5dur - Revision history

OCA at 22:00, 28 June 2023

OCA — Wed, 28 Jun 2023 22:00:56 GMT

←Older revision		Revision as of 22:00, 28 June 2023
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	<StructureSection load='5dur' size='340' side='right'caption='[[5dur]], [[Resolution\|resolution]] 2.82Å' scene=''>		<StructureSection load='5dur' size='340' side='right'caption='[[5dur]], [[Resolution\|resolution]] 2.82Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5dur]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~] and [~~http~~://en.wikipedia.org/wiki/~~Influenza_a_virus_~~(a/~~anhui~~/1/2005(~~h5n1~~)) Influenza a virus (a/~~anhui~~/1/2005(~~h5n1~~))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DUR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5DUR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5dur]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Anhui/1/2005(H5N1)) Influenza A virus (A/Anhui/1/2005(H5N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DUR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DUR FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=NAG:N~~-~~ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.82Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5dum\|5dum]], [[5dup\|5dup]], [[5dut\|5dut]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><~~b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=370810 Influenza A virus (A/Anhui/1/2005(H5N1))])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dur OCA], [https://pdbe.org/5dur PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dur RCSB], [https://www.ebi.ac.uk/pdbsum/5dur PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dur ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5dur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dur OCA], [~~http~~://pdbe.org/5dur PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5dur RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5dur PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5dur ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/Q1WDM0_9INFA Q1WDM0_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013829_004_327643]	+	[https://www.uniprot.org/uniprot/Q1WDM0_9INFA Q1WDM0_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013829_004_327643]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
	*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]		*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]
		+	*[[3D structures of human antibody\|3D structures of human antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Sun, J]]	+	[[Category: Sun J]]
-	[[Category: Wang, G]]	+	[[Category: Wang G]]
-	[[Category: Wang, X]]	+	[[Category: Wang X]]
-	[[Category: Zhang, L]]	+	[[Category: Zhang L]]
-	[[Category: Zhou, P]]	+	[[Category: Zhou P]]
-	[[Category: Zuo, T]]	+	[[Category: Zuo T]]
-	~~[[Category: Antibody]]~~	+
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Influenza virus]]~~	+
-	~~[[Category: Neutralize~~]]	+

OCA at 08:07, 15 April 2020

OCA — Wed, 15 Apr 2020 08:07:14 GMT

←Older revision		Revision as of 08:07, 15 April 2020
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		+
	==Influenza A virus H5 hemagglutinin globular head in complex with antibody 100F4==		==Influenza A virus H5 hemagglutinin globular head in complex with antibody 100F4==
-	<StructureSection load='5dur' size='340' side='right' caption='[[5dur]], [[Resolution\|resolution]] 2.82Å' scene=''>	+	<StructureSection load='5dur' size='340' side='right'caption='[[5dur]], [[Resolution\|resolution]] 2.82Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5dur]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DUR OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5DUR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5dur]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/anhui/1/2005(h5n1)) Influenza a virus (a/anhui/1/2005(h5n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DUR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5DUR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5dum\|5dum]], [[5dup\|5dup]], [[5dut\|5dut]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5dum\|5dum]], [[5dup\|5dup]], [[5dut\|5dut]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5dur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dur OCA], [http://pdbe.org/5dur PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dur RCSB], [http://www.ebi.ac.uk/pdbsum/5dur PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=370810 Influenza A virus (A/Anhui/1/2005(H5N1))])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5dur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dur OCA], [http://pdbe.org/5dur PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dur RCSB], [http://www.ebi.ac.uk/pdbsum/5dur PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dur ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 5dur" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5dur" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Sun, J]]		[[Category: Sun, J]]
	[[Category: Wang, G]]		[[Category: Wang, G]]

OCA at 13:48, 16 December 2015

OCA — Wed, 16 Dec 2015 13:48:41 GMT

←Older revision		Revision as of 13:48, 16 December 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Influenza A virus H5 hemagglutinin globular head in complex with antibody 100F4==
		+	<StructureSection load='5dur' size='340' side='right' caption='[[5dur]], [[Resolution\|resolution]] 2.82Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5dur]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DUR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DUR FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5dum\|5dum]], [[5dup\|5dup]], [[5dut\|5dut]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dur OCA], [http://pdbe.org/5dur PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dur RCSB], [http://www.ebi.ac.uk/pdbsum/5dur PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q1WDM0_9INFA Q1WDM0_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013829_004_327643]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Understanding the mechanism of protective antibody recognition against highly pathogenic avian influenza A virus H5N1 in humans is critical for the development of effective therapies and vaccines. Here we report the crystal structure of three H5-specific human monoclonal antibodies bound to the globular head of hemagglutinin (HA) with distinct epitope specificities, neutralization potencies and breadth. A structural and functional analysis of these epitopes combined with those reported elsewhere identifies four major vulnerable sites on the globular head of H5N1 HA. Chimeric and vulnerable site-specific mutant pseudoviruses are generated to delineate broad neutralization specificities of convalescent sera from two individuals who recovered from the infection with H5N1 virus. Our results show that the four vulnerable sites on the globular head rather than the stem region are the major neutralizing targets, suggesting that during natural H5N1 infection neutralizing antibodies against the globular head work in concert to provide protective antibody-mediated immunity.

-	~~The entry 5dur is ON HOLD~~	+	Comprehensive analysis of antibody recognition in convalescent humans from highly pathogenic avian influenza H5N1 infection.,Zuo T, Sun J, Wang G, Jiang L, Zuo Y, Li D, Shi X, Liu X, Fan S, Ren H, Hu H, Sun L, Zhou B, Liang M, Zhou P, Wang X, Zhang L Nat Commun. 2015 Dec 4;6:8855. doi: 10.1038/ncomms9855. PMID:26635249<ref>PMID:26635249</ref>

-	~~Authors: Zuo~~, T.~~, Sun, J~~.~~, Wang, G., Zhou, P., Wang, X., Zhang, L~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Influenza A virus H5 hemagglutinin globular head in complex with antibody 100F4~~	+	<div class="pdbe-citations 5dur" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Unreleased Structures~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Sun, J]]
	[[Category: Wang, G]]		[[Category: Wang, G]]
	[[Category: Wang, X]]		[[Category: Wang, X]]
-	[[Category: Sun, J]]
	[[Category: Zhang, L]]		[[Category: Zhang, L]]
		+	[[Category: Zhou, P]]
	[[Category: Zuo, T]]		[[Category: Zuo, T]]
-	[[Category: ~~Zhou, P~~]]	+	[[Category: Antibody]]
		+	[[Category: Complex]]
		+	[[Category: Immune system]]
		+	[[Category: Influenza virus]]
		+	[[Category: Neutralize]]

OCA at 12:36, 7 October 2015

OCA — Wed, 07 Oct 2015 12:36:41 GMT

←Older revision		Revision as of 12:36, 7 October 2015
Line 3:		Line 3:
	The entry 5dur is ON HOLD		The entry 5dur is ON HOLD

-	Authors: Zuo, T, Sun, J, Wang, G, Zhou, P, Wang, X, Zhang, L	+	Authors: Zuo, T., Sun, J., Wang, G., Zhou, P., Wang, X., Zhang, L.

	Description: Influenza A virus H5 hemagglutinin globular head in complex with antibody 100F4		Description: Influenza A virus H5 hemagglutinin globular head in complex with antibody 100F4
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Zuo~~, T, Sun, J, ~~Wang, G~~, Zhou, P~~, Wang, X, Zhang, L~~]]	+	[[Category: Wang, G]]
		+	[[Category: Wang, X]]
		+	[[Category: Sun, J]]
		+	[[Category: Zhang, L]]
		+	[[Category: Zuo, T]]
		+	[[Category: Zhou, P]]

OCA: Protected "5dur" [edit=sysop:move=sysop]

OCA — Wed, 30 Sep 2015 13:33:30 GMT

Protected "5dur" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:33, 30 September 2015

OCA: New page: '''Unreleased structure''' The entry 5dur is ON HOLD Authors: Zuo, T, Sun, J, Wang, G, Zhou, P, Wang, X, Zhang, L Description: Influenza A virus H5 hemagglutinin globular head in compl...

OCA — Wed, 30 Sep 2015 13:33:29 GMT

New page: '''Unreleased structure''' The entry 5dur is ON HOLD Authors: Zuo, T, Sun, J, Wang, G, Zhou, P, Wang, X, Zhang, L Description: Influenza A virus H5 hemagglutinin globular head in compl...

New page

'''Unreleased structure'''

The entry 5dur is ON HOLD

Authors: Zuo, T, Sun, J, Wang, G, Zhou, P, Wang, X, Zhang, L

Description: Influenza A virus H5 hemagglutinin globular head in complex with antibody 100F4
[[Category: Unreleased Structures]]
[[Category: Zuo, T, Sun, J, Wang, G, Zhou, P, Wang, X, Zhang, L]]