5bqg - Revision history

OCA at 12:17, 6 March 2024

OCA — Wed, 06 Mar 2024 12:17:40 GMT

←Older revision		Revision as of 12:17, 6 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5bqg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BQG FirstGlance]. <br>		<table><tr><td colspan='2'>[[5bqg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BQG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4UJ:2-CHLORO-N-(4-PHENYL-1,3-THIAZOL-2-YL)BENZAMIDE'>4UJ</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=JZR:HEXYL+BETA-D-GLUCOPYRANOSIDE'>JZR</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.436Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4UJ:2-CHLORO-N-(4-PHENYL-1,3-THIAZOL-2-YL)BENZAMIDE'>4UJ</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=JZR:HEXYL+BETA-D-GLUCOPYRANOSIDE'>JZR</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bqg OCA], [https://pdbe.org/5bqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bqg RCSB], [https://www.ebi.ac.uk/pdbsum/5bqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bqg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bqg OCA], [https://pdbe.org/5bqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bqg RCSB], [https://www.ebi.ac.uk/pdbsum/5bqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bqg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/PTGES_HUMAN PTGES_HUMAN] Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).<ref>PMID:18682561</ref>		[https://www.uniprot.org/uniprot/PTGES_HUMAN PTGES_HUMAN] Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).<ref>PMID:18682561</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	As part of a program aimed at the discovery of antinociceptive therapy for inflammatory conditions, a screening hit was found to inhibit microsomal prostaglandin E synthase-1 (mPGES-1) with an IC50 of 17.4 muM. Structural information was used to improve enzyme potency by over 1000-fold. Addition of an appropriate substituent alleviated time-dependent cytochrome P450 3A4 (CYP3A4) inhibition. Further structure-activity relationship (SAR) studies led to 8, which had desirable potency (IC50 = 12 nM in an ex vivo human whole blood (HWB) assay) and absorption, distribution, metabolism, and excretion (ADME) properties. Studies on the formulation of 8 identified 8.H3PO4 as suitable for clinical development. Omission of a lipophilic portion of the compound led to 26, a readily orally bioavailable inhibitor with potency in HWB comparable to celecoxib. Furthermore, 26 was selective for mPGES-1 inhibition versus other mechanisms in the prostanoid pathway. These factors led to the selection of 26 as a second clinical candidate.
-
-	Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors.,Schiffler MA, Antonysamy S, Bhattachar SN, Campanale KM, Chandrasekhar S, Condon B, Desai PV, Fisher MJ, Groshong C, Harvey A, Hickey MJ, Hughes NE, Jones SA, Kim EJ, Kuklish SL, Luz JG, Norman BH, Rathmell RE, Rizzo JR, Seng TW, Thibodeaux SJ, Woods TA, York JS, Yu XP J Med Chem. 2016 Jan 14;59(1):194-205. doi: 10.1021/acs.jmedchem.5b01249. Epub, 2015 Dec 18. PMID:26653180<ref>PMID:26653180</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 5bqg" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 06:03, 7 June 2023

OCA — Wed, 07 Jun 2023 06:03:54 GMT

←Older revision		Revision as of 06:03, 7 June 2023
Line 3:		Line 3:
	<StructureSection load='5bqg' size='340' side='right'caption='[[5bqg]], [[Resolution\|resolution]] 1.44Å' scene=''>		<StructureSection load='5bqg' size='340' side='right'caption='[[5bqg]], [[Resolution\|resolution]] 1.44Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5bqg]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BQG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5BQG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5bqg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BQG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4UJ:2-CHLORO-N-(4-PHENYL-1,3-THIAZOL-2-YL)BENZAMIDE'>4UJ</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=JZR:HEXYL+BETA-D-GLUCOPYRANOSIDE'>JZR</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4UJ:2-CHLORO-N-(4-PHENYL-1,3-THIAZOL-2-YL)BENZAMIDE'>4UJ</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=JZR:HEXYL+BETA-D-GLUCOPYRANOSIDE'>JZR</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PTGES, MGST1L1, MPGES1, PGES, PIG12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bqg OCA], [https://pdbe.org/5bqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bqg RCSB], [https://www.ebi.ac.uk/pdbsum/5bqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bqg ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-E_synthase Prostaglandin-E synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.3 5.3.99.3] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5bqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bqg OCA], [~~http~~://pdbe.org/5bqg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5bqg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5bqg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5bqg ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PTGES_HUMAN PTGES_HUMAN]] Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).<ref>PMID:18682561</ref>	+	[https://www.uniprot.org/uniprot/PTGES_HUMAN PTGES_HUMAN] Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).<ref>PMID:18682561</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Prostaglandin-E synthase]]~~	+	[[Category: Antonysamy S]]
-	[[Category: Antonysamy, S]]	+	[[Category: Fisher MJ]]
-	[[Category: Fisher~~, M J~~]]	+	[[Category: Kuklish SL]]
-	[[Category: Kuklish~~, S L~~]]	+	[[Category: Luz JG]]
-	[[Category: Luz~~, J G~~]]	+	[[Category: Schiffler MA]]
-	[[Category: Schiffler~~, M A]]~~	+
-	~~[[Category: Enzyme]]~~	+
-	~~[[Category: Integral membrane protein]]~~	+
-	~~[[Category: Isomerase-isomerase inhibitor complex]]~~	+
-	~~[[Category: Mpges-1~~]]	+

OCA at 08:54, 11 March 2020

OCA — Wed, 11 Mar 2020 08:54:28 GMT

←Older revision		Revision as of 08:54, 11 March 2020
Line 1:		Line 1:

	==Crystal Structure of mPGES-1 Bound to an Inhibitor==		==Crystal Structure of mPGES-1 Bound to an Inhibitor==
-	<StructureSection load='5bqg' size='340' side='right' caption='[[5bqg]], [[Resolution\|resolution]] 1.44Å' scene=''>	+	<StructureSection load='5bqg' size='340' side='right'caption='[[5bqg]], [[Resolution\|resolution]] 1.44Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5bqg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BQG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BQG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5bqg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BQG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BQG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4UJ:2-CHLORO-N-(4-PHENYL-1,3-THIAZOL-2-YL)BENZAMIDE'>4UJ</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=JZR:HEXYL+BETA-D-GLUCOPYRANOSIDE'>JZR</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4UJ:2-CHLORO-N-(4-PHENYL-1,3-THIAZOL-2-YL)BENZAMIDE'>4UJ</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=JZR:HEXYL+BETA-D-GLUCOPYRANOSIDE'>JZR</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PTGES, MGST1L1, MPGES1, PGES, PIG12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-E_synthase Prostaglandin-E synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.3 5.3.99.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-E_synthase Prostaglandin-E synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.3 5.3.99.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bqg OCA], [http://pdbe.org/5bqg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bqg RCSB], [http://www.ebi.ac.uk/pdbsum/5bqg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bqg OCA], [http://pdbe.org/5bqg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bqg RCSB], [http://www.ebi.ac.uk/pdbsum/5bqg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bqg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 5bqg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5bqg" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Prostaglandin E synthase\|Prostaglandin E synthase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Prostaglandin-E synthase]]		[[Category: Prostaglandin-E synthase]]
	[[Category: Antonysamy, S]]		[[Category: Antonysamy, S]]

OCA at 11:23, 12 May 2016

OCA — Thu, 12 May 2016 11:23:46 GMT

←Older revision		Revision as of 11:23, 12 May 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5bqg is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Crystal Structure of mPGES-1 Bound to an Inhibitor==
		+	<StructureSection load='5bqg' size='340' side='right' caption='[[5bqg]], [[Resolution\|resolution]] 1.44Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5bqg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BQG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BQG FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4UJ:2-CHLORO-N-(4-PHENYL-1,3-THIAZOL-2-YL)BENZAMIDE'>4UJ</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=JZR:HEXYL+BETA-D-GLUCOPYRANOSIDE'>JZR</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-E_synthase Prostaglandin-E synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.3 5.3.99.3] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bqg OCA], [http://pdbe.org/5bqg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bqg RCSB], [http://www.ebi.ac.uk/pdbsum/5bqg PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PTGES_HUMAN PTGES_HUMAN]] Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).<ref>PMID:18682561</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	As part of a program aimed at the discovery of antinociceptive therapy for inflammatory conditions, a screening hit was found to inhibit microsomal prostaglandin E synthase-1 (mPGES-1) with an IC50 of 17.4 muM. Structural information was used to improve enzyme potency by over 1000-fold. Addition of an appropriate substituent alleviated time-dependent cytochrome P450 3A4 (CYP3A4) inhibition. Further structure-activity relationship (SAR) studies led to 8, which had desirable potency (IC50 = 12 nM in an ex vivo human whole blood (HWB) assay) and absorption, distribution, metabolism, and excretion (ADME) properties. Studies on the formulation of 8 identified 8.H3PO4 as suitable for clinical development. Omission of a lipophilic portion of the compound led to 26, a readily orally bioavailable inhibitor with potency in HWB comparable to celecoxib. Furthermore, 26 was selective for mPGES-1 inhibition versus other mechanisms in the prostanoid pathway. These factors led to the selection of 26 as a second clinical candidate.

-	~~Authors: Fisher, M.J~~., Schiffler, ~~M.A.~~, ~~Kuklish~~, S~~.L.~~, ~~Antonysamy~~, S., Luz, J.G.	+	Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors.,Schiffler MA, Antonysamy S, Bhattachar SN, Campanale KM, Chandrasekhar S, Condon B, Desai PV, Fisher MJ, Groshong C, Harvey A, Hickey MJ, Hughes NE, Jones SA, Kim EJ, Kuklish SL, Luz JG, Norman BH, Rathmell RE, Rizzo JR, Seng TW, Thibodeaux SJ, Woods TA, York JS, Yu XP J Med Chem. 2016 Jan 14;59(1):194-205. doi: 10.1021/acs.jmedchem.5b01249. Epub, 2015 Dec 18. PMID:26653180<ref>PMID:26653180</ref>

-	~~Description: Crystal Structure~~ of ~~mPGES-1 Bound to an Inhibitor~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Luz, J.G]]~~	+	<div class="pdbe-citations 5bqg" style="background-color:#fffaf0;"></div>
-	~~[[Category: Fisher, M.J]]~~	+	== References ==
-	[[Category: ~~Kuklish, S.L~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Prostaglandin-E synthase]]
	[[Category: Antonysamy, S]]		[[Category: Antonysamy, S]]
-	[[Category: Schiffler, M.A]]	+	[[Category: Fisher, M J]]
		+	[[Category: Kuklish, S L]]
		+	[[Category: Luz, J G]]
		+	[[Category: Schiffler, M A]]
		+	[[Category: Enzyme]]
		+	[[Category: Integral membrane protein]]
		+	[[Category: Isomerase-isomerase inhibitor complex]]
		+	[[Category: Mpges-1]]

OCA at 11:34, 24 June 2015

OCA — Wed, 24 Jun 2015 11:34:59 GMT

←Older revision		Revision as of 11:34, 24 June 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5bqg is ON HOLD	+	The entry 5bqg is ON HOLD until Paper Publication

	Authors: Fisher, M.J., Schiffler, M.A., Kuklish, S.L., Antonysamy, S., Luz, J.G.		Authors: Fisher, M.J., Schiffler, M.A., Kuklish, S.L., Antonysamy, S., Luz, J.G.

OCA at 12:53, 10 June 2015

OCA — Wed, 10 Jun 2015 12:53:33 GMT

←Older revision		Revision as of 12:53, 10 June 2015
Line 3:		Line 3:
	The entry 5bqg is ON HOLD		The entry 5bqg is ON HOLD

-	Authors: Fisher, M.J., Schiffler, M.A., Kuklish, S.L., Antonysamy, S., Luz, J.G.,	+	Authors: Fisher, M.J., Schiffler, M.A., Kuklish, S.L., Antonysamy, S., Luz, J.G.

	Description: Crystal Structure of mPGES-1 Bound to an Inhibitor		Description: Crystal Structure of mPGES-1 Bound to an Inhibitor

OCA: Protected "5bqg" [edit=sysop:move=sysop]

OCA — Wed, 03 Jun 2015 11:49:04 GMT

Protected "5bqg" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:49, 3 June 2015

OCA: New page: '''Unreleased structure''' The entry 5bqg is ON HOLD Authors: Fisher, M.J., Schiffler, M.A., Kuklish, S.L., Antonysamy, S., Luz, J.G., Description: Crystal Structure of mPGES-1 Bound t...

OCA — Wed, 03 Jun 2015 11:49:03 GMT

New page: '''Unreleased structure''' The entry 5bqg is ON HOLD Authors: Fisher, M.J., Schiffler, M.A., Kuklish, S.L., Antonysamy, S., Luz, J.G., Description: Crystal Structure of mPGES-1 Bound t...

New page

'''Unreleased structure'''

The entry 5bqg is ON HOLD

Authors: Fisher, M.J., Schiffler, M.A., Kuklish, S.L., Antonysamy, S., Luz, J.G.,

Description: Crystal Structure of mPGES-1 Bound to an Inhibitor
[[Category: Unreleased Structures]]
[[Category: Luz, J.G]]
[[Category: Fisher, M.J]]
[[Category: Kuklish, S.L]]
[[Category: Antonysamy, S]]
[[Category: Schiffler, M.A]]