5ain - Revision history

OCA at 11:10, 10 January 2024

OCA — Wed, 10 Jan 2024 11:10:40 GMT

←Older revision		Revision as of 11:10, 10 January 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5ain]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AIN FirstGlance]. <br>		<table><tr><td colspan='2'>[[5ain]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AIN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QMR:VARENICLINE'>QMR</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QMR:VARENICLINE'>QMR</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ain FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ain OCA], [https://pdbe.org/5ain PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ain RCSB], [https://www.ebi.ac.uk/pdbsum/5ain PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ain ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ain FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ain OCA], [https://pdbe.org/5ain PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ain RCSB], [https://www.ebi.ac.uk/pdbsum/5ain PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ain ProSAT]</span></td></tr>
	</table>		</table>

OCA at 05:02, 25 May 2023

OCA — Thu, 25 May 2023 05:02:21 GMT

←Older revision		Revision as of 05:02, 25 May 2023
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	<StructureSection load='5ain' size='340' side='right'caption='[[5ain]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='5ain' size='340' side='right'caption='[[5ain]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ain]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Aplca Aplca~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AIN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5AIN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ain]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AIN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QMR:VARENICLINE'>QMR</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QMR:VARENICLINE'>QMR</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ain FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ain OCA], [~~http~~://pdbe.org/5ain PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ain RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ain PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ain ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ain FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ain OCA], [https://pdbe.org/5ain PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ain RCSB], [https://www.ebi.ac.uk/pdbsum/5ain PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ain ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8WSF8_APLCA Q8WSF8_APLCA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 5ain" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5ain" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Acetylcholine binding protein 3D structures\|Acetylcholine binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aplca~~]]	+	[[Category: Aplysia californica]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Lillestol, R]]	+	[[Category: Lillestol R]]
-	[[Category: Lummis~~, S C~~]]	+	[[Category: Lummis SC]]
-	[[Category: Price~~, K L~~]]	+	[[Category: Price KL]]
-	[[Category: Ulens, C]]	+	[[Category: Ulens C]]
-	~~[[Category: Serotonin binding protein~~]]	+

OCA at 07:57, 3 July 2019

OCA — Wed, 03 Jul 2019 07:57:08 GMT

←Older revision		Revision as of 07:57, 3 July 2019
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	==Varenicline Interactions at the 5HT3 Receptor Ligand Binding Site are Revealed by 5HTBP==		==Varenicline Interactions at the 5HT3 Receptor Ligand Binding Site are Revealed by 5HTBP==
-	<StructureSection load='5ain' size='340' side='right' caption='[[5ain]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='5ain' size='340' side='right'caption='[[5ain]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ain]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AIN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ain]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplca Aplca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AIN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QMR:VARENICLINE'>QMR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QMR:VARENICLINE'>QMR</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ain FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ain OCA], [http://pdbe.org/5ain PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ain RCSB], [http://www.ebi.ac.uk/pdbsum/5ain PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ain FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ain OCA], [http://pdbe.org/5ain PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ain RCSB], [http://www.ebi.ac.uk/pdbsum/5ain PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ain ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Aplca]]
		+	[[Category: Large Structures]]
	[[Category: Lillestol, R]]		[[Category: Lillestol, R]]
	[[Category: Lummis, S C]]		[[Category: Lummis, S C]]

OCA at 17:35, 10 May 2016

OCA — Tue, 10 May 2016 17:35:01 GMT

←Older revision		Revision as of 17:35, 10 May 2016
Line 1:		Line 1:
		+
	==Varenicline Interactions at the 5HT3 Receptor Ligand Binding Site are Revealed by 5HTBP==		==Varenicline Interactions at the 5HT3 Receptor Ligand Binding Site are Revealed by 5HTBP==
	<StructureSection load='5ain' size='340' side='right' caption='[[5ain]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='5ain' size='340' side='right' caption='[[5ain]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[5ain]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AIN FirstGlance]. <br>		<table><tr><td colspan='2'>[[5ain]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AIN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QMR:VARENICLINE'>QMR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QMR:VARENICLINE'>QMR</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ain FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ain OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5ain RCSB], [http://www.ebi.ac.uk/pdbsum/5ain PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ain FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ain OCA], [http://pdbe.org/5ain PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ain RCSB], [http://www.ebi.ac.uk/pdbsum/5ain PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cys-loop receptors are the site of action of many therapeutic drugs. One of these is the smoking cessation agent varenicline, which has its major therapeutic effects at nicotinic acetylcholine (nACh) receptors but also acts at 5-HT3 receptors. Here, we report the X-ray crystal structure of the 5-HT binding protein (5-HTBP) in complex with varenicline, and test the predicted interactions by probing the potency of varenicline in a range of mutant 5-HT3 receptors expressed in HEK293 cells and Xenopus oocytes. The structure reveals a range of interactions between varenicline and 5-HTBP. We identified residues within 5 A of varenicline and substituted the equivalent residues in the 5-HT3 receptor with Ala or a residue with similar chemical properties. Functional characterization of these mutant 5-HT3 receptors, using a fluorescent membrane potential dye in HEK cells and voltage clamp in oocytes, supports interactions between varenicline and the receptor that are similar to those in 5-HTBP. The structure also revealed C-loop closure that was less than in the 5-HT-bound 5-HTBP, and hydrogen bonding between varenicline and the complementary face of the binding pocket via a water molecule, which are characteristics consistent with partial agonist behavior of varenicline in the 5-HT3 receptor. Together, these data reveal detailed insights into the molecular interaction of varenicline in the 5-HT3 receptor.
		+
		+	Varenicline Interactions at the 5-HT3 Receptor Ligand Binding Site are Revealed by 5-HTBP.,Price KL, Lillestol RK, Ulens C, Lummis SC ACS Chem Neurosci. 2015 Jul 15;6(7):1151-7. doi: 10.1021/cn500369h. Epub 2015 Feb, 19. PMID:25648658<ref>PMID:25648658</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5ain" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 14:15, 26 March 2015

OCA — Thu, 26 Mar 2015 14:15:53 GMT

←Older revision		Revision as of 14:15, 26 March 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Varenicline Interactions at the 5HT3 Receptor Ligand Binding Site are Revealed by 5HTBP==
-		+	<StructureSection load='5ain' size='340' side='right' caption='[[5ain]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	~~The entry~~ 5ain is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5ain]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AIN FirstGlance]. <br>
-	~~Authors~~: ~~Price, K~~.L.~~, Lillestol, R~~.~~, Ulens, C~~.~~, Lummis, S~~.C.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QMR:VARENICLINE'>QMR</scene></td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ain FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ain OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5ain RCSB], [http://www.ebi.ac.uk/pdbsum/5ain PDBsum]</span></td></tr>
-	~~Description: Varenicline Interactions at the 5HT3 Receptor Ligand Binding Site are Revealed by 5HTBP~~	+	</table>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	__TOC__
-	[~~[Category~~: ~~Lummis, S~~.C]]	+	</StructureSection>
-	[~~[Category~~: ~~Price~~, K.L]]	+
	[[Category: Lillestol, R]]		[[Category: Lillestol, R]]
		+	[[Category: Lummis, S C]]
		+	[[Category: Price, K L]]
	[[Category: Ulens, C]]		[[Category: Ulens, C]]
		+	[[Category: Serotonin binding protein]]

OCA: Protected "5ain" [edit=sysop:move=sysop]

OCA — Wed, 25 Feb 2015 13:07:04 GMT

Protected "5ain" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:07, 25 February 2015

OCA: New page: '''Unreleased structure''' The entry 5ain is ON HOLD Authors: Price, K.L., Lillestol, R., Ulens, C., Lummis, S.C. Description: Varenicline Interactions at the 5HT3 Receptor Ligand Bind...

OCA — Wed, 25 Feb 2015 13:07:03 GMT

New page: '''Unreleased structure''' The entry 5ain is ON HOLD Authors: Price, K.L., Lillestol, R., Ulens, C., Lummis, S.C. Description: Varenicline Interactions at the 5HT3 Receptor Ligand Bind...

New page

'''Unreleased structure'''

The entry 5ain is ON HOLD

Authors: Price, K.L., Lillestol, R., Ulens, C., Lummis, S.C.

Description: Varenicline Interactions at the 5HT3 Receptor Ligand Binding Site are Revealed by 5HTBP
[[Category: Unreleased Structures]]
[[Category: Lummis, S.C]]
[[Category: Price, K.L]]
[[Category: Lillestol, R]]
[[Category: Ulens, C]]