY-N-[2-[4-[1-(3-METHOXY-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)-4-PIPERIDYL]PHENOXY]ETHYL]-N-METHYL-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-AMINE'>K6K</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ad2\|5ad2]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ad3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ad3 OCA], [http://pdbe.org/5ad3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ad3 RCSB], [http://www.ebi.ac.uk/pdbsum/5ad3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ad3 ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bobby, R]]
		+	[[Category: Boiko, S]]
		+	[[Category: Bradbury, R H]]
		+	[[Category: Callis, R]]
		+	[[Category: Chen, H]]
		+	[[Category: Dale, I]]
		+	[[Category: Daniels, D]]
		+	[[Category: Flavell, L]]
		+	[[Category: Holdgate, G]]
		+	[[Category: Jowitt, T A]]
		+	[[Category: Kikhney, A]]
		+	[[Category: McAlister, M]]
	[[Category: Ogg, D]]		[[Category: Ogg, D]]
		+	[[Category: Patel, J]]
		+	[[Category: Petteruti, P]]
		+	[[Category: Rabow, A A]]
		+	[[Category: Robb, G R]]
		+	[[Category: Robers, M]]
		+	[[Category: Stratton, N]]
		+	[[Category: Svergun, D I]]
	[[Category: Walker, G]]		[[Category: Walker, G]]
	[[Category: Wang, W]]		[[Category: Wang, W]]
-	~~[[Category: Rabow, A.A]]~~	+	[[Category: Waring, M J]]
-	~~[[Category: Stratton, N]]~~	+
-	~~[[Category: Robers, M]]~~	+
-	~~[[Category: Petteruti, P]]~~	+
-	~~[[Category: Dale, I]]~~	+
-	~~[[Category: Chen, H]]~~	+
-	~~[[Category: Robb, G.R]]~~	+
-	~~[[Category: Jowitt, T.A]]~~	+
-	[[Category: Waring, M.J]]	+
-	~~[[Category: Callis, R~~]]	+
	[[Category: Whittaker, D]]		[[Category: Whittaker, D]]
-	[[Category: ~~Svergun, D.I]]~~	+	[[Category: Transcription]]
-	~~[[Category: Flavell, L]]~~	+
-	~~[[Category: Patel, J]]~~	+
-	~~[[Category: Mcalister, M]]~~	+
-	~~[[Category: Bobby, R]]~~	+
-	~~[[Category: Kikhney, A]]~~	+
-	~~[[Category: Holdgate, G]]~~	+
-	~~[[Category: Bradbury, R.H]]~~	+
-	~~[[Category: Boiko, S]]~~	+
-	~~[[Category: Daniels, D~~]]	+

OCA at 09:45, 16 December 2015

OCA — Wed, 16 Dec 2015 09:45:41 GMT

←Older revision		Revision as of 09:45, 16 December 2015
Line 7:		Line 7:
	Description: Bivalent binding to BET bromodomains		Description: Bivalent binding to BET bromodomains
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Walker, G]]
-	[[Category: Rabow, A.A]]
-	[[Category: Dale, I]]
-	[[Category: Robb, G.R]]
-	[[Category: Whittaker, D]]
-	[[Category: Svergun, D.I]]
-	[[Category: Flavell, L]]
-	[[Category: Patel, J]]
-	[[Category: Bobby, R]]
-	[[Category: Holdgate, G]]
-	[[Category: Daniels, D]]
	[[Category: Ogg, D]]		[[Category: Ogg, D]]
		+	[[Category: Walker, G]]
	[[Category: Wang, W]]		[[Category: Wang, W]]
		+	[[Category: Rabow, A.A]]
	[[Category: Stratton, N]]		[[Category: Stratton, N]]
	[[Category: Robers, M]]		[[Category: Robers, M]]
	[[Category: Petteruti, P]]		[[Category: Petteruti, P]]
		+	[[Category: Dale, I]]
	[[Category: Chen, H]]		[[Category: Chen, H]]
		+	[[Category: Robb, G.R]]
	[[Category: Jowitt, T.A]]		[[Category: Jowitt, T.A]]
	[[Category: Waring, M.J]]		[[Category: Waring, M.J]]
	[[Category: Callis, R]]		[[Category: Callis, R]]
		+	[[Category: Whittaker, D]]
		+	[[Category: Svergun, D.I]]
		+	[[Category: Flavell, L]]
		+	[[Category: Patel, J]]
	[[Category: Mcalister, M]]		[[Category: Mcalister, M]]
		+	[[Category: Bobby, R]]
	[[Category: Kikhney, A]]		[[Category: Kikhney, A]]
		+	[[Category: Holdgate, G]]
	[[Category: Bradbury, R.H]]		[[Category: Bradbury, R.H]]
	[[Category: Boiko, S]]		[[Category: Boiko, S]]
		+	[[Category: Daniels, D]]

OCA: Protected "5ad3" [edit=sysop:move=sysop]

OCA — Wed, 26 Aug 2015 10:58:50 GMT

Protected "5ad3" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:58, 26 August 2015

OCA: New page: '''Unreleased structure''' The entry 5ad3 is ON HOLD until Paper Publication Authors: Waring, M.J., Chen, H., Rabow, A.A., Walker, G., Bobby, R., Boiko, S., Bradbury, R.H., Callis, R., ...

OCA — Wed, 26 Aug 2015 10:58:49 GMT

New page: '''Unreleased structure''' The entry 5ad3 is ON HOLD until Paper Publication Authors: Waring, M.J., Chen, H., Rabow, A.A., Walker, G., Bobby, R., Boiko, S., Bradbury, R.H., Callis, R., ...

New page

'''Unreleased structure'''

The entry 5ad3 is ON HOLD until Paper Publication

Authors: Waring, M.J., Chen, H., Rabow, A.A., Walker, G., Bobby, R., Boiko, S., Bradbury, R.H., Callis, R., Dale, I., Daniels, D., Flavell, L., Holdgate, G., Jowitt, T.A., Kikhney, A., McAlister, M., Ogg, D., Patel, J., Petteruti, P., Robb, G.R., Robers, M., Stratton, N., Svergun, D.I., Wang, W., Whittaker, D.

Description: Bivalent binding to BET bromodomains
[[Category: Unreleased Structures]]
[[Category: Walker, G]]
[[Category: Rabow, A.A]]
[[Category: Dale, I]]
[[Category: Robb, G.R]]
[[Category: Whittaker, D]]
[[Category: Svergun, D.I]]
[[Category: Flavell, L]]
[[Category: Patel, J]]
[[Category: Bobby, R]]
[[Category: Holdgate, G]]
[[Category: Daniels, D]]
[[Category: Ogg, D]]
[[Category: Wang, W]]
[[Category: Stratton, N]]
[[Category: Robers, M]]
[[Category: Petteruti, P]]
[[Category: Chen, H]]
[[Category: Jowitt, T.A]]
[[Category: Waring, M.J]]
[[Category: Callis, R]]
[[Category: Mcalister, M]]
[[Category: Kikhney, A]]
[[Category: Bradbury, R.H]]
[[Category: Boiko, S]]