5c5x - Revision history

OCA at 11:18, 10 January 2024

OCA — Wed, 10 Jan 2024 11:18:47 GMT

←Older revision		Revision as of 11:18, 10 January 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5c5x]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5C5X FirstGlance]. <br>		<table><tr><td colspan='2'>[[5c5x]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5C5X FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PS6:O-[(S)-{[(2S)-2-(HEXANOYLOXY)-3-(TETRADECANOYLOXY)PROPYL]OXY}(HYDROXY)PHOSPHORYL]-D-SERINE'>PS6</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PS6:O-[(S)-{[(2S)-2-(HEXANOYLOXY)-3-(TETRADECANOYLOXY)PROPYL]OXY}(HYDROXY)PHOSPHORYL]-D-SERINE'>PS6</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5c5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c5x OCA], [https://pdbe.org/5c5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5c5x RCSB], [https://www.ebi.ac.uk/pdbsum/5c5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5c5x ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5c5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c5x OCA], [https://pdbe.org/5c5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5c5x RCSB], [https://www.ebi.ac.uk/pdbsum/5c5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5c5x ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:21, 7 June 2023

OCA — Wed, 07 Jun 2023 06:21:12 GMT

←Older revision		Revision as of 06:21, 7 June 2023
Line 3:		Line 3:
	<StructureSection load='5c5x' size='340' side='right'caption='[[5c5x]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='5c5x' size='340' side='right'caption='[[5c5x]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5c5x]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C5X OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5C5X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5c5x]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5C5X FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PS6:O-[(S)-{[(2S)-2-(HEXANOYLOXY)-3-(TETRADECANOYLOXY)PROPYL]OXY}(HYDROXY)PHOSPHORYL]-D-SERINE'>PS6</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PS6:O-[(S)-{[(2S)-2-(HEXANOYLOXY)-3-(TETRADECANOYLOXY)PROPYL]OXY}(HYDROXY)PHOSPHORYL]-D-SERINE'>PS6</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3d9s\|3d9s]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5c5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c5x OCA], [https://pdbe.org/5c5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5c5x RCSB], [https://www.ebi.ac.uk/pdbsum/5c5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5c5x ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AQP5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5c5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c5x OCA], [~~http~~://pdbe.org/5c5x PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5c5x RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5c5x PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5c5x ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/AQP5_HUMAN AQP5_HUMAN]] Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions.	+	[https://www.uniprot.org/uniprot/AQP5_HUMAN AQP5_HUMAN] Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bill~~, R M~~]]	+	[[Category: Bill RM]]
-	[[Category: Conner~~, A C~~]]	+	[[Category: Conner AC]]
-	[[Category: Conner~~, M T~~]]	+	[[Category: Conner MT]]
-	[[Category: Hedfalk, K]]	+	[[Category: Hedfalk K]]
-	[[Category: Kitchen, P]]	+	[[Category: Kitchen P]]
-	[[Category: Oeberg, F]]	+	[[Category: Oeberg F]]
-	[[Category: Sjoehamn, J]]	+	[[Category: Sjoehamn J]]
-	[[Category: Toernroth-Horsefield, S]]	+	[[Category: Toernroth-Horsefield S]]
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 11:13, 18 March 2020

OCA — Wed, 18 Mar 2020 11:13:36 GMT

←Older revision		Revision as of 11:13, 18 March 2020
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF THE S156E MUTANT OF HUMAN AQUAPORIN 5==		==CRYSTAL STRUCTURE OF THE S156E MUTANT OF HUMAN AQUAPORIN 5==
-	<StructureSection load='5c5x' size='340' side='right' caption='[[5c5x]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='5c5x' size='340' side='right'caption='[[5c5x]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5c5x]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C5X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C5X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5c5x]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C5X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C5X FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PS6:O-[(S)-{[(2S)-2-(HEXANOYLOXY)-3-(TETRADECANOYLOXY)PROPYL]OXY}(HYDROXY)PHOSPHORYL]-D-SERINE'>PS6</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PS6:O-[(S)-{[(2S)-2-(HEXANOYLOXY)-3-(TETRADECANOYLOXY)PROPYL]OXY}(HYDROXY)PHOSPHORYL]-D-SERINE'>PS6</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3d9s\|3d9s]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3d9s\|3d9s]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c5x OCA], [http://pdbe.org/5c5x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5c5x RCSB], [http://www.ebi.ac.uk/pdbsum/5c5x PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AQP5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c5x OCA], [http://pdbe.org/5c5x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5c5x RCSB], [http://www.ebi.ac.uk/pdbsum/5c5x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5c5x ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 5c5x" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5c5x" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aquaporin 3D structures\|Aquaporin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bill, R M]]		[[Category: Bill, R M]]
	[[Category: Conner, A C]]		[[Category: Conner, A C]]

OCA at 16:12, 2 December 2015

OCA — Wed, 02 Dec 2015 16:12:30 GMT

←Older revision		Revision as of 16:12, 2 December 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==CRYSTAL STRUCTURE OF THE S156E MUTANT OF HUMAN AQUAPORIN 5==
		+	<StructureSection load='5c5x' size='340' side='right' caption='[[5c5x]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5c5x]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C5X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C5X FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PS6:O-[(S)-{[(2S)-2-(HEXANOYLOXY)-3-(TETRADECANOYLOXY)PROPYL]OXY}(HYDROXY)PHOSPHORYL]-D-SERINE'>PS6</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3d9s\|3d9s]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c5x OCA], [http://pdbe.org/5c5x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5c5x RCSB], [http://www.ebi.ac.uk/pdbsum/5c5x PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/AQP5_HUMAN AQP5_HUMAN]] Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Aquaporin membrane protein channels mediate cellular water flow. Human aquaporin 5 (AQP5) is highly expressed in the respiratory system and secretory glands where it facilitates the osmotically-driven generation of pulmonary secretions, saliva, sweat and tears. Dysfunctional trafficking of AQP5 has been implicated in several human disease states, including Sjogren's syndrome, bronchitis and cystic fibrosis. In order to investigate how the plasma membrane expression levels of AQP5 are regulated, we studied real-time translocation of GFP-tagged AQP5 in HEK293 cells. We show that AQP5 plasma membrane abundance in transfected HEK293 cells is rapidly and reversibly regulated by at least three independent mechanisms involving phosphorylation at Ser156, protein kinase A activity and extracellular tonicity. The crystal structure of a Ser156 phosphomimetic mutant indicates that its involvement in regulating AQP5 membrane abundance is not mediated by a conformational change of the carboxy-terminus. We suggest that together these pathways regulate cellular water flow.

-	~~The entry 5c5x is ON HOLD~~	+	Plasma Membrane Abundance of Human Aquaporin 5 Is Dynamically Regulated by Multiple Pathways.,Kitchen P, Oberg F, Sjohamn J, Hedfalk K, Bill RM, Conner AC, Conner MT, Tornroth-Horsefield S PLoS One. 2015 Nov 16;10(11):e0143027. doi: 10.1371/journal.pone.0143027., eCollection 2015. PMID:26569106<ref>PMID:26569106</ref>

-	~~Authors: Kitchen~~, P.~~, Oeberg, F~~.~~, Sjoehamn, J., Hedfalk, K., Bill, R.M., Conner, A.C., Conner, M.T., Toernroth-Horsefield, S~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~CRYSTAL STRUCTURE OF THE S156E MUTANT OF HUMAN AQUAPORIN 5~~	+	<div class="pdbe-citations 5c5x" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Unreleased Structures~~]]	+	== References ==
-	[[Category: Conner, A.C]]	+	<references/>
-	[[Category: ~~Bill~~, R.M]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Bill, R M]]
		+	[[Category: Conner, A C]]
		+	[[Category: Conner, M T]]
		+	[[Category: Hedfalk, K]]
	[[Category: Kitchen, P]]		[[Category: Kitchen, P]]
	[[Category: Oeberg, F]]		[[Category: Oeberg, F]]
		+	[[Category: Sjoehamn, J]]
	[[Category: Toernroth-Horsefield, S]]		[[Category: Toernroth-Horsefield, S]]
-	[[Category: ~~Hedfalk, K~~]]	+	[[Category: Membrane protein]]
-	[[Category: ~~Conner, M.T]]~~	+	[[Category: Transport protein]]
-	~~[[Category: Sjoehamn, J~~]]	+

OCA: Protected "5c5x" [edit=sysop:move=sysop]

OCA — Wed, 01 Jul 2015 11:10:47 GMT

Protected "5c5x" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:10, 1 July 2015

OCA: New page: '''Unreleased structure''' The entry 5c5x is ON HOLD Authors: Kitchen, P., Oeberg, F., Sjoehamn, J., Hedfalk, K., Bill, R.M., Conner, A.C., Conner, M.T., Toernroth-Horsefield, S. Descr...

OCA — Wed, 01 Jul 2015 11:10:46 GMT

New page: '''Unreleased structure''' The entry 5c5x is ON HOLD Authors: Kitchen, P., Oeberg, F., Sjoehamn, J., Hedfalk, K., Bill, R.M., Conner, A.C., Conner, M.T., Toernroth-Horsefield, S. Descr...

New page

'''Unreleased structure'''

The entry 5c5x is ON HOLD

Authors: Kitchen, P., Oeberg, F., Sjoehamn, J., Hedfalk, K., Bill, R.M., Conner, A.C., Conner, M.T., Toernroth-Horsefield, S.

Description: CRYSTAL STRUCTURE OF THE S156E MUTANT OF HUMAN AQUAPORIN 5
[[Category: Unreleased Structures]]
[[Category: Conner, A.C]]
[[Category: Bill, R.M]]
[[Category: Kitchen, P]]
[[Category: Oeberg, F]]
[[Category: Toernroth-Horsefield, S]]
[[Category: Hedfalk, K]]
[[Category: Conner, M.T]]
[[Category: Sjoehamn, J]]