5aj1 - Revision history

OCA at 05:03, 25 May 2023

OCA — Thu, 25 May 2023 05:03:15 GMT

←Older revision		Revision as of 05:03, 25 May 2023
Line 1:		Line 1:

	==Solution Structure of the Smarc Domain==		==Solution Structure of the Smarc Domain==
-	<StructureSection load='5aj1' size='340' side='right'caption='[[5aj1~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='5aj1' size='340' side='right'caption='[[5aj1]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5aj1]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AJ1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5AJ1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5aj1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AJ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AJ1 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5aj1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aj1 OCA], [~~http~~://pdbe.org/5aj1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5aj1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5aj1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5aj1 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5aj1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aj1 OCA], [https://pdbe.org/5aj1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5aj1 RCSB], [https://www.ebi.ac.uk/pdbsum/5aj1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5aj1 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/SNF5_HUMAN SNF5_HUMAN]] Neurofibromatosis type 3;Atypical teratoid rhabdoid tumor;Familial rhabdoid tumor;Familial multiple meningioma;Coffin-Siris syndrome. The disease is caused by mutations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/SNF5_HUMAN SNF5_HUMAN] Neurofibromatosis type 3;Atypical teratoid rhabdoid tumor;Familial rhabdoid tumor;Familial multiple meningioma;Coffin-Siris syndrome. The disease is caused by mutations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SNF5_HUMAN SNF5_HUMAN]] Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1.<ref>PMID:10078207</ref> <ref>PMID:12226744</ref> <ref>PMID:14604992</ref> <ref>PMID:16267391</ref> <ref>PMID:16314535</ref> <ref>PMID:9448295</ref>	+	[https://www.uniprot.org/uniprot/SNF5_HUMAN SNF5_HUMAN] Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1.<ref>PMID:10078207</ref> <ref>PMID:12226744</ref> <ref>PMID:14604992</ref> <ref>PMID:16267391</ref> <ref>PMID:16314535</ref> <ref>PMID:9448295</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Allen~~, M D~~]]	+	[[Category: Allen MD]]
-	[[Category: Bycroft, M]]	+	[[Category: Bycroft M]]
-	[[Category: Freund~~, S M.V~~]]	+	[[Category: Freund SMV]]
-	[[Category: Zinzalla, G]]	+	[[Category: Zinzalla G]]
-	~~[[Category: Structural protein~~]]	+

OCA at 08:40, 11 March 2020

OCA — Wed, 11 Mar 2020 08:40:34 GMT

←Older revision		Revision as of 08:40, 11 March 2020
Line 1:		Line 1:

	==Solution Structure of the Smarc Domain==		==Solution Structure of the Smarc Domain==
-	<StructureSection load='5aj1' size='340' side='right' caption='[[5aj1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='5aj1' size='340' side='right'caption='[[5aj1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5aj1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AJ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AJ1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5aj1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AJ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AJ1 FirstGlance]. <br>
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Allen, M D]]		[[Category: Allen, M D]]
	[[Category: Bycroft, M]]		[[Category: Bycroft, M]]

OCA at 20:26, 24 January 2018

OCA — Wed, 24 Jan 2018 20:26:08 GMT

←Older revision		Revision as of 20:26, 24 January 2018
Line 3:		Line 3:
	<StructureSection load='5aj1' size='340' side='right' caption='[[5aj1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='5aj1' size='340' side='right' caption='[[5aj1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5aj1]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AJ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AJ1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5aj1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AJ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AJ1 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aj1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aj1 OCA], [http://pdbe.org/5aj1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aj1 RCSB], [http://www.ebi.ac.uk/pdbsum/5aj1 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aj1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aj1 OCA], [http://pdbe.org/5aj1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aj1 RCSB], [http://www.ebi.ac.uk/pdbsum/5aj1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5aj1 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Allen, M D]]		[[Category: Allen, M D]]
	[[Category: Bycroft, M]]		[[Category: Bycroft, M]]

OCA at 17:03, 10 May 2016

OCA — Tue, 10 May 2016 17:03:29 GMT

←Older revision		Revision as of 17:03, 10 May 2016
Line 1:		Line 1:
		+
	==Solution Structure of the Smarc Domain==		==Solution Structure of the Smarc Domain==
	<StructureSection load='5aj1' size='340' side='right' caption='[[5aj1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='5aj1' size='340' side='right' caption='[[5aj1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5aj1]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AJ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AJ1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5aj1]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AJ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AJ1 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aj1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aj1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5aj1 RCSB], [http://www.ebi.ac.uk/pdbsum/5aj1 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aj1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aj1 OCA], [http://pdbe.org/5aj1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aj1 RCSB], [http://www.ebi.ac.uk/pdbsum/5aj1 PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 5aj1" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:05, 5 August 2015

OCA — Wed, 05 Aug 2015 20:05:06 GMT

←Older revision		Revision as of 20:05, 5 August 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Solution Structure of the Smarc Domain==
		+	<StructureSection load='5aj1' size='340' side='right' caption='[[5aj1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5aj1]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AJ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AJ1 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aj1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aj1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5aj1 RCSB], [http://www.ebi.ac.uk/pdbsum/5aj1 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/SNF5_HUMAN SNF5_HUMAN]] Neurofibromatosis type 3;Atypical teratoid rhabdoid tumor;Familial rhabdoid tumor;Familial multiple meningioma;Coffin-Siris syndrome. The disease is caused by mutations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SNF5_HUMAN SNF5_HUMAN]] Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1.<ref>PMID:10078207</ref> <ref>PMID:12226744</ref> <ref>PMID:14604992</ref> <ref>PMID:16267391</ref> <ref>PMID:16314535</ref> <ref>PMID:9448295</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	SWI/SNF complexes use the energy of ATP hydrolysis to remodel chromatin. In mammals they play a central role in regulating gene expression during differentiation and proliferation. Mutations in SWI/SNF subunits are among the most frequent gene alterations in cancer. The INI1/hSNF5/SMARCB1 subunit is mutated in both malignant rhabdoid tumor, a highly aggressive childhood cancer, and schwannomatosis, a tumor-predisposing syndrome characterized by mostly benign tumors of the CNS. Here, we show that mutations in INI1 that cause schwannomatosis target a hitherto unidentified N-terminal winged helix DNA binding domain that is also present in the BAF45a/PHF10 subunit of the SWI/SNF complex. The domain is structurally related to the SKI/SNO/DAC domain, which is found in a number of metazoan chromatin-associated proteins.

-	The ~~entry 5aj1 is ON HOLD until Paper Publication~~	+	The SWI/SNF Subunit INI1 Contains an N-Terminal Winged Helix DNA Binding Domain that Is a Target for Mutations in Schwannomatosis.,Allen MD, Freund SM, Zinzalla G, Bycroft M Structure. 2015 Jul 7;23(7):1344-9. doi: 10.1016/j.str.2015.04.021. Epub 2015 Jun, 11. PMID:26073604<ref>PMID:26073604</ref>

-	~~Authors: Allen~~, M.~~D., Freund,~~ S.~~M.V., Bycroft, M~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: Solution Structure of the Smarc Domain~~	+	== References ==
-	~~[[Category: Unreleased Structures]]~~	+	<references/>
-	[[Category: Allen, M.D]]	+	__TOC__
-	~~[[Category: Freund, S.M.V~~]]	+	</StructureSection>
		+	[[Category: Allen, M D]]
	[[Category: Bycroft, M]]		[[Category: Bycroft, M]]
		+	[[Category: Freund, S M.V]]
		+	[[Category: Zinzalla, G]]
		+	[[Category: Structural protein]]

OCA at 11:53, 22 April 2015

OCA — Wed, 22 Apr 2015 11:53:22 GMT

←Older revision		Revision as of 11:53, 22 April 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5aj1 is ON HOLD	+	The entry 5aj1 is ON HOLD until Paper Publication

	Authors: Allen, M.D., Freund, S.M.V., Bycroft, M.		Authors: Allen, M.D., Freund, S.M.V., Bycroft, M.

OCA at 10:18, 8 April 2015

OCA — Wed, 08 Apr 2015 10:18:11 GMT

←Older revision		Revision as of 10:18, 8 April 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5aj1 is ON HOLD ~~until sometime in the future~~	+	The entry 5aj1 is ON HOLD

	Authors: Allen, M.D., Freund, S.M.V., Bycroft, M.		Authors: Allen, M.D., Freund, S.M.V., Bycroft, M.

OCA: Protected "5aj1" [edit=sysop:move=sysop]

OCA — Wed, 25 Feb 2015 13:08:21 GMT

Protected "5aj1" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:08, 25 February 2015

OCA: New page: '''Unreleased structure''' The entry 5aj1 is ON HOLD until sometime in the future Authors: Allen, M.D., Freund, S.M.V., Bycroft, M. Description: Solution Structure of the Smarc Domain ...

OCA — Wed, 25 Feb 2015 13:08:20 GMT

New page: '''Unreleased structure''' The entry 5aj1 is ON HOLD until sometime in the future Authors: Allen, M.D., Freund, S.M.V., Bycroft, M. Description: Solution Structure of the Smarc Domain ...

New page

'''Unreleased structure'''

The entry 5aj1 is ON HOLD until sometime in the future

Authors: Allen, M.D., Freund, S.M.V., Bycroft, M.

Description: Solution Structure of the Smarc Domain
[[Category: Unreleased Structures]]
[[Category: Allen, M.D]]
[[Category: Freund, S.M.V]]
[[Category: Bycroft, M]]