5e3b - Revision history

OCA at 06:11, 5 July 2023

OCA — Wed, 05 Jul 2023 06:11:34 GMT

←Older revision		Revision as of 06:11, 5 July 2023
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	<StructureSection load='5e3b' size='340' side='right'caption='[[5e3b]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='5e3b' size='340' side='right'caption='[[5e3b]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5e3b]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Strco Strco~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E3B OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5E3B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5e3b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_coelicolor_A3(2) Streptomyces coelicolor A3(2)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E3B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E3B FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=EDO:1,2~~-~~ETHANEDIOL'>EDO</scene>~~, ~~<scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~SCO6735 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=100226 STRCO])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5e3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e3b OCA], [~~http~~://pdbe.org/5e3b PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5e3b RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5e3b PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5e3b ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e3b OCA], [https://pdbe.org/5e3b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e3b RCSB], [https://www.ebi.ac.uk/pdbsum/5e3b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e3b ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9X7P1_STRCO Q9X7P1_STRCO]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Strco]]~~	+	[[Category: Ahel I]]
-	[[Category: Ahel, I]]	+	[[Category: Ahel M]]
-	[[Category: Ahel, M]]	+	[[Category: Bucca G]]
-	[[Category: Bucca, G]]	+	[[Category: Cetkovic H]]
-	[[Category: Cetkovic, H]]	+	[[Category: Imesek M]]
-	[[Category: Imesek, M]]	+	[[Category: Lalic J]]
-	[[Category: Lalic, J]]	+	[[Category: Luic M]]
-	[[Category: Luic, M]]	+	[[Category: Mikoc A]]
-	~~[[Category: Marjanovic, M Posavec~~]]	+	[[Category: Perina D]]
-	[[Category: Mikoc, A]]	+	[[Category: Plese B]]
-	[[Category: Perina, D]]	+	[[Category: Posavec Marjanovic M]]
-	[[Category: Plese, B]]	+	[[Category: Sabljic I]]
-	[[Category: ~~Sabljic, I~~]]	+	[[Category: Zaja R]]
-	[[Category: ~~Zaja, R~~]]	+
-	[[Category: ~~Hydrolase]]~~	+
-	~~[[Category: Macrodomain protein~~]]	+

OCA at 06:42, 22 April 2020

OCA — Wed, 22 Apr 2020 06:42:16 GMT

←Older revision		Revision as of 06:42, 22 April 2020
Line 1:		Line 1:

	==Structure of macrodomain protein from Streptomyces coelicolor==		==Structure of macrodomain protein from Streptomyces coelicolor==
-	<StructureSection load='5e3b' size='340' side='right' caption='[[5e3b]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='5e3b' size='340' side='right'caption='[[5e3b]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5e3b]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E3B OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5E3B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5e3b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strco Strco]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E3B OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5E3B FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5e3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e3b OCA], [http://pdbe.org/5e3b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e3b RCSB], [http://www.ebi.ac.uk/pdbsum/5e3b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e3b ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCO6735 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=100226 STRCO])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5e3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e3b OCA], [http://pdbe.org/5e3b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e3b RCSB], [http://www.ebi.ac.uk/pdbsum/5e3b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e3b ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Strco]]
	[[Category: Ahel, I]]		[[Category: Ahel, I]]
	[[Category: Ahel, M]]		[[Category: Ahel, M]]

OCA at 16:49, 3 October 2016

OCA — Mon, 03 Oct 2016 16:49:34 GMT

←Older revision		Revision as of 16:49, 3 October 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5e3b is ~~ON HOLD until Paper~~ Publication	+	==Structure of macrodomain protein from Streptomyces coelicolor==
		+	<StructureSection load='5e3b' size='340' side='right' caption='[[5e3b]], [[Resolution\|resolution]] 1.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5e3b]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E3B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E3B FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e3b OCA], [http://pdbe.org/5e3b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e3b RCSB], [http://www.ebi.ac.uk/pdbsum/5e3b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e3b ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	ADP-ribosylation is a post-translational modification that can alter the physical and chemical properties of target proteins and controls many important cellular processes. Macrodomains are evolutionarily conserved structural domains that bind ADP-ribose derivatives and are found in proteins with diverse cellular functions. Some proteins from the macrodomain family can hydrolyze ADP-ribosylated substrates and therefore reverse this post-translational modification. Bacteria and Streptomyces, in particular, are known to utilize protein ADP-ribosylation, yet very little is known about their enzymes that synthesise and remove this modification. We have determined the crystal structure and characterized, both biochemically and functionally, the macrodomain protein SCO6735 from Streptomyces coelicolor. This protein is a member of an uncharacterised subfamily of macrodomain proteins. Its crystal structure revealed a highly conserved macrodomain fold. We showed that SCO6735 possesses the ability to hydrolyse PARP-dependent protein ADP-ribosylation. Furthermore, we showed that expression of this protein is induced upon DNA damage and that deletion of this protein in S. coelicolor increases antibiotic production. Our results provide the first insights into the molecular basis of its action and impact on Streptomyces metabolism.

-	~~Authors:~~ Lalic, J., Posavec Marjanovic, M., Perina, D., Sabljic, I., Zaja, R., Plese, B., ~~Imesek~~, M., Bucca, G., Ahel, M., Cetkovic, H., Luic, M., Mikoc, A., Ahel, I.	+	Disruption of macrodomain protein SCO6735 increases antibiotic production in Streptomyces coelicolor.,Lalic J, Posavec Marjanovic M, Palazzo L, Perina D, Sabljic I, Zaja R, Colby T, Plese B, Halasz M, Jankevicius G, Bucca G, Ahel M, Matic I, Cetkovic H, Luic M, Mikoc A, Ahel I J Biol Chem. 2016 Sep 15. pii: jbc.M116.721894. PMID:27634042<ref>PMID:27634042</ref>

-	~~Description: Structure~~ of ~~macrodomain protein from Streptomyces coelicolor~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Plese, B]]~~	+	<div class="pdbe-citations 5e3b" style="background-color:#fffaf0;"></div>
-	~~[[Category: Zaja, R]]~~	+	== References ==
-	~~[[Category: Luic, M]]~~	+	<references/>
-	~~[[Category: Lalic, J]]~~	+	__TOC__
-	~~[[Category: Imesek, M]]~~	+	</StructureSection>
-	~~[[Category: Ahel, M]]~~	+
	[[Category: Ahel, I]]		[[Category: Ahel, I]]
-	[[Category: ~~Mikoc, A]]~~	+	[[Category: Ahel, M]]
-	~~[[Category: Posavec Marjanovic~~, M]]	+
	[[Category: Bucca, G]]		[[Category: Bucca, G]]
		+	[[Category: Cetkovic, H]]
		+	[[Category: Imesek, M]]
		+	[[Category: Lalic, J]]
		+	[[Category: Luic, M]]
		+	[[Category: Marjanovic, M Posavec]]
		+	[[Category: Mikoc, A]]
	[[Category: Perina, D]]		[[Category: Perina, D]]
		+	[[Category: Plese, B]]
	[[Category: Sabljic, I]]		[[Category: Sabljic, I]]
-	[[Category: ~~Cetkovic~~, H]]	+	[[Category: Zaja, R]]
		+	[[Category: Hydrolase]]
		+	[[Category: Macrodomain protein]]

OCA at 11:36, 16 December 2015

OCA — Wed, 16 Dec 2015 11:36:29 GMT

←Older revision		Revision as of 11:36, 16 December 2015
Line 9:		Line 9:
	[[Category: Plese, B]]		[[Category: Plese, B]]
	[[Category: Zaja, R]]		[[Category: Zaja, R]]
-	[[Category: Lalic, J]]
-	[[Category: Ahel, M]]
	[[Category: Luic, M]]		[[Category: Luic, M]]
		+	[[Category: Lalic, J]]
	[[Category: Imesek, M]]		[[Category: Imesek, M]]
		+	[[Category: Ahel, M]]
	[[Category: Ahel, I]]		[[Category: Ahel, I]]
	[[Category: Mikoc, A]]		[[Category: Mikoc, A]]

OCA at 02:56, 16 October 2015

OCA — Fri, 16 Oct 2015 02:56:07 GMT

←Older revision		Revision as of 02:56, 16 October 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5e3b is ON HOLD	+	The entry 5e3b is ON HOLD until Paper Publication

	Authors: Lalic, J., Posavec Marjanovic, M., Perina, D., Sabljic, I., Zaja, R., Plese, B., Imesek, M., Bucca, G., Ahel, M., Cetkovic, H., Luic, M., Mikoc, A., Ahel, I.		Authors: Lalic, J., Posavec Marjanovic, M., Perina, D., Sabljic, I., Zaja, R., Plese, B., Imesek, M., Bucca, G., Ahel, M., Cetkovic, H., Luic, M., Mikoc, A., Ahel, I.

OCA: Protected "5e3b" [edit=sysop:move=sysop]

OCA — Wed, 07 Oct 2015 12:54:44 GMT

Protected "5e3b" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:54, 7 October 2015

OCA: New page: '''Unreleased structure''' The entry 5e3b is ON HOLD Authors: Lalic, J., Posavec Marjanovic, M., Perina, D., Sabljic, I., Zaja, R., Plese, B., Imesek, M., Bucca, G., Ahel, M., Cetkovic,...

OCA — Wed, 07 Oct 2015 12:54:43 GMT

New page: '''Unreleased structure''' The entry 5e3b is ON HOLD Authors: Lalic, J., Posavec Marjanovic, M., Perina, D., Sabljic, I., Zaja, R., Plese, B., Imesek, M., Bucca, G., Ahel, M., Cetkovic,...

New page

'''Unreleased structure'''

The entry 5e3b is ON HOLD

Authors: Lalic, J., Posavec Marjanovic, M., Perina, D., Sabljic, I., Zaja, R., Plese, B., Imesek, M., Bucca, G., Ahel, M., Cetkovic, H., Luic, M., Mikoc, A., Ahel, I.

Description: Structure of macrodomain protein from Streptomyces coelicolor
[[Category: Unreleased Structures]]
[[Category: Plese, B]]
[[Category: Zaja, R]]
[[Category: Lalic, J]]
[[Category: Ahel, M]]
[[Category: Luic, M]]
[[Category: Imesek, M]]
[[Category: Ahel, I]]
[[Category: Mikoc, A]]
[[Category: Posavec Marjanovic, M]]
[[Category: Bucca, G]]
[[Category: Perina, D]]
[[Category: Sabljic, I]]
[[Category: Cetkovic, H]]