5aeo - Revision history

OCA at 11:08, 10 January 2024

OCA — Wed, 10 Jan 2024 11:08:22 GMT

←Older revision		Revision as of 11:08, 10 January 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5aeo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodococcus_hoagii_103S Rhodococcus hoagii 103S]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AEO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AEO FirstGlance]. <br>		<table><tr><td colspan='2'>[[5aeo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodococcus_hoagii_103S Rhodococcus hoagii 103S]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AEO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AEO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5aeo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aeo OCA], [https://pdbe.org/5aeo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5aeo RCSB], [https://www.ebi.ac.uk/pdbsum/5aeo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5aeo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5aeo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aeo OCA], [https://pdbe.org/5aeo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5aeo RCSB], [https://www.ebi.ac.uk/pdbsum/5aeo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5aeo ProSAT]</span></td></tr>
	</table>		</table>

OCA at 04:54, 25 May 2023

OCA — Thu, 25 May 2023 04:54:09 GMT

←Older revision		Revision as of 04:54, 25 May 2023
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	<StructureSection load='5aeo' size='340' side='right'caption='[[5aeo]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='5aeo' size='340' side='right'caption='[[5aeo]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5aeo]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Rhoh1 Rhoh1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AEO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5AEO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5aeo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodococcus_hoagii_103S Rhodococcus hoagii 103S]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AEO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AEO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5aeo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aeo OCA], [~~http~~://pdbe.org/5aeo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5aeo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5aeo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5aeo ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5aeo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aeo OCA], [https://pdbe.org/5aeo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5aeo RCSB], [https://www.ebi.ac.uk/pdbsum/5aeo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5aeo ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9EU62_RHOHA Q9EU62_RHOHA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Rhoh1~~]]	+	[[Category: Rhodococcus hoagii 103S]]
-	[[Category: Blagova~~, E V~~]]	+	[[Category: Blagova EV]]
-	[[Category: Dover~~, L G~~]]	+	[[Category: Dover LG]]
-	[[Category: Okoko, T]]	+	[[Category: Okoko T]]
-	[[Category: Whittingham~~, J L~~]]	+	[[Category: Whittingham JL]]
-	[[Category: Wilkinson~~, A J]]~~	+	[[Category: Wilkinson AJ]]
-	~~[[Category: Bacterial pathogen]]~~	+
-	~~[[Category: Beta barrel]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Intracellular pathogen]]~~	+
-	~~[[Category: Virulence protein~~]]	+

OCA at 07:52, 3 July 2019

OCA — Wed, 03 Jul 2019 07:52:14 GMT

←Older revision		Revision as of 07:52, 3 July 2019
Line 1:		Line 1:

	==Virulence-associated protein VapG from the intracellular pathogen Rhodococcus equi==		==Virulence-associated protein VapG from the intracellular pathogen Rhodococcus equi==
-	<StructureSection load='5aeo' size='340' side='right' caption='[[5aeo]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='5aeo' size='340' side='right'caption='[[5aeo]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5aeo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AEO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AEO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5aeo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhoh1 Rhoh1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AEO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AEO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aeo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aeo OCA], [http://pdbe.org/5aeo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aeo RCSB], [http://www.ebi.ac.uk/pdbsum/5aeo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5aeo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aeo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aeo OCA], [http://pdbe.org/5aeo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aeo RCSB], [http://www.ebi.ac.uk/pdbsum/5aeo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5aeo ProSAT]</span></td></tr>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Rhoh1]]
	[[Category: Blagova, E V]]		[[Category: Blagova, E V]]
	[[Category: Dover, L G]]		[[Category: Dover, L G]]

OCA at 13:21, 10 May 2017

OCA — Wed, 10 May 2017 13:21:56 GMT

←Older revision		Revision as of 13:21, 10 May 2017
Line 1:		Line 1:
		+
	==Virulence-associated protein VapG from the intracellular pathogen Rhodococcus equi==		==Virulence-associated protein VapG from the intracellular pathogen Rhodococcus equi==
	<StructureSection load='5aeo' size='340' side='right' caption='[[5aeo]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='5aeo' size='340' side='right' caption='[[5aeo]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[5aeo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AEO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AEO FirstGlance]. <br>		<table><tr><td colspan='2'>[[5aeo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AEO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AEO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aeo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aeo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5aeo RCSB], [http://www.ebi.ac.uk/pdbsum/5aeo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aeo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aeo OCA], [http://pdbe.org/5aeo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aeo RCSB], [http://www.ebi.ac.uk/pdbsum/5aeo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5aeo ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 5aeo" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:59, 26 March 2015

OCA — Thu, 26 Mar 2015 13:59:28 GMT

←Older revision		Revision as of 13:59, 26 March 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Virulence-associated protein VapG from the intracellular pathogen Rhodococcus equi==
		+	<StructureSection load='5aeo' size='340' side='right' caption='[[5aeo]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5aeo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AEO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AEO FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aeo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aeo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5aeo RCSB], [http://www.ebi.ac.uk/pdbsum/5aeo PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Virulence and host range in Rhodococcus equi depends on the variable pathogenicity island of their virulence plasmids. Notable gene products are a family of small secreted virulence-associated proteins (Vaps) that are critical to intramacrophagic proliferation. Equine-adapted strains, which cause severe pyogranulomatous pneumonia in foals, produce a cell-associated VapA that is necessary for virulence, alongside five other secreted homologues. In the absence of biochemical insight, attention has turned to the structures of these proteins to develop a functional hypothesis. Recent studies have described crystal structures for VapD and a truncate of the VapA orthologue of porcine-adapted strains, VapB. Here, we crystallised the full-length VapG and determined its structure by molecular replacement. Electron density corresponding to the N-terminal domain was not visible suggesting that it is disordered. The protein core adopted a compact elliptical, anti-parallel beta-barrel fold with beta1-beta2-beta3-beta8-beta5-beta6-beta7-beta4 topology decorated by a single peripheral alpha-helix unique to this family. The high glycine content of the protein allows close packing of secondary structural elements. Topologically, the surface has no indentations that indicate a nexus for molecular interactions. The distribution of polar and apolar groups on the surface of VapG is markedly uneven. One-third of the surface is dominated by exposed apolar side-chains, with no ionisable and only four polar side-chains exposed, giving rise to an expansive flat hydrophobic surface. Other surface regions are more polar, especially on or near the alpha-helix and a belt around the centre of the beta-barrel. Possible functional significance of these recent structures is discussed.

-	~~The entry 5aeo is ON HOLD until Paper Publication~~	+	Structural characterisation of the virulence-associated protein VapG from the horse pathogen Rhodococcus equi.,Okoko T, Blagova EV, Whittingham JL, Dover LG, Wilkinson AJ Vet Microbiol. 2015 Feb 9. pii: S0378-1135(15)00057-7. doi:, 10.1016/j.vetmic.2015.01.027. PMID:25746683<ref>PMID:25746683</ref>

-	~~Authors: Okoko~~, T.~~, Blagova, E~~.~~V., Whittingham, J.L., Dover, L.G., Wilkinson, A.J~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: Virulence-associated protein VapG from the intracellular pathogen Rhodococcus equi~~	+	== References ==
-	~~[[Category: Unreleased Structures]]~~	+	<references/>
-	~~[[Category: Whittingham, J.L]]~~	+	__TOC__
-	[[Category: ~~Wilkinson~~, ~~A.J~~]]	+	</StructureSection>
-	[[Category: ~~Blagova~~, ~~E.V~~]]	+	[[Category: Blagova, E V]]
		+	[[Category: Dover, L G]]
	[[Category: Okoko, T]]		[[Category: Okoko, T]]
-	[[Category: ~~Dover~~, L.G]]	+	[[Category: Whittingham, J L]]
		+	[[Category: Wilkinson, A J]]
		+	[[Category: Bacterial pathogen]]
		+	[[Category: Beta barrel]]
		+	[[Category: Immune system]]
		+	[[Category: Intracellular pathogen]]
		+	[[Category: Virulence protein]]

OCA at 15:50, 28 January 2015

OCA — Wed, 28 Jan 2015 15:50:37 GMT

←Older revision		Revision as of 15:50, 28 January 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5aeo is ON HOLD	+	The entry 5aeo is ON HOLD until Paper Publication

	Authors: Okoko, T., Blagova, E.V., Whittingham, J.L., Dover, L.G., Wilkinson, A.J.		Authors: Okoko, T., Blagova, E.V., Whittingham, J.L., Dover, L.G., Wilkinson, A.J.

OCA: Protected "5aeo" [edit=sysop:move=sysop]

OCA — Wed, 14 Jan 2015 12:49:24 GMT

Protected "5aeo" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:49, 14 January 2015

OCA: New page: '''Unreleased structure''' The entry 5aeo is ON HOLD Authors: Okoko, T., Blagova, E.V., Whittingham, J.L., Dover, L.G., Wilkinson, A.J. Description: Virulence-associated protein VapG f...

OCA — Wed, 14 Jan 2015 12:49:22 GMT

New page: '''Unreleased structure''' The entry 5aeo is ON HOLD Authors: Okoko, T., Blagova, E.V., Whittingham, J.L., Dover, L.G., Wilkinson, A.J. Description: Virulence-associated protein VapG f...

New page

'''Unreleased structure'''

The entry 5aeo is ON HOLD

Authors: Okoko, T., Blagova, E.V., Whittingham, J.L., Dover, L.G., Wilkinson, A.J.

Description: Virulence-associated protein VapG from the intracellular pathogen Rhodococcus equi
[[Category: Unreleased Structures]]
[[Category: Whittingham, J.L]]
[[Category: Wilkinson, A.J]]
[[Category: Blagova, E.V]]
[[Category: Okoko, T]]
[[Category: Dover, L.G]]