5dye - Revision history

OCA at 22:05, 28 June 2023

OCA — Wed, 28 Jun 2023 22:05:37 GMT

←Older revision		Revision as of 22:05, 28 June 2023
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	<StructureSection load='5dye' size='340' side='right'caption='[[5dye]], [[Resolution\|resolution]] 3.50Å' scene=''>		<StructureSection load='5dye' size='340' side='right'caption='[[5dye]], [[Resolution\|resolution]] 3.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5dye]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DYE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5DYE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5dye]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DYE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DYE FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=PS6:O~~-[~~(S)-{~~[~~(2S)-2-(HEXANOYLOXY)-3-(TETRADECANOYLOXY)PROPYL~~]~~OXY}(HYDROXY)PHOSPHORYL~~]~~-D-SERINE'>PS6</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.5Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5c5x\|5c5x]], [[3d9s\|3d9s]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PS6:O-[(S)-{[(2S)-2-(HEXANOYLOXY)-3-(TETRADECANOYLOXY)PROPYL]OXY}(HYDROXY)PHOSPHORYL]-D-SERINE'>PS6</scene></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><b>[[~~Gene\|Gene:~~]]~~</b~~></td>~~<td class="sblockDat">AQP5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dye OCA], [https://pdbe.org/5dye PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dye RCSB], [https://www.ebi.ac.uk/pdbsum/5dye PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dye ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5dye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dye OCA], [~~http~~://pdbe.org/5dye PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5dye RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5dye PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5dye ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/AQP5_HUMAN AQP5_HUMAN]] Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions.	+	[https://www.uniprot.org/uniprot/AQP5_HUMAN AQP5_HUMAN] Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bill~~, R M~~]]	+	[[Category: Bill RM]]
-	[[Category: Conner~~, A C~~]]	+	[[Category: Conner AC]]
-	[[Category: Conner~~, M T~~]]	+	[[Category: Conner MT]]
-	[[Category: Hedfalk, K]]	+	[[Category: Hedfalk K]]
-	[[Category: Kitchen, P]]	+	[[Category: Kitchen P]]
-	[[Category: Oeberg, F]]	+	[[Category: Oeberg F]]
-	[[Category: Sjoehamn, J]]	+	[[Category: Sjoehamn J]]
-	[[Category: Toernroth-Horsefield, S]]	+	[[Category: Toernroth-Horsefield S]]
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 08:13, 15 April 2020

OCA — Wed, 15 Apr 2020 08:13:07 GMT

←Older revision		Revision as of 08:13, 15 April 2020
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF THE FULL LENGTH S156E MUTANT OF HUMAN AQUAPORIN 5==		==CRYSTAL STRUCTURE OF THE FULL LENGTH S156E MUTANT OF HUMAN AQUAPORIN 5==
-	<StructureSection load='5dye' size='340' side='right' caption='[[5dye]], [[Resolution\|resolution]] 3.50Å' scene=''>	+	<StructureSection load='5dye' size='340' side='right'caption='[[5dye]], [[Resolution\|resolution]] 3.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5dye]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DYE OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5DYE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5dye]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DYE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5DYE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PS6:O-[(S)-{[(2S)-2-(HEXANOYLOXY)-3-(TETRADECANOYLOXY)PROPYL]OXY}(HYDROXY)PHOSPHORYL]-D-SERINE'>PS6</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PS6:O-[(S)-{[(2S)-2-(HEXANOYLOXY)-3-(TETRADECANOYLOXY)PROPYL]OXY}(HYDROXY)PHOSPHORYL]-D-SERINE'>PS6</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5c5x\|5c5x]], [[3d9s\|3d9s]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5c5x\|5c5x]], [[3d9s\|3d9s]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5dye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dye OCA], [http://pdbe.org/5dye PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dye RCSB], [http://www.ebi.ac.uk/pdbsum/5dye PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AQP5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5dye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dye OCA], [http://pdbe.org/5dye PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dye RCSB], [http://www.ebi.ac.uk/pdbsum/5dye PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dye ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 5dye" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5dye" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aquaporin 3D structures\|Aquaporin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bill, R M]]		[[Category: Bill, R M]]
	[[Category: Conner, A C]]		[[Category: Conner, A C]]

OCA at 16:13, 2 December 2015

OCA — Wed, 02 Dec 2015 16:13:50 GMT

←Older revision		Revision as of 16:13, 2 December 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==CRYSTAL STRUCTURE OF THE FULL LENGTH S156E MUTANT OF HUMAN AQUAPORIN 5==
		+	<StructureSection load='5dye' size='340' side='right' caption='[[5dye]], [[Resolution\|resolution]] 3.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5dye]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DYE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DYE FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PS6:O-[(S)-{[(2S)-2-(HEXANOYLOXY)-3-(TETRADECANOYLOXY)PROPYL]OXY}(HYDROXY)PHOSPHORYL]-D-SERINE'>PS6</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5c5x\|5c5x]], [[3d9s\|3d9s]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dye OCA], [http://pdbe.org/5dye PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dye RCSB], [http://www.ebi.ac.uk/pdbsum/5dye PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/AQP5_HUMAN AQP5_HUMAN]] Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Aquaporin membrane protein channels mediate cellular water flow. Human aquaporin 5 (AQP5) is highly expressed in the respiratory system and secretory glands where it facilitates the osmotically-driven generation of pulmonary secretions, saliva, sweat and tears. Dysfunctional trafficking of AQP5 has been implicated in several human disease states, including Sjogren's syndrome, bronchitis and cystic fibrosis. In order to investigate how the plasma membrane expression levels of AQP5 are regulated, we studied real-time translocation of GFP-tagged AQP5 in HEK293 cells. We show that AQP5 plasma membrane abundance in transfected HEK293 cells is rapidly and reversibly regulated by at least three independent mechanisms involving phosphorylation at Ser156, protein kinase A activity and extracellular tonicity. The crystal structure of a Ser156 phosphomimetic mutant indicates that its involvement in regulating AQP5 membrane abundance is not mediated by a conformational change of the carboxy-terminus. We suggest that together these pathways regulate cellular water flow.

-	~~The entry 5dye is ON HOLD~~	+	Plasma Membrane Abundance of Human Aquaporin 5 Is Dynamically Regulated by Multiple Pathways.,Kitchen P, Oberg F, Sjohamn J, Hedfalk K, Bill RM, Conner AC, Conner MT, Tornroth-Horsefield S PLoS One. 2015 Nov 16;10(11):e0143027. doi: 10.1371/journal.pone.0143027., eCollection 2015. PMID:26569106<ref>PMID:26569106</ref>

-	~~Authors: Kitchen~~, P.~~, Oeberg, F~~.~~, Sjoehamn, J., Hedfalk, K., Bill, R.M., Conner, A.C., Conner, M.T., Toernroth-Horsefield, S~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~CRYSTAL STRUCTURE OF THE FULL LENGTH S156E MUTANT OF HUMAN AQUAPORIN 5~~	+	<div class="pdbe-citations 5dye" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Unreleased Structures~~]]	+	== References ==
-	[[Category: Conner, A.C]]	+	<references/>
-	[[Category: ~~Bill~~, R.M]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Bill, R M]]
		+	[[Category: Conner, A C]]
		+	[[Category: Conner, M T]]
		+	[[Category: Hedfalk, K]]
	[[Category: Kitchen, P]]		[[Category: Kitchen, P]]
	[[Category: Oeberg, F]]		[[Category: Oeberg, F]]
		+	[[Category: Sjoehamn, J]]
	[[Category: Toernroth-Horsefield, S]]		[[Category: Toernroth-Horsefield, S]]
-	[[Category: ~~Hedfalk, K~~]]	+	[[Category: Membrane protein]]
-	[[Category: ~~Conner, M.T]]~~	+	[[Category: Transport protein]]
-	~~[[Category: Sjoehamn, J~~]]	+

OCA: Protected "5dye" [edit=sysop:move=sysop]

OCA — Wed, 30 Sep 2015 13:42:09 GMT

Protected "5dye" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:42, 30 September 2015

OCA: New page: '''Unreleased structure''' The entry 5dye is ON HOLD Authors: Kitchen, P., Oeberg, F., Sjoehamn, J., Hedfalk, K., Bill, R.M., Conner, A.C., Conner, M.T., Toernroth-Horsefield, S. Descr...

OCA — Wed, 30 Sep 2015 13:42:08 GMT

New page: '''Unreleased structure''' The entry 5dye is ON HOLD Authors: Kitchen, P., Oeberg, F., Sjoehamn, J., Hedfalk, K., Bill, R.M., Conner, A.C., Conner, M.T., Toernroth-Horsefield, S. Descr...

New page

'''Unreleased structure'''

The entry 5dye is ON HOLD

Authors: Kitchen, P., Oeberg, F., Sjoehamn, J., Hedfalk, K., Bill, R.M., Conner, A.C., Conner, M.T., Toernroth-Horsefield, S.

Description: CRYSTAL STRUCTURE OF THE FULL LENGTH S156E MUTANT OF HUMAN AQUAPORIN 5
[[Category: Unreleased Structures]]
[[Category: Conner, A.C]]
[[Category: Bill, R.M]]
[[Category: Kitchen, P]]
[[Category: Oeberg, F]]
[[Category: Toernroth-Horsefield, S]]
[[Category: Hedfalk, K]]
[[Category: Conner, M.T]]
[[Category: Sjoehamn, J]]