5ayq - Revision history

OCA at 06:31, 31 May 2023

OCA — Wed, 31 May 2023 06:31:38 GMT

←Older revision		Revision as of 06:31, 31 May 2023
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	<StructureSection load='5ayq' size='340' side='right'caption='[[5ayq]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='5ayq' size='340' side='right'caption='[[5ayq]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ayq]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AYQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5AYQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ayq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AYQ FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Scn4b, Gm1471 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ayq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ayq OCA], [https://pdbe.org/5ayq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ayq RCSB], [https://www.ebi.ac.uk/pdbsum/5ayq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ayq ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ayq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ayq OCA], [~~http~~://pdbe.org/5ayq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ayq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ayq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ayq ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SCN4B_MOUSE SCN4B_MOUSE]] Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the suceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom (By similarity).	+	[https://www.uniprot.org/uniprot/SCN4B_MOUSE SCN4B_MOUSE] Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the suceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Shimizu, H]]	+	[[Category: Shimizu H]]
-	~~[[Category: Metal transport]]~~	+
-	~~[[Category: Sodium channel beta subunit~~]]	+

OCA at 07:08, 19 February 2020

OCA — Wed, 19 Feb 2020 07:08:00 GMT

←Older revision		Revision as of 07:08, 19 February 2020
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	==Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of VGSC beta subunits==		==Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of VGSC beta subunits==
-	<StructureSection load='5ayq' size='340' side='right' caption='[[5ayq]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='5ayq' size='340' side='right'caption='[[5ayq]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ayq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AYQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ayq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AYQ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ayq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ayq OCA], [http://pdbe.org/5ayq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ayq RCSB], [http://www.ebi.ac.uk/pdbsum/5ayq PDBsum]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Scn4b, Gm1471 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ayq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ayq OCA], [http://pdbe.org/5ayq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ayq RCSB], [http://www.ebi.ac.uk/pdbsum/5ayq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ayq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5ayq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5ayq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ion channels 3D structures\|Ion channels 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Shimizu, H]]		[[Category: Shimizu, H]]
	[[Category: Metal transport]]		[[Category: Metal transport]]
	[[Category: Sodium channel beta subunit]]		[[Category: Sodium channel beta subunit]]

OCA at 15:19, 20 June 2016

OCA — Mon, 20 Jun 2016 15:19:24 GMT

←Older revision		Revision as of 15:19, 20 June 2016
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-	'''Unreleased structure'''

-	~~The entry~~ 5ayq is ~~ON HOLD until Paper~~ Publication	+	==Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of VGSC beta subunits==
		+	<StructureSection load='5ayq' size='340' side='right' caption='[[5ayq]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5ayq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AYQ FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ayq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ayq OCA], [http://pdbe.org/5ayq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ayq RCSB], [http://www.ebi.ac.uk/pdbsum/5ayq PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SCN4B_MOUSE SCN4B_MOUSE]] Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the suceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The beta1, beta2, and beta4 subunits of voltage-gated sodium channels reportedly function as cell adhesion molecules. The present crystallographic analysis of the beta4 extracellular domain revealed an antiparallel arrangement of the beta4 molecules in the crystal lattice. The interface between the two antiparallel beta4 molecules is asymmetric, and results in a multimeric assembly. Structure-based mutagenesis and site-directed photo-crosslinking analyses of the beta4-mediated cell-cell adhesion revealed that the interface between the antiparallel beta4 molecules corresponds to that in the trans homophilic interaction for the multimeric assembly of beta4 in cell-cell adhesion. This trans interaction mode is also employed in the beta1-mediated cell-cell adhesion. Moreover, the beta1 gene mutations associated with generalized epilepsy with febrile seizures plus (GEFS+) impaired the beta1-mediated cell-cell adhesion, which should underlie the GEFS+ pathogenesis. Thus, the structural basis for the beta-subunit-mediated cell-cell adhesion has been established.

-	~~Authors:~~ Shimizu, H.	+	Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of voltage-gated sodium channel beta subunits.,Shimizu H, Miyazaki H, Ohsawa N, Shoji S, Ishizuka-Katsura Y, Tosaki A, Oyama F, Terada T, Sakamoto K, Shirouzu M, Sekine S, Nukina N, Yokoyama S Sci Rep. 2016 May 24;6:26618. doi: 10.1038/srep26618. PMID:27216889<ref>PMID:27216889</ref>

-	~~Description: Structure-based site-directed photo-crosslinking analyses~~ of ~~multimeric cell-adhesive interactions~~ of ~~VGSC beta subunits~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
		+	<div class="pdbe-citations 5ayq" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Shimizu, H]]		[[Category: Shimizu, H]]
		+	[[Category: Metal transport]]
		+	[[Category: Sodium channel beta subunit]]

OCA at 11:32, 30 September 2015

OCA — Wed, 30 Sep 2015 11:32:43 GMT

←Older revision		Revision as of 11:32, 30 September 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5ayq is ON HOLD	+	The entry 5ayq is ON HOLD until Paper Publication

	Authors: Shimizu, H.		Authors: Shimizu, H.

OCA: Protected "5ayq" [edit=sysop:move=sysop]

OCA — Wed, 09 Sep 2015 08:34:04 GMT

Protected "5ayq" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:34, 9 September 2015

OCA: New page: '''Unreleased structure''' The entry 5ayq is ON HOLD Authors: Shimizu, H. Description: Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interaction...

OCA — Wed, 09 Sep 2015 08:34:02 GMT

New page: '''Unreleased structure''' The entry 5ayq is ON HOLD Authors: Shimizu, H. Description: Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interaction...

New page

'''Unreleased structure'''

The entry 5ayq is ON HOLD

Authors: Shimizu, H.

Description: Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of VGSC beta subunits
[[Category: Unreleased Structures]]
[[Category: Shimizu, H]]