5bpt - Revision history

OCA at 06:03, 7 June 2023

OCA — Wed, 07 Jun 2023 06:03:09 GMT

←Older revision		Revision as of 06:03, 7 June 2023
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	==Atomic-resolution structures of the APC/C subunits Apc4 and the Apc5 N-terminal domain==		==Atomic-resolution structures of the APC/C subunits Apc4 and the Apc5 N-terminal domain==
-	<StructureSection load='5bpt' size='340' side='right' caption='[[5bpt]], [[Resolution\|resolution]] 3.20Å' scene=''>	+	<StructureSection load='5bpt' size='340' side='right'caption='[[5bpt]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5bpt]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~African_clawed_frog African clawed frog~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5BPT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5bpt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BPT FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">anapc4, MGC81278 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 African clawed frog])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bpt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpt OCA], [https://pdbe.org/5bpt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bpt RCSB], [https://www.ebi.ac.uk/pdbsum/5bpt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bpt ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5bpt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpt OCA], [~~http~~://pdbe.org/5bpt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5bpt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5bpt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5bpt ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q6NU36_XENLA Q6NU36_XENLA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~African clawed frog~~]]	+	[[Category: Large Structures]]
-	[[Category: Barford, D]]	+	[[Category: Xenopus laevis]]
-	[[Category: Cronin, N]]	+	[[Category: Barford D]]
-	[[Category: Yang, J]]	+	[[Category: Cronin N]]
-	[[Category: Zhang, Z]]	+	[[Category: Yang J]]
-	~~[[Category: Anaphase promoting complex]]~~	+	[[Category: Zhang Z]]
-	~~[[Category: Apc/c]]~~	+
-	~~[[Category: Apc4]]~~	+
-	~~[[Category: Cell cycle~~]]	+

OCA at 16:39, 16 November 2017

OCA — Thu, 16 Nov 2017 16:39:12 GMT

←Older revision		Revision as of 16:39, 16 November 2017
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		+
	==Atomic-resolution structures of the APC/C subunits Apc4 and the Apc5 N-terminal domain==		==Atomic-resolution structures of the APC/C subunits Apc4 and the Apc5 N-terminal domain==
	<StructureSection load='5bpt' size='340' side='right' caption='[[5bpt]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='5bpt' size='340' side='right' caption='[[5bpt]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5bpt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BPT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5bpt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BPT FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bpt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpt OCA], [http://pdbe.org/5bpt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bpt RCSB], [http://www.ebi.ac.uk/pdbsum/5bpt PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">anapc4, MGC81278 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 African clawed frog])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bpt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpt OCA], [http://pdbe.org/5bpt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bpt RCSB], [http://www.ebi.ac.uk/pdbsum/5bpt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bpt ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: African clawed frog]]
	[[Category: Barford, D]]		[[Category: Barford, D]]
	[[Category: Cronin, N]]		[[Category: Cronin, N]]

OCA at 08:04, 30 September 2015

OCA — Wed, 30 Sep 2015 08:04:07 GMT

←Older revision		Revision as of 08:04, 30 September 2015
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	<table><tr><td colspan='2'>[[5bpt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BPT FirstGlance]. <br>		<table><tr><td colspan='2'>[[5bpt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BPT FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bpt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5bpt RCSB], [http://www.ebi.ac.uk/pdbsum/5bpt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bpt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpt OCA], [http://pdbe.org/5bpt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bpt RCSB], [http://www.ebi.ac.uk/pdbsum/5bpt PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Many essential biological processes are mediated by complex molecular machines comprising multiple subunits. Knowledge on the architecture of individual subunits and their positions within the overall multimeric complex is key to understanding the molecular mechanisms of macromolecular assemblies. The anaphase-promoting complex/cyclosome (APC/C) is a large multisubunit complex that regulates cell cycle progression by ubiquitinating cell cycle proteins for proteolysis by the proteasome. The holo-complex is composed of 15 different proteins that assemble to generate a complex of 20 subunits. Here, we describe the crystal structures of Apc4 and the N-terminal domain of Apc5 (Apc5(N)). Apc4 comprises a WD40 domain split by a long alpha-helical domain, whereas Apc5(N) has an alpha-helical fold. In a separate study, we had fitted these atomic models to a 3.6-A-resolution cryo-electron microscopy map of the APC/C. We describe how, in the context of the APC/C, regions of Apc4 disordered in the crystal assume order through contacts to Apc5, whereas Apc5(N) shows small conformational changes relative to its crystal structure. We discuss the complementary approaches of high-resolution electron microscopy and protein crystallography to the structure determination of subunits of multimeric complexes.
		+
		+	Atomic-Resolution Structures of the APC/C Subunits Apc4 and the Apc5 N-Terminal Domain.,Cronin NB, Yang J, Zhang Z, Kulkarni K, Chang L, Yamano H, Barford D J Mol Biol. 2015 Oct 9;427(20):3300-15. doi: 10.1016/j.jmb.2015.08.023. Epub 2015, Sep 4. PMID:26343760<ref>PMID:26343760</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5bpt" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 12:34, 2 September 2015

OCA — Wed, 02 Sep 2015 12:34:42 GMT

←Older revision		Revision as of 12:34, 2 September 2015
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-	~~'''Unreleased structure'''~~	+	==Atomic-resolution structures of the APC/C subunits Apc4 and the Apc5 N-terminal domain==
-		+	<StructureSection load='5bpt' size='340' side='right' caption='[[5bpt]], [[Resolution\|resolution]] 3.20Å' scene=''>
-	~~The entry 5bpt is ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5bpt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BPT FirstGlance]. <br>
-	~~Authors: Cronin, N., Yang, J., Zhang, Z., Barford, D.~~	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bpt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5bpt RCSB], [http://www.ebi.ac.uk/pdbsum/5bpt PDBsum]</span></td></tr>
-	~~Description:~~ Atomic-resolution structures of the APC/C subunits Apc4 and the Apc5 N-terminal domain	+	</table>
-	[[~~Category: Unreleased Structures~~]]	+	__TOC__
-	[[~~Category~~: ~~Zhang, Z~~]]	+	</StructureSection>
-	[[~~Category~~: ~~Yang, J~~]]	+
-	[[~~Category~~: ~~Cronin~~, N]]	+
	[[Category: Barford, D]]		[[Category: Barford, D]]
		+	[[Category: Cronin, N]]
		+	[[Category: Yang, J]]
		+	[[Category: Zhang, Z]]
		+	[[Category: Anaphase promoting complex]]
		+	[[Category: Apc/c]]
		+	[[Category: Apc4]]
		+	[[Category: Cell cycle]]

OCA at 13:46, 17 June 2015

OCA — Wed, 17 Jun 2015 13:46:27 GMT

←Older revision		Revision as of 13:46, 17 June 2015
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5bpt is ON HOLD ~~until sometime in the future~~	+	The entry 5bpt is ON HOLD

	Authors: Cronin, N., Yang, J., Zhang, Z., Barford, D.		Authors: Cronin, N., Yang, J., Zhang, Z., Barford, D.

OCA: Protected "5bpt" [edit=sysop:move=sysop]

OCA — Wed, 03 Jun 2015 11:47:04 GMT

Protected "5bpt" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:47, 3 June 2015

OCA: New page: '''Unreleased structure''' The entry 5bpt is ON HOLD until sometime in the future Authors: Cronin, N., Yang, J., Zhang, Z., Barford, D. Description: Atomic-resolution structures of the...

OCA — Wed, 03 Jun 2015 11:47:02 GMT

New page: '''Unreleased structure''' The entry 5bpt is ON HOLD until sometime in the future Authors: Cronin, N., Yang, J., Zhang, Z., Barford, D. Description: Atomic-resolution structures of the...

New page

'''Unreleased structure'''

The entry 5bpt is ON HOLD until sometime in the future

Authors: Cronin, N., Yang, J., Zhang, Z., Barford, D.

Description: Atomic-resolution structures of the APC/C subunits Apc4 and the Apc5 N-terminal domain
[[Category: Unreleased Structures]]
[[Category: Zhang, Z]]
[[Category: Yang, J]]
[[Category: Cronin, N]]
[[Category: Barford, D]]