5aqj - Revision history

OCA at 11:15, 10 January 2024

OCA — Wed, 10 Jan 2024 11:15:18 GMT

←Older revision		Revision as of 11:15, 10 January 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5aqj]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AQJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AQJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[5aqj]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AQJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AQJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=Q88:9H-PURINE-6,8-DIAMINE'>Q88</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.96Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=Q88:9H-PURINE-6,8-DIAMINE'>Q88</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5aqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aqj OCA], [https://pdbe.org/5aqj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5aqj RCSB], [https://www.ebi.ac.uk/pdbsum/5aqj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5aqj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5aqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aqj OCA], [https://pdbe.org/5aqj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5aqj RCSB], [https://www.ebi.ac.uk/pdbsum/5aqj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5aqj ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:24, 31 May 2023

OCA — Wed, 31 May 2023 06:24:13 GMT

←Older revision		Revision as of 06:24, 31 May 2023
Line 3:		Line 3:
	<StructureSection load='5aqj' size='340' side='right'caption='[[5aqj]], [[Resolution\|resolution]] 1.96Å' scene=''>		<StructureSection load='5aqj' size='340' side='right'caption='[[5aqj]], [[Resolution\|resolution]] 1.96Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5aqj]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AQJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5AQJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5aqj]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AQJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AQJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=Q88:9H-PURINE-6,8-DIAMINE'>Q88</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=Q88:9H-PURINE-6,8-DIAMINE'>Q88</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5aqf\|5aqf]], [[5aqg\|5aqg]], [[5aqh\|5aqh]], [[5aqi\|5aqi]], [[5aqk\|5aqk]], [[5aql\|5aql]], [[5aqm\|5aqm]], [[5aqn\|5aqn]], [[5aqo\|5aqo]], [[5aqp\|5aqp]], [[5aqq\|5aqq]], [[5aqr\|5aqr]], [[5aqs\|5aqs]], [[5aqt\|5aqt]], [[5aqu\|5aqu]], [[5aqv\|5aqv]], [[5aqw\|5aqw]], [[5aqx\|5aqx]], [[5aqy\|5aqy]], [[5aqz\|5aqz]], [[5ar0\|5ar0]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5aqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aqj OCA], [https://pdbe.org/5aqj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5aqj RCSB], [https://www.ebi.ac.uk/pdbsum/5aqj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5aqj ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitochondrial_protein-transporting_ATPase Mitochondrial protein-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.51 3.6.3.51] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5aqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aqj OCA], [~~http~~://pdbe.org/5aqj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5aqj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5aqj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5aqj ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/HSP7C_HUMAN HSP7C_HUMAN]] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex.<ref>PMID:10722728</ref> [[http://www.uniprot.org/uniprot/BAG1_HUMAN BAG1_HUMAN]] Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.<ref>PMID:9305631</ref> <ref>PMID:9873016</ref> <ref>PMID:12724406</ref>	+	[https://www.uniprot.org/uniprot/HSP7C_HUMAN HSP7C_HUMAN] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex.<ref>PMID:10722728</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:

	==See Also==		==See Also==
-	*[[Heat Shock ~~Proteins~~\|Heat Shock ~~Proteins~~]]	+	*[[BAG family proteins 3D structures\|BAG family proteins 3D structures]]
		+	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Mitochondrial protein-transporting ATPase]]~~	+	[[Category: Burke R]]
-	[[Category: Burke, R]]	+	[[Category: Cheeseman MD]]
-	[[Category: Cheeseman~~, M D~~]]	+	[[Category: Collins I]]
-	[[Category: Collins, I]]	+	[[Category: Dobson SE]]
-	[[Category: Dobson~~, S E~~]]	+	[[Category: Jeganathan F]]
-	[[Category: Jeganathan, F]]	+	[[Category: Jones AM]]
-	[[Category: Jones~~, A M~~]]	+	[[Category: Jones K]]
-	[[Category: Jones, K]]	+	[[Category: Kadi N]]
-	[[Category: Kadi, N]]	+	[[Category: Lee D]]
-	[[Category: Lee, D]]	+	[[Category: Liu M]]
-	[[Category: Liu, M]]	+	[[Category: Matthews TP]]
-	[[Category: Matthews~~, T P~~]]	+	[[Category: McAndrew C]]
-	[[Category: McAndrew, C]]	+	[[Category: Osborne JD]]
-	~~[[Category: Montfort, R L.M van~~]]	+	[[Category: Richards M]]
-	[[Category: Osborne~~, J D~~]]	+	[[Category: Rowlands MG]]
-	[[Category: Richards, M]]	+	[[Category: Westwood IM]]
-	[[Category: Rowlands~~, M G~~]]	+	[[Category: Workman P]]
-	[[Category: Westwood~~, I M~~]]	+	[[Category: Yahya N]]
-	[[Category: Workman, P]]	+	[[Category: Van Montfort RLM]]
-	[[Category: Yahya, N]]	+
-	[[Category: ~~Atpase]]~~	+
-	~~[[Category: Bag1]]~~	+
-	~~[[Category: Chaperone]]~~	+
-	~~[[Category: Fragment]]~~	+
-	~~[[Category: Heat shock protein]]~~	+
-	~~[[Category: Hsc70]]~~	+
-	~~[[Category: Hsp70]]~~	+
-	~~[[Category: Hsp72~~]]	+

OCA at 07:20, 10 July 2019

OCA — Wed, 10 Jul 2019 07:20:54 GMT

←Older revision		Revision as of 07:20, 10 July 2019
Line 1:		Line 1:

	==Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues==		==Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues==
-	<StructureSection load='5aqj' size='340' side='right' caption='[[5aqj]], [[Resolution\|resolution]] 1.96Å' scene=''>	+	<StructureSection load='5aqj' size='340' side='right'caption='[[5aqj]], [[Resolution\|resolution]] 1.96Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5aqj]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AQJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AQJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[5aqj]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AQJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AQJ FirstGlance]. <br>
Line 27:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mitochondrial protein-transporting ATPase]]		[[Category: Mitochondrial protein-transporting ATPase]]
	[[Category: Burke, R]]		[[Category: Burke, R]]

OCA at 10:43, 13 September 2017

OCA — Wed, 13 Sep 2017 10:43:42 GMT

←Older revision		Revision as of 10:43, 13 September 2017
Line 11:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/HSP7C_HUMAN HSP7C_HUMAN]] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex.<ref>PMID:10722728</ref> [[http://www.uniprot.org/uniprot/BAG1_HUMAN BAG1_HUMAN]] Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.<ref>PMID:9305631</ref> <ref>PMID:9873016</ref> <ref>PMID:12724406</ref>		[[http://www.uniprot.org/uniprot/HSP7C_HUMAN HSP7C_HUMAN]] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex.<ref>PMID:10722728</ref> [[http://www.uniprot.org/uniprot/BAG1_HUMAN BAG1_HUMAN]] Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.<ref>PMID:9305631</ref> <ref>PMID:9873016</ref> <ref>PMID:12724406</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The heat shock protein 70s (HSP70s) are molecular chaperones implicated in many cancers and of significant interest as targets for novel cancer therapies. Several HSP70 inhibitors have been reported, but because the majority have poor physicochemical properties and for many the exact mode of action is poorly understood, more detailed mechanistic and structural insight into ligand-binding to HSP70s is urgently needed. Here we describe the first comprehensive fragment-based inhibitor exploration of an HSP70 enzyme, which yielded an amino-quinazoline fragment that was elaborated to a novel ATP binding site ligand with different physicochemical properties to known adenosine-based HSP70 inhibitors. Crystal structures of amino-quinazoline ligands bound to the different conformational states of the HSP70 nucleotide binding domain highlighted the challenges of a fragment-based approach when applied to this particular flexible enzyme class with an ATP-binding site that changes shape and size during its catalytic cycle. In these studies we showed that Ser275 is a key residue in the selective binding of ATP. Additionally, the structural data revealed a potential functional role for the ATP ribose moiety in priming the protein for the formation of the ATP-bound pre-hydrolysis complex by influencing the conformation of one of the phosphate binding loops.
		+
		+	A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.,Jones AM, Westwood IM, Osborne JD, Matthews TP, Cheeseman MD, Rowlands MG, Jeganathan F, Burke R, Lee D, Kadi N, Liu M, Richards M, McAndrew C, Yahya N, Dobson SE, Jones K, Workman P, Collins I, van Montfort RL Sci Rep. 2016 Oct 6;6:34701. doi: 10.1038/srep34701. PMID:27708405<ref>PMID:27708405</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5aqj" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Heat Shock Proteins\|Heat Shock Proteins]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 21:20, 5 October 2016

OCA — Wed, 05 Oct 2016 21:20:35 GMT

←Older revision		Revision as of 21:20, 5 October 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5aqj ~~is ON HOLD until Paper Publication~~	+	==Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues==
-		+	<StructureSection load='5aqj' size='340' side='right' caption='[[5aqj]], [[Resolution\|resolution]] 1.96Å' scene=''>
-	~~Authors~~: ~~Jones, A~~.M.~~, Westwood, I~~.M.~~, Osborne, J~~.D.~~, Matthews, T~~.P., ~~Cheeseman~~, ~~M.D.~~, ~~Rowlands~~, ~~M.G.~~, ~~Jeganathan~~, F., ~~Burke~~, R., ~~Lee~~, D., ~~Kadi~~, N., ~~Liu~~, M., ~~Richards~~, M., ~~McAndrew~~, C., ~~Yahya~~, N., ~~Dobson~~, ~~S.E.~~, ~~Jones~~, K., ~~Workman~~, P., ~~Collins~~, I., ~~van Montfort~~, R.L.M.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5aqj]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AQJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AQJ FirstGlance]. <br>
-	~~Description~~: ~~Fragment-based screening~~ of ~~HSP70 sheds light~~ on the ~~functional~~ role of ~~ATP~~-~~binding site residues~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=Q88:9H-PURINE-6,8-DIAMINE'>Q88</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5aqf\|5aqf]], [[5aqg\|5aqg]], [[5aqh\|5aqh]], [[5aqi\|5aqi]], [[5aqk\|5aqk]], [[5aql\|5aql]], [[5aqm\|5aqm]], [[5aqn\|5aqn]], [[5aqo\|5aqo]], [[5aqp\|5aqp]], [[5aqq\|5aqq]], [[5aqr\|5aqr]], [[5aqs\|5aqs]], [[5aqt\|5aqt]], [[5aqu\|5aqu]], [[5aqv\|5aqv]], [[5aqw\|5aqw]], [[5aqx\|5aqx]], [[5aqy\|5aqy]], [[5aqz\|5aqz]], [[5ar0\|5ar0]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitochondrial_protein-transporting_ATPase Mitochondrial protein-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.51 3.6.3.51] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aqj OCA], [http://pdbe.org/5aqj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aqj RCSB], [http://www.ebi.ac.uk/pdbsum/5aqj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5aqj ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HSP7C_HUMAN HSP7C_HUMAN]] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex.<ref>PMID:10722728</ref> [[http://www.uniprot.org/uniprot/BAG1_HUMAN BAG1_HUMAN]] Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.<ref>PMID:9305631</ref> <ref>PMID:9873016</ref> <ref>PMID:12724406</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Mitochondrial protein-transporting ATPase]]
	[[Category: Burke, R]]		[[Category: Burke, R]]
-	[[Category: ~~Liu~~, M]]	+	[[Category: Cheeseman, M D]]
-	~~[[Category: Van Montfort, R.L.M]]~~	+
-	~~[[Category: Lee,~~ D]]	+
-	~~[[Category: Yahya, N]]~~	+
-	~~[[Category: Rowlands, M.G]]~~	+
-	~~[[Category: Dobson, S.E~~]]	+
	[[Category: Collins, I]]		[[Category: Collins, I]]
-	[[Category: ~~Workman~~, P]]	+	[[Category: Dobson, S E]]
		+	[[Category: Jeganathan, F]]
		+	[[Category: Jones, A M]]
	[[Category: Jones, K]]		[[Category: Jones, K]]
-	[[Category: ~~Cheeseman~~, M.D]]	+	[[Category: Kadi, N]]
-	[[Category: ~~Westwood~~, I.M]]	+	[[Category: Lee, D]]
-	[[Category: ~~Mcandrew~~, C]]	+	[[Category: Liu, M]]
-	[[Category: ~~Jones~~, A.M]]	+	[[Category: Matthews, T P]]
		+	[[Category: McAndrew, C]]
		+	[[Category: Montfort, R L.M van]]
		+	[[Category: Osborne, J D]]
	[[Category: Richards, M]]		[[Category: Richards, M]]
-	[[Category: ~~Kadi~~, N]]	+	[[Category: Rowlands, M G]]
-	[[Category: ~~Jeganathan~~, F]]	+	[[Category: Westwood, I M]]
-	[[Category: ~~Osborne~~, ~~J.D~~]]	+	[[Category: Workman, P]]
-	[[Category: ~~Matthews~~, ~~T.P~~]]	+	[[Category: Yahya, N]]
		+	[[Category: Atpase]]
		+	[[Category: Bag1]]
		+	[[Category: Chaperone]]
		+	[[Category: Fragment]]
		+	[[Category: Heat shock protein]]
		+	[[Category: Hsc70]]
		+	[[Category: Hsp70]]
		+	[[Category: Hsp72]]

OCA at 09:55, 16 December 2015

OCA — Wed, 16 Dec 2015 09:55:24 GMT

←Older revision		Revision as of 09:55, 16 December 2015
Line 10:		Line 10:
	[[Category: Liu, M]]		[[Category: Liu, M]]
	[[Category: Van Montfort, R.L.M]]		[[Category: Van Montfort, R.L.M]]
		+	[[Category: Lee, D]]
	[[Category: Yahya, N]]		[[Category: Yahya, N]]
		+	[[Category: Rowlands, M.G]]
	[[Category: Dobson, S.E]]		[[Category: Dobson, S.E]]
	[[Category: Collins, I]]		[[Category: Collins, I]]
Line 17:		Line 19:
	[[Category: Cheeseman, M.D]]		[[Category: Cheeseman, M.D]]
	[[Category: Westwood, I.M]]		[[Category: Westwood, I.M]]
		+	[[Category: Mcandrew, C]]
	[[Category: Jones, A.M]]		[[Category: Jones, A.M]]
	[[Category: Richards, M]]		[[Category: Richards, M]]
-	[[Category: Lee, D]]
-	[[Category: Rowlands, M.G]]
-	[[Category: Mcandrew, C]]
	[[Category: Kadi, N]]		[[Category: Kadi, N]]
	[[Category: Jeganathan, F]]		[[Category: Jeganathan, F]]
	[[Category: Osborne, J.D]]		[[Category: Osborne, J.D]]
	[[Category: Matthews, T.P]]		[[Category: Matthews, T.P]]

OCA: Protected "5aqj" [edit=sysop:move=sysop]

OCA — Wed, 30 Sep 2015 11:23:44 GMT

Protected "5aqj" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:23, 30 September 2015

OCA: New page: '''Unreleased structure''' The entry 5aqj is ON HOLD until Paper Publication Authors: Jones, A.M., Westwood, I.M., Osborne, J.D., Matthews, T.P., Cheeseman, M.D., Rowlands, M.G., Jegana...

OCA — Wed, 30 Sep 2015 11:23:43 GMT

New page: '''Unreleased structure''' The entry 5aqj is ON HOLD until Paper Publication Authors: Jones, A.M., Westwood, I.M., Osborne, J.D., Matthews, T.P., Cheeseman, M.D., Rowlands, M.G., Jegana...

New page

'''Unreleased structure'''

The entry 5aqj is ON HOLD until Paper Publication

Authors: Jones, A.M., Westwood, I.M., Osborne, J.D., Matthews, T.P., Cheeseman, M.D., Rowlands, M.G., Jeganathan, F., Burke, R., Lee, D., Kadi, N., Liu, M., Richards, M., McAndrew, C., Yahya, N., Dobson, S.E., Jones, K., Workman, P., Collins, I., van Montfort, R.L.M.

Description: Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues
[[Category: Unreleased Structures]]
[[Category: Burke, R]]
[[Category: Liu, M]]
[[Category: Van Montfort, R.L.M]]
[[Category: Yahya, N]]
[[Category: Dobson, S.E]]
[[Category: Collins, I]]
[[Category: Workman, P]]
[[Category: Jones, K]]
[[Category: Cheeseman, M.D]]
[[Category: Westwood, I.M]]
[[Category: Jones, A.M]]
[[Category: Richards, M]]
[[Category: Lee, D]]
[[Category: Rowlands, M.G]]
[[Category: Mcandrew, C]]
[[Category: Kadi, N]]
[[Category: Jeganathan, F]]
[[Category: Osborne, J.D]]
[[Category: Matthews, T.P]]