5dsh - Revision history

OCA at 21:57, 28 June 2023

OCA — Wed, 28 Jun 2023 21:57:41 GMT

←Older revision		Revision as of 21:57, 28 June 2023
Line 3:		Line 3:
	<StructureSection load='5dsh' size='340' side='right'caption='[[5dsh]], [[Resolution\|resolution]] 2.95Å' scene=''>		<StructureSection load='5dsh' size='340' side='right'caption='[[5dsh]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5dsh]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DSH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5DSH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5dsh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DSH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DSH FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=6BH:N~~-[~~3-(BENZYLOXY)PHENYL~~]~~-3-NITROBENZAMIDE'>6BH</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.95Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>PPARG, NR1C3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=9606 HUMAN])</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6BH:N-[3-(BENZYLOXY)PHENYL]-3-NITROBENZAMIDE'>6BH</scene></td></tr>
-	~~<tr id='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[http~~:~~//en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number~~ [~~http://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=2.~~3~~.1.48 2.3.1.48]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dsh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dsh OCA], [https://pdbe.org/5dsh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dsh RCSB], [https://www.ebi.ac.uk/pdbsum/5dsh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dsh ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5dsh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dsh OCA], [~~http~~://pdbe.org/5dsh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5dsh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5dsh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5dsh ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/PPARG_HUMAN PPARG_HUMAN]] Note=Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. PPARG mutations may be associated with colon cancer. Defects in PPARG may be associated with susceptibility to obesity (OBESITY) [MIM:[~~http~~://omim.org/entry/601665 601665]]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.<ref>PMID:9753710</ref> Defects in PPARG are the cause of familial partial lipodystrophy type 3 (FPLD3) [MIM:[~~http~~://omim.org/entry/604367 604367]]. Familial partial lipodystrophies (FPLD) are a heterogeneous group of genetic disorders characterized by marked loss of subcutaneous (sc) fat from the extremities. Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia.<ref>PMID:12453919</ref> <ref>PMID:11788685</ref> Genetic variations in PPARG can be associated with susceptibility to glioma type 1 (GLM1) [MIM:[~~http~~://omim.org/entry/137800 137800]]. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Note=Polymorphic PPARG alleles have been found to be significantly over-represented among a cohort of American patients with sporadic glioblastoma multiforme suggesting a possible contribution to disease susceptibility.	+	[https://www.uniprot.org/uniprot/PPARG_HUMAN PPARG_HUMAN] Note=Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. PPARG mutations may be associated with colon cancer. Defects in PPARG may be associated with susceptibility to obesity (OBESITY) [MIM:[https://omim.org/entry/601665 601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.<ref>PMID:9753710</ref> Defects in PPARG are the cause of familial partial lipodystrophy type 3 (FPLD3) [MIM:[https://omim.org/entry/604367 604367]. Familial partial lipodystrophies (FPLD) are a heterogeneous group of genetic disorders characterized by marked loss of subcutaneous (sc) fat from the extremities. Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia.<ref>PMID:12453919</ref> <ref>PMID:11788685</ref> Genetic variations in PPARG can be associated with susceptibility to glioma type 1 (GLM1) [MIM:[https://omim.org/entry/137800 137800]. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Note=Polymorphic PPARG alleles have been found to be significantly over-represented among a cohort of American patients with sporadic glioblastoma multiforme suggesting a possible contribution to disease susceptibility.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PPARG_HUMAN PPARG_HUMAN]] Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses.<ref>PMID:9065481</ref> <ref>PMID:16150867</ref> <ref>PMID:20829347</ref>	+	[https://www.uniprot.org/uniprot/PPARG_HUMAN PPARG_HUMAN] Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses.<ref>PMID:9065481</ref> <ref>PMID:16150867</ref> <ref>PMID:20829347</ref>

	==See Also==		==See Also==
-	*[[~~Phenylethanolamine N~~-~~methyltransferase~~ 3D structures\|~~Phenylethanolamine N~~-~~methyltransferase~~ 3D structures]]	+	*[[Peroxisome proliferator-activated receptor 3D structures\|Peroxisome proliferator-activated receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Histone acetyltransferase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Jang~~, J Y]]~~	+	[[Category: Jang JY]]
-	~~[[Category: Antagonist]]~~	+
-	~~[[Category: Ppargamma]]~~	+
-	~~[[Category: Transcription-transferase complex~~]]	+

OCA at 08:04, 15 April 2020

OCA — Wed, 15 Apr 2020 08:04:05 GMT

←Older revision		Revision as of 08:04, 15 April 2020
Line 1:		Line 1:

	==Human PPARgamma ligand binding dmain complexed with SB1406 in a covalent bonded form==		==Human PPARgamma ligand binding dmain complexed with SB1406 in a covalent bonded form==
-	<StructureSection load='5dsh' size='340' side='right' caption='[[5dsh]], [[Resolution\|resolution]] 2.95Å' scene=''>	+	<StructureSection load='5dsh' size='340' side='right'caption='[[5dsh]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5dsh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DSH OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5DSH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5dsh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DSH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5DSH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6BH:N-[3-(BENZYLOXY)PHENYL]-3-NITROBENZAMIDE'>6BH</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6BH:N-[3-(BENZYLOXY)PHENYL]-3-NITROBENZAMIDE'>6BH</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PPARG, NR1C3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5dsh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dsh OCA], [http://pdbe.org/5dsh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dsh RCSB], [http://www.ebi.ac.uk/pdbsum/5dsh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dsh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5dsh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dsh OCA], [http://pdbe.org/5dsh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dsh RCSB], [http://www.ebi.ac.uk/pdbsum/5dsh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dsh ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 12:		Line 13:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PPARG_HUMAN PPARG_HUMAN]] Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses.<ref>PMID:9065481</ref> <ref>PMID:16150867</ref> <ref>PMID:20829347</ref>		[[http://www.uniprot.org/uniprot/PPARG_HUMAN PPARG_HUMAN]] Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses.<ref>PMID:9065481</ref> <ref>PMID:16150867</ref> <ref>PMID:20829347</ref>
		+
		+	==See Also==
		+	*[[Phenylethanolamine N-methyltransferase 3D structures\|Phenylethanolamine N-methyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 17:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Histone acetyltransferase]]		[[Category: Histone acetyltransferase]]
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Jang, J Y]]		[[Category: Jang, J Y]]
	[[Category: Antagonist]]		[[Category: Antagonist]]
	[[Category: Ppargamma]]		[[Category: Ppargamma]]
	[[Category: Transcription-transferase complex]]		[[Category: Transcription-transferase complex]]

OCA at 13:47, 21 September 2016

OCA — Wed, 21 Sep 2016 13:47:05 GMT

←Older revision		Revision as of 13:47, 21 September 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5dsh is ~~ON HOLD until Paper Publication~~	+	==Human PPARgamma ligand binding dmain complexed with SB1406 in a covalent bonded form==
-		+	<StructureSection load='5dsh' size='340' side='right' caption='[[5dsh]], [[Resolution\|resolution]] 2.95Å' scene=''>
-	~~Authors~~: ~~Jang~~, J.Y.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5dsh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DSH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DSH FirstGlance]. <br>
-	~~Description~~: ~~Human PPARgamma ligand binding dmain complexed~~ with ~~SB1406~~ in a ~~covalent bonded form~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6BH:N-[3-(BENZYLOXY)PHENYL]-3-NITROBENZAMIDE'>6BH</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span></td></tr>
-	[[Category: Jang, J.Y]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dsh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dsh OCA], [http://pdbe.org/5dsh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dsh RCSB], [http://www.ebi.ac.uk/pdbsum/5dsh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dsh ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/PPARG_HUMAN PPARG_HUMAN]] Note=Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. PPARG mutations may be associated with colon cancer. Defects in PPARG may be associated with susceptibility to obesity (OBESITY) [MIM:[http://omim.org/entry/601665 601665]]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.<ref>PMID:9753710</ref> Defects in PPARG are the cause of familial partial lipodystrophy type 3 (FPLD3) [MIM:[http://omim.org/entry/604367 604367]]. Familial partial lipodystrophies (FPLD) are a heterogeneous group of genetic disorders characterized by marked loss of subcutaneous (sc) fat from the extremities. Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia.<ref>PMID:12453919</ref> <ref>PMID:11788685</ref> Genetic variations in PPARG can be associated with susceptibility to glioma type 1 (GLM1) [MIM:[http://omim.org/entry/137800 137800]]. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Note=Polymorphic PPARG alleles have been found to be significantly over-represented among a cohort of American patients with sporadic glioblastoma multiforme suggesting a possible contribution to disease susceptibility.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PPARG_HUMAN PPARG_HUMAN]] Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses.<ref>PMID:9065481</ref> <ref>PMID:16150867</ref> <ref>PMID:20829347</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Histone acetyltransferase]]
		+	[[Category: Jang, J Y]]
		+	[[Category: Antagonist]]
		+	[[Category: Ppargamma]]
		+	[[Category: Transcription-transferase complex]]

OCA at 02:08, 1 December 2015

OCA — Tue, 01 Dec 2015 02:08:29 GMT

←Older revision		Revision as of 02:08, 1 December 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5dsh is ON HOLD	+	The entry 5dsh is ON HOLD until Paper Publication

	Authors: Jang, J.Y.		Authors: Jang, J.Y.

-	Description: Human PPARgamma ligand binding dmain complexed with ~~BH206~~ in a covalent bonded form	+	Description: Human PPARgamma ligand binding dmain complexed with SB1406 in a covalent bonded form
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Jang, J.Y]]		[[Category: Jang, J.Y]]

OCA: Protected "5dsh" [edit=sysop:move=sysop]

OCA — Wed, 30 Sep 2015 13:28:01 GMT

Protected "5dsh" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:28, 30 September 2015

OCA: New page: '''Unreleased structure''' The entry 5dsh is ON HOLD Authors: Jang, J.Y. Description: Human PPARgamma ligand binding dmain complexed with BH206 in a covalent bonded form [[Category: Un...

OCA — Wed, 30 Sep 2015 13:27:59 GMT

New page: '''Unreleased structure''' The entry 5dsh is ON HOLD Authors: Jang, J.Y. Description: Human PPARgamma ligand binding dmain complexed with BH206 in a covalent bonded form [[Category: Un...

New page

'''Unreleased structure'''

The entry 5dsh is ON HOLD

Authors: Jang, J.Y.

Description: Human PPARgamma ligand binding dmain complexed with BH206 in a covalent bonded form
[[Category: Unreleased Structures]]
[[Category: Jang, J.Y]]