5aoq - Revision history

OCA at 06:20, 31 May 2023

OCA — Wed, 31 May 2023 06:20:29 GMT

←Older revision		Revision as of 06:20, 31 May 2023
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	<StructureSection load='5aoq' size='340' side='right'caption='[[5aoq]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='5aoq' size='340' side='right'caption='[[5aoq]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5aoq]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Bommo Bommo~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AOQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5AOQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5aoq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bombyx_mori Bombyx mori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AOQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AOQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5aoq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aoq OCA], [https://pdbe.org/5aoq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5aoq RCSB], [https://www.ebi.ac.uk/pdbsum/5aoq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5aoq ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5aoq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aoq OCA], [~~http~~://pdbe.org/5aoq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5aoq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5aoq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5aoq ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TORSO_BOMMO TORSO_BOMMO] Probable receptor tyrosine kinase. During postembryonic development, involved in the initiation of metamorphosis probably by inducing the production of ecdysone in response to prothoracicotropic hormone (PTTH) (By similarity). Binding to PTTH stimulates activation of canonical MAPK signaling leading to ERK phosphorylation (PubMed:19965758, PubMed:26928300).[UniProtKB:P18475]<ref>PMID:19965758</ref> <ref>PMID:26928300</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bommo~~]]	+	[[Category: Bombyx mori]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Receptor protein-tyrosine kinase]]~~	+	[[Category: Goyal Y]]
-	[[Category: Goyal, Y]]	+	[[Category: Jenni S]]
-	~~[[Category: Grotthuss, M von~~]]	+	[[Category: Klein DE]]
-	[[Category: Jenni, S]]	+	[[Category: Shvartsman SY]]
-	[[Category: Klein~~, D E~~]]	+	[[Category: Von Grotthuss M]]
-	[[Category: Shvartsman~~, S Y~~]]	+
-	[[Category: ~~Cystine knot]]~~	+
-	~~[[Category: Developmental timing]]~~	+
-	~~[[Category: Fibronectin type iii domain]]~~	+
-	~~[[Category: Metamorphosis]]~~	+
-	~~[[Category: Negative cooperativity]]~~	+
-	~~[[Category: Neurohormone]]~~	+
-	~~[[Category: Peptide hormone]]~~	+
-	~~[[Category: Prothoracicotropic hormone]]~~	+
-	~~[[Category: Ptth]]~~	+
-	~~[[Category: Receptor tyrosine kinase]]~~	+
-	~~[[Category: Rtk]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 08:42, 11 March 2020

OCA — Wed, 11 Mar 2020 08:42:24 GMT

←Older revision		Revision as of 08:42, 11 March 2020
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	==Structural basis of neurohormone perception by the receptor tyrosine kinase Torso==		==Structural basis of neurohormone perception by the receptor tyrosine kinase Torso==
-	<StructureSection load='5aoq' size='340' side='right' caption='[[5aoq]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='5aoq' size='340' side='right'caption='[[5aoq]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5aoq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bommo Bommo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AOQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AOQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[5aoq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bommo Bommo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AOQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AOQ FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Bommo]]		[[Category: Bommo]]
		+	[[Category: Large Structures]]
	[[Category: Receptor protein-tyrosine kinase]]		[[Category: Receptor protein-tyrosine kinase]]
	[[Category: Goyal, Y]]		[[Category: Goyal, Y]]

OCA at 07:21, 13 December 2017

OCA — Wed, 13 Dec 2017 07:21:32 GMT

←Older revision		Revision as of 07:21, 13 December 2017
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		+
	==Structural basis of neurohormone perception by the receptor tyrosine kinase Torso==		==Structural basis of neurohormone perception by the receptor tyrosine kinase Torso==
	<StructureSection load='5aoq' size='340' side='right' caption='[[5aoq]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='5aoq' size='340' side='right' caption='[[5aoq]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5aoq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AOQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AOQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5aoq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bommo Bommo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AOQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AOQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aoq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aoq OCA], [http://pdbe.org/5aoq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aoq RCSB], [http://www.ebi.ac.uk/pdbsum/5aoq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aoq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aoq OCA], [http://pdbe.org/5aoq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aoq RCSB], [http://www.ebi.ac.uk/pdbsum/5aoq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5aoq ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bommo]]
	[[Category: Receptor protein-tyrosine kinase]]		[[Category: Receptor protein-tyrosine kinase]]
	[[Category: Goyal, Y]]		[[Category: Goyal, Y]]

OCA at 12:24, 13 January 2016

OCA — Wed, 13 Jan 2016 12:24:30 GMT

←Older revision		Revision as of 12:24, 13 January 2016
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aoq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aoq OCA], [http://pdbe.org/5aoq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aoq RCSB], [http://www.ebi.ac.uk/pdbsum/5aoq PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aoq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aoq OCA], [http://pdbe.org/5aoq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aoq RCSB], [http://www.ebi.ac.uk/pdbsum/5aoq PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In insects, brain-derived Prothoracicotropic hormone (PTTH) activates the receptor tyrosine kinase (RTK) Torso to initiate metamorphosis through the release of ecdysone. We have determined the crystal structure of silkworm PTTH in complex with the ligand-binding region of Torso. Here we show that ligand-induced Torso dimerization results from the sequential and negatively cooperative formation of asymmetric heterotetramers. Mathematical modeling of receptor activation based upon our biophysical studies shows that ligand pulses are "buffered" at low receptor levels, leading to a sustained signal. By contrast, high levels of Torso develop the signal intensity and duration of a noncooperative system. We propose that this may allow Torso to coordinate widely different functions from a single ligand by tuning receptor levels. Phylogenic analysis indicates that Torso is found outside arthropods, including human parasitic roundworms. Together, our findings provide mechanistic insight into how this receptor system, with roles in embryonic and adult development, is regulated.
		+
		+	Structural Basis of Neurohormone Perception by the Receptor Tyrosine Kinase Torso.,Jenni S, Goyal Y, von Grotthuss M, Shvartsman SY, Klein DE Mol Cell. 2015 Dec 17;60(6):941-52. doi: 10.1016/j.molcel.2015.10.026. Epub 2015 , Nov 19. PMID:26698662<ref>PMID:26698662</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5aoq" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 04:43, 1 December 2015

OCA — Tue, 01 Dec 2015 04:43:27 GMT

←Older revision		Revision as of 04:43, 1 December 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Structural basis of neurohormone perception by the receptor tyrosine kinase Torso==
-		+	<StructureSection load='5aoq' size='340' side='right' caption='[[5aoq]], [[Resolution\|resolution]] 2.70Å' scene=''>
-	~~The entry~~ 5aoq is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5aoq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AOQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AOQ FirstGlance]. <br>
-	~~Authors~~: ~~Jenni, S~~.~~, Goyal, Y~~.~~, von Grotthuss, M~~.~~, Shvartsman, S~~.Y.~~, Klein, D~~.E.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
-	~~Description: Structural basis of neurohormone perception by the receptor tyrosine kinase Torso~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aoq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aoq OCA], [http://pdbe.org/5aoq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aoq RCSB], [http://www.ebi.ac.uk/pdbsum/5aoq PDBsum]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[~~[Category~~: ~~Shvartsman~~, S.Y]]	+	__TOC__
-	[[~~Category~~: ~~Von Grotthuss~~, M]]	+	</StructureSection>
-	[[Category: ~~Klein, D.E~~]]	+	[[Category: Receptor protein-tyrosine kinase]]
	[[Category: Goyal, Y]]		[[Category: Goyal, Y]]
		+	[[Category: Grotthuss, M von]]
	[[Category: Jenni, S]]		[[Category: Jenni, S]]
		+	[[Category: Klein, D E]]
		+	[[Category: Shvartsman, S Y]]
		+	[[Category: Cystine knot]]
		+	[[Category: Developmental timing]]
		+	[[Category: Fibronectin type iii domain]]
		+	[[Category: Metamorphosis]]
		+	[[Category: Negative cooperativity]]
		+	[[Category: Neurohormone]]
		+	[[Category: Peptide hormone]]
		+	[[Category: Prothoracicotropic hormone]]
		+	[[Category: Ptth]]
		+	[[Category: Receptor tyrosine kinase]]
		+	[[Category: Rtk]]
		+	[[Category: Transferase]]

OCA: Protected "5aoq" [edit=sysop:move=sysop]

OCA — Wed, 30 Sep 2015 11:17:26 GMT

Protected "5aoq" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:17, 30 September 2015

OCA: New page: '''Unreleased structure''' The entry 5aoq is ON HOLD Authors: Jenni, S., Goyal, Y., von Grotthuss, M., Shvartsman, S.Y., Klein, D.E. Description: Structural basis of neurohormone perce...

OCA — Wed, 30 Sep 2015 11:17:24 GMT

New page: '''Unreleased structure''' The entry 5aoq is ON HOLD Authors: Jenni, S., Goyal, Y., von Grotthuss, M., Shvartsman, S.Y., Klein, D.E. Description: Structural basis of neurohormone perce...

New page

'''Unreleased structure'''

The entry 5aoq is ON HOLD

Authors: Jenni, S., Goyal, Y., von Grotthuss, M., Shvartsman, S.Y., Klein, D.E.

Description: Structural basis of neurohormone perception by the receptor tyrosine kinase Torso
[[Category: Unreleased Structures]]
[[Category: Shvartsman, S.Y]]
[[Category: Von Grotthuss, M]]
[[Category: Klein, D.E]]
[[Category: Goyal, Y]]
[[Category: Jenni, S]]