5ajq - Revision history

OCA at 05:04, 25 May 2023

OCA — Thu, 25 May 2023 05:04:19 GMT

←Older revision		Revision as of 05:04, 25 May 2023
Line 3:		Line 3:
	<StructureSection load='5ajq' size='340' side='right'caption='[[5ajq]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='5ajq' size='340' side='right'caption='[[5ajq]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ajq]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AJQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5AJQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ajq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AJQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AJQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DB8:4-[(2,4-DICHLORO-5-METHOXYPHENYL)AMINO]-6-METHOXY-7-[3-(4-METHYLPIPERAZIN-1-YL)PROPOXY]QUINOLINE-3-CARBONITRILE'>DB8</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DB8:4-[(2,4-DICHLORO-5-METHOXYPHENYL)AMINO]-6-METHOXY-7-[3-(4-METHYLPIPERAZIN-1-YL)PROPOXY]QUINOLINE-3-CARBONITRILE'>DB8</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ajq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ajq OCA], [https://pdbe.org/5ajq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ajq RCSB], [https://www.ebi.ac.uk/pdbsum/5ajq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ajq ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ajq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ajq OCA], [~~http~~://pdbe.org/5ajq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ajq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ajq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ajq ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/STK10_HUMAN STK10_HUMAN]] The disease may be caused by mutations affecting the gene represented in this entry.<ref>PMID:16175573</ref>	+	[https://www.uniprot.org/uniprot/STK10_HUMAN STK10_HUMAN] The disease may be caused by mutations affecting the gene represented in this entry.<ref>PMID:16175573</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/STK10_HUMAN STK10_HUMAN]] Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.<ref>PMID:11903060</ref> <ref>PMID:12639966</ref> <ref>PMID:19255442</ref>	+	[https://www.uniprot.org/uniprot/STK10_HUMAN STK10_HUMAN] Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.<ref>PMID:11903060</ref> <ref>PMID:12639966</ref> <ref>PMID:19255442</ref>

	==See Also==		==See Also==
-	*[[Serine/threonine protein kinase\|Serine/threonine protein kinase]]	+	*[[Serine/threonine protein kinase 3D structures\|Serine/threonine protein kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Non-specific serine/threonine protein kinase]]~~	+	[[Category: Bountra C]]
-	[[Category: Bountra, C]]	+	[[Category: Edwards AM]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Elkins JM]]
-	[[Category: Elkins~~, J M~~]]	+	[[Category: Knapp S]]
-	[[Category: Knapp, S]]	+	[[Category: Kopec J]]
-	[[Category: Kopec, J]]	+	[[Category: Krojer T]]
-	[[Category: Krojer, T]]	+	[[Category: Pinkas DM]]
-	[[Category: Pinkas~~, D M~~]]	+	[[Category: Salah E]]
-	[[Category: Salah, E]]	+
-	~~[[Category: Transferase~~]]	+

OCA at 07:54, 3 July 2019

OCA — Wed, 03 Jul 2019 07:54:09 GMT

←Older revision		Revision as of 07:54, 3 July 2019
Line 1:		Line 1:

	==Human LOK (STK10) in complex with Bosutinib==		==Human LOK (STK10) in complex with Bosutinib==
-	<StructureSection load='5ajq' size='340' side='right' caption='[[5ajq]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='5ajq' size='340' side='right'caption='[[5ajq]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ajq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AJQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AJQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ajq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AJQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AJQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DB8:4-[(2,4-DICHLORO-5-METHOXYPHENYL)AMINO]-6-METHOXY-7-[3-(4-METHYLPIPERAZIN-1-YL)PROPOXY]QUINOLINE-3-CARBONITRILE'>DB8</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DB8:4-[(2,4-DICHLORO-5-METHOXYPHENYL)AMINO]-6-METHOXY-7-[3-(4-METHYLPIPERAZIN-1-YL)PROPOXY]QUINOLINE-3-CARBONITRILE'>DB8</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA at 10:01, 10 March 2017

OCA — Fri, 10 Mar 2017 10:01:15 GMT

←Older revision		Revision as of 10:01, 10 March 2017
Line 1:		Line 1:
		+
	==Human LOK (STK10) in complex with Bosutinib==		==Human LOK (STK10) in complex with Bosutinib==
	<StructureSection load='5ajq' size='340' side='right' caption='[[5ajq]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='5ajq' size='340' side='right' caption='[[5ajq]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DB8:4-[(2,4-DICHLORO-5-METHOXYPHENYL)AMINO]-6-METHOXY-7-[3-(4-METHYLPIPERAZIN-1-YL)PROPOXY]QUINOLINE-3-CARBONITRILE'>DB8</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DB8:4-[(2,4-DICHLORO-5-METHOXYPHENYL)AMINO]-6-METHOXY-7-[3-(4-METHYLPIPERAZIN-1-YL)PROPOXY]QUINOLINE-3-CARBONITRILE'>DB8</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ajq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ajq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5ajq RCSB], [http://www.ebi.ac.uk/pdbsum/5ajq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ajq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ajq OCA], [http://pdbe.org/5ajq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ajq RCSB], [http://www.ebi.ac.uk/pdbsum/5ajq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ajq ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 11:		Line 12:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/STK10_HUMAN STK10_HUMAN]] Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.<ref>PMID:11903060</ref> <ref>PMID:12639966</ref> <ref>PMID:19255442</ref>		[[http://www.uniprot.org/uniprot/STK10_HUMAN STK10_HUMAN]] Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.<ref>PMID:11903060</ref> <ref>PMID:12639966</ref> <ref>PMID:19255442</ref>
		+
		+	==See Also==
		+	*[[Serine/threonine protein kinase\|Serine/threonine protein kinase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:36, 8 April 2015

OCA — Wed, 08 Apr 2015 05:36:49 GMT

←Older revision		Revision as of 05:36, 8 April 2015
Line 22:		Line 22:
	[[Category: Kopec, J]]		[[Category: Kopec, J]]
	[[Category: Krojer, T]]		[[Category: Krojer, T]]
		+	[[Category: Pinkas, D M]]
	[[Category: Salah, E]]		[[Category: Salah, E]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 12:03, 11 March 2015

OCA — Wed, 11 Mar 2015 12:03:03 GMT

←Older revision		Revision as of 12:03, 11 March 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Human LOK (STK10) in complex with Bosutinib==
-		+	<StructureSection load='5ajq' size='340' side='right' caption='[[5ajq]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	~~The entry~~ 5ajq is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5ajq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AJQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AJQ FirstGlance]. <br>
-	~~Authors~~: ~~Elkins, J~~.M.~~, Salah, E~~.~~, Krojer, T~~.~~, Kopec, J~~.~~, Bountra, C~~.~~, Edwards, A~~.M.~~, Knapp, S~~.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DB8:4-[(2,4-DICHLORO-5-METHOXYPHENYL)AMINO]-6-METHOXY-7-[3-(4-METHYLPIPERAZIN-1-YL)PROPOXY]QUINOLINE-3-CARBONITRILE'>DB8</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	~~Description~~: ~~Human LOK~~ (~~STK10~~) ~~in complex~~ with ~~Bosutinib~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ajq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ajq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5ajq RCSB], [http://www.ebi.ac.uk/pdbsum/5ajq PDBsum]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Elkins, J~~.M]]	+	== Disease ==
-	[[~~Category~~: ~~Knapp, S~~]]	+	[[http://www.uniprot.org/uniprot/STK10_HUMAN STK10_HUMAN]] The disease may be caused by mutations affecting the gene represented in this entry.<ref>PMID:16175573</ref>
-	[[Category: ~~Krojer, T~~]]	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/STK10_HUMAN STK10_HUMAN]] Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.<ref>PMID:11903060</ref> <ref>PMID:12639966</ref> <ref>PMID:19255442</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]
		+	[[Category: Edwards, A M]]
		+	[[Category: Elkins, J M]]
		+	[[Category: Knapp, S]]
	[[Category: Kopec, J]]		[[Category: Kopec, J]]
-	[[Category: ~~Edwards~~, ~~A.M~~]]	+	[[Category: Krojer, T]]
	[[Category: Salah, E]]		[[Category: Salah, E]]
		+	[[Category: Transferase]]

OCA: Protected "5ajq" [edit=sysop:move=sysop]

OCA — Wed, 04 Mar 2015 10:41:07 GMT

Protected "5ajq" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:41, 4 March 2015

OCA: New page: '''Unreleased structure''' The entry 5ajq is ON HOLD Authors: Elkins, J.M., Salah, E., Krojer, T., Kopec, J., Bountra, C., Edwards, A.M., Knapp, S. Description: Human LOK (STK10) in co...

OCA — Wed, 04 Mar 2015 10:41:06 GMT

New page: '''Unreleased structure''' The entry 5ajq is ON HOLD Authors: Elkins, J.M., Salah, E., Krojer, T., Kopec, J., Bountra, C., Edwards, A.M., Knapp, S. Description: Human LOK (STK10) in co...

New page

'''Unreleased structure'''

The entry 5ajq is ON HOLD

Authors: Elkins, J.M., Salah, E., Krojer, T., Kopec, J., Bountra, C., Edwards, A.M., Knapp, S.

Description: Human LOK (STK10) in complex with Bosutinib
[[Category: Unreleased Structures]]
[[Category: Elkins, J.M]]
[[Category: Knapp, S]]
[[Category: Krojer, T]]
[[Category: Bountra, C]]
[[Category: Kopec, J]]
[[Category: Edwards, A.M]]
[[Category: Salah, E]]