5dtj - Revision history

OCA at 21:58, 28 June 2023

OCA — Wed, 28 Jun 2023 21:58:32 GMT

←Older revision		Revision as of 21:58, 28 June 2023
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	<StructureSection load='5dtj' size='340' side='right'caption='[[5dtj]], [[Resolution\|resolution]] 2.71Å' scene=''>		<StructureSection load='5dtj' size='340' side='right'caption='[[5dtj]], [[Resolution\|resolution]] 2.71Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5dtj]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DTJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5DTJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5dtj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DTJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DTJ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=5G8:1-[5-(2,4-DICHLOROPHENOXY)PENTYL]-1H-IMIDAZOLE'>5G8</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.71Å</td></tr>
-	~~<tr~~ id~~='NonStdRes'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Non-Standard_Residue~~\|~~NonStd Res:~~]]~~</b></td><td class="sblockDat"><scene name='pdbligand=MIS:MONOISOPROPYLPHOSPHORYLSERINE'>MIS</scene>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5G8:1-[5-(2,4-DICHLOROPHENOXY)PENTYL]-1H-IMIDAZOLE'>5G8</scene>, <scene name='pdbligand=MIS:MONOISOPROPYLPHOSPHORYLSERINE'>MIS</scene></td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5dtg\|5dtg]], [[5dti\|5dti]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dtj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dtj OCA], [https://pdbe.org/5dtj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dtj RCSB], [https://www.ebi.ac.uk/pdbsum/5dtj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dtj ProSAT]</span></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><~~b>[[Gene\|Gene~~:~~]]</b></td><td class="sblockDat">Ache (~~[~~http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=~~5~~&id=10090 LK3 transgenic mice~~]~~)</td~~></tr>	+
-	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5dtj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dtj OCA], [~~http~~://pdbe.org/5dtj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5dtj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5dtj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5dtj ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.	+	[https://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Acetylcholinesterase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Tong, L]]	+	[[Category: Tong L]]
-	[[Category: Tran~~, T H]]~~	+	[[Category: Tran TH]]
-	~~[[Category: Hydrolase-hydrolase inhibitor complex~~]]	+

OCA at 07:38, 10 April 2019

OCA — Wed, 10 Apr 2019 07:38:23 GMT

←Older revision		Revision as of 07:38, 10 April 2019
Line 1:		Line 1:
		+
	==Crystal Structure of dfp-inhibited mouse acetylcholinesterase in complex with the reactivator SP-134==		==Crystal Structure of dfp-inhibited mouse acetylcholinesterase in complex with the reactivator SP-134==
-	<StructureSection load='5dtj' size='340' side='right' caption='[[5dtj]], [[Resolution\|resolution]] 2.71Å' scene=''>	+	<StructureSection load='5dtj' size='340' side='right'caption='[[5dtj]], [[Resolution\|resolution]] 2.71Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5dtj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DTJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DTJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5dtj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DTJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DTJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5G8:1-[5-(2,4-DICHLOROPHENOXY)PENTYL]-1H-IMIDAZOLE'>5G8</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5G8:1-[5-(2,4-DICHLOROPHENOXY)PENTYL]-1H-IMIDAZOLE'>5G8</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MIS:MONOISOPROPYLPHOSPHORYLSERINE'>MIS</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MIS:MONOISOPROPYLPHOSPHORYLSERINE'>MIS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5dtg\|5dtg]], [[5dti\|5dti]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5dtg\|5dtg]], [[5dti\|5dti]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ache ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dtj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dtj OCA], [http://pdbe.org/5dtj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dtj RCSB], [http://www.ebi.ac.uk/pdbsum/5dtj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dtj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dtj OCA], [http://pdbe.org/5dtj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dtj RCSB], [http://www.ebi.ac.uk/pdbsum/5dtj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dtj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5dtj" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5dtj" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Acetylcholinesterase 3D structures\|Acetylcholinesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
		+	[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Tong, L]]		[[Category: Tong, L]]
	[[Category: Tran, T H]]		[[Category: Tran, T H]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 05:23, 22 October 2015

OCA — Thu, 22 Oct 2015 05:23:12 GMT

←Older revision		Revision as of 05:23, 22 October 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal Structure of dfp-inhibited mouse acetylcholinesterase in complex with the reactivator SP-134==
		+	<StructureSection load='5dtj' size='340' side='right' caption='[[5dtj]], [[Resolution\|resolution]] 2.71Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5dtj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DTJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DTJ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5G8:1-[5-(2,4-DICHLOROPHENOXY)PENTYL]-1H-IMIDAZOLE'>5G8</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MIS:MONOISOPROPYLPHOSPHORYLSERINE'>MIS</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5dtg\|5dtg]], [[5dti\|5dti]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dtj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dtj OCA], [http://pdbe.org/5dtj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dtj RCSB], [http://www.ebi.ac.uk/pdbsum/5dtj PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Acetylcholinesterase (AChE) that has been covalently inhibited by organophosphate compounds (OPCs), such as nerve agents and pesticides, has traditionally been reactivated by using nucleophilic oximes. There is, however, a clearly recognized need for new classes of compounds with the ability to reactivate inhibited AChE with improved in vivo efficacy. Here we describe our discovery of new functional groups-Mannich phenols and general bases-that are capable of reactivating OPC-inhibited AChE more efficiently than standard oximes and we describe the cooperative mechanism by which these functionalities are delivered to the active site. These discoveries, supported by preliminary in vivo results and crystallographic data, significantly broaden the available approaches for reactivation of AChE.

-	~~The entry 5dtj is ON HOLD~~	+	Discovery of New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by Organophosphates.,Katz FS, Pecic S, Tran TH, Trakht I, Schneider L, Zhu Z, Ton-That L, Luzac M, Zlatanic V, Damera S, Macdonald J, Landry DW, Tong L, Stojanovic MN Chembiochem. 2015 Oct;16(15):2205-15. doi: 10.1002/cbic.201500348. Epub 2015 Sep , 9. PMID:26350723<ref>PMID:26350723</ref>

-	~~Authors: Tran~~, T.H.~~, Tong, L~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: Crystal Structure of dfp~~-~~inhibited mouse acetylcholinesterase in complex with the reactivator SP~~-~~134~~	+	<div class="pdbe-citations 5dtj" style="background-color:#fffaf0;"></div>
-	~~[[Category: Unreleased Structures]]~~	+	== References ==
-	[[Category: ~~Tran, T.H~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Acetylcholinesterase]]
	[[Category: Tong, L]]		[[Category: Tong, L]]
		+	[[Category: Tran, T H]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 02:40, 16 October 2015

OCA — Fri, 16 Oct 2015 02:40:32 GMT

←Older revision		Revision as of 02:40, 16 October 2015
Line 5:		Line 5:
	Authors: Tran, T.H., Tong, L.		Authors: Tran, T.H., Tong, L.

-	Description: ~~Discovery~~ of ~~New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by Organophosphates~~	+	Description: Crystal Structure of dfp-inhibited mouse acetylcholinesterase in complex with the reactivator SP-134
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Tran, T.H]]		[[Category: Tran, T.H]]
	[[Category: Tong, L]]		[[Category: Tong, L]]

OCA: Protected "5dtj" [edit=sysop:move=sysop]

OCA — Wed, 30 Sep 2015 13:30:29 GMT

Protected "5dtj" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:30, 30 September 2015

OCA: New page: '''Unreleased structure''' The entry 5dtj is ON HOLD Authors: Tran, T.H., Tong, L. Description: Discovery of New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by ...

OCA — Wed, 30 Sep 2015 13:30:28 GMT

New page: '''Unreleased structure''' The entry 5dtj is ON HOLD Authors: Tran, T.H., Tong, L. Description: Discovery of New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by ...

New page

'''Unreleased structure'''

The entry 5dtj is ON HOLD

Authors: Tran, T.H., Tong, L.

Description: Discovery of New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by Organophosphates
[[Category: Unreleased Structures]]
[[Category: Tran, T.H]]
[[Category: Tong, L]]