5e4l - Revision history

OCA at 06:12, 5 July 2023

OCA — Wed, 05 Jul 2023 06:12:44 GMT

←Older revision		Revision as of 06:12, 5 July 2023
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	<StructureSection load='5e4l' size='340' side='right'caption='[[5e4l]], [[Resolution\|resolution]] 2.44Å' scene=''>		<StructureSection load='5e4l' size='340' side='right'caption='[[5e4l]], [[Resolution\|resolution]] 2.44Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5e4l]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E4L OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5E4L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5e4l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E4L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E4L FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~, ~~<scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.44Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5e4k\|5e4k]]~~<~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">MRC2, CLEC13E, ENDO180, KIAA0709, UPARAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e4l OCA], [https://pdbe.org/5e4l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e4l RCSB], [https://www.ebi.ac.uk/pdbsum/5e4l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e4l ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5e4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e4l OCA], [~~http~~://pdbe.org/5e4l PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5e4l RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5e4l PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5e4l ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MRC2_HUMAN MRC2_HUMAN]] May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).<ref>PMID:10683150</ref> <ref>PMID:12972549</ref>	+	[https://www.uniprot.org/uniprot/MRC2_HUMAN MRC2_HUMAN] May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).<ref>PMID:10683150</ref> <ref>PMID:12972549</ref>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Huang, M]]	+	[[Category: Huang M]]
-	[[Category: Yuan, C]]	+	[[Category: Yuan C]]
-	~~[[Category: Endocytic collagen receptor]]~~	+
-	~~[[Category: Sugar binding protein~~]]	+

OCA at 06:43, 22 April 2020

OCA — Wed, 22 Apr 2020 06:43:46 GMT

←Older revision		Revision as of 06:43, 22 April 2020
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	==Structure of ligand binding region of uPARAP at pH 5.3==		==Structure of ligand binding region of uPARAP at pH 5.3==
-	<StructureSection load='5e4l' size='340' side='right' caption='[[5e4l]], [[Resolution\|resolution]] 2.44Å' scene=''>	+	<StructureSection load='5e4l' size='340' side='right'caption='[[5e4l]], [[Resolution\|resolution]] 2.44Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5e4l]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E4L OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5E4L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5e4l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E4L OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5E4L FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5e4k\|5e4k]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5e4k\|5e4k]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5e4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e4l OCA], [http://pdbe.org/5e4l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e4l RCSB], [http://www.ebi.ac.uk/pdbsum/5e4l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e4l ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MRC2, CLEC13E, ENDO180, KIAA0709, UPARAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5e4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e4l OCA], [http://pdbe.org/5e4l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e4l RCSB], [http://www.ebi.ac.uk/pdbsum/5e4l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e4l ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Huang, M]]		[[Category: Huang, M]]
	[[Category: Yuan, C]]		[[Category: Yuan, C]]
	[[Category: Endocytic collagen receptor]]		[[Category: Endocytic collagen receptor]]
	[[Category: Sugar binding protein]]		[[Category: Sugar binding protein]]

OCA at 17:37, 19 October 2016

OCA — Wed, 19 Oct 2016 17:37:34 GMT

←Older revision		Revision as of 17:37, 19 October 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 5e4l is ON HOLD until Paper Publication~~	+	==Structure of ligand binding region of uPARAP at pH 5.3==
-		+	<StructureSection load='5e4l' size='340' side='right' caption='[[5e4l]], [[Resolution\|resolution]] 2.44Å' scene=''>
-	~~Authors: Yuan, C., Huang, M.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5e4l]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E4L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E4L FirstGlance]. <br>
-	~~Description:~~ Structure of ligand binding region of uPARAP at pH 5.3	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5e4k\|5e4k]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e4l OCA], [http://pdbe.org/5e4l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e4l RCSB], [http://www.ebi.ac.uk/pdbsum/5e4l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e4l ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MRC2_HUMAN MRC2_HUMAN]] May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).<ref>PMID:10683150</ref> <ref>PMID:12972549</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Huang, M]]		[[Category: Huang, M]]
	[[Category: Yuan, C]]		[[Category: Yuan, C]]
		+	[[Category: Endocytic collagen receptor]]
		+	[[Category: Sugar binding protein]]

OCA at 13:10, 20 January 2016

OCA — Wed, 20 Jan 2016 13:10:28 GMT

←Older revision		Revision as of 13:10, 20 January 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5e4l is ON HOLD	+	The entry 5e4l is ON HOLD until Paper Publication

	Authors: Yuan, C., Huang, M.		Authors: Yuan, C., Huang, M.

OCA at 16:51, 13 January 2016

OCA — Wed, 13 Jan 2016 16:51:22 GMT

←Older revision		Revision as of 16:51, 13 January 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5e4l is ON HOLD ~~until Paper Publication~~	+	The entry 5e4l is ON HOLD

	Authors: Yuan, C., Huang, M.		Authors: Yuan, C., Huang, M.

OCA at 11:38, 16 December 2015

OCA — Wed, 16 Dec 2015 11:38:05 GMT

←Older revision		Revision as of 11:38, 16 December 2015
Line 7:		Line 7:
	Description: Structure of ligand binding region of uPARAP at pH 5.3		Description: Structure of ligand binding region of uPARAP at pH 5.3
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Yuan, C]]
	[[Category: Huang, M]]		[[Category: Huang, M]]
		+	[[Category: Yuan, C]]

OCA at 02:24, 1 December 2015

OCA — Tue, 01 Dec 2015 02:24:49 GMT

←Older revision		Revision as of 02:24, 1 December 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5e4l is ON HOLD	+	The entry 5e4l is ON HOLD until Paper Publication

	Authors: Yuan, C., Huang, M.		Authors: Yuan, C., Huang, M.

OCA: Protected "5e4l" [edit=sysop:move=sysop]

OCA — Fri, 16 Oct 2015 02:59:27 GMT

Protected "5e4l" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:59, 16 October 2015

OCA: New page: '''Unreleased structure''' The entry 5e4l is ON HOLD Authors: Yuan, C., Huang, M. Description: Structure of ligand binding region of uPARAP at pH 5.3 [[Category: Unreleased Structures]...

OCA — Fri, 16 Oct 2015 02:59:26 GMT

New page: '''Unreleased structure''' The entry 5e4l is ON HOLD Authors: Yuan, C., Huang, M. Description: Structure of ligand binding region of uPARAP at pH 5.3 [[Category: Unreleased Structures]...

New page

'''Unreleased structure'''

The entry 5e4l is ON HOLD

Authors: Yuan, C., Huang, M.

Description: Structure of ligand binding region of uPARAP at pH 5.3
[[Category: Unreleased Structures]]
[[Category: Yuan, C]]
[[Category: Huang, M]]