5drw - Revision history

OCA at 11:50, 1 February 2024

OCA — Thu, 01 Feb 2024 11:50:07 GMT

←Older revision		Revision as of 11:50, 1 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5drw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DRW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DRW FirstGlance]. <br>		<table><tr><td colspan='2'>[[5drw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DRW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DRW FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5drw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5drw OCA], [https://pdbe.org/5drw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5drw RCSB], [https://www.ebi.ac.uk/pdbsum/5drw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5drw ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.27Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5drw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5drw OCA], [https://pdbe.org/5drw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5drw RCSB], [https://www.ebi.ac.uk/pdbsum/5drw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5drw ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:14, 26 October 2022

OCA — Wed, 26 Oct 2022 06:14:55 GMT

←Older revision		Revision as of 06:14, 26 October 2022
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	<StructureSection load='5drw' size='340' side='right'caption='[[5drw]], [[Resolution\|resolution]] 2.27Å' scene=''>		<StructureSection load='5drw' size='340' side='right'caption='[[5drw]], [[Resolution\|resolution]] 2.27Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5drw]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DRW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5DRW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5drw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DRW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DRW FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IGHV4-34, IGHJ6, IGHG103 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IGKV2-30, IGKJ2, IGKC01 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5drw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5drw OCA], [https://pdbe.org/5drw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5drw RCSB], [https://www.ebi.ac.uk/pdbsum/5drw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5drw ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5drw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5drw OCA], [~~http~~://pdbe.org/5drw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5drw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5drw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5drw ProSAT]</span></td></tr>	+
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cell-autonomous B-cell receptor (BcR)-mediated signalling is a hallmark feature of the neoplastic B lymphocytes in chronic lymphocytic leukaemia (CLL). Here we elucidate the structural basis of autonomous activation of CLL B cells, showing that BcR immunoglobulins initiate intracellular signalling through homotypic interactions between epitopes that are specific for each subgroup of patients with homogeneous clinicobiological profiles. The molecular details of the BcR-BcR interactions apparently dictate the clinical course of disease, with stronger affinities and longer half-lives in indolent cases, and weaker, short-lived contacts mediating the aggressive ones. The diversity of homotypic BcR contacts leading to cell-autonomous signalling reconciles the existence of a shared pathogenic mechanism with the biological and clinical heterogeneity of CLL and offers opportunities for innovative treatment strategies.
		+
		+	Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia.,Minici C, Gounari M, Ubelhart R, Scarfo L, Duhren-von Minden M, Schneider D, Tasdogan A, Alkhatib A, Agathangelidis A, Ntoufa S, Chiorazzi N, Jumaa H, Stamatopoulos K, Ghia P, Degano M Nat Commun. 2017 Jun 9;8:15746. doi: 10.1038/ncomms15746. PMID:28598442<ref>PMID:28598442</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5drw" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Sandbox 20009\|Sandbox 20009]]
		+	*[[3D structures of human antibody\|3D structures of human antibody]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Degano, M]]	+	[[Category: Degano M]]
-	[[Category: Minici, C]]	+	[[Category: Minici C]]
-	~~[[Category: B-cell receptor]]~~	+
-	~~[[Category: Chronic lymphocytic leukemia]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunoglobulin fold]]~~	+
-	~~[[Category: Receptor-ligand complex~~]]	+

OCA at 08:03, 15 April 2020

OCA — Wed, 15 Apr 2020 08:03:50 GMT

←Older revision		Revision as of 08:03, 15 April 2020
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	==Crystal structure of the BCR Fab fragment from subset #4 case CLL183==		==Crystal structure of the BCR Fab fragment from subset #4 case CLL183==
-	<StructureSection load='5drw' size='340' side='right' caption='[[5drw]], [[Resolution\|resolution]] 2.27Å' scene=''>	+	<StructureSection load='5drw' size='340' side='right'caption='[[5drw]], [[Resolution\|resolution]] 2.27Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5drw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DRW OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5DRW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5drw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DRW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5DRW FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5drw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5drw OCA], [http://pdbe.org/5drw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5drw RCSB], [http://www.ebi.ac.uk/pdbsum/5drw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5drw ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IGHV4-34, IGHJ6, IGHG103 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IGKV2-30, IGKJ2, IGKC01 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5drw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5drw OCA], [http://pdbe.org/5drw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5drw RCSB], [http://www.ebi.ac.uk/pdbsum/5drw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5drw ProSAT]</span></td></tr>
	</table>		</table>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Degano, M]]		[[Category: Degano, M]]
	[[Category: Minici, C]]		[[Category: Minici, C]]

OCA at 17:04, 3 October 2016

OCA — Mon, 03 Oct 2016 17:04:53 GMT

←Older revision		Revision as of 17:04, 3 October 2016
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-	'''Unreleased structure'''

-	~~The entry 5drw is ON HOLD until Paper Publication~~	+	==Crystal structure of the BCR Fab fragment from subset #4 case CLL183==
-		+	<StructureSection load='5drw' size='340' side='right' caption='[[5drw]], [[Resolution\|resolution]] 2.27Å' scene=''>
-	~~Authors: Minici, C., Degano, M.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5drw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DRW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DRW FirstGlance]. <br>
-	~~Description:~~ Crystal structure of the BCR Fab fragment from subset #4 case CLL183	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5drw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5drw OCA], [http://pdbe.org/5drw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5drw RCSB], [http://www.ebi.ac.uk/pdbsum/5drw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5drw ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
	[[Category: Degano, M]]		[[Category: Degano, M]]
	[[Category: Minici, C]]		[[Category: Minici, C]]
		+	[[Category: B-cell receptor]]
		+	[[Category: Chronic lymphocytic leukemia]]
		+	[[Category: Immune system]]
		+	[[Category: Immunoglobulin fold]]
		+	[[Category: Receptor-ligand complex]]

OCA at 11:22, 16 December 2015

OCA — Wed, 16 Dec 2015 11:22:21 GMT

←Older revision		Revision as of 11:22, 16 December 2015
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	Description: Crystal structure of the BCR Fab fragment from subset #4 case CLL183		Description: Crystal structure of the BCR Fab fragment from subset #4 case CLL183
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Minici, C]]
	[[Category: Degano, M]]		[[Category: Degano, M]]
		+	[[Category: Minici, C]]

OCA at 12:32, 7 October 2015

OCA — Wed, 07 Oct 2015 12:32:10 GMT

←Older revision		Revision as of 12:32, 7 October 2015
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5drw is ON HOLD	+	The entry 5drw is ON HOLD until Paper Publication

	Authors: Minici, C., Degano, M.		Authors: Minici, C., Degano, M.

OCA: Protected "5drw" [edit=sysop:move=sysop]

OCA — Wed, 30 Sep 2015 13:26:03 GMT

Protected "5drw" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:26, 30 September 2015

OCA: New page: '''Unreleased structure''' The entry 5drw is ON HOLD Authors: Minici, C., Degano, M. Description: Crystal structure of the BCR Fab fragment from subset #4 case CLL183 [[Category: Unrel...

OCA — Wed, 30 Sep 2015 13:26:01 GMT

New page: '''Unreleased structure''' The entry 5drw is ON HOLD Authors: Minici, C., Degano, M. Description: Crystal structure of the BCR Fab fragment from subset #4 case CLL183 [[Category: Unrel...

New page

'''Unreleased structure'''

The entry 5drw is ON HOLD

Authors: Minici, C., Degano, M.

Description: Crystal structure of the BCR Fab fragment from subset #4 case CLL183
[[Category: Unreleased Structures]]
[[Category: Minici, C]]
[[Category: Degano, M]]