5c5q - Revision history

OCA at 08:34, 27 September 2023

OCA — Wed, 27 Sep 2023 08:34:59 GMT

←Older revision		Revision as of 08:34, 27 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5c5q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C5Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5C5Q FirstGlance]. <br>		<table><tr><td colspan='2'>[[5c5q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C5Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5C5Q FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G9W:(3R)-10-METHYL-3-(PROPAN-2-YL)-1,3,4,5-TETRAHYDRO-6H-PYRANO[4,3-C]ISOQUINOLIN-6-ONE'>G9W</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G9W:(3R)-10-METHYL-3-(PROPAN-2-YL)-1,3,4,5-TETRAHYDRO-6H-PYRANO[4,3-C]ISOQUINOLIN-6-ONE'>G9W</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5c5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c5q OCA], [https://pdbe.org/5c5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5c5q RCSB], [https://www.ebi.ac.uk/pdbsum/5c5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5c5q ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5c5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c5q OCA], [https://pdbe.org/5c5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5c5q RCSB], [https://www.ebi.ac.uk/pdbsum/5c5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5c5q ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:21, 7 June 2023

OCA — Wed, 07 Jun 2023 06:21:02 GMT

←Older revision		Revision as of 06:21, 7 June 2023
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF HUMAN TANKYRASE-2 IN COMPLEX WITH A PYRANOPYRIDONE INHIBITOR==		==CRYSTAL STRUCTURE OF HUMAN TANKYRASE-2 IN COMPLEX WITH A PYRANOPYRIDONE INHIBITOR==
-	<StructureSection load='5c5q' size='340' side='right' caption='[[5c5q]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='5c5q' size='340' side='right'caption='[[5c5q]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5c5q]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C5Q OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5C5Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5c5q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C5Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5C5Q FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G9W:(3R)-10-METHYL-3-(PROPAN-2-YL)-1,3,4,5-TETRAHYDRO-6H-PYRANO[4,3-C]ISOQUINOLIN-6-ONE'>G9W</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G9W:(3R)-10-METHYL-3-(PROPAN-2-YL)-1,3,4,5-TETRAHYDRO-6H-PYRANO[4,3-C]ISOQUINOLIN-6-ONE'>G9W</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5c5p\|5c5p]], [[5c5r\|5c5r]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5c5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c5q OCA], [https://pdbe.org/5c5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5c5q RCSB], [https://www.ebi.ac.uk/pdbsum/5c5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5c5q ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TNKS2, PARP5B, TANK2, TNKL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5c5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c5q OCA], [~~http~~://pdbe.org/5c5q PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5c5q RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5c5q PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5c5q ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>	+	[https://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 5c5q" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5c5q" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Poly(ADP-ribose) polymerase 3D structures\|Poly(ADP-ribose) polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Janson, C A~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Lukacs, C M~~]]	+	[[Category: Janson CA]]
-	[[Category: ~~Adp-ribosylation]]~~	+	[[Category: Lukacs CM]]
-	~~[[Category: Axin]]~~	+
-	~~[[Category: Beta-catenin]]~~	+
-	~~[[Category: Parp-domain]]~~	+
-	~~[[Category: Transferase-transferase inhibitor complex]]~~	+
-	~~[[Category: Wnt-signalling~~]]	+

OCA at 09:48, 22 November 2017

OCA — Wed, 22 Nov 2017 09:48:53 GMT

←Older revision		Revision as of 09:48, 22 November 2017
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF HUMAN TANKYRASE-2 IN COMPLEX WITH A PYRANOPYRIDONE INHIBITOR==		==CRYSTAL STRUCTURE OF HUMAN TANKYRASE-2 IN COMPLEX WITH A PYRANOPYRIDONE INHIBITOR==
	<StructureSection load='5c5q' size='340' side='right' caption='[[5c5q]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='5c5q' size='340' side='right' caption='[[5c5q]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5c5q]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C5Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C5Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5c5q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C5Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C5Q FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G9W:(3R)-10-METHYL-3-(PROPAN-2-YL)-1,3,4,5-TETRAHYDRO-6H-PYRANO[4,3-C]ISOQUINOLIN-6-ONE'>G9W</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G9W:(3R)-10-METHYL-3-(PROPAN-2-YL)-1,3,4,5-TETRAHYDRO-6H-PYRANO[4,3-C]ISOQUINOLIN-6-ONE'>G9W</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5c5p\|5c5p]], [[5c5r\|5c5r]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5c5p\|5c5p]], [[5c5r\|5c5r]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TNKS2, PARP5B, TANK2, TNKL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c5q OCA], [http://pdbe.org/5c5q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5c5q RCSB], [http://www.ebi.ac.uk/pdbsum/5c5q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c5q OCA], [http://pdbe.org/5c5q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5c5q RCSB], [http://www.ebi.ac.uk/pdbsum/5c5q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5c5q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 23:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Janson, C A]]		[[Category: Janson, C A]]
	[[Category: Lukacs, C M]]		[[Category: Lukacs, C M]]

OCA at 07:24, 7 October 2015

OCA — Wed, 07 Oct 2015 07:24:59 GMT

←Older revision		Revision as of 07:24, 7 October 2015
Line 6:		Line 6:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5c5p\|5c5p]], [[5c5r\|5c5r]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5c5p\|5c5p]], [[5c5r\|5c5r]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c5q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5c5q RCSB], [http://www.ebi.ac.uk/pdbsum/5c5q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c5q OCA], [http://pdbe.org/5c5q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5c5q RCSB], [http://www.ebi.ac.uk/pdbsum/5c5q PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>		[[http://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Tankyrase activity has been linked to the regulation of intracellular axin levels, which have been shown to be crucial for the Wnt pathway. Deregulated Wnt signaling is important for the genesis of many diseases including cancer. We describe herein the discovery and development of a new series of tankyrase inhibitors. These pyranopyridones are highly active in various cell-based assays. A fragment/structure based optimization strategy led to a compound with good pharmacokinetic properties that is suitable for in vivo studies and further development.
		+
		+	Fragment-Based Drug Design of Novel Pyranopyridones as Cell Active and Orally Bioavailable Tankyrase Inhibitors.,de Vicente J, Tivitmahaisoon P, Berry P, Bolin DR, Carvajal D, He W, Huang KS, Janson C, Liang L, Lukacs C, Petersen A, Qian H, Yi L, Zhuang Y, Hermann JC ACS Med Chem Lett. 2015 Aug 4;6(9):1019-24. doi: 10.1021/acsmedchemlett.5b00251. , eCollection 2015 Sep 10. PMID:26396691<ref>PMID:26396691</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5c5q" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:54, 12 August 2015

OCA — Wed, 12 Aug 2015 14:54:15 GMT

←Older revision		Revision as of 14:54, 12 August 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==CRYSTAL STRUCTURE OF HUMAN TANKYRASE-2 IN COMPLEX WITH A PYRANOPYRIDONE INHIBITOR==
-		+	<StructureSection load='5c5q' size='340' side='right' caption='[[5c5q]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~The entry~~ 5c5q is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5c5q]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C5Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C5Q FirstGlance]. <br>
-	~~Authors~~: ~~Lukacs~~, C.M., ~~Janson, C~~.A.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G9W:(3R)-10-METHYL-3-(PROPAN-2-YL)-1,3,4,5-TETRAHYDRO-6H-PYRANO[4,3-C]ISOQUINOLIN-6-ONE'>G9W</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5c5p\|5c5p]], [[5c5r\|5c5r]]</td></tr>
-	~~Description~~: ~~CRYSTAL STRUCTURE OF HUMAN TANKYRASE~~-~~2 IN COMPLEX WITH A PYRANOPYRIDONE INHIBITOR~~	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c5q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5c5q RCSB], [http://www.ebi.ac.uk/pdbsum/5c5q PDBsum]</span></td></tr>
-	[[Category: Janson, C.A]]	+	</table>
-	[[Category: Lukacs, C.M]]	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Janson, C A]]
		+	[[Category: Lukacs, C M]]
		+	[[Category: Adp-ribosylation]]
		+	[[Category: Axin]]
		+	[[Category: Beta-catenin]]
		+	[[Category: Parp-domain]]
		+	[[Category: Transferase-transferase inhibitor complex]]
		+	[[Category: Wnt-signalling]]

OCA at 12:48, 22 July 2015

OCA — Wed, 22 Jul 2015 12:48:33 GMT

←Older revision		Revision as of 12:48, 22 July 2015
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5c5q is ON HOLD	+	The entry 5c5q is ON HOLD until Paper Publication

	Authors: Lukacs, C.M., Janson, C.A.		Authors: Lukacs, C.M., Janson, C.A.

OCA: Protected "5c5q" [edit=sysop:move=sysop]

OCA — Wed, 01 Jul 2015 11:10:08 GMT

Protected "5c5q" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:10, 1 July 2015

OCA: New page: '''Unreleased structure''' The entry 5c5q is ON HOLD Authors: Lukacs, C.M., Janson, C.A. Description: CRYSTAL STRUCTURE OF HUMAN TANKYRASE-2 IN COMPLEX WITH A PYRANOPYRIDONE INHIBITOR ...

OCA — Wed, 01 Jul 2015 11:10:06 GMT

New page: '''Unreleased structure''' The entry 5c5q is ON HOLD Authors: Lukacs, C.M., Janson, C.A. Description: CRYSTAL STRUCTURE OF HUMAN TANKYRASE-2 IN COMPLEX WITH A PYRANOPYRIDONE INHIBITOR ...

New page

'''Unreleased structure'''

The entry 5c5q is ON HOLD

Authors: Lukacs, C.M., Janson, C.A.

Description: CRYSTAL STRUCTURE OF HUMAN TANKYRASE-2 IN COMPLEX WITH A PYRANOPYRIDONE INHIBITOR
[[Category: Unreleased Structures]]
[[Category: Janson, C.A]]
[[Category: Lukacs, C.M]]