5bt1 - Revision history

OCA at 16:05, 8 November 2023

OCA — Wed, 08 Nov 2023 16:05:09 GMT

←Older revision		Revision as of 16:05, 8 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5bt1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BT1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BT1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5bt1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BT1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BT1 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bt1 OCA], [https://pdbe.org/5bt1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bt1 RCSB], [https://www.ebi.ac.uk/pdbsum/5bt1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bt1 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.62Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bt1 OCA], [https://pdbe.org/5bt1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bt1 RCSB], [https://www.ebi.ac.uk/pdbsum/5bt1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bt1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 06:07, 7 June 2023

OCA — Wed, 07 Jun 2023 06:07:09 GMT

←Older revision		Revision as of 06:07, 7 June 2023
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	<StructureSection load='5bt1' size='340' side='right'caption='[[5bt1]], [[Resolution\|resolution]] 2.62Å' scene=''>		<StructureSection load='5bt1' size='340' side='right'caption='[[5bt1]], [[Resolution\|resolution]] 2.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5bt1]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BT1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5BT1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5bt1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BT1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BT1 FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nq0\|4nq0]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bt1 OCA], [https://pdbe.org/5bt1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bt1 RCSB], [https://www.ebi.ac.uk/pdbsum/5bt1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bt1 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5bt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bt1 OCA], [~~http~~://pdbe.org/5bt1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5bt1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5bt1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5bt1 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/HIF1_YEAST HIF1_YEAST]] Histone H3 and H4 specific chaperone component of the nuclear histone acetyltransferase B (HAT-B) complex. Involved in chromatin assembly and telomere silencing.<ref>PMID:14761951</ref> <ref>PMID:15099519</ref> [[http://www.uniprot.org/uniprot/H2B1_YEAST H2B1_YEAST]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11973294</ref> <ref>PMID:12152067</ref> <ref>PMID:14752010</ref> <ref>PMID:15280549</ref> <ref>PMID:15652479</ref> <ref>PMID:15970663</ref> <ref>PMID:15632126</ref> <ref>PMID:15632065</ref> <ref>PMID:16598039</ref> [[http://www.uniprot.org/uniprot/H2A1_YEAST H2A1_YEAST]] Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11140636</ref> <ref>PMID:15458641</ref> <ref>PMID:15610741</ref> <ref>PMID:16299494</ref>	+	[https://www.uniprot.org/uniprot/HIF1_YEAST HIF1_YEAST] Histone H3 and H4 specific chaperone component of the nuclear histone acetyltransferase B (HAT-B) complex. Involved in chromatin assembly and telomere silencing.<ref>PMID:14761951</ref> <ref>PMID:15099519</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gao, Y]]	+	[[Category: Saccharomyces cerevisiae S288C]]
-	[[Category: Liu, H]]	+	[[Category: Gao Y]]
-	[[Category: Niu, L]]	+	[[Category: Liu H]]
-	[[Category: Teng, M]]	+	[[Category: Niu L]]
-	[[Category: Zhang, M]]	+	[[Category: Teng M]]
-	~~[[Category: Assembly]]~~	+	[[Category: Zhang M]]
-	~~[[Category: Chaperone]]~~	+
-	~~[[Category: Histone chaperone complex]]~~	+
-	~~[[Category: Nasp homolog]]~~	+
-	~~[[Category: Tpr~~]]	+

OCA at 10:59, 18 March 2020

OCA — Wed, 18 Mar 2020 10:59:46 GMT

←Older revision		Revision as of 10:59, 18 March 2020
Line 1:		Line 1:

	==histone chaperone Hif1 playing with histone H2A-H2B dimer==		==histone chaperone Hif1 playing with histone H2A-H2B dimer==
-	<StructureSection load='5bt1' size='340' side='right' caption='[[5bt1]], [[Resolution\|resolution]] 2.62Å' scene=''>	+	<StructureSection load='5bt1' size='340' side='right'caption='[[5bt1]], [[Resolution\|resolution]] 2.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5bt1]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BT1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BT1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5bt1]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BT1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BT1 FirstGlance]. <br>
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Gao, Y]]		[[Category: Gao, Y]]
	[[Category: Liu, H]]		[[Category: Liu, H]]

OCA at 18:36, 26 October 2016

OCA — Wed, 26 Oct 2016 18:36:08 GMT

←Older revision		Revision as of 18:36, 26 October 2016
Line 1:		Line 1:
-	~~WITHDRAWN~~: ~~The PDB entry~~ 5BT1 ~~was withdrawn~~.	+
		+	==histone chaperone Hif1 playing with histone H2A-H2B dimer==
		+	<StructureSection load='5bt1' size='340' side='right' caption='[[5bt1]], [[Resolution\|resolution]] 2.62Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5bt1]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BT1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BT1 FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nq0\|4nq0]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bt1 OCA], [http://pdbe.org/5bt1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bt1 RCSB], [http://www.ebi.ac.uk/pdbsum/5bt1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bt1 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HIF1_YEAST HIF1_YEAST]] Histone H3 and H4 specific chaperone component of the nuclear histone acetyltransferase B (HAT-B) complex. Involved in chromatin assembly and telomere silencing.<ref>PMID:14761951</ref> <ref>PMID:15099519</ref> [[http://www.uniprot.org/uniprot/H2B1_YEAST H2B1_YEAST]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11973294</ref> <ref>PMID:12152067</ref> <ref>PMID:14752010</ref> <ref>PMID:15280549</ref> <ref>PMID:15652479</ref> <ref>PMID:15970663</ref> <ref>PMID:15632126</ref> <ref>PMID:15632065</ref> <ref>PMID:16598039</ref> [[http://www.uniprot.org/uniprot/H2A1_YEAST H2A1_YEAST]] Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11140636</ref> <ref>PMID:15458641</ref> <ref>PMID:15610741</ref> <ref>PMID:16299494</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Histone chaperones are critical for guiding specific post-transcriptional modifications of histones, safeguarding the histone deposition (or disassociation) of nucleosome (dis)assembly, and regulating chromatin structures to change gene activities. HAT1-interacting factor 1 (Hif1) has been reported to be an H3-H4 chaperone and to be involved in telomeric silencing and nucleosome (dis)assembly. However, the structural basis for the interaction of Hif1 with histones remains unknown. Here, we report the complex structure of Hif1 binding to H2A-H2B for uncovering the chaperone specificities of Hif1 on binding to both the H2A-H2B dimer and the H3-H4 tetramer. Our findings reveal that Hif1 interacts with the H2A-H2B dimer and the H3-H4 tetramer via distinct mechanisms, suggesting that Hif1 is a pivotal scaffold on alternate binding of H2A-H2B and H3-H4. These specificities are conserved features of the Sim3-Hif1-NASP interrupted tetratricopeptide repeat proteins, which provide clues for investigating their potential roles in nucleosome (dis)assembly.
		+
		+	Structural Insights into the Association of Hif1 with Histones H2A-H2B Dimer and H3-H4 Tetramer.,Zhang M, Liu H, Gao Y, Zhu Z, Chen Z, Zheng P, Xue L, Li J, Teng M, Niu L Structure. 2016 Oct 4;24(10):1810-1820. doi: 10.1016/j.str.2016.08.001. Epub 2016, Sep 8. PMID:27618665<ref>PMID:27618665</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5bt1" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Gao, Y]]
		+	[[Category: Liu, H]]
		+	[[Category: Niu, L]]
		+	[[Category: Teng, M]]
		+	[[Category: Zhang, M]]
		+	[[Category: Assembly]]
		+	[[Category: Chaperone]]
		+	[[Category: Histone chaperone complex]]
		+	[[Category: Nasp homolog]]
		+	[[Category: Tpr]]

OCA at 15:07, 1 June 2016

OCA — Wed, 01 Jun 2016 15:07:24 GMT

←Older revision		Revision as of 15:07, 1 June 2016
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-	~~'''Unreleased structure'''~~	+	WITHDRAWN: The PDB entry 5BT1 was withdrawn.
-		+
-	The entry ~~5bt1 is ON HOLD until Paper Publication~~	+
-		+
-	~~Authors: Liu, H~~.~~, Zhang, M., Gao, Y., Teng, M., Niu, L.~~	+
-		+
-	~~Description: histone chaperone Hif1 playing with histone H2A-H2B dimer~~	+
-	~~[[Category: Unreleased Structures]]~~	+
-	~~[[Category: Gao, Y]]~~	+
-	~~[[Category: Teng, M]]~~	+
-	~~[[Category: Niu, L]]~~	+
-	~~[[Category: Zhang, M]]~~	+
-	~~[[Category: Liu, H]]~~	+

OCA at 10:11, 16 December 2015

OCA — Wed, 16 Dec 2015 10:11:12 GMT

←Older revision		Revision as of 10:11, 16 December 2015
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	Description: histone chaperone Hif1 playing with histone H2A-H2B dimer		Description: histone chaperone Hif1 playing with histone H2A-H2B dimer
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Niu, L]]
-	[[Category: Liu, H]]
	[[Category: Gao, Y]]		[[Category: Gao, Y]]
	[[Category: Teng, M]]		[[Category: Teng, M]]
		+	[[Category: Niu, L]]
	[[Category: Zhang, M]]		[[Category: Zhang, M]]
		+	[[Category: Liu, H]]

OCA at 13:52, 17 June 2015

OCA — Wed, 17 Jun 2015 13:52:21 GMT

←Older revision		Revision as of 13:52, 17 June 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5bt1 is ON HOLD	+	The entry 5bt1 is ON HOLD until Paper Publication

	Authors: Liu, H., Zhang, M., Gao, Y., Teng, M., Niu, L.		Authors: Liu, H., Zhang, M., Gao, Y., Teng, M., Niu, L.

OCA: Protected "5bt1" [edit=sysop:move=sysop]

OCA — Wed, 10 Jun 2015 13:01:28 GMT

Protected "5bt1" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:01, 10 June 2015

OCA: New page: '''Unreleased structure''' The entry 5bt1 is ON HOLD Authors: Liu, H., Zhang, M., Gao, Y., Teng, M., Niu, L. Description: histone chaperone Hif1 playing with histone H2A-H2B dimer [[Ca...

OCA — Wed, 10 Jun 2015 13:01:27 GMT

New page: '''Unreleased structure''' The entry 5bt1 is ON HOLD Authors: Liu, H., Zhang, M., Gao, Y., Teng, M., Niu, L. Description: histone chaperone Hif1 playing with histone H2A-H2B dimer [[Ca...

New page

'''Unreleased structure'''

The entry 5bt1 is ON HOLD

Authors: Liu, H., Zhang, M., Gao, Y., Teng, M., Niu, L.

Description: histone chaperone Hif1 playing with histone H2A-H2B dimer
[[Category: Unreleased Structures]]
[[Category: Niu, L]]
[[Category: Liu, H]]
[[Category: Gao, Y]]
[[Category: Teng, M]]
[[Category: Zhang, M]]