5d6o - Revision history

OCA at 07:22, 1 May 2024

OCA — Wed, 01 May 2024 07:22:09 GMT

←Older revision		Revision as of 07:22, 1 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5d6o]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Corynebacterium_glutamicum_ATCC_13032 Corynebacterium glutamicum ATCC 13032]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D6O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D6O FirstGlance]. <br>		<table><tr><td colspan='2'>[[5d6o]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Corynebacterium_glutamicum_ATCC_13032 Corynebacterium glutamicum ATCC 13032]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D6O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D6O FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d6o OCA], [https://pdbe.org/5d6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d6o RCSB], [https://www.ebi.ac.uk/pdbsum/5d6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d6o ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d6o OCA], [https://pdbe.org/5d6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d6o RCSB], [https://www.ebi.ac.uk/pdbsum/5d6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d6o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/Q8NS43_CORGL Q8NS43_CORGL]		[https://www.uniprot.org/uniprot/Q8NS43_CORGL Q8NS43_CORGL]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	MekB from Pseudomonas veronii and CgHle from Corynebacteriumglutamicum belong to the superfamily of alpha/beta-hydrolase fold proteins. Based on sequence comparisons, they are annotated as homoserine transacetylases in popular databases like UNIPROT, PFAM or ESTHER. However, experimentally, MekB and CgHle were shown to be esterases that hydrolyse preferentially acetic acid esters. We describe the x-ray structures of these enzymes solved to high resolution. The overall structures confirm the close relatedness to experimentally validated homoserine acetyl transferases, but simultaneously the structures exclude the ability of MekB and CgHle to bind homoserine and acetyl-CoA. Insofar the MekB and CgHle structures suggest dividing the homoserine transacetylase family into subfamilies, namely genuine acetyl transferases and acetyl esterases with MekB and CgHle as constituting members of the latter.
-
-	A novel esterase subfamily with alpha/beta-hydrolase fold suggested by structures of two bacterial enzymes homologous to l-homoserine O-acetyl transferases.,Tolzer C, Pal S, Watzlawick H, Altenbuchner J, Niefind K FEBS Lett. 2016 Jan;590(1):174-84. doi: 10.1002/1873-3468.12031. Epub 2015 Dec, 28. PMID:26787467<ref>PMID:26787467</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 5d6o" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 10:23, 21 June 2023

OCA — Wed, 21 Jun 2023 10:23:42 GMT

←Older revision		Revision as of 10:23, 21 June 2023
Line 3:		Line 3:
	<StructureSection load='5d6o' size='340' side='right'caption='[[5d6o]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='5d6o' size='340' side='right'caption='[[5d6o]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5d6o]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Corgl Corgl~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D6O OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5D6O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5d6o]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Corynebacterium_glutamicum_ATCC_13032 Corynebacterium glutamicum ATCC 13032]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D6O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D6O FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cg0961, Cgl0839 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=196627 CORGL])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d6o OCA], [https://pdbe.org/5d6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d6o RCSB], [https://www.ebi.ac.uk/pdbsum/5d6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d6o ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5d6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d6o OCA], [~~http~~://pdbe.org/5d6o PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5d6o RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5d6o PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5d6o ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8NS43_CORGL Q8NS43_CORGL]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Corgl~~]]	+	[[Category: Corynebacterium glutamicum ATCC 13032]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Altenbuchner, J]]	+	[[Category: Altenbuchner J]]
-	[[Category: Niefind, K]]	+	[[Category: Niefind K]]
-	[[Category: Toelzer, C]]	+	[[Category: Toelzer C]]
-	[[Category: Watzlawick, H]]	+	[[Category: Watzlawick H]]
-	~~[[Category: Acetylester hydrolase]]~~	+
-	~~[[Category: Alpha/beta hydrolase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 10:40, 1 April 2020

OCA — Wed, 01 Apr 2020 10:40:26 GMT

←Older revision		Revision as of 10:40, 1 April 2020
Line 1:		Line 1:
		+
	==Orthorhombic Crystal Structure of an acetylester hydrolase from Corynebacterium glutamicum==		==Orthorhombic Crystal Structure of an acetylester hydrolase from Corynebacterium glutamicum==
-	<StructureSection load='5d6o' size='340' side='right' caption='[[5d6o]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='5d6o' size='340' side='right'caption='[[5d6o]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5d6o]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D6O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D6O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5d6o]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Corgl Corgl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D6O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D6O FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d6o OCA], [http://pdbe.org/5d6o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d6o RCSB], [http://www.ebi.ac.uk/pdbsum/5d6o PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cg0961, Cgl0839 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=196627 CORGL])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d6o OCA], [http://pdbe.org/5d6o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d6o RCSB], [http://www.ebi.ac.uk/pdbsum/5d6o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5d6o ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 19:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Corgl]]
		+	[[Category: Large Structures]]
	[[Category: Altenbuchner, J]]		[[Category: Altenbuchner, J]]
	[[Category: Niefind, K]]		[[Category: Niefind, K]]

OCA at 07:49, 3 February 2016

OCA — Wed, 03 Feb 2016 07:49:02 GMT

←Older revision		Revision as of 07:49, 3 February 2016
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d6o OCA], [http://pdbe.org/5d6o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d6o RCSB], [http://www.ebi.ac.uk/pdbsum/5d6o PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d6o OCA], [http://pdbe.org/5d6o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d6o RCSB], [http://www.ebi.ac.uk/pdbsum/5d6o PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	MekB from Pseudomonas veronii and CgHle from Corynebacteriumglutamicum belong to the superfamily of alpha/beta-hydrolase fold proteins. Based on sequence comparisons, they are annotated as homoserine transacetylases in popular databases like UNIPROT, PFAM or ESTHER. However, experimentally, MekB and CgHle were shown to be esterases that hydrolyse preferentially acetic acid esters. We describe the x-ray structures of these enzymes solved to high resolution. The overall structures confirm the close relatedness to experimentally validated homoserine acetyl transferases, but simultaneously the structures exclude the ability of MekB and CgHle to bind homoserine and acetyl-CoA. Insofar the MekB and CgHle structures suggest dividing the homoserine transacetylase family into subfamilies, namely genuine acetyl transferases and acetyl esterases with MekB and CgHle as constituting members of the latter.
		+
		+	A novel esterase subfamily with alpha/beta-hydrolase fold suggested by structures of two bacterial enzymes homologous to l-homoserine O-acetyl transferases.,Tolzer C, Pal S, Watzlawick H, Altenbuchner J, Niefind K FEBS Lett. 2016 Jan;590(1):174-84. doi: 10.1002/1873-3468.12031. Epub 2015 Dec, 28. PMID:26787467<ref>PMID:26787467</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5d6o" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 13:49, 9 December 2015

OCA — Wed, 09 Dec 2015 13:49:20 GMT

←Older revision		Revision as of 13:49, 9 December 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Orthorhombic Crystal Structure of an acetylester hydrolase from Corynebacterium glutamicum==
-		+	<StructureSection load='5d6o' size='340' side='right' caption='[[5d6o]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~The entry~~ 5d6o is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5d6o]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D6O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D6O FirstGlance]. <br>
-	~~Authors~~: ~~Niefind, K~~.~~, Toelzer, C~~.~~, Altenbuchner, J~~.~~, Watzlawick, H~~.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d6o OCA], [http://pdbe.org/5d6o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d6o RCSB], [http://www.ebi.ac.uk/pdbsum/5d6o PDBsum]</span></td></tr>
-	~~Description~~:	+	</table>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	__TOC__
-	[[~~Category~~: ~~Toelzer~~, C]]	+	</StructureSection>
	[[Category: Altenbuchner, J]]		[[Category: Altenbuchner, J]]
-	[[Category: Watzlawick, H]]
	[[Category: Niefind, K]]		[[Category: Niefind, K]]
		+	[[Category: Toelzer, C]]
		+	[[Category: Watzlawick, H]]
		+	[[Category: Acetylester hydrolase]]
		+	[[Category: Alpha/beta hydrolase]]
		+	[[Category: Transferase]]

OCA at 11:16, 2 September 2015

OCA — Wed, 02 Sep 2015 11:16:08 GMT

←Older revision		Revision as of 11:16, 2 September 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5d6o is ON HOLD	+	The entry 5d6o is ON HOLD until Paper Publication

	Authors: Niefind, K., Toelzer, C., Altenbuchner, J., Watzlawick, H.		Authors: Niefind, K., Toelzer, C., Altenbuchner, J., Watzlawick, H.

OCA: Protected "5d6o" [edit=sysop:move=sysop]

OCA — Thu, 20 Aug 2015 11:26:38 GMT

Protected "5d6o" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:26, 20 August 2015

OCA: New page: '''Unreleased structure''' The entry 5d6o is ON HOLD Authors: Niefind, K., Toelzer, C., Altenbuchner, J., Watzlawick, H. Description: Category: Unreleased Structures [[Category: T...

OCA — Thu, 20 Aug 2015 11:26:37 GMT

New page: '''Unreleased structure''' The entry 5d6o is ON HOLD Authors: Niefind, K., Toelzer, C., Altenbuchner, J., Watzlawick, H. Description: Category: Unreleased Structures [[Category: T...

New page

'''Unreleased structure'''

The entry 5d6o is ON HOLD

Authors: Niefind, K., Toelzer, C., Altenbuchner, J., Watzlawick, H.

Description:
[[Category: Unreleased Structures]]
[[Category: Toelzer, C]]
[[Category: Altenbuchner, J]]
[[Category: Watzlawick, H]]
[[Category: Niefind, K]]