5aut - Revision history

OCA at 15:48, 8 November 2023

OCA — Wed, 08 Nov 2023 15:48:55 GMT

←Older revision		Revision as of 15:48, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5aut]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AUT FirstGlance]. <br>		<table><tr><td colspan='2'>[[5aut]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AUT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2AN:8-ANILINO-1-NAPHTHALENE+SULFONATE'>2AN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2AN:8-ANILINO-1-NAPHTHALENE+SULFONATE'>2AN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5aut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aut OCA], [https://pdbe.org/5aut PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5aut RCSB], [https://www.ebi.ac.uk/pdbsum/5aut PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5aut ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5aut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aut OCA], [https://pdbe.org/5aut PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5aut RCSB], [https://www.ebi.ac.uk/pdbsum/5aut PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5aut ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:26, 31 May 2023

OCA — Wed, 31 May 2023 06:26:36 GMT

←Older revision		Revision as of 06:26, 31 May 2023
Line 3:		Line 3:
	<StructureSection load='5aut' size='340' side='right'caption='[[5aut]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='5aut' size='340' side='right'caption='[[5aut]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5aut]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AUT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5AUT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5aut]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AUT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2AN:8-ANILINO-1-NAPHTHALENE+SULFONATE'>2AN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2AN:8-ANILINO-1-NAPHTHALENE+SULFONATE'>2AN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5auu\|5auu]], [[5auv\|5auv]], [[5auw\|5auw]], [[5aux\|5aux]], [[5auy\|5auy]], [[5auz\|5auz]], [[5av0\|5av0]], [[5av1\|5av1]], [[5av2\|5av2]], [[5av3\|5av3]], [[5av4\|5av4]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5aut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aut OCA], [https://pdbe.org/5aut PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5aut RCSB], [https://www.ebi.ac.uk/pdbsum/5aut PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5aut ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DAPK1, DAPK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5aut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aut OCA], [~~http~~://pdbe.org/5aut PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5aut RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5aut PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5aut ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DAPK1_HUMAN DAPK1_HUMAN]] Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca(2+) influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition.<ref>PMID:7828849</ref> <ref>PMID:10629061</ref> <ref>PMID:11579085</ref> <ref>PMID:11980920</ref> <ref>PMID:12730201</ref> <ref>PMID:15367680</ref> <ref>PMID:17703233</ref> <ref>PMID:17895359</ref> <ref>PMID:18422656</ref> <ref>PMID:18195017</ref> <ref>PMID:18995835</ref> <ref>PMID:19180116</ref> <ref>PMID:18974095</ref> <ref>PMID:21497122</ref> <ref>PMID:21408167</ref> Isoform 2 cannot induce apoptosis but can induce membrane blebbing.<ref>PMID:7828849</ref> <ref>PMID:10629061</ref> <ref>PMID:11579085</ref> <ref>PMID:11980920</ref> <ref>PMID:12730201</ref> <ref>PMID:15367680</ref> <ref>PMID:17703233</ref> <ref>PMID:17895359</ref> <ref>PMID:18422656</ref> <ref>PMID:18195017</ref> <ref>PMID:18995835</ref> <ref>PMID:19180116</ref> <ref>PMID:18974095</ref> <ref>PMID:21497122</ref> <ref>PMID:21408167</ref>	+	[https://www.uniprot.org/uniprot/DAPK1_HUMAN DAPK1_HUMAN] Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca(2+) influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition.<ref>PMID:7828849</ref> <ref>PMID:10629061</ref> <ref>PMID:11579085</ref> <ref>PMID:11980920</ref> <ref>PMID:12730201</ref> <ref>PMID:15367680</ref> <ref>PMID:17703233</ref> <ref>PMID:17895359</ref> <ref>PMID:18422656</ref> <ref>PMID:18195017</ref> <ref>PMID:18995835</ref> <ref>PMID:19180116</ref> <ref>PMID:18974095</ref> <ref>PMID:21497122</ref> <ref>PMID:21408167</ref> Isoform 2 cannot induce apoptosis but can induce membrane blebbing.<ref>PMID:7828849</ref> <ref>PMID:10629061</ref> <ref>PMID:11579085</ref> <ref>PMID:11980920</ref> <ref>PMID:12730201</ref> <ref>PMID:15367680</ref> <ref>PMID:17703233</ref> <ref>PMID:17895359</ref> <ref>PMID:18422656</ref> <ref>PMID:18195017</ref> <ref>PMID:18995835</ref> <ref>PMID:19180116</ref> <ref>PMID:18974095</ref> <ref>PMID:21497122</ref> <ref>PMID:21408167</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Non-specific serine/threonine protein kinase]]~~	+	[[Category: Kosaka Y]]
-	[[Category: Kosaka, Y]]	+	[[Category: Mizuguchi M]]
-	[[Category: Mizuguchi, M]]	+	[[Category: Yokoyama T]]
-	[[Category: Yokoyama, T]]	+
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Death-associated protein kinase 1]]~~	+
-	~~[[Category: Serin/threonine protein kinase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 07:18, 3 July 2019

OCA — Wed, 03 Jul 2019 07:18:02 GMT

←Older revision		Revision as of 07:18, 3 July 2019
Line 1:		Line 1:
		+
	==Crystal structure of DAPK1 in complex with ANS.==		==Crystal structure of DAPK1 in complex with ANS.==
-	<StructureSection load='5aut' size='340' side='right' caption='[[5aut]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='5aut' size='340' side='right'caption='[[5aut]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5aut]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AUT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5aut]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AUT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2AN:8-ANILINO-1-NAPHTHALENE+SULFONATE'>2AN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2AN:8-ANILINO-1-NAPHTHALENE+SULFONATE'>2AN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5auu\|5auu]], [[5auv\|5auv]], [[5auw\|5auw]], [[5aux\|5aux]], [[5auy\|5auy]], [[5auz\|5auz]], [[5av0\|5av0]], [[5av1\|5av1]], [[5av2\|5av2]], [[5av3\|5av3]], [[5av4\|5av4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5auu\|5auu]], [[5auv\|5auv]], [[5auw\|5auw]], [[5aux\|5aux]], [[5auy\|5auy]], [[5auz\|5auz]], [[5av0\|5av0]], [[5av1\|5av1]], [[5av2\|5av2]], [[5av3\|5av3]], [[5av4\|5av4]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DAPK1, DAPK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aut OCA], [http://pdbe.org/5aut PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aut RCSB], [http://www.ebi.ac.uk/pdbsum/5aut PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aut OCA], [http://pdbe.org/5aut PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aut RCSB], [http://www.ebi.ac.uk/pdbsum/5aut PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5aut ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 5aut" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5aut" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Death-associated protein kinase 3D structures\|Death-associated protein kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Kosaka, Y]]		[[Category: Kosaka, Y]]
Line 30:		Line 37:
	[[Category: Death-associated protein kinase 1]]		[[Category: Death-associated protein kinase 1]]
	[[Category: Serin/threonine protein kinase]]		[[Category: Serin/threonine protein kinase]]
		+	[[Category: Transferase]]

OCA at 13:45, 7 October 2015

OCA — Wed, 07 Oct 2015 13:45:39 GMT

←Older revision		Revision as of 13:45, 7 October 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of DAPK1 in complex with ANS.==
		+	<StructureSection load='5aut' size='340' side='right' caption='[[5aut]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5aut]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AUT FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2AN:8-ANILINO-1-NAPHTHALENE+SULFONATE'>2AN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5auu\|5auu]], [[5auv\|5auv]], [[5auw\|5auw]], [[5aux\|5aux]], [[5auy\|5auy]], [[5auz\|5auz]], [[5av0\|5av0]], [[5av1\|5av1]], [[5av2\|5av2]], [[5av3\|5av3]], [[5av4\|5av4]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aut OCA], [http://pdbe.org/5aut PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aut RCSB], [http://www.ebi.ac.uk/pdbsum/5aut PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DAPK1_HUMAN DAPK1_HUMAN]] Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca(2+) influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition.<ref>PMID:7828849</ref> <ref>PMID:10629061</ref> <ref>PMID:11579085</ref> <ref>PMID:11980920</ref> <ref>PMID:12730201</ref> <ref>PMID:15367680</ref> <ref>PMID:17703233</ref> <ref>PMID:17895359</ref> <ref>PMID:18422656</ref> <ref>PMID:18195017</ref> <ref>PMID:18995835</ref> <ref>PMID:19180116</ref> <ref>PMID:18974095</ref> <ref>PMID:21497122</ref> <ref>PMID:21408167</ref> Isoform 2 cannot induce apoptosis but can induce membrane blebbing.<ref>PMID:7828849</ref> <ref>PMID:10629061</ref> <ref>PMID:11579085</ref> <ref>PMID:11980920</ref> <ref>PMID:12730201</ref> <ref>PMID:15367680</ref> <ref>PMID:17703233</ref> <ref>PMID:17895359</ref> <ref>PMID:18422656</ref> <ref>PMID:18195017</ref> <ref>PMID:18995835</ref> <ref>PMID:19180116</ref> <ref>PMID:18974095</ref> <ref>PMID:21497122</ref> <ref>PMID:21408167</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Death-associated protein kinase 1 (DAPK1) is a 160 kDa serine/threonine protein kinase that belongs to the Ca(2+)/calmodulin-dependent protein kinase subfamily. DAPK1 is a possible target for the treatment of acute ischemic stroke and endometrial adenocarcinomas. In the present study, we investigated the binding characteristics of 17 natural flavonoids to DAPK1 using a 1-anilinonaphthalene-8-sulfonic acid competitive binding assay and revealed that morin was the strongest binder among the selected compounds. The crystallographic analysis of DAPK1 and 7 selected flavonoid complexes revealed the structure-binding affinity relationship in atomic-level detail. It was suggested that the high affinity of morin could be accounted for by the ionic interaction between 2'-OH and K42 and that such an interaction would not take place with either cyclin-dependent protein kinases or PIM kinases because of their broader entrance regions. Thus, morin would be a more selective inhibitor of DAPK1 than either of these other types of kinases. In addition, we found that the binding of kaempferol to DAPK1 was associated with a chloride ion. The present study provides a better understanding of the molecular properties of the ATP site of DAPK1 and may be useful for the design of specific DAPK1 inhibitors.

-	~~The entry 5aut is ON HOLD until Paper Publication~~	+	Structural Insight into the Interactions between Death-Associated Protein Kinase 1 and Natural Flavonoids.,Yokoyama T, Kosaka Y, Mizuguchi M J Med Chem. 2015 Sep 24;58(18):7400-8. doi: 10.1021/acs.jmedchem.5b00893. Epub, 2015 Sep 4. PMID:26322379<ref>PMID:26322379</ref>

-	~~Authors: Yokoyama~~, T.~~, Mizuguchi, M~~.~~, Kosaka, Y~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~:	+	<div class="pdbe-citations 5aut" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Unreleased Structures~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Non-specific serine/threonine protein kinase]]
		+	[[Category: Kosaka, Y]]
		+	[[Category: Mizuguchi, M]]
	[[Category: Yokoyama, T]]		[[Category: Yokoyama, T]]
-	[[Category: ~~Mizuguchi, M~~]]	+	[[Category: Complex]]
-	[[Category: ~~Kosaka, Y~~]]	+	[[Category: Death-associated protein kinase 1]]
		+	[[Category: Serin/threonine protein kinase]]

OCA at 09:56, 2 September 2015

OCA — Wed, 02 Sep 2015 09:56:03 GMT

←Older revision		Revision as of 09:56, 2 September 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5aut is ON HOLD	+	The entry 5aut is ON HOLD until Paper Publication

	Authors: Yokoyama, T., Mizuguchi, M., Kosaka, Y.		Authors: Yokoyama, T., Mizuguchi, M., Kosaka, Y.

OCA at 11:27, 24 June 2015

OCA — Wed, 24 Jun 2015 11:27:19 GMT

←Older revision		Revision as of 11:27, 24 June 2015
Line 3:		Line 3:
	The entry 5aut is ON HOLD		The entry 5aut is ON HOLD

-	Authors: Yokoyama, T., Mizuguchi, M, Kosaka, Y	+	Authors: Yokoyama, T., Mizuguchi, M., Kosaka, Y.

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Yokoyama, T]]		[[Category: Yokoyama, T]]
-	[[Category: Mizuguchi, M, Kosaka, Y]]	+	[[Category: Mizuguchi, M]]
		+	[[Category: Kosaka, Y]]

OCA: Protected "5aut" [edit=sysop:move=sysop]

OCA — Wed, 17 Jun 2015 13:40:06 GMT

Protected "5aut" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:40, 17 June 2015

OCA: New page: '''Unreleased structure''' The entry 5aut is ON HOLD Authors: Yokoyama, T., Mizuguchi, M, Kosaka, Y Description: Category: Unreleased Structures Category: Yokoyama, T [[Catego...

OCA — Wed, 17 Jun 2015 13:40:05 GMT

New page: '''Unreleased structure''' The entry 5aut is ON HOLD Authors: Yokoyama, T., Mizuguchi, M, Kosaka, Y Description: Category: Unreleased Structures Category: Yokoyama, T [[Catego...

New page

'''Unreleased structure'''

The entry 5aut is ON HOLD

Authors: Yokoyama, T., Mizuguchi, M, Kosaka, Y

Description:
[[Category: Unreleased Structures]]
[[Category: Yokoyama, T]]
[[Category: Mizuguchi, M, Kosaka, Y]]