5dti - Revision history

OCA at 21:58, 28 June 2023

OCA — Wed, 28 Jun 2023 21:58:29 GMT

←Older revision		Revision as of 21:58, 28 June 2023
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	<StructureSection load='5dti' size='340' side='right'caption='[[5dti]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='5dti' size='340' side='right'caption='[[5dti]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5dti]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DTI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5DTI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5dti]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DTI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DTI FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5dtg\|5dtg]], [[5dtj\|5dtj]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.003Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">Ache ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=10090 LK3 transgenic mice])</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dti OCA], [https://pdbe.org/5dti PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dti RCSB], [https://www.ebi.ac.uk/pdbsum/5dti PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dti ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5dti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dti OCA], [~~http~~://pdbe.org/5dti PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5dti RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5dti PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5dti ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.	+	[https://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Acetylcholinesterase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Tong, L]]	+	[[Category: Tong L]]
-	[[Category: Tran~~, T H]]~~	+	[[Category: Tran TH]]
-	~~[[Category: Hydrolase~~]]	+

OCA at 08:05, 15 April 2020

OCA — Wed, 15 Apr 2020 08:05:05 GMT

←Older revision		Revision as of 08:05, 15 April 2020
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		+
	==Crystal structure of mouse acetylcholinesterase==		==Crystal structure of mouse acetylcholinesterase==
-	<StructureSection load='5dti' size='340' side='right' caption='[[5dti]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='5dti' size='340' side='right'caption='[[5dti]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5dti]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DTI OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5DTI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5dti]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DTI OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5DTI FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5dtg\|5dtg]], [[5dtj\|5dtj]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5dtg\|5dtg]], [[5dtj\|5dtj]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ache ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5dti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dti OCA], [http://pdbe.org/5dti PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dti RCSB], [http://www.ebi.ac.uk/pdbsum/5dti PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5dti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dti OCA], [http://pdbe.org/5dti PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dti RCSB], [http://www.ebi.ac.uk/pdbsum/5dti PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dti ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5dti" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5dti" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Acetylcholinesterase 3D structures\|Acetylcholinesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
		+	[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Tong, L]]		[[Category: Tong, L]]
	[[Category: Tran, T H]]		[[Category: Tran, T H]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 05:23, 22 October 2015

OCA — Thu, 22 Oct 2015 05:23:22 GMT

←Older revision		Revision as of 05:23, 22 October 2015
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-	'''~~Unreleased~~ structure'''	+	==Crystal structure of mouse acetylcholinesterase==
		+	<StructureSection load='5dti' size='340' side='right' caption='[[5dti]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5dti]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DTI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DTI FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5dtg\|5dtg]], [[5dtj\|5dtj]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dti OCA], [http://pdbe.org/5dti PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dti RCSB], [http://www.ebi.ac.uk/pdbsum/5dti PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Acetylcholinesterase (AChE) that has been covalently inhibited by organophosphate compounds (OPCs), such as nerve agents and pesticides, has traditionally been reactivated by using nucleophilic oximes. There is, however, a clearly recognized need for new classes of compounds with the ability to reactivate inhibited AChE with improved in vivo efficacy. Here we describe our discovery of new functional groups-Mannich phenols and general bases-that are capable of reactivating OPC-inhibited AChE more efficiently than standard oximes and we describe the cooperative mechanism by which these functionalities are delivered to the active site. These discoveries, supported by preliminary in vivo results and crystallographic data, significantly broaden the available approaches for reactivation of AChE.

-	~~The entry 5dti is ON HOLD~~	+	Discovery of New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by Organophosphates.,Katz FS, Pecic S, Tran TH, Trakht I, Schneider L, Zhu Z, Ton-That L, Luzac M, Zlatanic V, Damera S, Macdonald J, Landry DW, Tong L, Stojanovic MN Chembiochem. 2015 Oct;16(15):2205-15. doi: 10.1002/cbic.201500348. Epub 2015 Sep , 9. PMID:26350723<ref>PMID:26350723</ref>

-	~~Authors: Tran~~, T.H.~~, Tong, L~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of mouse acetylcholinesterase~~	+	<div class="pdbe-citations 5dti" style="background-color:#fffaf0;"></div>
-	~~[[Category: Unreleased Structures]]~~	+	== References ==
-	[[Category: ~~Tran, T.H~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Acetylcholinesterase]]
	[[Category: Tong, L]]		[[Category: Tong, L]]
		+	[[Category: Tran, T H]]
		+	[[Category: Hydrolase]]

OCA at 02:40, 16 October 2015

OCA — Fri, 16 Oct 2015 02:40:30 GMT

←Older revision		Revision as of 02:40, 16 October 2015
Line 5:		Line 5:
	Authors: Tran, T.H., Tong, L.		Authors: Tran, T.H., Tong, L.

-	Description: ~~Discovery~~ of ~~New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by Organophosphates~~	+	Description: Crystal structure of mouse acetylcholinesterase
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Tran, T.H]]		[[Category: Tran, T.H]]
	[[Category: Tong, L]]		[[Category: Tong, L]]

OCA: Protected "5dti" [edit=sysop:move=sysop]

OCA — Wed, 30 Sep 2015 13:30:27 GMT

Protected "5dti" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:30, 30 September 2015

OCA: New page: '''Unreleased structure''' The entry 5dti is ON HOLD Authors: Tran, T.H., Tong, L. Description: Discovery of New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by ...

OCA — Wed, 30 Sep 2015 13:30:26 GMT

New page: '''Unreleased structure''' The entry 5dti is ON HOLD Authors: Tran, T.H., Tong, L. Description: Discovery of New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by ...

New page

'''Unreleased structure'''

The entry 5dti is ON HOLD

Authors: Tran, T.H., Tong, L.

Description: Discovery of New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by Organophosphates
[[Category: Unreleased Structures]]
[[Category: Tran, T.H]]
[[Category: Tong, L]]