5d5x - Revision history

OCA at 11:24, 10 January 2024

OCA — Wed, 10 Jan 2024 11:24:49 GMT

←Older revision		Revision as of 11:24, 10 January 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5d5x]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum Chaetomium thermophilum] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D5X FirstGlance]. <br>		<table><tr><td colspan='2'>[[5d5x]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum Chaetomium thermophilum] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D5X FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d5x OCA], [https://pdbe.org/5d5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d5x RCSB], [https://www.ebi.ac.uk/pdbsum/5d5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d5x ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d5x OCA], [https://pdbe.org/5d5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d5x RCSB], [https://www.ebi.ac.uk/pdbsum/5d5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d5x ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 10:23, 21 June 2023

OCA — Wed, 21 Jun 2023 10:23:05 GMT

←Older revision		Revision as of 10:23, 21 June 2023
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	<StructureSection load='5d5x' size='340' side='right'caption='[[5d5x]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='5d5x' size='340' side='right'caption='[[5d5x]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5d5x]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Cbs_144~~.~~50 Cbs 144~~.50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D5X OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5D5X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5d5x]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum Chaetomium thermophilum] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D5X FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTHT_0048700 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=209285 CBS 144.50])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d5x OCA], [https://pdbe.org/5d5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d5x RCSB], [https://www.ebi.ac.uk/pdbsum/5d5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d5x ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5d5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d5x OCA], [~~http~~://pdbe.org/5d5x PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5d5x RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5d5x PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5d5x ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SKN7_CHATD SKN7_CHATD] Transcription factor that is part of a SLN1-YPD1-SKN7 two-component regulatory system, which controls gene expression in response to changes in the osmolarity of the extracellular environment. Under low osmotic conditions, phosphorylated and activated by the phosphorelay intermediate protein YPD1. Also activated in response to oxidative stress, independent on the two-component regulatory system. Regulates heat shock genes in response to oxidative stress and genes involved in cell wall integrity in response to osmotic changes.[UniProtKB:P38889]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cbs 144 50~~]]	+	[[Category: Chaetomium thermophilum]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bracher, A]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: Hartl~~, F U~~]]	+	[[Category: Bracher A]]
-	[[Category: Hayer-Hartl, M]]	+	[[Category: Hartl FU]]
-	[[Category: Neudegger, T]]	+	[[Category: Hayer-Hartl M]]
-	[[Category: Verghese, J]]	+	[[Category: Neudegger T]]
-	~~[[Category: Double helix]]~~	+	[[Category: Verghese J]]
-	~~[[Category: Helix-turn-helix]]~~	+
-	~~[[Category: Protein-dna complex]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 10:39, 1 April 2020

OCA — Wed, 01 Apr 2020 10:39:19 GMT

←Older revision		Revision as of 10:39, 1 April 2020
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		+
	==Crystal structure of Chaetomium thermophilum Skn7 with SSRE DNA==		==Crystal structure of Chaetomium thermophilum Skn7 with SSRE DNA==
-	<StructureSection load='5d5x' size='340' side='right' caption='[[5d5x]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='5d5x' size='340' side='right'caption='[[5d5x]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5d5x]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D5X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D5X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5d5x]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_144.50 Cbs 144.50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D5X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D5X FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d5x OCA], [http://pdbe.org/5d5x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d5x RCSB], [http://www.ebi.ac.uk/pdbsum/5d5x PDBsum]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTHT_0048700 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=209285 CBS 144.50])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d5x OCA], [http://pdbe.org/5d5x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d5x RCSB], [http://www.ebi.ac.uk/pdbsum/5d5x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5d5x ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Cbs 144 50]]
		+	[[Category: Large Structures]]
	[[Category: Bracher, A]]		[[Category: Bracher, A]]
	[[Category: Hartl, F U]]		[[Category: Hartl, F U]]

OCA at 08:48, 20 January 2016

OCA — Wed, 20 Jan 2016 08:48:29 GMT

←Older revision		Revision as of 08:48, 20 January 2016
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	</StructureSection>		</StructureSection>
	[[Category: Bracher, A]]		[[Category: Bracher, A]]
		+	[[Category: Hartl, F U]]
		+	[[Category: Hayer-Hartl, M]]
		+	[[Category: Neudegger, T]]
		+	[[Category: Verghese, J]]
	[[Category: Double helix]]		[[Category: Double helix]]
	[[Category: Helix-turn-helix]]		[[Category: Helix-turn-helix]]
	[[Category: Protein-dna complex]]		[[Category: Protein-dna complex]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 12:17, 13 January 2016

OCA — Wed, 13 Jan 2016 12:17:35 GMT

←Older revision		Revision as of 12:17, 13 January 2016
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	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d5x OCA], [http://pdbe.org/5d5x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d5x RCSB], [http://www.ebi.ac.uk/pdbsum/5d5x PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d5x OCA], [http://pdbe.org/5d5x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d5x RCSB], [http://www.ebi.ac.uk/pdbsum/5d5x PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Heat-shock transcription factor 1 (HSF1) has a central role in mediating the protective response to protein conformational stresses in eukaryotes. HSF1 consists of an N-terminal DNA-binding domain (DBD), a coiled-coil oligomerization domain, a regulatory domain and a transactivation domain. Upon stress, HSF1 trimerizes via its coiled-coil domain and binds to the promoters of heat shock protein-encoding genes. Here, we present cocrystal structures of the human HSF1 DBD in complex with cognate DNA. A comparative analysis of the HSF1 paralog Skn7 from Chaetomium thermophilum showed that single amino acid changes in the DBD can switch DNA binding specificity, thus revealing the structural basis for the interaction of HSF1 with cognate DNA. We used a crystal structure of the coiled-coil domain of C. thermophilum Skn7 to develop a model of the active human HSF1 trimer in which HSF1 embraces the heat-shock-element DNA.
		+
		+	Structure of human heat-shock transcription factor 1 in complex with DNA.,Neudegger T, Verghese J, Hayer-Hartl M, Hartl FU, Bracher A Nat Struct Mol Biol. 2016 Jan 4. doi: 10.1038/nsmb.3149. PMID:26727489<ref>PMID:26727489</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5d5x" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 19:38, 30 December 2015

OCA — Wed, 30 Dec 2015 19:38:06 GMT

←Older revision		Revision as of 19:38, 30 December 2015
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-	'''~~Unreleased structure~~'''	+	==Crystal structure of Chaetomium thermophilum Skn7 with SSRE DNA==
-		+	<StructureSection load='5d5x' size='340' side='right' caption='[[5d5x]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~The entry~~ 5d5x is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5d5x]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D5X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D5X FirstGlance]. <br>
-	~~Authors~~: ~~Bracher, A~~.	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d5x OCA], [http://pdbe.org/5d5x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d5x RCSB], [http://www.ebi.ac.uk/pdbsum/5d5x PDBsum]</span></td></tr>
-		+	</table>
-	~~Description~~:	+	__TOC__
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</StructureSection>
	[[Category: Bracher, A]]		[[Category: Bracher, A]]
		+	[[Category: Double helix]]
		+	[[Category: Helix-turn-helix]]
		+	[[Category: Protein-dna complex]]
		+	[[Category: Transcription]]

OCA at 12:27, 26 August 2015

OCA — Wed, 26 Aug 2015 12:27:46 GMT

←Older revision		Revision as of 12:27, 26 August 2015
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5d5x is ON HOLD	+	The entry 5d5x is ON HOLD until Paper Publication

	Authors: Bracher, A.		Authors: Bracher, A.

OCA: Protected "5d5x" [edit=sysop:move=sysop]

OCA — Thu, 20 Aug 2015 11:24:49 GMT

Protected "5d5x" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:24, 20 August 2015

OCA: New page: '''Unreleased structure''' The entry 5d5x is ON HOLD Authors: Bracher, A. Description: Category: Unreleased Structures Category: Bracher, A

OCA — Thu, 20 Aug 2015 11:24:48 GMT

New page: '''Unreleased structure''' The entry 5d5x is ON HOLD Authors: Bracher, A. Description: Category: Unreleased Structures Category: Bracher, A

New page

'''Unreleased structure'''

The entry 5d5x is ON HOLD

Authors: Bracher, A.

Description:
[[Category: Unreleased Structures]]
[[Category: Bracher, A]]