5bvr - Revision history

OCA at 11:17, 10 January 2024

OCA — Wed, 10 Jan 2024 11:17:22 GMT

←Older revision		Revision as of 11:17, 10 January 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5bvr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BVR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BVR FirstGlance]. <br>		<table><tr><td colspan='2'>[[5bvr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BVR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BVR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.46Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bvr OCA], [https://pdbe.org/5bvr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bvr RCSB], [https://www.ebi.ac.uk/pdbsum/5bvr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bvr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bvr OCA], [https://pdbe.org/5bvr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bvr RCSB], [https://www.ebi.ac.uk/pdbsum/5bvr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bvr ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:10, 7 June 2023

OCA — Wed, 07 Jun 2023 06:10:22 GMT

←Older revision		Revision as of 06:10, 7 June 2023
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	<StructureSection load='5bvr' size='340' side='right'caption='[[5bvr]], [[Resolution\|resolution]] 1.46Å' scene=''>		<StructureSection load='5bvr' size='340' side='right'caption='[[5bvr]], [[Resolution\|resolution]] 1.46Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5bvr]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Fission_yeast Fission yeast~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BVR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5BVR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5bvr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BVR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BVR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ain1, SPAC15A10.08 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284812 Fission yeast])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bvr OCA], [https://pdbe.org/5bvr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bvr RCSB], [https://www.ebi.ac.uk/pdbsum/5bvr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bvr ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5bvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bvr OCA], [~~http~~://pdbe.org/5bvr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5bvr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5bvr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5bvr ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/AIN1_SCHPO AIN1_SCHPO]] Binds to actin and is involved in actin-ring formation and organization. Plays a role in cytokinesis and is involved in septation.<ref>PMID:11294907</ref>	+	[https://www.uniprot.org/uniprot/AIN1_SCHPO AIN1_SCHPO] Binds to actin and is involved in actin-ring formation and organization. Plays a role in cytokinesis and is involved in septation.<ref>PMID:11294907</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Fission yeast]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Addario, B~~]]	+	[[Category: Schizosaccharomyces pombe 972h-]]
-	[[Category: ~~Backman, L~~]]	+	[[Category: Addario B]]
-	[[Category: ~~Persson, K~~]]	+	[[Category: Backman L]]
-	[[Category: ~~Alpha-actinin actin binding schizosaccharomyces pombe]]~~	+	[[Category: Persson K]]
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Cell division~~]]	+

OCA at 11:02, 18 March 2020

OCA — Wed, 18 Mar 2020 11:02:22 GMT

←Older revision		Revision as of 11:02, 18 March 2020
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	==Actin binding domain of alpha-actinin from Schizosaccharomyces pombe==		==Actin binding domain of alpha-actinin from Schizosaccharomyces pombe==
-	<StructureSection load='5bvr' size='340' side='right' caption='[[5bvr]], [[Resolution\|resolution]] 1.46Å' scene=''>	+	<StructureSection load='5bvr' size='340' side='right'caption='[[5bvr]], [[Resolution\|resolution]] 1.46Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5bvr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BVR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BVR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5bvr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Fission_yeast Fission yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BVR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BVR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bvr OCA], [http://pdbe.org/5bvr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bvr RCSB], [http://www.ebi.ac.uk/pdbsum/5bvr PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ain1, SPAC15A10.08 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284812 Fission yeast])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bvr OCA], [http://pdbe.org/5bvr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bvr RCSB], [http://www.ebi.ac.uk/pdbsum/5bvr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bvr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Fission yeast]]
		+	[[Category: Large Structures]]
	[[Category: Addario, B]]		[[Category: Addario, B]]
	[[Category: Backman, L]]		[[Category: Backman, L]]

OCA at 17:02, 10 May 2016

OCA — Tue, 10 May 2016 17:02:27 GMT

←Older revision		Revision as of 17:02, 10 May 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5bvr is ~~ON HOLD~~	+	==Actin binding domain of alpha-actinin from Schizosaccharomyces pombe==
		+	<StructureSection load='5bvr' size='340' side='right' caption='[[5bvr]], [[Resolution\|resolution]] 1.46Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5bvr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BVR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BVR FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bvr OCA], [http://pdbe.org/5bvr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bvr RCSB], [http://www.ebi.ac.uk/pdbsum/5bvr PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/AIN1_SCHPO AIN1_SCHPO]] Binds to actin and is involved in actin-ring formation and organization. Plays a role in cytokinesis and is involved in septation.<ref>PMID:11294907</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The actin cytoskeleton plays a fundamental role in eukaryotic cells. Its reorganization is regulated by a plethora of actin-modulating proteins, such as a-actinin. In higher organisms, alpha-actinin is characterized by the presence of three distinct structural domains: an N-terminal actin-binding domain and a C-terminal region with EF-hand motif separated by a central rod domain with four spectrin repeats. Sequence analysis has revealed that the central rod domain of alpha-actinin from the fission yeast Schizosaccharomyces pombe consists of only two spectrin repeats. To obtain a firmer understanding of the structure and function of this unconventional alpha-actinin, we have cloned and characterized each structural domain. Our results show that this a-actinin isoform is capable of forming dimers and that the rod domain is required for this. However, its actin-binding and cross-linking activity appears less efficient compared to conventional alpha-actinins. The solved crystal structure of the actin-binding domain indicates that the closed state is stabilised by hydrogen bonds and a salt bridge not present in other alpha-actinins, which may reduce the affinity for actin.

-	~~Authors: Persson, K~~., ~~Backman~~, L., ~~Addario~~, B.	+	Characterisation of Schizosaccharomyces pombe alpha-actinin.,Addario B, Sandblad L, Persson K, Backman L PeerJ. 2016 Mar 28;4:e1858. doi: 10.7717/peerj.1858. eCollection 2016. PMID:27069798<ref>PMID:27069798</ref>

-	~~Description: Actin binding domain~~ of ~~alpha-actinin from Schizosaccharomyces pombe~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Backman, L]]~~	+	<div class="pdbe-citations 5bvr" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Addario, B]]		[[Category: Addario, B]]
		+	[[Category: Backman, L]]
	[[Category: Persson, K]]		[[Category: Persson, K]]
		+	[[Category: Alpha-actinin actin binding schizosaccharomyces pombe]]
		+	[[Category: Cell cycle]]
		+	[[Category: Cell division]]

OCA at 10:13, 16 December 2015

OCA — Wed, 16 Dec 2015 10:13:26 GMT

←Older revision		Revision as of 10:13, 16 December 2015
Line 7:		Line 7:
	Description: Actin binding domain of alpha-actinin from Schizosaccharomyces pombe		Description: Actin binding domain of alpha-actinin from Schizosaccharomyces pombe
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Backman, L]]
	[[Category: Addario, B]]		[[Category: Addario, B]]
	[[Category: Persson, K]]		[[Category: Persson, K]]
-	[[Category: Backman, L]]

OCA at 13:57, 17 June 2015

OCA — Wed, 17 Jun 2015 13:57:20 GMT

←Older revision		Revision as of 13:57, 17 June 2015
Line 3:		Line 3:
	The entry 5bvr is ON HOLD		The entry 5bvr is ON HOLD

-	Authors: Persson, K, Backman, L, Addario, B	+	Authors: Persson, K., Backman, L., Addario, B.

	Description: Actin binding domain of alpha-actinin from Schizosaccharomyces pombe		Description: Actin binding domain of alpha-actinin from Schizosaccharomyces pombe
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Persson, K, Backman, L~~, Addario, B~~]]	+	[[Category: Addario, B]]
		+	[[Category: Persson, K]]
		+	[[Category: Backman, L]]

OCA: Protected "5bvr" [edit=sysop:move=sysop]

OCA — Wed, 10 Jun 2015 13:09:42 GMT

Protected "5bvr" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:09, 10 June 2015

OCA: New page: '''Unreleased structure''' The entry 5bvr is ON HOLD Authors: Persson, K, Backman, L, Addario, B Description: Actin binding domain of alpha-actinin from Schizosaccharomyces pombe [[Cat...

OCA — Wed, 10 Jun 2015 13:09:40 GMT

New page: '''Unreleased structure''' The entry 5bvr is ON HOLD Authors: Persson, K, Backman, L, Addario, B Description: Actin binding domain of alpha-actinin from Schizosaccharomyces pombe [[Cat...

New page

'''Unreleased structure'''

The entry 5bvr is ON HOLD

Authors: Persson, K, Backman, L, Addario, B

Description: Actin binding domain of alpha-actinin from Schizosaccharomyces pombe
[[Category: Unreleased Structures]]
[[Category: Persson, K, Backman, L, Addario, B]]