5ctx - Revision history

OCA at 08:40, 27 September 2023

OCA — Wed, 27 Sep 2023 08:40:26 GMT

←Older revision		Revision as of 08:40, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5ctx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CTX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CTX FirstGlance]. <br>		<table><tr><td colspan='2'>[[5ctx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CTX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CTX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=55G:4-PHENYL-3-[2-(PYRIDIN-3-YL)-1,3-THIAZOL-5-YL]-2,7-DIHYDRO-6H-PYRAZOLO[3,4-B]PYRIDIN-6-ONE'>55G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=55G:4-PHENYL-3-[2-(PYRIDIN-3-YL)-1,3-THIAZOL-5-YL]-2,7-DIHYDRO-6H-PYRAZOLO[3,4-B]PYRIDIN-6-ONE'>55G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ctx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ctx OCA], [https://pdbe.org/5ctx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ctx RCSB], [https://www.ebi.ac.uk/pdbsum/5ctx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ctx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ctx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ctx OCA], [https://pdbe.org/5ctx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ctx RCSB], [https://www.ebi.ac.uk/pdbsum/5ctx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ctx ProSAT]</span></td></tr>
	</table>		</table>

OCA at 12:27, 14 June 2023

OCA — Wed, 14 Jun 2023 12:27:47 GMT

←Older revision		Revision as of 12:27, 14 June 2023
Line 3:		Line 3:
	<StructureSection load='5ctx' size='340' side='right'caption='[[5ctx]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='5ctx' size='340' side='right'caption='[[5ctx]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ctx]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus~~ aureus~~" (rosenbach 1884) zopf 1885~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CTX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5CTX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ctx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CTX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CTX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=55G:4-PHENYL-3-[2-(PYRIDIN-3-YL)-1,3-THIAZOL-5-YL]-2,7-DIHYDRO-6H-PYRAZOLO[3,4-B]PYRIDIN-6-ONE'>55G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=55G:4-PHENYL-3-[2-(PYRIDIN-3-YL)-1,3-THIAZOL-5-YL]-2,7-DIHYDRO-6H-PYRAZOLO[3,4-B]PYRIDIN-6-ONE'>55G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cph\|5cph]], [[5ctu\|5ctu]], [[5ctw\|5ctw]], [[5cty\|5cty]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ctx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ctx OCA], [https://pdbe.org/5ctx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ctx RCSB], [https://www.ebi.ac.uk/pdbsum/5ctx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ctx ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gyrB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ctx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ctx OCA], [~~http~~://pdbe.org/5ctx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ctx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ctx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ctx ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GYRB_STAAU GYRB_STAAU]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.[HAMAP-Rule:MF_01898]	+	[https://www.uniprot.org/uniprot/GYRB_STAAU GYRB_STAAU] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.[HAMAP-Rule:MF_01898]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 29:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Andersen~~, O A~~]]	+	[[Category: Staphylococcus aureus]]
-	[[Category: Barker, J]]	+	[[Category: Andersen OA]]
-	[[Category: Cheng~~, R K~~]]	+	[[Category: Barker J]]
-	[[Category: Cross~~, J B~~]]	+	[[Category: Cheng RK]]
-	[[Category: Felicetti, B]]	+	[[Category: Cross JB]]
-	[[Category: Kahmann, J]]	+	[[Category: Felicetti B]]
-	[[Category: Lippa, B]]	+	[[Category: Kahmann J]]
-	[[Category: Mesleh, M]]	+	[[Category: Lippa B]]
-	[[Category: Ryan~~, M D~~]]	+	[[Category: Mesleh M]]
-	[[Category: Scheich, C]]	+	[[Category: Ryan MD]]
-	[[Category: Wood, M]]	+	[[Category: Scheich C]]
-	[[Category: Yang, Q]]	+	[[Category: Wood M]]
-	[[Category: Zhang, J]]	+	[[Category: Yang Q]]
-	~~[[Category: Dna gyrase]]~~	+	[[Category: Zhang J]]
-	~~[[Category: Fragment-based screening]]~~	+
-	~~[[Category: Gyrb]]~~	+
-	~~[[Category: Isomerase-isomerase inhibitor complex]]~~	+
-	~~[[Category: Structure-based design~~]]	+

OCA at 10:23, 1 April 2020

OCA — Wed, 01 Apr 2020 10:23:48 GMT

←Older revision		Revision as of 10:23, 1 April 2020
Line 1:		Line 1:

	==Crystal structure of the ATP binding domain of S. aureus GyrB complexed with a fragment==		==Crystal structure of the ATP binding domain of S. aureus GyrB complexed with a fragment==
-	<StructureSection load='5ctx' size='340' side='right' caption='[[5ctx]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='5ctx' size='340' side='right'caption='[[5ctx]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ctx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CTX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CTX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ctx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CTX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CTX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=55G:4-PHENYL-3-[2-(PYRIDIN-3-YL)-1,3-THIAZOL-5-YL]-2,7-DIHYDRO-6H-PYRAZOLO[3,4-B]PYRIDIN-6-ONE'>55G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=55G:4-PHENYL-3-[2-(PYRIDIN-3-YL)-1,3-THIAZOL-5-YL]-2,7-DIHYDRO-6H-PYRAZOLO[3,4-B]PYRIDIN-6-ONE'>55G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cph\|5cph]], [[5ctu\|5ctu]], [[5ctw\|5ctw]], [[5cty\|5cty]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cph\|5cph]], [[5ctu\|5ctu]], [[5ctw\|5ctw]], [[5cty\|5cty]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gyrB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ctx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ctx OCA], [http://pdbe.org/5ctx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ctx RCSB], [http://www.ebi.ac.uk/pdbsum/5ctx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ctx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ctx OCA], [http://pdbe.org/5ctx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ctx RCSB], [http://www.ebi.ac.uk/pdbsum/5ctx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ctx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 20:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 5ctx" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5ctx" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Gyrase 3D Structures\|Gyrase 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Andersen, O A]]		[[Category: Andersen, O A]]
	[[Category: Barker, J]]		[[Category: Barker, J]]

OCA at 18:54, 20 February 2016

OCA — Sat, 20 Feb 2016 18:54:44 GMT

←Older revision		Revision as of 18:54, 20 February 2016
Line 1:		Line 1:
		+
	==Crystal structure of the ATP binding domain of S. aureus GyrB complexed with a fragment==		==Crystal structure of the ATP binding domain of S. aureus GyrB complexed with a fragment==
	<StructureSection load='5ctx' size='340' side='right' caption='[[5ctx]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='5ctx' size='340' side='right' caption='[[5ctx]], [[Resolution\|resolution]] 1.60Å' scene=''>

OCA at 15:33, 3 February 2016

OCA — Wed, 03 Feb 2016 15:33:10 GMT

←Older revision		Revision as of 15:33, 3 February 2016
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of the ATP binding domain of S. aureus GyrB complexed with a fragment==
		+	<StructureSection load='5ctx' size='340' side='right' caption='[[5ctx]], [[Resolution\|resolution]] 1.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5ctx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CTX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CTX FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=55G:4-PHENYL-3-[2-(PYRIDIN-3-YL)-1,3-THIAZOL-5-YL]-2,7-DIHYDRO-6H-PYRAZOLO[3,4-B]PYRIDIN-6-ONE'>55G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5cph\|5cph]], [[5ctu\|5ctu]], [[5ctw\|5ctw]], [[5cty\|5cty]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ctx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ctx OCA], [http://pdbe.org/5ctx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ctx RCSB], [http://www.ebi.ac.uk/pdbsum/5ctx PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GYRB_STAAU GYRB_STAAU]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.[HAMAP-Rule:MF_01898]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Inhibitors of the ATPase function of bacterial DNA gyrase, located in the GyrB subunit and its related ParE subunit in topoisomerase IV, have demonstrated antibacterial activity. In this study we describe an NMR fragment-based screening effort targeting Staphylococcus aureus GyrB that identified several attractive and novel starting points with good ligand efficiency. Fragment hits were further characterized using NMR binding studies against full-length S. aureus GyrB and Escherichia coli ParE. X-ray co-crystal structures of select fragment hits confirmed binding and suggested a path for medicinal chemistry optimization. The identification, characterization, and elaboration of one of these fragment series to a 0.265muM inhibitor is described herein.

-	~~The entry 5ctx is ON HOLD~~	+	Fragment-based discovery of DNA gyrase inhibitors targeting the ATPase subunit of GyrB.,Mesleh MF, Cross JB, Zhang J, Kahmann J, Andersen OA, Barker J, Cheng RK, Felicetti B, Wood M, Hadfield AT, Scheich C, Moy TI, Yang Q, Shotwell J, Nguyen K, Lippa B, Dolle R, Ryan MD Bioorg Med Chem Lett. 2016 Jan 6. pii: S0960-894X(16)30009-9. doi:, 10.1016/j.bmcl.2016.01.009. PMID:26786695<ref>PMID:26786695</ref>

-	~~Authors~~: Andersen, O.A., Barker, J~~., Cheng, R.K, Kahmann, J., Felicetti, B., Wood, M., Scheich, C., Mesleh, M., Cross, J.B., Zhang, J., Yang, Q., Lippa, B., Ryan, M.D.~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: Crystal structure of the ATP binding domain of S. aureus GyrB complexed with a fragment~~	+	<div class="pdbe-citations 5ctx" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Unreleased Structures~~]]	+	== References ==
-	[[Category: ~~Yang~~, Q]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Andersen, O A]]
		+	[[Category: Barker, J]]
		+	[[Category: Cheng, R K]]
		+	[[Category: Cross, J B]]
	[[Category: Felicetti, B]]		[[Category: Felicetti, B]]
-	[[Category: ~~Scheich, C]]~~	+	[[Category: Kahmann, J]]
-	~~[[Category: Andersen, O.A]]~~	+
-	~~[[Category: Barker~~, J]]	+
	[[Category: Lippa, B]]		[[Category: Lippa, B]]
-	[[Category: Cheng, R.K, Kahmann, J]]
-	[[Category: Ryan, M.D]]
-	[[Category: Cross, J.B]]
	[[Category: Mesleh, M]]		[[Category: Mesleh, M]]
		+	[[Category: Ryan, M D]]
		+	[[Category: Scheich, C]]
		+	[[Category: Wood, M]]
		+	[[Category: Yang, Q]]
	[[Category: Zhang, J]]		[[Category: Zhang, J]]
-	[[Category: ~~Wood, M~~]]	+	[[Category: Dna gyrase]]
		+	[[Category: Fragment-based screening]]
		+	[[Category: Gyrb]]
		+	[[Category: Isomerase-isomerase inhibitor complex]]
		+	[[Category: Structure-based design]]

OCA at 10:43, 16 December 2015

OCA — Wed, 16 Dec 2015 10:43:07 GMT

←Older revision		Revision as of 10:43, 16 December 2015
Line 7:		Line 7:
	Description: Crystal structure of the ATP binding domain of S. aureus GyrB complexed with a fragment		Description: Crystal structure of the ATP binding domain of S. aureus GyrB complexed with a fragment
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Felicetti, B]]
-	[[Category: Andersen, O.A]]
-	[[Category: Cross, J.B]]
-	[[Category: Mesleh, M]]
-	[[Category: Zhang, J]]
-	[[Category: Wood, M]]
	[[Category: Yang, Q]]		[[Category: Yang, Q]]
		+	[[Category: Felicetti, B]]
	[[Category: Scheich, C]]		[[Category: Scheich, C]]
		+	[[Category: Andersen, O.A]]
	[[Category: Barker, J]]		[[Category: Barker, J]]
	[[Category: Lippa, B]]		[[Category: Lippa, B]]
	[[Category: Cheng, R.K, Kahmann, J]]		[[Category: Cheng, R.K, Kahmann, J]]
	[[Category: Ryan, M.D]]		[[Category: Ryan, M.D]]
		+	[[Category: Cross, J.B]]
		+	[[Category: Mesleh, M]]
		+	[[Category: Zhang, J]]
		+	[[Category: Wood, M]]

OCA at 12:08, 26 August 2015

OCA — Wed, 26 Aug 2015 12:08:23 GMT

←Older revision		Revision as of 12:08, 26 August 2015
Line 3:		Line 3:
	The entry 5ctx is ON HOLD		The entry 5ctx is ON HOLD

-	Authors: Andersen, O.A., Barker, J., Cheng, R.K., Kahmann, J., Felicetti, B., Wood, M., Scheich, C., Mesleh, M., Cross, J.B., Zhang, J., Yang, Q., Lippa, B., Ryan, M.D.	+	Authors: Andersen, O.A., Barker, J., Cheng, R.K, Kahmann, J., Felicetti, B., Wood, M., Scheich, C., Mesleh, M., Cross, J.B., Zhang, J., Yang, Q., Lippa, B., Ryan, M.D.

	Description: Crystal structure of the ATP binding domain of S. aureus GyrB complexed with a fragment		Description: Crystal structure of the ATP binding domain of S. aureus GyrB complexed with a fragment
Line 9:		Line 9:
	[[Category: Felicetti, B]]		[[Category: Felicetti, B]]
	[[Category: Andersen, O.A]]		[[Category: Andersen, O.A]]
-	[[Category: Kahmann, J]]
	[[Category: Cross, J.B]]		[[Category: Cross, J.B]]
-	[[Category: Cheng, R.K]]
	[[Category: Mesleh, M]]		[[Category: Mesleh, M]]
	[[Category: Zhang, J]]		[[Category: Zhang, J]]
Line 19:		Line 17:
	[[Category: Barker, J]]		[[Category: Barker, J]]
	[[Category: Lippa, B]]		[[Category: Lippa, B]]
		+	[[Category: Cheng, R.K, Kahmann, J]]
	[[Category: Ryan, M.D]]		[[Category: Ryan, M.D]]

OCA at 13:27, 12 August 2015

OCA — Wed, 12 Aug 2015 13:27:48 GMT

←Older revision		Revision as of 13:27, 12 August 2015
Line 3:		Line 3:
	The entry 5ctx is ON HOLD		The entry 5ctx is ON HOLD

-	Authors: Andersen, O.A., Barker, J., Cheng, R.K, Kahmann, J., Felicetti, B., Wood, M., Scheich, C., Mesleh, M., Cross, J.B., Zhang, J., Yang, Q., Lippa, B., Ryan, M.D.	+	Authors: Andersen, O.A., Barker, J., Cheng, R.K., Kahmann, J., Felicetti, B., Wood, M., Scheich, C., Mesleh, M., Cross, J.B., Zhang, J., Yang, Q., Lippa, B., Ryan, M.D.

	Description: Crystal structure of the ATP binding domain of S. aureus GyrB complexed with a fragment		Description: Crystal structure of the ATP binding domain of S. aureus GyrB complexed with a fragment
Line 9:		Line 9:
	[[Category: Felicetti, B]]		[[Category: Felicetti, B]]
	[[Category: Andersen, O.A]]		[[Category: Andersen, O.A]]
		+	[[Category: Kahmann, J]]
	[[Category: Cross, J.B]]		[[Category: Cross, J.B]]
		+	[[Category: Cheng, R.K]]
	[[Category: Mesleh, M]]		[[Category: Mesleh, M]]
	[[Category: Zhang, J]]		[[Category: Zhang, J]]
Line 17:		Line 19:
	[[Category: Barker, J]]		[[Category: Barker, J]]
	[[Category: Lippa, B]]		[[Category: Lippa, B]]
-	[[Category: Cheng, R.K, Kahmann, J]]
	[[Category: Ryan, M.D]]		[[Category: Ryan, M.D]]

OCA: Protected "5ctx" [edit=sysop:move=sysop]

OCA — Wed, 29 Jul 2015 13:53:13 GMT

Protected "5ctx" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:53, 29 July 2015

OCA: New page: '''Unreleased structure''' The entry 5ctx is ON HOLD Authors: Andersen, O.A., Barker, J., Cheng, R.K, Kahmann, J., Felicetti, B., Wood, M., Scheich, C., Mesleh, M., Cross, J.B., Zhang, ...

OCA — Wed, 29 Jul 2015 13:53:12 GMT

New page: '''Unreleased structure''' The entry 5ctx is ON HOLD Authors: Andersen, O.A., Barker, J., Cheng, R.K, Kahmann, J., Felicetti, B., Wood, M., Scheich, C., Mesleh, M., Cross, J.B., Zhang, ...

New page

'''Unreleased structure'''

The entry 5ctx is ON HOLD

Authors: Andersen, O.A., Barker, J., Cheng, R.K, Kahmann, J., Felicetti, B., Wood, M., Scheich, C., Mesleh, M., Cross, J.B., Zhang, J., Yang, Q., Lippa, B., Ryan, M.D.

Description: Crystal structure of the ATP binding domain of S. aureus GyrB complexed with a fragment
[[Category: Unreleased Structures]]
[[Category: Felicetti, B]]
[[Category: Andersen, O.A]]
[[Category: Cross, J.B]]
[[Category: Mesleh, M]]
[[Category: Zhang, J]]
[[Category: Wood, M]]
[[Category: Yang, Q]]
[[Category: Scheich, C]]
[[Category: Barker, J]]
[[Category: Lippa, B]]
[[Category: Cheng, R.K, Kahmann, J]]
[[Category: Ryan, M.D]]