5dtg - Revision history

OCA: Redirecting to 5hcu

OCA — Wed, 20 Jan 2016 16:52:15 GMT

Redirecting to 5hcu

←Older revision		Revision as of 16:52, 20 January 2016
Line 1:		Line 1:
-	~~==Crystal structure of mouse acetylchoinesterase inhibited by DFP==~~	+	#REDIRECT [[5hcu]] This PDB entry is obsolete and replaced by 5hcu
-	~~<StructureSection load='5dtg' size='340' side='right' caption='~~[[~~5dtg]], [[Resolution\|resolution]] 2.40Å' scene=''>~~	+
-	~~== Structural highlights ==~~	+
-	~~<table><tr><td colspan='2'>[[5dtg~~]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DTG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DTG FirstGlance]. <br>	+
-	~~</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MIS:MONOISOPROPYLPHOSPHORYLSERINE'>MIS</scene></td></tr>~~	+
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5dti\|5dti]], [[5dtj\|5dtj]]</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dtg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dtg OCA], [http://pdbe.org/5dtg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dtg RCSB], [http://www.ebi.ac.uk/pdbsum/5dtg PDBsum]</span></td></tr>	+
-	~~</table>~~	+
-	~~== Function ==~~	+
-	~~[[http://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.~~	+
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	~~Acetylcholinesterase (AChE) that has been covalently inhibited by organophosphate compounds (OPCs), such as nerve agents~~ and ~~pesticides, has traditionally been reactivated~~ by using nucleophilic oximes. There is, however, a clearly recognized need for new classes of compounds with the ability to reactivate inhibited AChE with improved in vivo efficacy. Here we describe our discovery of new functional groups-Mannich phenols and general bases-that are capable of reactivating OPC-inhibited AChE more efficiently than standard oximes and we describe the cooperative mechanism by which these functionalities are delivered to the active site. These discoveries, supported by preliminary in vivo results and crystallographic data, significantly broaden the available approaches for reactivation of AChE.	+
-		+
-	Discovery of New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by Organophosphates.,Katz FS, Pecic S, Tran TH, Trakht I, Schneider L, Zhu Z, Ton-That L, Luzac M, Zlatanic V, Damera S, Macdonald J, Landry DW, Tong L, Stojanovic MN Chembiochem. 2015 Oct;16(15):2205-15. doi: 10.1002/cbic.201500348. Epub 2015 Sep , 9. PMID:26350723<ref>PMID:26350723</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 5dtg" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references/>~~	+
-	~~__TOC__~~	+
-	~~</StructureSection>~~	+
-	~~[[Category: Acetylcholinesterase]]~~	+
-	~~[[Category: Tong, L]]~~	+
-	~~[[Category: Tran, T H]]~~	+
-	~~[[Category: Hydrolase]]~~	+

OCA at 05:23, 22 October 2015

OCA — Thu, 22 Oct 2015 05:23:15 GMT

←Older revision		Revision as of 05:23, 22 October 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of mouse acetylchoinesterase inhibited by DFP==
		+	<StructureSection load='5dtg' size='340' side='right' caption='[[5dtg]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5dtg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DTG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DTG FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MIS:MONOISOPROPYLPHOSPHORYLSERINE'>MIS</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5dti\|5dti]], [[5dtj\|5dtj]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dtg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dtg OCA], [http://pdbe.org/5dtg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dtg RCSB], [http://www.ebi.ac.uk/pdbsum/5dtg PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Acetylcholinesterase (AChE) that has been covalently inhibited by organophosphate compounds (OPCs), such as nerve agents and pesticides, has traditionally been reactivated by using nucleophilic oximes. There is, however, a clearly recognized need for new classes of compounds with the ability to reactivate inhibited AChE with improved in vivo efficacy. Here we describe our discovery of new functional groups-Mannich phenols and general bases-that are capable of reactivating OPC-inhibited AChE more efficiently than standard oximes and we describe the cooperative mechanism by which these functionalities are delivered to the active site. These discoveries, supported by preliminary in vivo results and crystallographic data, significantly broaden the available approaches for reactivation of AChE.

-	~~The entry 5dtg is ON HOLD~~	+	Discovery of New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by Organophosphates.,Katz FS, Pecic S, Tran TH, Trakht I, Schneider L, Zhu Z, Ton-That L, Luzac M, Zlatanic V, Damera S, Macdonald J, Landry DW, Tong L, Stojanovic MN Chembiochem. 2015 Oct;16(15):2205-15. doi: 10.1002/cbic.201500348. Epub 2015 Sep , 9. PMID:26350723<ref>PMID:26350723</ref>

-	~~Authors: Tran~~, T.H.~~, Tong, L~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of mouse acetylchoinesterase inhibited by DFP~~	+	<div class="pdbe-citations 5dtg" style="background-color:#fffaf0;"></div>
-	~~[[Category: Unreleased Structures]]~~	+	== References ==
-	[[Category: ~~Tran, T.H~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Acetylcholinesterase]]
	[[Category: Tong, L]]		[[Category: Tong, L]]
		+	[[Category: Tran, T H]]
		+	[[Category: Hydrolase]]

OCA at 02:40, 16 October 2015

OCA — Fri, 16 Oct 2015 02:40:24 GMT

←Older revision		Revision as of 02:40, 16 October 2015
Line 5:		Line 5:
	Authors: Tran, T.H., Tong, L.		Authors: Tran, T.H., Tong, L.

-	Description: ~~Discovery~~ of ~~New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited~~ by ~~Organophosphates~~	+	Description: Crystal structure of mouse acetylchoinesterase inhibited by DFP
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Tran, T.H]]		[[Category: Tran, T.H]]
	[[Category: Tong, L]]		[[Category: Tong, L]]

OCA: Protected "5dtg" [edit=sysop:move=sysop]

OCA — Wed, 30 Sep 2015 13:30:19 GMT

Protected "5dtg" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:30, 30 September 2015

OCA: New page: '''Unreleased structure''' The entry 5dtg is ON HOLD Authors: Tran, T.H., Tong, L. Description: Discovery of New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by ...

OCA — Wed, 30 Sep 2015 13:30:17 GMT

New page: '''Unreleased structure''' The entry 5dtg is ON HOLD Authors: Tran, T.H., Tong, L. Description: Discovery of New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by ...

New page

'''Unreleased structure'''

The entry 5dtg is ON HOLD

Authors: Tran, T.H., Tong, L.

Description: Discovery of New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by Organophosphates
[[Category: Unreleased Structures]]
[[Category: Tran, T.H]]
[[Category: Tong, L]]