5e5u - Revision history

OCA at 06:14, 5 July 2023

OCA — Wed, 05 Jul 2023 06:14:05 GMT

←Older revision		Revision as of 06:14, 5 July 2023
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	<StructureSection load='5e5u' size='340' side='right'caption='[[5e5u]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='5e5u' size='340' side='right'caption='[[5e5u]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5e5u]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E5U OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5E5U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5e5u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E5U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E5U FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PS:3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE'>1PS</scene>, <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=MLT:D-MALATE'>MLT</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5e4q\|5e4q]], [[5e4i\|5e4i]], [[5e4s\|5e4s]], [[5e52\|5e52]], [[5e53\|5e53]], [[5e55\|5e55]], [[5e5r\|5e5r]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PS:3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE'>1PS</scene>, <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=MLT:D-MALATE'>MLT</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ptprg ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Cntn6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e5u OCA], [https://pdbe.org/5e5u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e5u RCSB], [https://www.ebi.ac.uk/pdbsum/5e5u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e5u ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5e5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e5u OCA], [~~http~~://pdbe.org/5e5u PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5e5u RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5e5u PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5e5u ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PTPRG_MOUSE PTPRG_MOUSE]] Possesses tyrosine phosphatase activity (By similarity). [[http://www.uniprot.org/uniprot/CNTN6_MOUSE CNTN6_MOUSE]] Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus (By similarity). Involved in motor coordination.<ref>PMID:12884264</ref>	+	[https://www.uniprot.org/uniprot/PTPRG_MOUSE PTPRG_MOUSE] Possesses tyrosine phosphatase activity (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
-	*[[Contactin\|Contactin]]	+	*[[Tyrosine phosphatase 3D structures\|Tyrosine phosphatase 3D structures]]
-	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]	+
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice]]~~	+	[[Category: Mus musculus]]
-	~~[[Category: Protein-tyrosine-phosphatase~~]]	+	[[Category: Bouyain S]]
-	[[Category: Bouyain, S]]	+	[[Category: Nikolaienko RM]]
-	[[Category: Nikolaienko~~, R M]]~~	+
-	~~[[Category: Carbonic anhydrase-like domain]]~~	+
-	~~[[Category: Cell adhesion-hydrolase complex]]~~	+
-	~~[[Category: Immunoglobulin domain]]~~	+
-	~~[[Category: Neural cell adhesion molecule]]~~	+
-	~~[[Category: Receptor-type protein tyrosine phosphatase~~]]	+

OCA at 11:30, 25 December 2019

OCA — Wed, 25 Dec 2019 11:30:48 GMT

←Older revision		Revision as of 11:30, 25 December 2019
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	==Crystal structure of the complex between Carbonic anhydrase-like domain of PTPRG and Immunoglobulin domains 2-3 of CNTN6==		==Crystal structure of the complex between Carbonic anhydrase-like domain of PTPRG and Immunoglobulin domains 2-3 of CNTN6==
-	<StructureSection load='5e5u' size='340' side='right' caption='[[5e5u]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='5e5u' size='340' side='right'caption='[[5e5u]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5e5u]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E5U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5e5u]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E5U FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PS:3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE'>1PS</scene>, <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=MLT:D-MALATE'>MLT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PS:3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE'>1PS</scene>, <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=MLT:D-MALATE'>MLT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5e4q\|5e4q]], [[5e4i\|5e4i]], [[5e4s\|5e4s]], [[5e52\|5e52]], [[5e53\|5e53]], [[5e55\|5e55]], [[5e5r\|5e5r]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5e4q\|5e4q]], [[5e4i\|5e4i]], [[5e4s\|5e4s]], [[5e52\|5e52]], [[5e53\|5e53]], [[5e55\|5e55]], [[5e5r\|5e5r]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ptprg ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Cntn6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e5u OCA], [http://pdbe.org/5e5u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e5u RCSB], [http://www.ebi.ac.uk/pdbsum/5e5u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e5u ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e5u OCA], [http://pdbe.org/5e5u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e5u RCSB], [http://www.ebi.ac.uk/pdbsum/5e5u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e5u ProSAT]</span></td></tr>
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	==See Also==		==See Also==
	*[[Contactin\|Contactin]]		*[[Contactin\|Contactin]]
		+	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]
	[[Category: Bouyain, S]]		[[Category: Bouyain, S]]

OCA at 12:36, 6 November 2017

OCA — Mon, 06 Nov 2017 12:36:42 GMT

←Older revision		Revision as of 12:36, 6 November 2017
Line 23:		Line 23:
	==See Also==		==See Also==
	*[[Contactin\|Contactin]]		*[[Contactin\|Contactin]]
-	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:57, 27 September 2017

OCA — Wed, 27 Sep 2017 09:57:06 GMT

←Older revision		Revision as of 09:57, 27 September 2017
Line 22:		Line 22:

	==See Also==		==See Also==
		+	*[[Contactin\|Contactin]]
	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]		*[[Tyrosine phosphatase\|Tyrosine phosphatase]]
	== References ==		== References ==

OCA at 11:04, 10 December 2016

OCA — Sat, 10 Dec 2016 11:04:34 GMT

←Older revision		Revision as of 11:04, 10 December 2016
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 5e5u" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5e5u" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:54, 10 September 2016

OCA — Sat, 10 Sep 2016 13:54:41 GMT

←Older revision		Revision as of 13:54, 10 September 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5e5u is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Crystal structure of the complex between Carbonic anhydrase-like domain of PTPRG and Immunoglobulin domains 2-3 of CNTN6==
		+	<StructureSection load='5e5u' size='340' side='right' caption='[[5e5u]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5e5u]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E5U FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PS:3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE'>1PS</scene>, <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=MLT:D-MALATE'>MLT</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5e4q\|5e4q]], [[5e4i\|5e4i]], [[5e4s\|5e4s]], [[5e52\|5e52]], [[5e53\|5e53]], [[5e55\|5e55]], [[5e5r\|5e5r]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e5u OCA], [http://pdbe.org/5e5u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e5u RCSB], [http://www.ebi.ac.uk/pdbsum/5e5u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e5u ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PTPRG_MOUSE PTPRG_MOUSE]] Possesses tyrosine phosphatase activity (By similarity). [[http://www.uniprot.org/uniprot/CNTN6_MOUSE CNTN6_MOUSE]] Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus (By similarity). Involved in motor coordination.<ref>PMID:12884264</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Protein tyrosine phosphatase receptor type G (RPTPgamma/PTPRG) interacts in vitro with contactin-3-6 (CNTN3-6), a group of glycosylphosphatidyl-anchored cell adhesion molecules involved in the wiring of the nervous system. In addition to PTPRG, CNTNs associate with multiple transmembrane proteins and signal inside the cell via cis-binding partners to alleviate the absence of an intracellular region. Here, we use comprehensive biochemical and structural analyses to demonstrate that PTPRG[middot]CNTN3-6 complexes share similar binding affinities and a conserved arrangement. Furthermore, as a first step to identifying PTPRG.CNTN complexes in vivo, we found that PTPRG and CNTN3 associate in the outer segments of mouse rod photoreceptor cells. In particular, PTPRG and CNTN3 form cis-complexes at the surface of photoreceptors, yet interact in trans when expressed on the surfaces of apposing cells. Further structural analyses suggest that all CNTN ectodomains adopt a bent conformation and might lie parallel to the cell surface to accommodate these cis and trans binding modes. Taken together, these studies identify a PTPRG.CNTN complex in vivo and provide novel insights into PTPRG- and CNTN- mediated signaling.

-	~~Authors:~~ Nikolaienko, R.M., ~~Bouyain~~, S.	+	Structural Basis for Interactions Between Contactin Family Members and Protein Tyrosine Phosphatase Receptor Type G in Neural Tissues.,Nikolaienko RM, Hammel M, Dubreuil V, Zalmai R, Hall DR, Mehzabeen N, Karuppan SJ, Harroch S, Stella SL, Bouyain S J Biol Chem. 2016 Aug 18. pii: jbc.M116.742163. PMID:27539848<ref>PMID:27539848</ref>

-	~~Description: Crystal structure~~ of the ~~complex between Carbonic anhydrase-like domain~~ of ~~PTPRG and Immunoglobulin domains 2-3 of CNTN6~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	[[Category: ~~Nikolaienko, R.M~~]]	+	<div class="pdbe-citations 5e5u" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Protein-tyrosine-phosphatase]]
	[[Category: Bouyain, S]]		[[Category: Bouyain, S]]
		+	[[Category: Nikolaienko, R M]]
		+	[[Category: Carbonic anhydrase-like domain]]
		+	[[Category: Cell adhesion-hydrolase complex]]
		+	[[Category: Immunoglobulin domain]]
		+	[[Category: Neural cell adhesion molecule]]
		+	[[Category: Receptor-type protein tyrosine phosphatase]]

OCA at 04:23, 22 October 2015

OCA — Thu, 22 Oct 2015 04:23:10 GMT

←Older revision		Revision as of 04:23, 22 October 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5e5u is ON HOLD	+	The entry 5e5u is ON HOLD until Paper Publication

-	Authors: Nikolaienko R.M., Bouyain S.	+	Authors: Nikolaienko, R.M., Bouyain, S.

	Description: Crystal structure of the complex between Carbonic anhydrase-like domain of PTPRG and Immunoglobulin domains 2-3 of CNTN6		Description: Crystal structure of the complex between Carbonic anhydrase-like domain of PTPRG and Immunoglobulin domains 2-3 of CNTN6
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Bouyain S~~]]	+	[[Category: Nikolaienko, R.M]]
-	[[Category: ~~Nikolaienko R.M~~]]	+	[[Category: Bouyain, S]]

OCA: Protected "5e5u" [edit=sysop:move=sysop]

OCA — Fri, 16 Oct 2015 03:03:11 GMT

Protected "5e5u" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:03, 16 October 2015

OCA: New page: '''Unreleased structure''' The entry 5e5u is ON HOLD Authors: Nikolaienko R.M., Bouyain S. Description: Crystal structure of the complex between Carbonic anhydrase-like domain of PTPRG...

OCA — Fri, 16 Oct 2015 03:03:09 GMT

New page: '''Unreleased structure''' The entry 5e5u is ON HOLD Authors: Nikolaienko R.M., Bouyain S. Description: Crystal structure of the complex between Carbonic anhydrase-like domain of PTPRG...

New page

'''Unreleased structure'''

The entry 5e5u is ON HOLD

Authors: Nikolaienko R.M., Bouyain S.

Description: Crystal structure of the complex between Carbonic anhydrase-like domain of PTPRG and Immunoglobulin domains 2-3 of CNTN6
[[Category: Unreleased Structures]]
[[Category: Bouyain S]]
[[Category: Nikolaienko R.M]]