5ame - Revision history

OCA at 07:21, 1 May 2024

OCA — Wed, 01 May 2024 07:21:39 GMT

←Older revision		Revision as of 07:21, 1 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5ame]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AME FirstGlance]. <br>		<table><tr><td colspan='2'>[[5ame]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AME FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PW3:4-ACETYL-PIPERAZIN-2-ONE'>PW3</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.578Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PW3:4-ACETYL-PIPERAZIN-2-ONE'>PW3</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ame FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ame OCA], [https://pdbe.org/5ame PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ame RCSB], [https://www.ebi.ac.uk/pdbsum/5ame PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ame ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ame FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ame OCA], [https://pdbe.org/5ame PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ame RCSB], [https://www.ebi.ac.uk/pdbsum/5ame PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ame ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:14, 31 May 2023

OCA — Wed, 31 May 2023 06:14:27 GMT

←Older revision		Revision as of 06:14, 31 May 2023
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	==Crystal structure of the bromodomain of human surface epitope engineered BRD1A in complex with 3D Consortium fragment 4-acetyl- piperazin-2-one (SGC - Diamond I04-1 fragment screening)==		==Crystal structure of the bromodomain of human surface epitope engineered BRD1A in complex with 3D Consortium fragment 4-acetyl- piperazin-2-one (SGC - Diamond I04-1 fragment screening)==
-	<StructureSection load='5ame' size='340' side='right' caption='[[5ame]], [[Resolution\|resolution]] 1.58Å' scene=''>	+	<StructureSection load='5ame' size='340' side='right'caption='[[5ame]], [[Resolution\|resolution]] 1.58Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ame]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AME OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5AME FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ame]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AME FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PW3:4-ACETYL-PIPERAZIN-2-ONE'>PW3</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PW3:4-ACETYL-PIPERAZIN-2-ONE'>PW3</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5amf\|5amf]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ame FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ame OCA], [https://pdbe.org/5ame PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ame RCSB], [https://www.ebi.ac.uk/pdbsum/5ame PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ame ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ame FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ame OCA], [~~http~~://pdbe.org/5ame PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ame RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ame PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ame ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/BRD1_HUMAN BRD1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.<ref>PMID:16387653</ref> <ref>PMID:21880731</ref>	+	[https://www.uniprot.org/uniprot/BRD1_HUMAN BRD1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.<ref>PMID:16387653</ref> <ref>PMID:21880731</ref>

	==See Also==		==See Also==
-	*[[Bromodomain-containing protein\|Bromodomain-containing protein]]	+	*[[Bromodomain-containing protein 3D structures\|Bromodomain-containing protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Large Structures]]
-	[[Category: Bountra, C]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Bowkett, D]]	+	[[Category: Bountra C]]
-	[[Category: Bradley, A]]	+	[[Category: Bowkett D]]
-	[[Category: Brandao-Neto, J]]	+	[[Category: Bradley A]]
-	[[Category: Brennan, P]]	+	[[Category: Brandao-Neto J]]
-	[[Category: Burgess-Brown, N]]	+	[[Category: Brennan P]]
-	[[Category: Collins, P]]	+	[[Category: Burgess-Brown N]]
-	[[Category: Cox, O]]	+	[[Category: Collins P]]
-	~~[[Category: Delft, F von~~]]	+	[[Category: Cox O]]
-	[[Category: Douangamath, A]]	+	[[Category: Douangamath A]]
-	[[Category: Edwards, E]]	+	[[Category: Edwards E]]
-	[[Category: Fairhead, M]]	+	[[Category: Fairhead M]]
-	[[Category: Krojer, T]]	+	[[Category: Krojer T]]
-	[[Category: Ng~~, J T~~]]	+	[[Category: Ng JT]]
-	[[Category: Pearce~~, N M~~]]	+	[[Category: Pearce NM]]
-	[[Category: Strain-Damerell, C]]	+	[[Category: Strain-Damerell C]]
-	[[Category: Talon, R]]	+	[[Category: Talon R]]
-	[[Category: Wright, N]]	+	[[Category: Wright N]]
-	[[Category: ~~Bromodomain]]~~	+	[[Category: Von Delft F]]
-	~~[[Category: Diamond i04-1]]~~	+
-	~~[[Category: Epigenetic]]~~	+
-	~~[[Category: Fragmentscreening]]~~	+
-	~~[[Category: Histone-binding protein]]~~	+
-	~~[[Category: Sgc]]~~	+
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 08:14, 6 March 2019

OCA — Wed, 06 Mar 2019 08:14:07 GMT

←Older revision		Revision as of 08:14, 6 March 2019
Line 1:		Line 1:

	==Crystal structure of the bromodomain of human surface epitope engineered BRD1A in complex with 3D Consortium fragment 4-acetyl- piperazin-2-one (SGC - Diamond I04-1 fragment screening)==		==Crystal structure of the bromodomain of human surface epitope engineered BRD1A in complex with 3D Consortium fragment 4-acetyl- piperazin-2-one (SGC - Diamond I04-1 fragment screening)==
-	<StructureSection load='5ame' size='340' side='right' caption='[[5ame]], [[Resolution\|resolution]] 1.58Å' scene=''>	+	<StructureSection load='5ame' size='340' side='right' caption='[[5ame]], [[Resolution\|resolution]] 1.58Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5ame]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AME OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AME FirstGlance]. <br>		<table><tr><td colspan='2'>[[5ame]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AME OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AME FirstGlance]. <br>
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/BRD1_HUMAN BRD1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.<ref>PMID:16387653</ref> <ref>PMID:21880731</ref>		[[http://www.uniprot.org/uniprot/BRD1_HUMAN BRD1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.<ref>PMID:16387653</ref> <ref>PMID:21880731</ref>
		+
		+	==See Also==
		+	*[[Bromodomain-containing protein\|Bromodomain-containing protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:26, 24 January 2018

OCA — Wed, 24 Jan 2018 20:26:12 GMT

←Older revision		Revision as of 20:26, 24 January 2018
Line 3:		Line 3:
	<StructureSection load='5ame' size='340' side='right' caption='[[5ame]], [[Resolution\|resolution]] 1.58Å' scene=''>		<StructureSection load='5ame' size='340' side='right' caption='[[5ame]], [[Resolution\|resolution]] 1.58Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ame]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AME OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AME FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ame]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AME OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AME FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PW3:4-ACETYL-PIPERAZIN-2-ONE'>PW3</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PW3:4-ACETYL-PIPERAZIN-2-ONE'>PW3</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5amf\|5amf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5amf\|5amf]]</td></tr>
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/BRD1_HUMAN BRD1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.<ref>PMID:16387653</ref> <ref>PMID:21880731</ref>		[[http://www.uniprot.org/uniprot/BRD1_HUMAN BRD1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.<ref>PMID:16387653</ref> <ref>PMID:21880731</ref>
-
-	==See Also==
-	*[[Bromodomain-containing protein\|Bromodomain-containing protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA at 09:56, 10 March 2017

OCA — Fri, 10 Mar 2017 09:56:49 GMT

←Older revision		Revision as of 09:56, 10 March 2017
Line 1:		Line 1:
		+
	==Crystal structure of the bromodomain of human surface epitope engineered BRD1A in complex with 3D Consortium fragment 4-acetyl- piperazin-2-one (SGC - Diamond I04-1 fragment screening)==		==Crystal structure of the bromodomain of human surface epitope engineered BRD1A in complex with 3D Consortium fragment 4-acetyl- piperazin-2-one (SGC - Diamond I04-1 fragment screening)==
	<StructureSection load='5ame' size='340' side='right' caption='[[5ame]], [[Resolution\|resolution]] 1.58Å' scene=''>		<StructureSection load='5ame' size='340' side='right' caption='[[5ame]], [[Resolution\|resolution]] 1.58Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PW3:4-ACETYL-PIPERAZIN-2-ONE'>PW3</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PW3:4-ACETYL-PIPERAZIN-2-ONE'>PW3</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5amf\|5amf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5amf\|5amf]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ame FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ame OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5ame RCSB], [http://www.ebi.ac.uk/pdbsum/5ame PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ame FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ame OCA], [http://pdbe.org/5ame PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ame RCSB], [http://www.ebi.ac.uk/pdbsum/5ame PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ame ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/BRD1_HUMAN BRD1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.<ref>PMID:16387653</ref> <ref>PMID:21880731</ref>		[[http://www.uniprot.org/uniprot/BRD1_HUMAN BRD1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.<ref>PMID:16387653</ref> <ref>PMID:21880731</ref>
		+
		+	==See Also==
		+	*[[Bromodomain-containing protein\|Bromodomain-containing protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA: Protected "5ame" [edit=sysop:move=sysop]

OCA — Wed, 18 Mar 2015 12:20:03 GMT

Protected "5ame" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:20, 18 March 2015

OCA: New page: ==Crystal structure of the bromodomain of human surface epitope engineered BRD1A in complex with 3D Consortium fragment 4-acetyl- piperazin-2-one (SGC - Diamond I04-1 fragment screening)==...

OCA — Wed, 18 Mar 2015 12:20:00 GMT

New page: ==Crystal structure of the bromodomain of human surface epitope engineered BRD1A in complex with 3D Consortium fragment 4-acetyl- piperazin-2-one (SGC - Diamond I04-1 fragment screening)==...

New page

==Crystal structure of the bromodomain of human surface epitope engineered BRD1A in complex with 3D Consortium fragment 4-acetyl- piperazin-2-one (SGC - Diamond I04-1 fragment screening)==
<StructureSection load='5ame' size='340' side='right' caption='[[5ame]], [[Resolution|resolution]] 1.58Å' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5ame]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AME OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AME FirstGlance]. 
</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PW3:4-ACETYL-PIPERAZIN-2-ONE'>PW3</scene></td></tr>
<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5amf|5amf]]</td></tr>
<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ame FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ame OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5ame RCSB], [http://www.ebi.ac.uk/pdbsum/5ame PDBsum]</td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/BRD1_HUMAN BRD1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.<ref>PMID:16387653</ref> <ref>PMID:21880731</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Bowkett, D]]
[[Category: Bradley, A]]
[[Category: Brandao-Neto, J]]
[[Category: Brennan, P]]
[[Category: Burgess-Brown, N]]
[[Category: Collins, P]]
[[Category: Cox, O]]
[[Category: Delft, F von]]
[[Category: Douangamath, A]]
[[Category: Edwards, E]]
[[Category: Fairhead, M]]
[[Category: Krojer, T]]
[[Category: Ng, J T]]
[[Category: Pearce, N M]]
[[Category: Strain-Damerell, C]]
[[Category: Talon, R]]
[[Category: Wright, N]]
[[Category: Bromodomain]]
[[Category: Diamond i04-1]]
[[Category: Epigenetic]]
[[Category: Fragmentscreening]]
[[Category: Histone-binding protein]]
[[Category: Sgc]]
[[Category: Structural genomic]]
[[Category: Transcription]]