5agt - Revision history

OCA at 11:09, 10 January 2024

OCA — Wed, 10 Jan 2024 11:09:28 GMT

←Older revision		Revision as of 11:09, 10 January 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5agt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AGT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AGT FirstGlance]. <br>		<table><tr><td colspan='2'>[[5agt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AGT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AGT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2H:4-CHLORO-3-AMINOMETHYL-7-[ETHOXY]-3H-BENZO[C][1,2]OXABOROL-1-OL+MODIFIED+ADENOSINE'>A2H</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.45Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2H:4-CHLORO-3-AMINOMETHYL-7-[ETHOXY]-3H-BENZO[C][1,2]OXABOROL-1-OL+MODIFIED+ADENOSINE'>A2H</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5agt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5agt OCA], [https://pdbe.org/5agt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5agt RCSB], [https://www.ebi.ac.uk/pdbsum/5agt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5agt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5agt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5agt OCA], [https://pdbe.org/5agt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5agt RCSB], [https://www.ebi.ac.uk/pdbsum/5agt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5agt ProSAT]</span></td></tr>
	</table>		</table>

OCA at 04:58, 25 May 2023

OCA — Thu, 25 May 2023 04:58:28 GMT

←Older revision		Revision as of 04:58, 25 May 2023
Line 3:		Line 3:
	<StructureSection load='5agt' size='340' side='right'caption='[[5agt]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='5agt' size='340' side='right'caption='[[5agt]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5agt]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Myctu Myctu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AGT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5AGT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5agt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AGT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AGT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2H:4-CHLORO-3-AMINOMETHYL-7-[ETHOXY]-3H-BENZO[C][1,2]OXABOROL-1-OL+MODIFIED+ADENOSINE'>A2H</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2H:4-CHLORO-3-AMINOMETHYL-7-[ETHOXY]-3H-BENZO[C][1,2]OXABOROL-1-OL+MODIFIED+ADENOSINE'>A2H</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5agr\|5agr]], [[5ags\|5ags]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5agt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5agt OCA], [https://pdbe.org/5agt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5agt RCSB], [https://www.ebi.ac.uk/pdbsum/5agt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5agt ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leucine--tRNA_ligase Leucine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.4 6.1.1.4] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5agt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5agt OCA], [~~http~~://pdbe.org/5agt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5agt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5agt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5agt ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SYL_MYCTU SYL_MYCTU]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Leucine--tRNA ligase]]~~	+	[[Category: Mycobacterium tuberculosis H37Rv]]
-	~~[[Category: Myctu~~]]	+	[[Category: Alley MRK]]
-	[[Category: Alley~~, M R.K~~]]	+	[[Category: Barros D]]
-	[[Category: Barros, D]]	+	[[Category: Cooper CB]]
-	[[Category: Cooper~~, C B~~]]	+	[[Category: Cusack S]]
-	[[Category: Cusack, S]]	+	[[Category: Ding C]]
-	[[Category: Ding, C]]	+	[[Category: Easom EE]]
-	[[Category: Easom~~, E E~~]]	+	[[Category: Franzblau SG]]
-	[[Category: Franzblau~~, S G~~]]	+	[[Category: Hernandez V]]
-	[[Category: Hernandez, V]]	+	[[Category: Lenaerts AJ]]
-	[[Category: Lenaerts~~, A J~~]]	+	[[Category: Li X]]
-	[[Category: Li, X]]	+	[[Category: Ma Z]]
-	[[Category: Ma, Z]]	+	[[Category: Meewan M]]
-	[[Category: Meewan, M]]	+	[[Category: Mendoza A]]
-	[[Category: Mendoza, A]]	+	[[Category: Mohan M]]
-	[[Category: Mohan, M]]	+	[[Category: Palencia A]]
-	[[Category: Palencia, A]]	+	[[Category: Parish T]]
-	[[Category: Parish, T]]	+	[[Category: Plattner JJ]]
-	[[Category: Plattner~~, J J~~]]	+	[[Category: Rock FL]]
-	[[Category: Rock~~, F L~~]]	+	[[Category: Wang Y]]
-	[[Category: Wang, Y]]	+	[[Category: Waters MG]]
-	[[Category: Waters~~, M G]]~~	+
-	~~[[Category: Aminoacyl-trna synthetase]]~~	+
-	~~[[Category: Leucine-trna ligase activity]]~~	+
-	~~[[Category: Ligase]]~~	+
-	~~[[Category: Novel boron inhibitors of leur]]~~	+
-	~~[[Category: Protein biosynthesis~~]]	+

OCA at 07:30, 3 July 2019

OCA — Wed, 03 Jul 2019 07:30:00 GMT

←Older revision		Revision as of 07:30, 3 July 2019
Line 1:		Line 1:

	==Crystal structure of the LeuRS editing domain of Mycobacterium tuberculosis in complex with the adduct (S)-3-(Aminomethyl)-4-chloro-7-ethoxybenzo[c][1,2]oxaborol-1(3H)-ol-AMP==		==Crystal structure of the LeuRS editing domain of Mycobacterium tuberculosis in complex with the adduct (S)-3-(Aminomethyl)-4-chloro-7-ethoxybenzo[c][1,2]oxaborol-1(3H)-ol-AMP==
-	<StructureSection load='5agt' size='340' side='right' caption='[[5agt]], [[Resolution\|resolution]] 1.45Å' scene=''>	+	<StructureSection load='5agt' size='340' side='right'caption='[[5agt]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5agt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AGT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AGT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5agt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AGT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AGT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2H:4-CHLORO-3-AMINOMETHYL-7-[ETHOXY]-3H-BENZO[C][1,2]OXABOROL-1-OL+MODIFIED+ADENOSINE'>A2H</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2H:4-CHLORO-3-AMINOMETHYL-7-[ETHOXY]-3H-BENZO[C][1,2]OXABOROL-1-OL+MODIFIED+ADENOSINE'>A2H</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5agr\|5agr]], [[5ags\|5ags]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5agr\|5agr]], [[5ags\|5ags]]</td></tr>
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 5agt" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5agt" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aminoacyl tRNA synthetase 3D structures\|Aminoacyl tRNA synthetase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Leucine--tRNA ligase]]		[[Category: Leucine--tRNA ligase]]
		+	[[Category: Myctu]]
	[[Category: Alley, M R.K]]		[[Category: Alley, M R.K]]
	[[Category: Barros, D]]		[[Category: Barros, D]]

OCA at 05:01, 9 September 2016

OCA — Fri, 09 Sep 2016 05:01:06 GMT

←Older revision		Revision as of 05:01, 9 September 2016
Line 7:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5agr\|5agr]], [[5ags\|5ags]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5agr\|5agr]], [[5ags\|5ags]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leucine--tRNA_ligase Leucine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.4 6.1.1.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leucine--tRNA_ligase Leucine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.4 6.1.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5agt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5agt OCA], [http://pdbe.org/5agt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5agt RCSB], [http://www.ebi.ac.uk/pdbsum/5agt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5agt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5agt OCA], [http://pdbe.org/5agt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5agt RCSB], [http://www.ebi.ac.uk/pdbsum/5agt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5agt ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The recent development and spread of extensively (XDR) and totally resistant (TDR) strains of Mycobacterium tuberculosis, highlights the need for new antitubercular drugs. Protein synthesis inhibitors have played an important role in the treatment of tuberculosis (TB) starting with the inclusion of streptomycin in the first combination therapies. Although the parenteral aminoglycosides are a key component in multidrug-resistant (MDR) TB therapy, the oxazolidinone, linezolid, is the only orally available protein synthesis inhibitor that is effective against TB. Herein, we show that small molecule inhibitors of aminoacyl-tRNA synthetases (AARS), known to be excellent antibacterial protein synthesis targets, can be designed that are orally bioavailable and effective against M. tuberculosis in TB mouse infection models. We applied the oxaborole tRNA trapping (OBORT) mechanism, which was first developed to target fungal cytoplasmic leucyl-tRNA synthetase (LeuRS), to M. tuberculosis LeuRS. X-ray crystallography was used to guide design of LeuRS inhibitors that have good biochemical potency and excellent whole cell activity against M. tuberculosis Importantly, their good oral bioavailability translates into in vivo efficacy in both the acute and chronic mouse models of TB with comparable potency to the frontline drug isoniazid.
		+
		+	Discovery of novel oral protein synthesis inhibitors of Mycobacterium tuberculosis that target leucyl-tRNA synthetase.,Palencia A, Li X, Bu W, Choi W, Ding CZ, Easom EE, Feng L, Hernandez V, Houston P, Liu L, Meewan M, Mohan M, Rock FL, Sexton H, Zhang S, Zhou Y, Wan B, Wang Y, Franzblau SG, Woolhiser L, Gruppo V, Lenaerts AJ, O'Malley T, Parish T, Cooper CB, Waters MG, Ma Z, Ioerger TR, Sacchettini JC, Rullas J, Angulo-Barturen I, Perez-Herran E, Mendoza A, Barros D, Cusack S, Plattner JJ, Alley MR Antimicrob Agents Chemother. 2016 Aug 8. pii: AAC.01339-16. PMID:27503647<ref>PMID:27503647</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5agt" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 15:20, 2 March 2016

OCA — Wed, 02 Mar 2016 15:20:49 GMT

←Older revision		Revision as of 15:20, 2 March 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5agt ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of the LeuRS editing domain of Mycobacterium tuberculosis in complex with the adduct (S)-3-(Aminomethyl)-4-chloro-7-ethoxybenzo[c][1,2]oxaborol-1(3H)-ol-AMP==
-		+	<StructureSection load='5agt' size='340' side='right' caption='[[5agt]], [[Resolution\|resolution]] 1.45Å' scene=''>
-	~~Authors~~: ~~Palencia, A~~.~~, Li, X~~.~~, Alley, M~~.R.K.~~, Ding, C~~.~~, Easom, E~~.E.~~, Hernandez, V~~., ~~Meewan~~, M., ~~Mohan~~, M., ~~Rock, F~~.L.~~, Franzblau, S~~.G.~~, Wang, Y~~.~~, Lenaerts, A~~.J.~~, Parish, T~~.~~, Cooper, C~~.B.~~, Waters, M~~.G.~~, Ma, Z~~., ~~Mendoza, A~~., ~~Barros, D~~., ~~Cusack, S~~., ~~Plattner, J~~.J.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5agt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AGT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AGT FirstGlance]. <br>
-	~~Description: Crystal structure of the LeuRS editing domain of Mycobacterium tuberculosis in complex with the adduct AN6426-AMP~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2H:4-CHLORO-3-AMINOMETHYL-7-[ETHOXY]-3H-BENZO[C][1,2]OXABOROL-1-OL+MODIFIED+ADENOSINE'>A2H</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene></td></tr>
-	~~[[Category: Unreleased Structures]]~~	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5agr\|5agr]], [[5ags\|5ags]]</td></tr>
-	[[Category: ~~Mendoza, A~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leucine--tRNA_ligase Leucine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.4 6.1.1.4] </span></td></tr>
-	[[Category: ~~Waters~~, M.G]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5agt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5agt OCA], [http://pdbe.org/5agt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5agt RCSB], [http://www.ebi.ac.uk/pdbsum/5agt PDBsum]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Leucine--tRNA ligase]]
		+	[[Category: Alley, M R.K]]
	[[Category: Barros, D]]		[[Category: Barros, D]]
-	[[Category: ~~Rock~~, ~~F.L]]~~	+	[[Category: Cooper, C B]]
-	~~[[Category: Franzblau, S.G]]~~	+
-	~~[[Category: Alley, M.R.K~~]]	+
	[[Category: Cusack, S]]		[[Category: Cusack, S]]
-	[[Category: ~~Cooper~~, C.B]]	+	[[Category: Ding, C]]
-	[[Category: ~~Wang~~, Y]]	+	[[Category: Easom, E E]]
		+	[[Category: Franzblau, S G]]
		+	[[Category: Hernandez, V]]
		+	[[Category: Lenaerts, A J]]
		+	[[Category: Li, X]]
		+	[[Category: Ma, Z]]
	[[Category: Meewan, M]]		[[Category: Meewan, M]]
-	[[Category: ~~Plattner, J.J]]~~	+	[[Category: Mendoza, A]]
-	~~[[Category: Li, X]]~~	+
-	~~[[Category: Lenaerts~~, A~~.J]]~~	+
-	~~[[Category: Ding, C~~]]	+
	[[Category: Mohan, M]]		[[Category: Mohan, M]]
	[[Category: Palencia, A]]		[[Category: Palencia, A]]
-	[[Category: Ma, Z]]
-	[[Category: Hernandez, V]]
	[[Category: Parish, T]]		[[Category: Parish, T]]
-	[[Category: ~~Easom~~, ~~E.E~~]]	+	[[Category: Plattner, J J]]
		+	[[Category: Rock, F L]]
		+	[[Category: Wang, Y]]
		+	[[Category: Waters, M G]]
		+	[[Category: Aminoacyl-trna synthetase]]
		+	[[Category: Leucine-trna ligase activity]]
		+	[[Category: Ligase]]
		+	[[Category: Novel boron inhibitors of leur]]
		+	[[Category: Protein biosynthesis]]

OCA at 09:48, 16 December 2015

OCA — Wed, 16 Dec 2015 09:48:20 GMT

←Older revision		Revision as of 09:48, 16 December 2015
Line 7:		Line 7:
	Description: Crystal structure of the LeuRS editing domain of Mycobacterium tuberculosis in complex with the adduct AN6426-AMP		Description: Crystal structure of the LeuRS editing domain of Mycobacterium tuberculosis in complex with the adduct AN6426-AMP
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Mendoza, A]]
	[[Category: Waters, M.G]]		[[Category: Waters, M.G]]
	[[Category: Barros, D]]		[[Category: Barros, D]]
		+	[[Category: Rock, F.L]]
	[[Category: Franzblau, S.G]]		[[Category: Franzblau, S.G]]
	[[Category: Alley, M.R.K]]		[[Category: Alley, M.R.K]]
Line 14:		Line 16:
	[[Category: Cooper, C.B]]		[[Category: Cooper, C.B]]
	[[Category: Wang, Y]]		[[Category: Wang, Y]]
		+	[[Category: Meewan, M]]
	[[Category: Plattner, J.J]]		[[Category: Plattner, J.J]]
		+	[[Category: Li, X]]
	[[Category: Lenaerts, A.J]]		[[Category: Lenaerts, A.J]]
	[[Category: Ding, C]]		[[Category: Ding, C]]
Line 23:		Line 27:
	[[Category: Parish, T]]		[[Category: Parish, T]]
	[[Category: Easom, E.E]]		[[Category: Easom, E.E]]
-	[[Category: Mendoza, A]]
-	[[Category: Rock, F.L]]
-	[[Category: Meewan, M]]
-	[[Category: Li, X]]

OCA at 11:23, 24 June 2015

OCA — Wed, 24 Jun 2015 11:23:01 GMT

←Older revision		Revision as of 11:23, 24 June 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5agt is ON HOLD	+	The entry 5agt is ON HOLD until Paper Publication

	Authors: Palencia, A., Li, X., Alley, M.R.K., Ding, C., Easom, E.E., Hernandez, V., Meewan, M., Mohan, M., Rock, F.L., Franzblau, S.G., Wang, Y., Lenaerts, A.J., Parish, T., Cooper, C.B., Waters, M.G., Ma, Z., Mendoza, A., Barros, D., Cusack, S., Plattner, J.J.		Authors: Palencia, A., Li, X., Alley, M.R.K., Ding, C., Easom, E.E., Hernandez, V., Meewan, M., Mohan, M., Rock, F.L., Franzblau, S.G., Wang, Y., Lenaerts, A.J., Parish, T., Cooper, C.B., Waters, M.G., Ma, Z., Mendoza, A., Barros, D., Cusack, S., Plattner, J.J.

OCA: Protected "5agt" [edit=sysop:move=sysop]

OCA — Thu, 12 Feb 2015 11:03:35 GMT

Protected "5agt" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:03, 12 February 2015

OCA: New page: '''Unreleased structure''' The entry 5agt is ON HOLD Authors: Palencia, A., Li, X., Alley, M.R.K., Ding, C., Easom, E.E., Hernandez, V., Meewan, M., Mohan, M., Rock, F.L., Franzblau, S....

OCA — Thu, 12 Feb 2015 11:03:34 GMT

New page: '''Unreleased structure''' The entry 5agt is ON HOLD Authors: Palencia, A., Li, X., Alley, M.R.K., Ding, C., Easom, E.E., Hernandez, V., Meewan, M., Mohan, M., Rock, F.L., Franzblau, S....

New page

'''Unreleased structure'''

The entry 5agt is ON HOLD

Authors: Palencia, A., Li, X., Alley, M.R.K., Ding, C., Easom, E.E., Hernandez, V., Meewan, M., Mohan, M., Rock, F.L., Franzblau, S.G., Wang, Y., Lenaerts, A.J., Parish, T., Cooper, C.B., Waters, M.G., Ma, Z., Mendoza, A., Barros, D., Cusack, S., Plattner, J.J.

Description: Crystal structure of the LeuRS editing domain of Mycobacterium tuberculosis in complex with the adduct AN6426-AMP
[[Category: Unreleased Structures]]
[[Category: Waters, M.G]]
[[Category: Barros, D]]
[[Category: Franzblau, S.G]]
[[Category: Alley, M.R.K]]
[[Category: Cusack, S]]
[[Category: Cooper, C.B]]
[[Category: Wang, Y]]
[[Category: Plattner, J.J]]
[[Category: Lenaerts, A.J]]
[[Category: Ding, C]]
[[Category: Mohan, M]]
[[Category: Palencia, A]]
[[Category: Ma, Z]]
[[Category: Hernandez, V]]
[[Category: Parish, T]]
[[Category: Easom, E.E]]
[[Category: Mendoza, A]]
[[Category: Rock, F.L]]
[[Category: Meewan, M]]
[[Category: Li, X]]