5cp9 - Revision history

OCA at 11:22, 10 January 2024

OCA — Wed, 10 Jan 2024 11:22:08 GMT

←Older revision		Revision as of 11:22, 10 January 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5cp9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CP9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5cp9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CP9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6O5:3-(FURAN-2-YL)PROPANOIC+ACID'>6O5</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6O5:3-(FURAN-2-YL)PROPANOIC+ACID'>6O5</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cp9 OCA], [https://pdbe.org/5cp9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cp9 RCSB], [https://www.ebi.ac.uk/pdbsum/5cp9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cp9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cp9 OCA], [https://pdbe.org/5cp9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cp9 RCSB], [https://www.ebi.ac.uk/pdbsum/5cp9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cp9 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 12:21, 14 June 2023

OCA — Wed, 14 Jun 2023 12:21:55 GMT

←Older revision		Revision as of 12:21, 14 June 2023
Line 1:		Line 1:

	==The structure of the NK1 fragment of HGF/SF complexed with MB605==		==The structure of the NK1 fragment of HGF/SF complexed with MB605==
-	<StructureSection load='5cp9' size='340' side='right' caption='[[5cp9]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='5cp9' size='340' side='right'caption='[[5cp9]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5cp9]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CP9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5CP9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5cp9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CP9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6O5:3-(FURAN-2-YL)PROPANOIC+ACID'>6O5</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6O5:3-(FURAN-2-YL)PROPANOIC+ACID'>6O5</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HGF, HPTA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cp9 OCA], [https://pdbe.org/5cp9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cp9 RCSB], [https://www.ebi.ac.uk/pdbsum/5cp9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cp9 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5cp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cp9 OCA], [~~http~~://pdbe.org/5cp9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5cp9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5cp9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5cp9 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/HGF_HUMAN HGF_HUMAN]] Defects in HGF are the cause of deafness autosomal recessive type 39 (DFNB39) [MIM:[~~http~~://omim.org/entry/608265 608265]]. A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:19576567</ref>	+	[https://www.uniprot.org/uniprot/HGF_HUMAN HGF_HUMAN] Defects in HGF are the cause of deafness autosomal recessive type 39 (DFNB39) [MIM:[https://omim.org/entry/608265 608265]. A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:19576567</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/HGF_HUMAN HGF_HUMAN]] Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.<ref>PMID:15167892</ref> <ref>PMID:20624990</ref>	+	[https://www.uniprot.org/uniprot/HGF_HUMAN HGF_HUMAN] Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.<ref>PMID:15167892</ref> <ref>PMID:20624990</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Ascher~~, D B~~]]	+	[[Category: Large Structures]]
-	[[Category: Blundell~~, T L~~]]	+	[[Category: Ascher DB]]
-	[[Category: Chirgadze~~, D Y~~]]	+	[[Category: Blundell TL]]
-	[[Category: Fragai, M]]	+	[[Category: Chirgadze DY]]
-	[[Category: Gherardi, E]]	+	[[Category: Fragai M]]
-	[[Category: Sigurdardottir~~, A G~~]]	+	[[Category: Gherardi E]]
-	[[Category: Sobkowicz, A]]	+	[[Category: Sigurdardottir AG]]
-	[[Category: Winter, A]]	+	[[Category: Sobkowicz A]]
-	~~[[Category: Cell cycle]]~~	+	[[Category: Winter A]]
-	~~[[Category: Fragment based drug discovery]]~~	+
-	~~[[Category: Growth factor]]~~	+
-	~~[[Category: Hgf/sf]]~~	+
-	~~[[Category: Hormone]]~~	+
-	~~[[Category: New chemical entity]]~~	+
-	~~[[Category: Nk1 fragment~~]]	+

OCA at 07:45, 29 August 2018

OCA — Wed, 29 Aug 2018 07:45:30 GMT

←Older revision		Revision as of 07:45, 29 August 2018
Line 3:		Line 3:
	<StructureSection load='5cp9' size='340' side='right' caption='[[5cp9]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='5cp9' size='340' side='right' caption='[[5cp9]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5cp9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CP9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CP9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5cp9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CP9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CP9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6O5:3-(FURAN-2-YL)PROPANOIC+ACID'>6O5</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6O5:3-(FURAN-2-YL)PROPANOIC+ACID'>6O5</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HGF, HPTA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cp9 OCA], [http://pdbe.org/5cp9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cp9 RCSB], [http://www.ebi.ac.uk/pdbsum/5cp9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cp9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cp9 OCA], [http://pdbe.org/5cp9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cp9 RCSB], [http://www.ebi.ac.uk/pdbsum/5cp9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cp9 ProSAT]</span></td></tr>
	</table>		</table>
Line 11:		Line 12:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/HGF_HUMAN HGF_HUMAN]] Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.<ref>PMID:15167892</ref> <ref>PMID:20624990</ref>		[[http://www.uniprot.org/uniprot/HGF_HUMAN HGF_HUMAN]] Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.<ref>PMID:15167892</ref> <ref>PMID:20624990</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The growth/motility factor hepatocyte growth factor/scatter factor (HGF/SF) and its receptor, the tyrosine kinase MET, constitute a signalling system essential for embryogenesis and for tissue/organ regeneration in post-natal life. HGF/SF-MET signalling, however, also plays a key role in the onset of metastasis of a large number of human tumours. Both HGF/SF and MET are high molecular weight proteins that bury an extensive interface upon complex formation and thus constitute a challenging target for the development of low molecular weight inhibitors. Here we have used surface plasmon resonance (SPR), nuclear magnetic resonance (NMR) and X-ray crystallography to screen a diverse fragment library of 1338 members as well as a range of piperazine-like compounds. Several small molecules were found to bind in the lysine-binding pocket of the kringle 1 domain of HGF/SF and its truncated splice variant NK1. We have defined the binding mode of these compounds, explored their biological activity and we show that selected fragments inhibit MET downstream signalling. Thus we demonstrate that targeting the lysine-binding pocket of NK1 is an effective strategy to generate MET receptor antagonists and we offer proof of concept that the HGF/SF-MET interface may be successfully targeted with small molecules. These studies have broad implications for the development of HGF/SF-MET therapeutics and cancer treatment.
		+
		+	Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding.,Sigurdardottir AG, Winter A, Sobkowicz A, Fragai M, Chirgadze D, Ascher DB, Blundell TL, Gherardi E Chem Sci. 2015 Nov 1;6(11):6147-6157. doi: 10.1039/c5sc02155c. Epub 2015 Jul 31. PMID:30090230<ref>PMID:30090230</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5cp9" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Hepatocyte growth factor\|Hepatocyte growth factor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Ascher, D B]]		[[Category: Ascher, D B]]
	[[Category: Blundell, T L]]		[[Category: Blundell, T L]]

OCA at 11:22, 26 October 2016

OCA — Wed, 26 Oct 2016 11:22:46 GMT

←Older revision		Revision as of 11:22, 26 October 2016
Line 1:		Line 1:
		+
	==The structure of the NK1 fragment of HGF/SF complexed with MB605==		==The structure of the NK1 fragment of HGF/SF complexed with MB605==
	<StructureSection load='5cp9' size='340' side='right' caption='[[5cp9]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='5cp9' size='340' side='right' caption='[[5cp9]], [[Resolution\|resolution]] 1.90Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[5cp9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CP9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CP9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5cp9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CP9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CP9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6O5:3-(FURAN-2-YL)PROPANOIC+ACID'>6O5</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6O5:3-(FURAN-2-YL)PROPANOIC+ACID'>6O5</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cp9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5cp9 RCSB], [http://www.ebi.ac.uk/pdbsum/5cp9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cp9 OCA], [http://pdbe.org/5cp9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cp9 RCSB], [http://www.ebi.ac.uk/pdbsum/5cp9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cp9 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 14:55, 12 August 2015

OCA — Wed, 12 Aug 2015 14:55:51 GMT

←Older revision		Revision as of 14:55, 12 August 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==The structure of the NK1 fragment of HGF/SF complexed with MB605==
-		+	<StructureSection load='5cp9' size='340' side='right' caption='[[5cp9]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~The entry~~ 5cp9 is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5cp9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CP9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CP9 FirstGlance]. <br>
-	~~Authors~~: ~~Sigurdardottir, A~~.G.~~, Winter, A~~.~~, Sobkowicz, A~~., ~~Fragai~~, M., ~~Chirgadze, D~~.Y., ~~Ascher, D~~.B., ~~Blundell, T~~.L., ~~Gherardi~~, E.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6O5:3-(FURAN-2-YL)PROPANOIC+ACID'>6O5</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cp9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5cp9 RCSB], [http://www.ebi.ac.uk/pdbsum/5cp9 PDBsum]</span></td></tr>
-	~~Description~~: ~~The structure~~ of the ~~NK1 fragment of HGF~~/~~SF complexed with MB605~~	+	</table>
-	[[Category: ~~Unreleased Structures~~]]	+	== Disease ==
-	[[Category: ~~Gherardi~~, E]]	+	[[http://www.uniprot.org/uniprot/HGF_HUMAN HGF_HUMAN]] Defects in HGF are the cause of deafness autosomal recessive type 39 (DFNB39) [MIM:[http://omim.org/entry/608265 608265]]. A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:19576567</ref>
-	[[Category: Chirgadze, D.Y]]	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HGF_HUMAN HGF_HUMAN]] Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.<ref>PMID:15167892</ref> <ref>PMID:20624990</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ascher, D B]]
		+	[[Category: Blundell, T L]]
		+	[[Category: Chirgadze, D Y]]
	[[Category: Fragai, M]]		[[Category: Fragai, M]]
-	[[Category: ~~Sigurdardottir~~, ~~A.G~~]]	+	[[Category: Gherardi, E]]
-	[[Category: ~~Blundell~~, ~~T.L]]~~	+	[[Category: Sigurdardottir, A G]]
-	~~[[Category: Ascher, D.B~~]]	+
	[[Category: Sobkowicz, A]]		[[Category: Sobkowicz, A]]
	[[Category: Winter, A]]		[[Category: Winter, A]]
		+	[[Category: Cell cycle]]
		+	[[Category: Fragment based drug discovery]]
		+	[[Category: Growth factor]]
		+	[[Category: Hgf/sf]]
		+	[[Category: Hormone]]
		+	[[Category: New chemical entity]]
		+	[[Category: Nk1 fragment]]

OCA: Protected "5cp9" [edit=sysop:move=sysop]

OCA — Wed, 29 Jul 2015 13:40:50 GMT

Protected "5cp9" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:40, 29 July 2015

OCA: New page: '''Unreleased structure''' The entry 5cp9 is ON HOLD until Paper Publication Authors: Sigurdardottir, A.G., Winter, A., Sobkowicz, A., Fragai, M., Chirgadze, D.Y., Ascher, D.B., Blundel...

OCA — Wed, 29 Jul 2015 13:40:49 GMT

New page: '''Unreleased structure''' The entry 5cp9 is ON HOLD until Paper Publication Authors: Sigurdardottir, A.G., Winter, A., Sobkowicz, A., Fragai, M., Chirgadze, D.Y., Ascher, D.B., Blundel...

New page

'''Unreleased structure'''

The entry 5cp9 is ON HOLD until Paper Publication

Authors: Sigurdardottir, A.G., Winter, A., Sobkowicz, A., Fragai, M., Chirgadze, D.Y., Ascher, D.B., Blundell, T.L., Gherardi, E.

Description: The structure of the NK1 fragment of HGF/SF complexed with MB605
[[Category: Unreleased Structures]]
[[Category: Gherardi, E]]
[[Category: Chirgadze, D.Y]]
[[Category: Fragai, M]]
[[Category: Sigurdardottir, A.G]]
[[Category: Blundell, T.L]]
[[Category: Ascher, D.B]]
[[Category: Sobkowicz, A]]
[[Category: Winter, A]]