5bvs - Revision history

OCA at 06:10, 7 June 2023

OCA — Wed, 07 Jun 2023 06:10:30 GMT

←Older revision		Revision as of 06:10, 7 June 2023
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	<StructureSection load='5bvs' size='340' side='right'caption='[[5bvs]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='5bvs' size='340' side='right'caption='[[5bvs]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5bvs]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Gentoo_penguin Gentoo penguin~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BVS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5BVS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5bvs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pygoscelis_papua Pygoscelis papua]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BVS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BVS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EIC:LINOLEIC+ACID'>EIC</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EIC:LINOLEIC+ACID'>EIC</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5bvq\|5bvq]], [[5bvt\|5bvt]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bvs OCA], [https://pdbe.org/5bvs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bvs RCSB], [https://www.ebi.ac.uk/pdbsum/5bvs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bvs ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5bvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bvs OCA], [~~http~~://pdbe.org/5bvs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5bvs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5bvs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5bvs ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/FABP4_PYGPA FABP4_PYGPA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Gentoo penguin]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Do, H~~]]	+	[[Category: Pygoscelis papua]]
-	[[Category: ~~Lee, C W~~]]	+	[[Category: Do H]]
-	[[Category: Lee~~, J H~~]]	+	[[Category: Lee CW]]
-	[[Category: ~~Beta-barrel protein]]~~	+	[[Category: Lee JH]]
-	~~[[Category: Fatty acid-binding protein]]~~	+
-	~~[[Category: Lipid binding protein~~]]	+

OCA at 11:02, 18 March 2020

OCA — Wed, 18 Mar 2020 11:02:17 GMT

←Older revision		Revision as of 11:02, 18 March 2020
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	==Linoleate-bound pFABP4==		==Linoleate-bound pFABP4==
-	<StructureSection load='5bvs' size='340' side='right' caption='[[5bvs]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='5bvs' size='340' side='right'caption='[[5bvs]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5bvs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Gentoo_penguin Gentoo penguin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BVS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BVS FirstGlance]. <br>		<table><tr><td colspan='2'>[[5bvs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Gentoo_penguin Gentoo penguin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BVS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BVS FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 5bvs" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5bvs" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Fatty acid-binding protein 3D structures\|Fatty acid-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Gentoo penguin]]		[[Category: Gentoo penguin]]
		+	[[Category: Large Structures]]
	[[Category: Do, H]]		[[Category: Do, H]]
	[[Category: Lee, C W]]		[[Category: Lee, C W]]

OCA at 18:06, 16 November 2017

OCA — Thu, 16 Nov 2017 18:06:42 GMT

←Older revision		Revision as of 18:06, 16 November 2017
Line 1:		Line 1:
		+
	==Linoleate-bound pFABP4==		==Linoleate-bound pFABP4==
	<StructureSection load='5bvs' size='340' side='right' caption='[[5bvs]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='5bvs' size='340' side='right' caption='[[5bvs]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5bvs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BVS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BVS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5bvs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Gentoo_penguin Gentoo penguin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BVS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BVS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EIC:LINOLEIC+ACID'>EIC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EIC:LINOLEIC+ACID'>EIC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5bvq\|5bvq]], [[5bvt\|5bvt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5bvq\|5bvq]], [[5bvt\|5bvt]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bvs OCA], [http://pdbe.org/5bvs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bvs RCSB], [http://www.ebi.ac.uk/pdbsum/5bvs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bvs OCA], [http://pdbe.org/5bvs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bvs RCSB], [http://www.ebi.ac.uk/pdbsum/5bvs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bvs ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Gentoo penguin]]
	[[Category: Do, H]]		[[Category: Do, H]]
	[[Category: Lee, C W]]		[[Category: Lee, C W]]

OCA at 07:47, 30 September 2015

OCA — Wed, 30 Sep 2015 07:47:53 GMT

←Older revision		Revision as of 07:47, 30 September 2015
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EIC:LINOLEIC+ACID'>EIC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EIC:LINOLEIC+ACID'>EIC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5bvq\|5bvq]], [[5bvt\|5bvt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5bvq\|5bvq]], [[5bvt\|5bvt]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bvs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5bvs RCSB], [http://www.ebi.ac.uk/pdbsum/5bvs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bvs OCA], [http://pdbe.org/5bvs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bvs RCSB], [http://www.ebi.ac.uk/pdbsum/5bvs PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 5bvs" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:57, 5 August 2015

OCA — Wed, 05 Aug 2015 19:57:31 GMT

←Older revision		Revision as of 19:57, 5 August 2015
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-	'''~~Unreleased~~ structure'''	+	==Linoleate-bound pFABP4==
		+	<StructureSection load='5bvs' size='340' side='right' caption='[[5bvs]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5bvs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BVS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BVS FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EIC:LINOLEIC+ACID'>EIC</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5bvq\|5bvq]], [[5bvt\|5bvt]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bvs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5bvs RCSB], [http://www.ebi.ac.uk/pdbsum/5bvs PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Fatty acid-binding proteins (FABPs) are involved in transporting hydrophobic fatty acids between various aqueous compartments of the cell by directly binding ligands inside their beta-barrel cavities. Here, we report the crystal structures of ligand-unbound pFABP4, linoleate-bound pFABP4, and palmitate-bound pFABP5, obtained from gentoo penguin (Pygoscelis papua), at a resolution of 2.1 A, 2.2 A, and 2.3 A, respectively. The pFABP4 and pFABP5 proteins have a canonical beta-barrel structure with two short alpha-helices that form a cap region and fatty acid ligand binding sites in the hydrophobic cavity within the beta-barrel structure. Linoleate-bound pFABP4 and palmitate-bound pFABP5 possess different ligand-binding modes and a unique ligand-binding pocket due to several sequence dissimilarities (A76/L78, T30/M32, underlining indicates pFABP4 residues) between the two proteins. Structural comparison revealed significantly different conformational changes in the beta3-beta4 loop region (residues 57-62) as well as the flipped Phe60 residue of pFABP5 than that in pFABP4 (the corresponding residue is Phe58). A ligand-binding study using fluorophore displacement assays shows that pFABP4 has a relatively strong affinity for linoleate as compared to pFABP5. In contrast, pFABP5 exhibits higher affinity for palmitate than that for pFABP4. In conclusion, our high-resolution structures and ligand-binding studies provide useful insights into the ligand-binding preferences of pFABPs based on key protein-ligand interactions.

-	~~The entry 5bvs is ON HOLD until Paper Publication~~	+	Structural basis for the ligand-binding specificity of fatty acid-binding proteins (pFABP4 and pFABP5) in gentoo penguin.,Lee CW, Kim JE, Do H, Kim RO, Lee SG, Park HH, Chang JH, Yim JH, Park H, Kim IC, Lee JH Biochem Biophys Res Commun. 2015 Jul 20. pii: S0006-291X(15)30317-X. doi:, 10.1016/j.bbrc.2015.07.087. PMID:26206084<ref>PMID:26206084</ref>

-	~~Authors: Lee~~, J.H.~~, Lee, C.W., Do, H~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: Linoleate-bound pFABP4~~	+	== References ==
-	~~[[Category: Unreleased Structures]]~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Do, H]]		[[Category: Do, H]]
-	[[Category: Lee, C.W]]	+	[[Category: Lee, C W]]
-	[[Category: Lee, J.H]]	+	[[Category: Lee, J H]]
		+	[[Category: Beta-barrel protein]]
		+	[[Category: Fatty acid-binding protein]]
		+	[[Category: Lipid binding protein]]

OCA at 10:52, 1 July 2015

OCA — Wed, 01 Jul 2015 10:52:44 GMT

←Older revision		Revision as of 10:52, 1 July 2015
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5bvs is ON HOLD	+	The entry 5bvs is ON HOLD until Paper Publication

	Authors: Lee, J.H., Lee, C.W., Do, H.		Authors: Lee, J.H., Lee, C.W., Do, H.

-	Description: ~~Ligand~~-~~unbound~~ pFABP4	+	Description: Linoleate-bound pFABP4
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Do, H]]		[[Category: Do, H]]
	[[Category: Lee, C.W]]		[[Category: Lee, C.W]]
	[[Category: Lee, J.H]]		[[Category: Lee, J.H]]

OCA at 11:43, 24 June 2015

OCA — Wed, 24 Jun 2015 11:43:54 GMT

←Older revision		Revision as of 11:43, 24 June 2015
Line 5:		Line 5:
	Authors: Lee, J.H., Lee, C.W., Do, H.		Authors: Lee, J.H., Lee, C.W., Do, H.

-	Description: ~~ligand~~-unbound pFABP4	+	Description: Ligand-unbound pFABP4
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Do, H]]		[[Category: Do, H]]
	[[Category: Lee, C.W]]		[[Category: Lee, C.W]]
	[[Category: Lee, J.H]]		[[Category: Lee, J.H]]

OCA: Protected "5bvs" [edit=sysop:move=sysop]

OCA — Wed, 10 Jun 2015 13:09:48 GMT

Protected "5bvs" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:09, 10 June 2015

OCA: New page: '''Unreleased structure''' The entry 5bvs is ON HOLD Authors: Lee, J.H., Lee, C.W., Do, H. Description: ligand-unbound pFABP4 Category: Unreleased Structures Category: Do, H [[...

OCA — Wed, 10 Jun 2015 13:09:46 GMT

New page: '''Unreleased structure''' The entry 5bvs is ON HOLD Authors: Lee, J.H., Lee, C.W., Do, H. Description: ligand-unbound pFABP4 Category: Unreleased Structures Category: Do, H [[...

New page

'''Unreleased structure'''

The entry 5bvs is ON HOLD

Authors: Lee, J.H., Lee, C.W., Do, H.

Description: ligand-unbound pFABP4
[[Category: Unreleased Structures]]
[[Category: Do, H]]
[[Category: Lee, C.W]]
[[Category: Lee, J.H]]