5djm - Revision history

OCA at 21:44, 28 June 2023

OCA — Wed, 28 Jun 2023 21:44:08 GMT

←Older revision		Revision as of 21:44, 28 June 2023
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	<StructureSection load='5djm' size='340' side='right'caption='[[5djm]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='5djm' size='340' side='right'caption='[[5djm]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5djm]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DJM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5DJM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5djm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DJM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DJM FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5djl\|5djl]]~~, [[~~5dcg~~\|~~5dcg~~]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>GSTP1, FAEES3, GST3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])</td~~><~~/tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5djm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5djm OCA], [https://pdbe.org/5djm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5djm RCSB], [https://www.ebi.ac.uk/pdbsum/5djm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5djm ProSAT]</span></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5djm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5djm OCA], [~~http~~://pdbe.org/5djm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5djm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5djm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5djm ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GSTP1_HUMAN GSTP1_HUMAN]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.<ref>PMID:21668448</ref>	+	[https://www.uniprot.org/uniprot/GSTP1_HUMAN GSTP1_HUMAN] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.<ref>PMID:21668448</ref>

	==See Also==		==See Also==
-	*[[Glutathione S-transferase\|Glutathione S-transferase]]	+	*[[Glutathione S-transferase 3D structures\|Glutathione S-transferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Glutathione transferase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Parker~~, L J]]~~	+	[[Category: Parker LJ]]
-	~~[[Category: Anticancer cisplatin]]~~	+
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 06:22, 19 June 2019

OCA — Wed, 19 Jun 2019 06:22:03 GMT

←Older revision		Revision as of 06:22, 19 June 2019
Line 1:		Line 1:

	==Structure of WT Human Glutathione Transferase in complex with cisplatin in the absence of glutathione.==		==Structure of WT Human Glutathione Transferase in complex with cisplatin in the absence of glutathione.==
-	<StructureSection load='5djm' size='340' side='right' caption='[[5djm]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='5djm' size='340' side='right'caption='[[5djm]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5djm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DJM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DJM FirstGlance]. <br>		<table><tr><td colspan='2'>[[5djm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DJM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DJM FirstGlance]. <br>
Line 12:		Line 12:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/GSTP1_HUMAN GSTP1_HUMAN]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.<ref>PMID:21668448</ref>		[[http://www.uniprot.org/uniprot/GSTP1_HUMAN GSTP1_HUMAN]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.<ref>PMID:21668448</ref>
		+
		+	==See Also==
		+	*[[Glutathione S-transferase\|Glutathione S-transferase]]
	== References ==		== References ==
	<references/>		<references/>
Line 18:		Line 21:
	[[Category: Glutathione transferase]]		[[Category: Glutathione transferase]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Parker, L J]]		[[Category: Parker, L J]]
	[[Category: Anticancer cisplatin]]		[[Category: Anticancer cisplatin]]
	[[Category: Transferase-transferase inhibitor complex]]		[[Category: Transferase-transferase inhibitor complex]]

OCA at 09:52, 22 November 2017

OCA — Wed, 22 Nov 2017 09:52:31 GMT

←Older revision		Revision as of 09:52, 22 November 2017
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	<StructureSection load='5djm' size='340' side='right' caption='[[5djm]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='5djm' size='340' side='right' caption='[[5djm]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5djm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DJM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DJM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5djm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DJM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DJM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5djl\|5djl]], [[5dcg\|5dcg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5djl\|5djl]], [[5dcg\|5dcg]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GSTP1, FAEES3, GST3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5djm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5djm OCA], [http://pdbe.org/5djm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5djm RCSB], [http://www.ebi.ac.uk/pdbsum/5djm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5djm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5djm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5djm OCA], [http://pdbe.org/5djm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5djm RCSB], [http://www.ebi.ac.uk/pdbsum/5djm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5djm ProSAT]</span></td></tr>
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	</StructureSection>		</StructureSection>
	[[Category: Glutathione transferase]]		[[Category: Glutathione transferase]]
		+	[[Category: Human]]
	[[Category: Parker, L J]]		[[Category: Parker, L J]]
	[[Category: Anticancer cisplatin]]		[[Category: Anticancer cisplatin]]
	[[Category: Transferase-transferase inhibitor complex]]		[[Category: Transferase-transferase inhibitor complex]]

OCA at 18:25, 2 November 2016

OCA — Wed, 02 Nov 2016 18:25:02 GMT

←Older revision		Revision as of 18:25, 2 November 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5djm is ~~ON HOLD~~ ~~until Nov 01 2017~~	+	==Structure of WT Human Glutathione Transferase in complex with cisplatin in the absence of glutathione.==
-		+	<StructureSection load='5djm' size='340' side='right' caption='[[5djm]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5djm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DJM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DJM FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5djl\|5djl]], [[5dcg\|5dcg]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5djm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5djm OCA], [http://pdbe.org/5djm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5djm RCSB], [http://www.ebi.ac.uk/pdbsum/5djm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5djm ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GSTP1_HUMAN GSTP1_HUMAN]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.<ref>PMID:21668448</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Glutathione transferase]]
		+	[[Category: Parker, L J]]
		+	[[Category: Anticancer cisplatin]]
		+	[[Category: Transferase-transferase inhibitor complex]]

OCA at 10:40, 9 September 2016

OCA — Fri, 09 Sep 2016 10:40:02 GMT

←Older revision		Revision as of 10:40, 9 September 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5djm is ON HOLD until ~~Paper Publication~~	+	The entry 5djm is ON HOLD until Nov 01 2017

	Authors:		Authors:

OCA at 11:55, 15 May 2016

OCA — Sun, 15 May 2016 11:55:55 GMT

←Older revision		Revision as of 11:55, 15 May 2016
Line 3:		Line 3:
	The entry 5djm is ON HOLD until Paper Publication		The entry 5djm is ON HOLD until Paper Publication

-	Authors: ~~Parker, L.J.~~	+	Authors:

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Parker, L.J]]

OCA at 13:04, 30 September 2015

OCA — Wed, 30 Sep 2015 13:04:35 GMT

←Older revision		Revision as of 13:04, 30 September 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5djm is ON HOLD	+	The entry 5djm is ON HOLD until Paper Publication

	Authors: Parker, L.J.		Authors: Parker, L.J.

OCA: Protected "5djm" [edit=sysop:move=sysop]

OCA — Wed, 09 Sep 2015 10:18:39 GMT

Protected "5djm" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:18, 9 September 2015

OCA: New page: '''Unreleased structure''' The entry 5djm is ON HOLD Authors: Parker, L.J. Description: Category: Unreleased Structures Category: Parker, L.J

OCA — Wed, 09 Sep 2015 10:18:38 GMT

New page: '''Unreleased structure''' The entry 5djm is ON HOLD Authors: Parker, L.J. Description: Category: Unreleased Structures Category: Parker, L.J

New page

'''Unreleased structure'''

The entry 5djm is ON HOLD

Authors: Parker, L.J.

Description:
[[Category: Unreleased Structures]]
[[Category: Parker, L.J]]