5amg - Revision history

OCA at 11:13, 10 January 2024

OCA — Wed, 10 Jan 2024 11:13:24 GMT

←Older revision		Revision as of 11:13, 10 January 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5amg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AMG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AMG FirstGlance]. <br>		<table><tr><td colspan='2'>[[5amg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AMG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AMG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IW7:2-(PENTYLSULFAMOYL)-4-SULFAMOYLBENZOIC+ACID'>IW7</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.55Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IW7:2-(PENTYLSULFAMOYL)-4-SULFAMOYLBENZOIC+ACID'>IW7</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5amg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5amg OCA], [https://pdbe.org/5amg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5amg RCSB], [https://www.ebi.ac.uk/pdbsum/5amg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5amg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5amg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5amg OCA], [https://pdbe.org/5amg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5amg RCSB], [https://www.ebi.ac.uk/pdbsum/5amg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5amg ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:14, 31 May 2023

OCA — Wed, 31 May 2023 06:14:40 GMT

←Older revision		Revision as of 06:14, 31 May 2023
Line 3:		Line 3:
	<StructureSection load='5amg' size='340' side='right'caption='[[5amg]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='5amg' size='340' side='right'caption='[[5amg]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5amg]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AMG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5AMG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5amg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AMG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AMG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IW7:2-(PENTYLSULFAMOYL)-4-SULFAMOYLBENZOIC+ACID'>IW7</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IW7:2-(PENTYLSULFAMOYL)-4-SULFAMOYLBENZOIC+ACID'>IW7</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5amd\|5amd]], [[5aml\|5aml]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5amg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5amg OCA], [https://pdbe.org/5amg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5amg RCSB], [https://www.ebi.ac.uk/pdbsum/5amg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5amg ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5amg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5amg OCA], [~~http~~://pdbe.org/5amg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5amg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5amg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5amg ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[~~http~~://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>	+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[https://omim.org/entry/259730 259730]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>	+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Carbonate dehydratase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Leitans, J]]	+	[[Category: Leitans J]]
-	[[Category: Tars, K]]	+	[[Category: Tars K]]
-	[[Category: Zalubovskis, R]]	+	[[Category: Zalubovskis R]]
-	~~[[Category: Ca 2]]~~	+
-	~~[[Category: Ca ii]]~~	+
-	~~[[Category: Lyase~~]]	+

OCA at 08:24, 4 November 2020

OCA — Wed, 04 Nov 2020 08:24:00 GMT

←Older revision		Revision as of 08:24, 4 November 2020
Line 1:		Line 1:

	==Three dimensional structure of human carbonic anhydrase II in complex with 2-(Pentylsulfamoyl)-4-sulfamoylbenzoic acid==		==Three dimensional structure of human carbonic anhydrase II in complex with 2-(Pentylsulfamoyl)-4-sulfamoylbenzoic acid==
-	<StructureSection load='5amg' size='340' side='right' caption='[[5amg]], [[Resolution\|resolution]] 1.55Å' scene=''>	+	<StructureSection load='5amg' size='340' side='right'caption='[[5amg]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5amg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AMG OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5AMG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5amg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AMG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5AMG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IW7:2-(PENTYLSULFAMOYL)-4-SULFAMOYLBENZOIC+ACID'>IW7</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IW7:2-(PENTYLSULFAMOYL)-4-SULFAMOYLBENZOIC+ACID'>IW7</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5amd\|5amd]], [[5aml\|5aml]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5amd\|5amd]], [[5aml\|5aml]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5amg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5amg OCA], [http://pdbe.org/5amg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5amg RCSB], [http://www.ebi.ac.uk/pdbsum/5amg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5amg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5amg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5amg OCA], [http://pdbe.org/5amg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5amg RCSB], [http://www.ebi.ac.uk/pdbsum/5amg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5amg ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 24:		Line 24:

	==See Also==		==See Also==
-	*[[Carbonic anhydrase\|Carbonic anhydrase]]	+	*[[Carbonic anhydrase 3D structures\|Carbonic anhydrase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 31:		Line 31:
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Leitans, J]]		[[Category: Leitans, J]]
	[[Category: Tars, K]]		[[Category: Tars, K]]

OCA at 09:17, 30 January 2019

OCA — Wed, 30 Jan 2019 09:17:04 GMT

←Older revision		Revision as of 09:17, 30 January 2019
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	</div>		</div>
	<div class="pdbe-citations 5amg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5amg" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Carbonic anhydrase\|Carbonic anhydrase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:02, 17 January 2018

OCA — Wed, 17 Jan 2018 08:02:08 GMT

←Older revision		Revision as of 08:02, 17 January 2018
Line 3:		Line 3:
	<StructureSection load='5amg' size='340' side='right' caption='[[5amg]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='5amg' size='340' side='right' caption='[[5amg]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5amg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AMG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AMG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5amg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AMG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AMG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IW7:2-(PENTYLSULFAMOYL)-4-SULFAMOYLBENZOIC+ACID'>IW7</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IW7:2-(PENTYLSULFAMOYL)-4-SULFAMOYLBENZOIC+ACID'>IW7</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5amd\|5amd]], [[5aml\|5aml]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5amd\|5amd]], [[5aml\|5aml]]</td></tr>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
		+	[[Category: Human]]
	[[Category: Leitans, J]]		[[Category: Leitans, J]]
	[[Category: Tars, K]]		[[Category: Tars, K]]

OCA at 10:01, 10 March 2017

OCA — Fri, 10 Mar 2017 10:01:04 GMT

←Older revision		Revision as of 10:01, 10 March 2017
Line 1:		Line 1:
		+
	==Three dimensional structure of human carbonic anhydrase II in complex with 2-(Pentylsulfamoyl)-4-sulfamoylbenzoic acid==		==Three dimensional structure of human carbonic anhydrase II in complex with 2-(Pentylsulfamoyl)-4-sulfamoylbenzoic acid==
	<StructureSection load='5amg' size='340' side='right' caption='[[5amg]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='5amg' size='340' side='right' caption='[[5amg]], [[Resolution\|resolution]] 1.55Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5amd\|5amd]], [[5aml\|5aml]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5amd\|5amd]], [[5aml\|5aml]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5amg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5amg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5amg RCSB], [http://www.ebi.ac.uk/pdbsum/5amg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5amg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5amg OCA], [http://pdbe.org/5amg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5amg RCSB], [http://www.ebi.ac.uk/pdbsum/5amg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5amg ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 5amg" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:06, 8 April 2015

OCA — Wed, 08 Apr 2015 11:06:13 GMT

←Older revision		Revision as of 11:06, 8 April 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Three dimensional structure of human carbonic anhydrase II in complex with 2-(Pentylsulfamoyl)-4-sulfamoylbenzoic acid==
		+	<StructureSection load='5amg' size='340' side='right' caption='[[5amg]], [[Resolution\|resolution]] 1.55Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5amg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AMG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AMG FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IW7:2-(PENTYLSULFAMOYL)-4-SULFAMOYLBENZOIC+ACID'>IW7</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5amd\|5amd]], [[5aml\|5aml]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5amg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5amg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5amg RCSB], [http://www.ebi.ac.uk/pdbsum/5amg PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[http://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	1-N-Alkylated-6-sulfamoyl saccharin derivatives were prepared and assayed as carbonic anhydrase inhibitors (CAIs). During X-ray crystallographic experiments an unexpected hydrolysis of the isothiazole ring was evidenced which allowed us to prepare highly potent enzyme inhibitors with selectivity for some isoforms with medical applications.

-	~~The entry 5amg is ON HOLD until Paper Publication~~	+	X-ray crystallography-promoted drug design of carbonic anhydrase inhibitors.,Ivanova J, Leitans J, Tanc M, Kazaks A, Zalubovskis R, Supuran CT, Tars K Chem Commun (Camb). 2015 Mar 27. PMID:25813715<ref>PMID:25813715</ref>

-	~~Authors: Leitans~~, J.~~, Tars, K~~.~~, Zalubovskis, R~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Three dimensional structure of human carbonic anhydrase II in complex with 2-(Pentylsulfamoyl)-4-sulfamoylbenzoic acid~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Carbonate dehydratase]]
		+	[[Category: Leitans, J]]
		+	[[Category: Tars, K]]
	[[Category: Zalubovskis, R]]		[[Category: Zalubovskis, R]]
-	[[Category: ~~Tars, K~~]]	+	[[Category: Ca 2]]
-	[[Category: ~~Leitans, J~~]]	+	[[Category: Ca ii]]
		+	[[Category: Lyase]]

OCA: Protected "5amg" [edit=sysop:move=sysop]

OCA — Wed, 18 Mar 2015 11:14:52 GMT

Protected "5amg" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:14, 18 March 2015

OCA: New page: '''Unreleased structure''' The entry 5amg is ON HOLD until Paper Publication Authors: Leitans, J., Tars, K., Zalubovskis, R. Description: Three dimensional structure of human carbonic ...

OCA — Wed, 18 Mar 2015 11:14:51 GMT

New page: '''Unreleased structure''' The entry 5amg is ON HOLD until Paper Publication Authors: Leitans, J., Tars, K., Zalubovskis, R. Description: Three dimensional structure of human carbonic ...

New page

'''Unreleased structure'''

The entry 5amg is ON HOLD until Paper Publication

Authors: Leitans, J., Tars, K., Zalubovskis, R.

Description: Three dimensional structure of human carbonic anhydrase II in complex with 2-(Pentylsulfamoyl)-4-sulfamoylbenzoic acid
[[Category: Unreleased Structures]]
[[Category: Zalubovskis, R]]
[[Category: Tars, K]]
[[Category: Leitans, J]]