5bvw - Revision history

OCA at 06:10, 7 June 2023

OCA — Wed, 07 Jun 2023 06:10:36 GMT

←Older revision		Revision as of 06:10, 7 June 2023
Line 3:		Line 3:
	<StructureSection load='5bvw' size='340' side='right'caption='[[5bvw]], [[Resolution\|resolution]] 1.94Å' scene=''>		<StructureSection load='5bvw' size='340' side='right'caption='[[5bvw]], [[Resolution\|resolution]] 1.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5bvw]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BVW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5BVW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5bvw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BVW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BVW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1N1:N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE'>1N1</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1N1:N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE'>1N1</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bvw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bvw OCA], [https://pdbe.org/5bvw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bvw RCSB], [https://www.ebi.ac.uk/pdbsum/5bvw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bvw ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5bvw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bvw OCA], [~~http~~://pdbe.org/5bvw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5bvw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5bvw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5bvw ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/DDR1_HUMAN DDR1_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Receptor protein-tyrosine kinase]]~~	+	[[Category: Berdini V]]
-	[[Category: Berdini, V]]	+	[[Category: Buck I]]
-	[[Category: Buck, I]]	+	[[Category: Carr M]]
-	[[Category: Carr, M]]	+	[[Category: Cleasby A]]
-	[[Category: Cleasby, A]]	+	[[Category: Coyle J]]
-	[[Category: Coyle, J]]	+	[[Category: Curry J]]
-	[[Category: Curry, J]]	+	[[Category: Day J]]
-	[[Category: Day, J]]	+	[[Category: Hearn K]]
-	[[Category: Hearn, K]]	+	[[Category: Iqbal A]]
-	[[Category: Iqbal, A]]	+	[[Category: Kirsten T]]
-	[[Category: Kirsten, T]]	+	[[Category: Lee L]]
-	[[Category: Lee, L]]	+	[[Category: Martins V]]
-	[[Category: Martins, V]]	+	[[Category: Mortenson P]]
-	[[Category: Mortenson, P]]	+	[[Category: Munck J]]
-	[[Category: Munck, J]]	+	[[Category: Murray C]]
-	[[Category: Murray, C]]	+	[[Category: Page L]]
-	[[Category: Page, L]]	+	[[Category: Patel S]]
-	[[Category: Patel, S]]	+	[[Category: Roomans S]]
-	[[Category: Roomans, S]]	+	[[Category: Saxty G]]
-	[[Category: Saxty, G]]	+
-	~~[[Category: Ddr1]]~~	+
-	~~[[Category: Fragment]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 11:02, 18 March 2020

OCA — Wed, 18 Mar 2020 11:02:30 GMT

←Older revision		Revision as of 11:02, 18 March 2020
Line 1:		Line 1:

	==Fragment-based discovery of potent and selective DDR1/2 inhibitors==		==Fragment-based discovery of potent and selective DDR1/2 inhibitors==
-	<StructureSection load='5bvw' size='340' side='right' caption='[[5bvw]], [[Resolution\|resolution]] 1.94Å' scene=''>	+	<StructureSection load='5bvw' size='340' side='right'caption='[[5bvw]], [[Resolution\|resolution]] 1.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5bvw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BVW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BVW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5bvw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BVW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BVW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1N1:N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE'>1N1</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1N1:N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE'>1N1</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bvw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bvw OCA], [http://pdbe.org/5bvw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bvw RCSB], [http://www.ebi.ac.uk/pdbsum/5bvw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bvw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bvw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bvw OCA], [http://pdbe.org/5bvw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bvw RCSB], [http://www.ebi.ac.uk/pdbsum/5bvw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bvw ProSAT]</span></td></tr>
Line 17:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 5bvw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5bvw" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Epithelial discoidin domain-containing receptor\|Epithelial discoidin domain-containing receptor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Receptor protein-tyrosine kinase]]		[[Category: Receptor protein-tyrosine kinase]]
	[[Category: Berdini, V]]		[[Category: Berdini, V]]

OCA at 13:19, 10 May 2017

OCA — Wed, 10 May 2017 13:19:31 GMT

←Older revision		Revision as of 13:19, 10 May 2017
Line 1:		Line 1:
		+
	==Fragment-based discovery of potent and selective DDR1/2 inhibitors==		==Fragment-based discovery of potent and selective DDR1/2 inhibitors==
	<StructureSection load='5bvw' size='340' side='right' caption='[[5bvw]], [[Resolution\|resolution]] 1.94Å' scene=''>		<StructureSection load='5bvw' size='340' side='right' caption='[[5bvw]], [[Resolution\|resolution]] 1.94Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1N1:N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE'>1N1</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1N1:N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE'>1N1</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bvw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bvw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5bvw RCSB], [http://www.ebi.ac.uk/pdbsum/5bvw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bvw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bvw OCA], [http://pdbe.org/5bvw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bvw RCSB], [http://www.ebi.ac.uk/pdbsum/5bvw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bvw ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 5bvw" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:58, 5 August 2015

OCA — Wed, 05 Aug 2015 19:58:44 GMT

←Older revision		Revision as of 19:58, 5 August 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Fragment-based discovery of potent and selective DDR1/2 inhibitors==
		+	<StructureSection load='5bvw' size='340' side='right' caption='[[5bvw]], [[Resolution\|resolution]] 1.94Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5bvw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BVW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BVW FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1N1:N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE'>1N1</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bvw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bvw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5bvw RCSB], [http://www.ebi.ac.uk/pdbsum/5bvw PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The DDR1 and DDR2 receptor tyrosine kinases are activated by extracellular collagen and have been implicated in a number of human diseases including cancer. We performed a fragment-based screen against DDR1 and identified fragments that bound either at the hinge or in the back pocket associated with the DFG-out conformation of the kinase. Modeling based on crystal structures of potent kinase inhibitors facilitated the "back-to-front" design of potent DDR1/2 inhibitors that incorporated one of the DFG-out fragments. Further optimization led to low nanomolar, orally bioavailable inhibitors that were selective for DDR1 and DDR2. The inhibitors were shown to potently inhibit DDR2 activity in cells but in contrast to unselective inhibitors such as dasatinib, they did not inhibit proliferation of mutant DDR2 lung SCC cell lines.

-	~~The entry 5bvw is ON HOLD until Paper Publication~~	+	Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors.,Murray CW, Berdini V, Buck IM, Carr ME, Cleasby A, Coyle JE, Curry JE, Day JE, Day PJ, Hearn K, Iqbal A, Lee LY, Martins V, Mortenson PN, Munck JM, Page LW, Patel S, Roomans S, Smith K, Tamanini E, Saxty G ACS Med Chem Lett. 2015 Jun 4;6(7):798-803. doi: 10.1021/acsmedchemlett.5b00143. , eCollection 2015 Jul 9. PMID:26191369<ref>PMID:26191369</ref>

-	~~Authors: Murray~~, C.~~, Berdini, V., Buck, I., Carr, M., Cleasby, A., Coyle, J., Curry, J., Day, J., Hearn, K., Iqbal, A., Lee, L., Martins, V., Mortenson, P., Munck, J., Page, L., Patel,~~ S.~~, Roomans, S., Kirsten, T., Saxty, G~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Fragment~~-~~based discovery of potent and selective DDR1/2 inhibitors~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
-	[[Category: ~~Roomans~~, S]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Receptor protein-tyrosine kinase]]
		+	[[Category: Berdini, V]]
		+	[[Category: Buck, I]]
		+	[[Category: Carr, M]]
		+	[[Category: Cleasby, A]]
	[[Category: Coyle, J]]		[[Category: Coyle, J]]
		+	[[Category: Curry, J]]
		+	[[Category: Day, J]]
		+	[[Category: Hearn, K]]
		+	[[Category: Iqbal, A]]
	[[Category: Kirsten, T]]		[[Category: Kirsten, T]]
		+	[[Category: Lee, L]]
	[[Category: Martins, V]]		[[Category: Martins, V]]
-	[[Category: ~~Lee~~, ~~L]]~~	+	[[Category: Mortenson, P]]
-	~~[[Category: Day, J]]~~	+
-	~~[[Category: Hearn, K]]~~	+
-	~~[[Category: Berdini, V~~]]	+
	[[Category: Munck, J]]		[[Category: Munck, J]]
-	[[Category: ~~Buck~~, ~~I]]~~	+	[[Category: Murray, C]]
-	~~[[Category: Saxty, G~~]]	+
	[[Category: Page, L]]		[[Category: Page, L]]
-	[[Category: Iqbal, A]]
-	[[Category: Cleasby, A]]
	[[Category: Patel, S]]		[[Category: Patel, S]]
-	[[Category: ~~Curry~~, J]]	+	[[Category: Roomans, S]]
-	[[Category: ~~Mortenson~~, P]]	+	[[Category: Saxty, G]]
-	[[Category: ~~Carr, M~~]]	+	[[Category: Ddr1]]
-	[[Category: ~~Murray, C~~]]	+	[[Category: Fragment]]
		+	[[Category: Transferase]]

OCA at 13:57, 17 June 2015

OCA — Wed, 17 Jun 2015 13:57:38 GMT

←Older revision		Revision as of 13:57, 17 June 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5bvw is ON HOLD	+	The entry 5bvw is ON HOLD until Paper Publication

-	Authors: Murray, ~~Christopher;~~ Berdini, ~~Valerio;~~ Buck, ~~Ildiko;~~ Carr, ~~Maria;~~ Cleasby, ~~Anne;~~ Coyle, ~~Joseph;~~ Curry, ~~Jayne; Day~~, ~~James;~~ Day, ~~Philip;~~ Hearn, ~~Keisha;~~ Iqbal, ~~Aman;~~ Lee, ~~Lydia;~~ Martins, ~~Vanessa;~~ Mortenson, ~~Paul;~~ Munck, ~~Joanne;~~ Page, ~~Lee;~~ Patel, ~~Sahil;~~ Roomans, ~~Susan; Smith~~, Kirsten~~; Tamanini~~, ~~Emiliano;~~ Saxty, ~~Gordon~~	+	Authors: Murray, C., Berdini, V., Buck, I., Carr, M., Cleasby, A., Coyle, J., Curry, J., Day, J., Hearn, K., Iqbal, A., Lee, L., Martins, V., Mortenson, P., Munck, J., Page, L., Patel, S., Roomans, S., Kirsten, T., Saxty, G.

	Description: Fragment-based discovery of potent and selective DDR1/2 inhibitors		Description: Fragment-based discovery of potent and selective DDR1/2 inhibitors
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Murray~~, ~~Christopher; Berdini~~, ~~Valerio; Buck~~, ~~Ildiko; Carr~~, ~~Maria; Cleasby~~, ~~Anne; Coyle, Joseph; Curry, Jayne; Day, James;~~ Day, ~~Philip;~~ Hearn, ~~Keisha; Iqbal~~, ~~Aman; Lee~~, ~~Lydia; Martins~~, ~~Vanessa; Mortenson, Paul; Munck~~, ~~Joanne;~~ Page, ~~Lee;~~ Patel, ~~Sahil; Roomans~~, ~~Susan; Smith~~, ~~Kirsten; Tamanini~~, ~~Emiliano; Saxty~~, ~~Gordon~~]]	+	[[Category: Roomans, S]]
		+	[[Category: Coyle, J]]
		+	[[Category: Kirsten, T]]
		+	[[Category: Martins, V]]
		+	[[Category: Lee, L]]
		+	[[Category: Day, J]]
		+	[[Category: Hearn, K]]
		+	[[Category: Berdini, V]]
		+	[[Category: Munck, J]]
		+	[[Category: Buck, I]]
		+	[[Category: Saxty, G]]
		+	[[Category: Page, L]]
		+	[[Category: Iqbal, A]]
		+	[[Category: Cleasby, A]]
		+	[[Category: Patel, S]]
		+	[[Category: Curry, J]]
		+	[[Category: Mortenson, P]]
		+	[[Category: Carr, M]]
		+	[[Category: Murray, C]]

OCA: Protected "5bvw" [edit=sysop:move=sysop]

OCA — Wed, 10 Jun 2015 13:10:12 GMT

Protected "5bvw" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:10, 10 June 2015

OCA: New page: '''Unreleased structure''' The entry 5bvw is ON HOLD Authors: Murray, Christopher; Berdini, Valerio; Buck, Ildiko; Carr, Maria; Cleasby, Anne; Coyle, Joseph; Curry, Jayne; Day, James; D...

OCA — Wed, 10 Jun 2015 13:10:10 GMT

New page: '''Unreleased structure''' The entry 5bvw is ON HOLD Authors: Murray, Christopher; Berdini, Valerio; Buck, Ildiko; Carr, Maria; Cleasby, Anne; Coyle, Joseph; Curry, Jayne; Day, James; D...

New page

'''Unreleased structure'''

The entry 5bvw is ON HOLD

Authors: Murray, Christopher; Berdini, Valerio; Buck, Ildiko; Carr, Maria; Cleasby, Anne; Coyle, Joseph; Curry, Jayne; Day, James; Day, Philip; Hearn, Keisha; Iqbal, Aman; Lee, Lydia; Martins, Vanessa; Mortenson, Paul; Munck, Joanne; Page, Lee; Patel, Sahil; Roomans, Susan; Smith, Kirsten; Tamanini, Emiliano; Saxty, Gordon

Description: Fragment-based discovery of potent and selective DDR1/2 inhibitors
[[Category: Unreleased Structures]]
[[Category: Murray, Christopher; Berdini, Valerio; Buck, Ildiko; Carr, Maria; Cleasby, Anne; Coyle, Joseph; Curry, Jayne; Day, James; Day, Philip; Hearn, Keisha; Iqbal, Aman; Lee, Lydia; Martins, Vanessa; Mortenson, Paul; Munck, Joanne; Page, Lee; Patel, Sahil; Roomans, Susan; Smith, Kirsten; Tamanini, Emiliano; Saxty, Gordon]]