5e0r - Revision history

OCA at 22:08, 28 June 2023

OCA — Wed, 28 Jun 2023 22:08:51 GMT

←Older revision		Revision as of 22:08, 28 June 2023
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	<StructureSection load='5e0r' size='340' side='right'caption='[[5e0r]], [[Resolution\|resolution]] 1.35Å' scene=''>		<StructureSection load='5e0r' size='340' side='right'caption='[[5e0r]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5e0r]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E0R OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5E0R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5e0r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E0R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E0R FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5J5:2-[(CHLOROACETYL)AMINO]-5-[(E)-(4-SULFOPHENYL)DIAZENYL]BENZENESULFONIC+ACID'>5J5</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.352Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5J5:2-[(CHLOROACETYL)AMINO]-5-[(E)-(4-SULFOPHENYL)DIAZENYL]BENZENESULFONIC+ACID'>5J5</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5e0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e0r OCA], [~~http~~://pdbe.org/5e0r PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5e0r RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5e0r PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5e0r ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e0r OCA], [https://pdbe.org/5e0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e0r RCSB], [https://www.ebi.ac.uk/pdbsum/5e0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e0r ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>	+	[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).	+	[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

	==See Also==		==See Also==
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Caflisch, A]]	+	[[Category: Caflisch A]]
-	[[Category: Dong, J]]	+	[[Category: Dong J]]
-	~~[[Category: Transcription-transcription inhibitor complex~~]]	+

OCA at 08:16, 15 April 2020

OCA — Wed, 15 Apr 2020 08:16:45 GMT

←Older revision		Revision as of 08:16, 15 April 2020
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	==Crystal Structure of the first bromodomain of BRD4 in complex with AYC==		==Crystal Structure of the first bromodomain of BRD4 in complex with AYC==
-	<StructureSection load='5e0r' size='340' side='right' caption='[[5e0r]], [[Resolution\|resolution]] 1.35Å' scene=''>	+	<StructureSection load='5e0r' size='340' side='right'caption='[[5e0r]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5e0r]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E0R OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5E0R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5e0r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E0R OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5E0R FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5J5:2-[(CHLOROACETYL)AMINO]-5-[(E)-(4-SULFOPHENYL)DIAZENYL]BENZENESULFONIC+ACID'>5J5</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5J5:2-[(CHLOROACETYL)AMINO]-5-[(E)-(4-SULFOPHENYL)DIAZENYL]BENZENESULFONIC+ACID'>5J5</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5e0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e0r OCA], [http://pdbe.org/5e0r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e0r RCSB], [http://www.ebi.ac.uk/pdbsum/5e0r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e0r ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5e0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e0r OCA], [http://pdbe.org/5e0r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e0r RCSB], [http://www.ebi.ac.uk/pdbsum/5e0r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e0r ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 11:		Line 12:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).		[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
		+
		+	==See Also==
		+	*[[Bromodomain-containing protein 3D structures\|Bromodomain-containing protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Caflisch, A]]		[[Category: Caflisch, A]]
	[[Category: Dong, J]]		[[Category: Dong, J]]
	[[Category: Transcription-transcription inhibitor complex]]		[[Category: Transcription-transcription inhibitor complex]]

OCA at 17:37, 19 October 2016

OCA — Wed, 19 Oct 2016 17:37:13 GMT

←Older revision		Revision as of 17:37, 19 October 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5e0r is ~~ON HOLD until Sep 29 2017~~	+	==Crystal Structure of the first bromodomain of BRD4 in complex with AYC==
-		+	<StructureSection load='5e0r' size='340' side='right' caption='[[5e0r]], [[Resolution\|resolution]] 1.35Å' scene=''>
-	~~Authors~~: ~~Dong~~, J., ~~Caflisch~~, A.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5e0r]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E0R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E0R FirstGlance]. <br>
-	~~Description~~: ~~Crystal Structure of the first bromodomain of~~ BRD4 in ~~complex~~ with ~~AYC~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5J5:2-[(CHLOROACETYL)AMINO]-5-[(E)-(4-SULFOPHENYL)DIAZENYL]BENZENESULFONIC+ACID'>5J5</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e0r OCA], [http://pdbe.org/5e0r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e0r RCSB], [http://www.ebi.ac.uk/pdbsum/5e0r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e0r ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Caflisch, A]]
	[[Category: Dong, J]]		[[Category: Dong, J]]
-	[[Category: ~~Caflisch, A~~]]	+	[[Category: Transcription-transcription inhibitor complex]]

OCA: Protected "5e0r" [edit=sysop:move=sysop]

OCA — Wed, 07 Oct 2015 12:48:08 GMT

Protected "5e0r" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:48, 7 October 2015

OCA: New page: '''Unreleased structure''' The entry 5e0r is ON HOLD until Sep 29 2017 Authors: Dong, J., Caflisch, A. Description: Crystal Structure of the first bromodomain of BRD4 in complex with A...

OCA — Wed, 07 Oct 2015 12:48:07 GMT

New page: '''Unreleased structure''' The entry 5e0r is ON HOLD until Sep 29 2017 Authors: Dong, J., Caflisch, A. Description: Crystal Structure of the first bromodomain of BRD4 in complex with A...

New page

'''Unreleased structure'''

The entry 5e0r is ON HOLD until Sep 29 2017

Authors: Dong, J., Caflisch, A.

Description: Crystal Structure of the first bromodomain of BRD4 in complex with AYC
[[Category: Unreleased Structures]]
[[Category: Dong, J]]
[[Category: Caflisch, A]]