5ci1 - Revision history

OCA at 08:38, 27 September 2023

OCA — Wed, 27 Sep 2023 08:38:08 GMT

←Older revision		Revision as of 08:38, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5ci1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_1303 Escherichia coli 1303]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CI1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CI1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5ci1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_1303 Escherichia coli 1303]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CI1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CI1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FEO:MU-OXO-DIIRON'>FEO</scene>, <scene name='pdbligand=FY2:2,3-DIFLUORO-L-TYROSINE'>FY2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.95Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FEO:MU-OXO-DIIRON'>FEO</scene>, <scene name='pdbligand=FY2:2,3-DIFLUORO-L-TYROSINE'>FY2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ci1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ci1 OCA], [https://pdbe.org/5ci1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ci1 RCSB], [https://www.ebi.ac.uk/pdbsum/5ci1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ci1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ci1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ci1 OCA], [https://pdbe.org/5ci1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ci1 RCSB], [https://www.ebi.ac.uk/pdbsum/5ci1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ci1 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 12:07, 14 June 2023

OCA — Wed, 14 Jun 2023 12:07:28 GMT

←Older revision		Revision as of 12:07, 14 June 2023
Line 3:		Line 3:
	<StructureSection load='5ci1' size='340' side='right'caption='[[5ci1]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='5ci1' size='340' side='right'caption='[[5ci1]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ci1]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Escherichia_coli_1303 Escherichia coli 1303]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CI1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5CI1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ci1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_1303 Escherichia coli 1303]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CI1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CI1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FEO:MU-OXO-DIIRON'>FEO</scene>, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FEO:MU-OXO-DIIRON'>FEO</scene>, <scene name='pdbligand=FY2:2,3-DIFLUORO-L-TYROSINE'>FY2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=FY2:2,3-DIFLUORO-L-TYROSINE'>FY2</scene>~~</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ci1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ci1 OCA], [https://pdbe.org/5ci1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ci1 RCSB], [https://www.ebi.ac.uk/pdbsum/5ci1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ci1 ProSAT]</span></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ci0\|5ci0]]~~, ~~[[5ci2\|5ci2]], [[5ci3\|5ci3]], [[5ci4\|5ci4]]~~<~~/td></tr>~~	+
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b></td><td class="sblockDat">nrdB, EC1303_c24130 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=745156 Escherichia coli 1303])</td></tr>~~	+
-	~~<tr id='activity~~'>~~<td class="sblockLbl"><b>Activity:~~</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ci1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ci1 OCA], [~~http~~://pdbe.org/5ci1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ci1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ci1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ci1 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0E1LZC3_ECOLX A0A0E1LZC3_ECOLX]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:

	==See Also==		==See Also==
-	*[[Ribonucleotide reductase\|Ribonucleotide reductase]]	+	*[[Ribonucleotide reductase 3D structures\|Ribonucleotide reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 27:
	[[Category: Escherichia coli 1303]]		[[Category: Escherichia coli 1303]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Ribonucleoside-diphosphate reductase]]~~	+	[[Category: Drennan CL]]
-	[[Category: Drennan~~, C L~~]]	+	[[Category: Funk MA]]
-	[[Category: Funk~~, M A]]~~	+
-	~~[[Category: Ferritin superfamily]]~~	+
-	~~[[Category: Fluorotyrosine]]~~	+
-	~~[[Category: Metalloenzyme]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Unnatural amino acid~~]]	+

OCA at 07:27, 27 November 2019

OCA — Wed, 27 Nov 2019 07:27:46 GMT

←Older revision		Revision as of 07:27, 27 November 2019
Line 1:		Line 1:

	==Ribonucleotide reductase Y122 2,3-F2Y variant==		==Ribonucleotide reductase Y122 2,3-F2Y variant==
-	<StructureSection load='5ci1' size='340' side='right' caption='[[5ci1]], [[Resolution\|resolution]] 1.95Å' scene=''>	+	<StructureSection load='5ci1' size='340' side='right'caption='[[5ci1]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5ci1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_1303 Escherichia coli 1303]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CI1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5ci1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_1303 Escherichia coli 1303]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CI1 FirstGlance]. <br>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli 1303]]		[[Category: Escherichia coli 1303]]
		+	[[Category: Large Structures]]
	[[Category: Ribonucleoside-diphosphate reductase]]		[[Category: Ribonucleoside-diphosphate reductase]]
	[[Category: Drennan, C L]]		[[Category: Drennan, C L]]

OCA at 07:50, 21 March 2018

OCA — Wed, 21 Mar 2018 07:50:49 GMT

←Older revision		Revision as of 07:50, 21 March 2018
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 5ci1" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5ci1" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ribonucleotide reductase\|Ribonucleotide reductase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:35, 15 November 2017

OCA — Wed, 15 Nov 2017 16:35:23 GMT

←Older revision		Revision as of 16:35, 15 November 2017
Line 3:		Line 3:
	<StructureSection load='5ci1' size='340' side='right' caption='[[5ci1]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='5ci1' size='340' side='right' caption='[[5ci1]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ci1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CI1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ci1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_1303 Escherichia coli 1303]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CI1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FEO:MU-OXO-DIIRON'>FEO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FEO:MU-OXO-DIIRON'>FEO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=FY2:2,3-DIFLUORO-L-TYROSINE'>FY2</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=FY2:2,3-DIFLUORO-L-TYROSINE'>FY2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ci0\|5ci0]], [[5ci2\|5ci2]], [[5ci3\|5ci3]], [[5ci4\|5ci4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ci0\|5ci0]], [[5ci2\|5ci2]], [[5ci3\|5ci3]], [[5ci4\|5ci4]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nrdB, EC1303_c24130 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=745156 Escherichia coli 1303])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ci1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ci1 OCA], [http://pdbe.org/5ci1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ci1 RCSB], [http://www.ebi.ac.uk/pdbsum/5ci1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ci1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ci1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ci1 OCA], [http://pdbe.org/5ci1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ci1 RCSB], [http://www.ebi.ac.uk/pdbsum/5ci1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ci1 ProSAT]</span></td></tr>
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Escherichia coli 1303]]
	[[Category: Ribonucleoside-diphosphate reductase]]		[[Category: Ribonucleoside-diphosphate reductase]]
	[[Category: Drennan, C L]]		[[Category: Drennan, C L]]

OCA at 02:23, 13 July 2016

OCA — Wed, 13 Jul 2016 02:23:57 GMT

←Older revision		Revision as of 02:23, 13 July 2016
Line 8:		Line 8:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ci0\|5ci0]], [[5ci2\|5ci2]], [[5ci3\|5ci3]], [[5ci4\|5ci4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ci0\|5ci0]], [[5ci2\|5ci2]], [[5ci3\|5ci3]], [[5ci4\|5ci4]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ci1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ci1 OCA], [http://pdbe.org/5ci1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ci1 RCSB], [http://www.ebi.ac.uk/pdbsum/5ci1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ci1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ci1 OCA], [http://pdbe.org/5ci1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ci1 RCSB], [http://www.ebi.ac.uk/pdbsum/5ci1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ci1 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:20, 23 June 2016

OCA — Thu, 23 Jun 2016 23:20:26 GMT

←Older revision		Revision as of 23:20, 23 June 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5ci1 is ~~ON HOLD until Paper~~ Publication	+	==Ribonucleotide reductase Y122 2,3-F2Y variant==
		+	<StructureSection load='5ci1' size='340' side='right' caption='[[5ci1]], [[Resolution\|resolution]] 1.95Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5ci1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CI1 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FEO:MU-OXO-DIIRON'>FEO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=FY2:2,3-DIFLUORO-L-TYROSINE'>FY2</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ci0\|5ci0]], [[5ci2\|5ci2]], [[5ci3\|5ci3]], [[5ci4\|5ci4]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ci1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ci1 OCA], [http://pdbe.org/5ci1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ci1 RCSB], [http://www.ebi.ac.uk/pdbsum/5ci1 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Fluorinated tyrosines (FnY's, n = 2 and 3) have been site-specifically incorporated into E. coli class Ia ribonucleotide reductase (RNR) using the recently evolved M. jannaschii Y-tRNA synthetase/tRNA pair. Class Ia RNRs require four redox active Y's, a stable Y radical (Y.) in the beta subunit (position 122 in E. coli), and three transiently oxidized Y's (356 in beta and 731 and 730 in alpha) to initiate the radical-dependent nucleotide reduction process. FnY (3,5; 2,3; 2,3,5; and 2,3,6) incorporation in place of Y122-beta and the X-ray structures of each resulting beta with a diferric cluster are reported and compared with wt-beta2 crystallized under the same conditions. The essential diferric-FnY. cofactor is self-assembled from apo FnY-beta2, Fe2+, and O2 to produce approximately 1 Y./beta2 and approximately 3 Fe3+/beta2. The FnY. are stable and active in nucleotide reduction with activities that vary from 5% to 85% that of wt-beta2. Each FnY.-beta2 has been characterized by 9 and 130 GHz electron paramagnetic resonance and high-field electron nuclear double resonance spectroscopies. The hyperfine interactions associated with the 19F nucleus provide unique signatures of each FnY. that are readily distinguishable from unlabeled Y.'s. The variability of the abiotic FnY pKa's (6.4 to 7.8) and reduction potentials (-30 to +130 mV relative to Y at pH 7.5) provide probes of enzymatic reactions proposed to involve Y.'s in catalysis and to investigate the importance and identity of hopping Y.'s within redox active proteins proposed to protect them from uncoupled radical chemistry.

-	~~Authors~~: ~~Funk, M~~.A., Drennan, C.L.	+	Biophysical Characterization of Fluorotyrosine Probes Site-Specifically Incorporated into Enzymes: E. coli Ribonucleotide Reductase As an Example.,Oyala PH, Ravichandran KR, Funk MA, Stucky PA, Stich TA, Drennan CL, Britt RD, Stubbe J J Am Chem Soc. 2016 Jun 21. PMID:27276098<ref>PMID:27276098</ref>

-	~~Description: Ribonucleotide reductase Y122 2~~,3-~~F2Y variant~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: Funk, M.A]]	+	<div class="pdbe-citations 5ci1" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Drennan, C.L~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ribonucleoside-diphosphate reductase]]
		+	[[Category: Drennan, C L]]
		+	[[Category: Funk, M A]]
		+	[[Category: Ferritin superfamily]]
		+	[[Category: Fluorotyrosine]]
		+	[[Category: Metalloenzyme]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Unnatural amino acid]]

OCA at 13:09, 12 August 2015

OCA — Wed, 12 Aug 2015 13:09:44 GMT

←Older revision		Revision as of 13:09, 12 August 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5ci1 is ON HOLD	+	The entry 5ci1 is ON HOLD until Paper Publication

	Authors: Funk, M.A., Drennan, C.L.		Authors: Funk, M.A., Drennan, C.L.

OCA: Protected "5ci1" [edit=sysop:move=sysop]

OCA — Wed, 22 Jul 2015 13:09:28 GMT

Protected "5ci1" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:09, 22 July 2015

OCA: New page: '''Unreleased structure''' The entry 5ci1 is ON HOLD Authors: Funk, M.A., Drennan, C.L. Description: Ribonucleotide reductase Y122 2,3-F2Y variant Category: Unreleased Structures [...

OCA — Wed, 22 Jul 2015 13:09:26 GMT

New page: '''Unreleased structure''' The entry 5ci1 is ON HOLD Authors: Funk, M.A., Drennan, C.L. Description: Ribonucleotide reductase Y122 2,3-F2Y variant Category: Unreleased Structures [...

New page

'''Unreleased structure'''

The entry 5ci1 is ON HOLD

Authors: Funk, M.A., Drennan, C.L.

Description: Ribonucleotide reductase Y122 2,3-F2Y variant
[[Category: Unreleased Structures]]
[[Category: Funk, M.A]]
[[Category: Drennan, C.L]]