5ako - Revision history

OCA at 11:11, 10 January 2024

OCA — Wed, 10 Jan 2024 11:11:50 GMT

←Older revision		Revision as of 11:11, 10 January 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5ako]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AKO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AKO FirstGlance]. <br>		<table><tr><td colspan='2'>[[5ako]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AKO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AKO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ako FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ako OCA], [https://pdbe.org/5ako PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ako RCSB], [https://www.ebi.ac.uk/pdbsum/5ako PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ako ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ako FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ako OCA], [https://pdbe.org/5ako PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ako RCSB], [https://www.ebi.ac.uk/pdbsum/5ako PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ako ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 05:06, 25 May 2023

OCA — Thu, 25 May 2023 05:06:38 GMT

←Older revision		Revision as of 05:06, 25 May 2023
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	<StructureSection load='5ako' size='340' side='right'caption='[[5ako]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='5ako' size='340' side='right'caption='[[5ako]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ako]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AKO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5AKO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ako]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AKO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AKO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ako FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ako OCA], [~~http~~://pdbe.org/5ako PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ako RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ako PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ako ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ako FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ako OCA], [https://pdbe.org/5ako PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ako RCSB], [https://www.ebi.ac.uk/pdbsum/5ako PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ako ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TSI2_PSEAE TSI2_PSEAE] Immunity protein that plays a role in preventing early activation of toxin Tse2. Binds to a large surface of Tse2 and thereby occludes the active site to specifically inhibits Tse2.<ref>PMID:22310046</ref> <ref>PMID:22511866</ref> <ref>PMID:26749446</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Boraston, A B~~]]	+	[[Category: Pseudomonas aeruginosa]]
-	[[Category: ~~Nano, F E~~]]	+	[[Category: Boraston AB]]
-	[[Category: ~~Robb, C S~~]]	+	[[Category: Nano FE]]
-	[[Category: ~~Immunity protein]]~~	+	[[Category: Robb CS]]
-	~~[[Category: T6ss]]~~	+
-	~~[[Category: Toxin]]~~	+
-	~~[[Category: Unknown function~~]]	+

OCA at 08:41, 11 March 2020

OCA — Wed, 11 Mar 2020 08:41:05 GMT

←Older revision		Revision as of 08:41, 11 March 2020
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	==The complex of Tse2 and Tsi2 from Pseudomonas aeruginosa==		==The complex of Tse2 and Tsi2 from Pseudomonas aeruginosa==
-	<StructureSection load='5ako' size='340' side='right' caption='[[5ako]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='5ako' size='340' side='right'caption='[[5ako]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5ako]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AKO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AKO FirstGlance]. <br>		<table><tr><td colspan='2'>[[5ako]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AKO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AKO FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Boraston, A B]]		[[Category: Boraston, A B]]
	[[Category: Nano, F E]]		[[Category: Nano, F E]]

OCA at 22:59, 15 November 2017

OCA — Wed, 15 Nov 2017 22:59:50 GMT

←Older revision		Revision as of 22:59, 15 November 2017
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	<StructureSection load='5ako' size='340' side='right' caption='[[5ako]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='5ako' size='340' side='right' caption='[[5ako]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ako]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AKO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AKO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ako]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AKO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AKO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ako FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ako OCA], [http://pdbe.org/5ako PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ako RCSB], [http://www.ebi.ac.uk/pdbsum/5ako PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ako FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ako OCA], [http://pdbe.org/5ako PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ako RCSB], [http://www.ebi.ac.uk/pdbsum/5ako PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ako ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:46, 2 March 2016

OCA — Wed, 02 Mar 2016 06:46:42 GMT

←Older revision		Revision as of 06:46, 2 March 2016
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		+
	==The complex of Tse2 and Tsi2 from Pseudomonas aeruginosa==		==The complex of Tse2 and Tsi2 from Pseudomonas aeruginosa==
	<StructureSection load='5ako' size='340' side='right' caption='[[5ako]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='5ako' size='340' side='right' caption='[[5ako]], [[Resolution\|resolution]] 2.40Å' scene=''>

OCA at 08:44, 20 January 2016

OCA — Wed, 20 Jan 2016 08:44:54 GMT

←Older revision		Revision as of 08:44, 20 January 2016
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	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ako FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ako OCA], [http://pdbe.org/5ako PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ako RCSB], [http://www.ebi.ac.uk/pdbsum/5ako PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ako FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ako OCA], [http://pdbe.org/5ako PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ako RCSB], [http://www.ebi.ac.uk/pdbsum/5ako PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Tse2 is a cytoactive toxin secreted by a type six secretion apparatus of Pseudomonas aeruginosa. The Tse2 toxin naturally attacks a target in the cytoplasm of bacterial cells, and can cause toxicity if artificially introduced into eukaryotic cells. The X-ray crystal structure of the complex of Tse2 and its cognate immunity protein Tsi2 revealed a heterotetrameric structure with an extensive binding interface. Structural identity was found between Tse2 and NAD-dependent enzymes, especially ADP-ribosylating toxins, which facilitated the identification of the Tse2 active site and revealed it to be occluded upon binding the inhibitor Tsi2. The structural identity shared with NAD-dependent enzymes, including conserved catalytic residues, suggests that the mechanism of Tse2 toxicity may be NAD dependent.
		+
		+	The Structure of the Toxin and Type Six Secretion System Substrate Tse2 in Complex with Its Immunity Protein.,Robb CS, Robb M, Nano FE, Boraston AB Structure. 2015 Dec 28. pii: S0969-2126(15)00501-8. doi:, 10.1016/j.str.2015.11.012. PMID:26749446<ref>PMID:26749446</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5ako" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 12:47, 23 December 2015

OCA — Wed, 23 Dec 2015 12:47:46 GMT

←Older revision		Revision as of 12:47, 23 December 2015
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-	'''~~Unreleased structure~~'''	+	==The complex of Tse2 and Tsi2 from Pseudomonas aeruginosa==
-		+	<StructureSection load='5ako' size='340' side='right' caption='[[5ako]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~The entry~~ 5ako is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5ako]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AKO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AKO FirstGlance]. <br>
-	~~Authors~~: ~~Robb~~, C.S., ~~Nano~~, F.E., ~~Boraston, A~~.B.	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ako FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ako OCA], [http://pdbe.org/5ako PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ako RCSB], [http://www.ebi.ac.uk/pdbsum/5ako PDBsum]</span></td></tr>
-		+	</table>
-	~~Description: The complex of Tse2 and Tsi2 from Pseudomonas aeruginosa~~	+	__TOC__
-	~~[[Category: Unreleased Structures]]~~	+	</StructureSection>
-	[[Category: Boraston, A.B]]	+	[[Category: Boraston, A B]]
-	[[Category: Nano, F.E]]	+	[[Category: Nano, F E]]
-	[[Category: Robb, C.S]]	+	[[Category: Robb, C S]]
		+	[[Category: Immunity protein]]
		+	[[Category: T6ss]]
		+	[[Category: Toxin]]
		+	[[Category: Unknown function]]

OCA at 09:49, 16 December 2015

OCA — Wed, 16 Dec 2015 09:49:22 GMT

←Older revision		Revision as of 09:49, 16 December 2015
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	Description: The complex of Tse2 and Tsi2 from Pseudomonas aeruginosa		Description: The complex of Tse2 and Tsi2 from Pseudomonas aeruginosa
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Robb, C.S]]
	[[Category: Boraston, A.B]]		[[Category: Boraston, A.B]]
	[[Category: Nano, F.E]]		[[Category: Nano, F.E]]
		+	[[Category: Robb, C.S]]

OCA at 12:19, 12 August 2015

OCA — Wed, 12 Aug 2015 12:19:32 GMT

←Older revision		Revision as of 12:19, 12 August 2015
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5ako is ON HOLD	+	The entry 5ako is ON HOLD until Paper Publication

	Authors: Robb, C.S., Nano, F.E., Boraston, A.B.		Authors: Robb, C.S., Nano, F.E., Boraston, A.B.

OCA: Protected "5ako" [edit=sysop:move=sysop]

OCA — Wed, 11 Mar 2015 11:02:57 GMT

Protected "5ako" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:02, 11 March 2015