5dl8 - Revision history

OCA at 21:47, 28 June 2023

OCA — Wed, 28 Jun 2023 21:47:26 GMT

←Older revision		Revision as of 21:47, 28 June 2023
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	<StructureSection load='5dl8' size='340' side='right'caption='[[5dl8]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='5dl8' size='340' side='right'caption='[[5dl8]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5dl8]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Acib3 Acib3~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DL8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5DL8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5dl8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii_AB307-0294 Acinetobacter baumannii AB307-0294]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DL8 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene>~~, ~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~benP1, ABUW_1854 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=557600 ACIB3])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5dl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dl8 OCA], [~~http~~://pdbe.org/5dl8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5dl8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5dl8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5dl8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dl8 OCA], [https://pdbe.org/5dl8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dl8 RCSB], [https://www.ebi.ac.uk/pdbsum/5dl8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dl8 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0D5YI36_ACIBA A0A0D5YI36_ACIBA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Acib3~~]]	+	[[Category: Acinetobacter baumannii AB307-0294]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Basle, A]]	+	[[Category: Basle A]]
-	~~[[Category: Berg, B van den~~]]	+	[[Category: Zahn M]]
-	[[Category: Zahn, M]]	+	[[Category: Van den Berg B]]
-	[[Category: ~~Acinetobacter baumannii]]~~	+
-	~~[[Category: Antibiotic uptake]]~~	+
-	~~[[Category: Beta-barrel]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Outer membrane protein~~]]	+

OCA at 08:09, 8 April 2020

OCA — Wed, 08 Apr 2020 08:09:04 GMT

←Older revision		Revision as of 08:09, 8 April 2020
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		+
	==Crystal structure of Acinetobacter baumannii OccAB4==		==Crystal structure of Acinetobacter baumannii OccAB4==
-	<StructureSection load='5dl8' size='340' side='right' caption='[[5dl8]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='5dl8' size='340' side='right'caption='[[5dl8]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5dl8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DL8 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5DL8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5dl8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Acib3 Acib3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DL8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5DL8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5dl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dl8 OCA], [http://pdbe.org/5dl8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dl8 RCSB], [http://www.ebi.ac.uk/pdbsum/5dl8 PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">benP1, ABUW_1854 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=557600 ACIB3])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5dl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dl8 OCA], [http://pdbe.org/5dl8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dl8 RCSB], [http://www.ebi.ac.uk/pdbsum/5dl8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dl8 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Acib3]]
		+	[[Category: Large Structures]]
	[[Category: Basle, A]]		[[Category: Basle, A]]
	[[Category: Berg, B van den]]		[[Category: Berg, B van den]]

OCA at 15:42, 3 February 2016

OCA — Wed, 03 Feb 2016 15:42:15 GMT

←Older revision		Revision as of 15:42, 3 February 2016
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-	'''~~Unreleased~~ structure'''	+	==Crystal structure of Acinetobacter baumannii OccAB4==
		+	<StructureSection load='5dl8' size='340' side='right' caption='[[5dl8]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5dl8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DL8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DL8 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dl8 OCA], [http://pdbe.org/5dl8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dl8 RCSB], [http://www.ebi.ac.uk/pdbsum/5dl8 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bacterial resistance against antibiotics is an increasing global health problem. In Gram-negative bacteria the low permeability of the outer membrane (OM) is a major factor contributing to resistance, making it important to understand channel-mediated small-molecule passage of the OM. Acinetobacter baumannii has five Occ (OM carboxylate channel) proteins, which collectively are of major importance for the entry of small molecules. To improve our understanding of the OM permeability of A. baumannii, we present here the X-ray crystal structures of four Occ proteins, renamed OccAB1 to OccAB4. In addition we have carried out a biochemical and biophysical characterization using electrophysiology and liposome swelling experiments, providing information on substrate specificities. We identify OccAB1 as having the largest pore of the Occ proteins with corresponding high rates of small-molecule uptake, and we suggest that the future design of efficient antibiotics should focus on scaffolds that can permeate efficiently through the OccAB1 channel.

-	~~The entry 5dl8 is ON HOLD until Paper Publication~~	+	Structural Insights into Outer Membrane Permeability of Acinetobacter baumannii.,Zahn M, Bhamidimarri SP, Basle A, Winterhalter M, van den Berg B Structure. 2016 Jan 20. pii: S0969-2126(15)00535-3. doi:, 10.1016/j.str.2015.12.009. PMID:26805524<ref>PMID:26805524</ref>

-	~~Authors: Zahn~~, M.~~, Basle, A~~.~~, van den Berg, B~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of Acinetobacter baumannii OccAB4~~	+	<div class="pdbe-citations 5dl8" style="background-color:#fffaf0;"></div>
-	~~[[Category: Unreleased Structures]]~~	+	== References ==
-	~~[[Category: Van Den Berg, B]]~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Basle, A]]		[[Category: Basle, A]]
		+	[[Category: Berg, B van den]]
	[[Category: Zahn, M]]		[[Category: Zahn, M]]
		+	[[Category: Acinetobacter baumannii]]
		+	[[Category: Antibiotic uptake]]
		+	[[Category: Beta-barrel]]
		+	[[Category: Membrane protein]]
		+	[[Category: Outer membrane protein]]

OCA: Protected "5dl8" [edit=sysop:move=sysop]

OCA — Wed, 30 Sep 2015 13:07:41 GMT

Protected "5dl8" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:07, 30 September 2015

OCA: New page: '''Unreleased structure''' The entry 5dl8 is ON HOLD until Paper Publication Authors: Zahn, M., Basle, A., van den Berg, B. Description: Crystal structure of Acinetobacter baumannii Oc...

OCA — Wed, 30 Sep 2015 13:07:40 GMT

New page: '''Unreleased structure''' The entry 5dl8 is ON HOLD until Paper Publication Authors: Zahn, M., Basle, A., van den Berg, B. Description: Crystal structure of Acinetobacter baumannii Oc...

New page

'''Unreleased structure'''

The entry 5dl8 is ON HOLD until Paper Publication

Authors: Zahn, M., Basle, A., van den Berg, B.

Description: Crystal structure of Acinetobacter baumannii OccAB4
[[Category: Unreleased Structures]]
[[Category: Van Den Berg, B]]
[[Category: Basle, A]]
[[Category: Zahn, M]]