5ecc - Revision history

OCA at 12:28, 6 March 2024

OCA — Wed, 06 Mar 2024 12:28:03 GMT

←Older revision		Revision as of 12:28, 6 March 2024
Line 10:		Line 10:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/A4GRC7_KLEPN A4GRC7_KLEPN]		[https://www.uniprot.org/uniprot/A4GRC7_KLEPN A4GRC7_KLEPN]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Multidrug-resistant Enterobacteriaceae, notably Escherichia coli and Klebsiella pneumoniae, have become major health concerns worldwide. Resistance to effective therapeutics is often carried by class I and II integrons that can confer insensitivity to carbapenems, extended spectrum beta-lactamases, the antifolate trimethoprim, fluoroquinolones, and aminoglycosides. Specifically of interest to the study here, a prevalent gene (dfrA1) coding for an insensitive dihydrofolate reductase (DHFR) confers 190- or 1000-fold resistance to trimethoprim for K. pneumoniae and E. coli, respectively. Attaining inhibition of both the wild-type and resistant forms of the enzyme is critical for new antifolates. For several years, we have been developing the propargyl-linked antifolates (PLAs) as effective inhibitors against trimethoprim-resistant DHFR enzymes. Here, we show that the PLAs are active against both the wild-type and DfrA1 DHFR proteins. We report two high-resolution crystal structures of DfrA1 bound to potent PLAs. The structure-activity relationships and crystal structures will be critical in driving the design of broadly active inhibitors against wild-type and resistant DHFR.
-
-	Crystal Structures of Trimethoprim-Resistant DfrA1 Rationalize Potent Inhibition by Propargyl-Linked Antifolates.,Lombardo MN, G-Dayanandan N, Wright DL, Anderson AC ACS Infect Dis. 2016 Feb 12;2(2):149-56. doi: 10.1021/acsinfecdis.5b00129. Epub, 2016 Jan 4. PMID:27624966<ref>PMID:27624966</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 5ecc" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Dihydrofolate reductase 3D structures\|Dihydrofolate reductase 3D structures]]		*[[Dihydrofolate reductase 3D structures\|Dihydrofolate reductase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:21, 5 July 2023

OCA — Wed, 05 Jul 2023 06:21:07 GMT

←Older revision		Revision as of 06:21, 5 July 2023
Line 3:		Line 3:
	<StructureSection load='5ecc' size='340' side='right'caption='[[5ecc]], [[Resolution\|resolution]] 1.87Å' scene=''>		<StructureSection load='5ecc' size='340' side='right'caption='[[5ecc]], [[Resolution\|resolution]] 1.87Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ecc]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus~~ pneumoniae~~" (schroeter 1886) flugge 1886~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ECC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ECC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ecc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ECC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ECC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6DR:6-ETHYL-5-{3-[2-METHOXY-5-(PYRIDIN-4-YL)PHENYL]PROP-1-YN-1-YL}PYRIMIDINE-2,4-DIAMINE'>6DR</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.87Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ecx\|5ecx]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6DR:6-ETHYL-5-{3-[2-METHOXY-5-(PYRIDIN-4-YL)PHENYL]PROP-1-YN-1-YL}PYRIMIDINE-2,4-DIAMINE'>6DR</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dfrA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ecc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ecc OCA], [https://pdbe.org/5ecc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ecc RCSB], [https://www.ebi.ac.uk/pdbsum/5ecc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ecc ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ecc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ecc OCA], [~~http~~://pdbe.org/5ecc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ecc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ecc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ecc ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A4GRC7_KLEPN A4GRC7_KLEPN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Klebsiella pneumoniae]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Anderson~~, A C~~]]	+	[[Category: Anderson AC]]
-	[[Category: Lombardo~~, M N]]~~	+	[[Category: Lombardo MN]]
-	~~[[Category: Antifolate]]~~	+
-	~~[[Category: Dfra1]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]~~	+
-	~~[[Category: Plasmid borne resistance~~]]	+

OCA at 16:06, 11 December 2019

OCA — Wed, 11 Dec 2019 16:06:21 GMT

←Older revision		Revision as of 16:06, 11 December 2019
Line 1:		Line 1:

	==Klebsiella pneumoniae DfrA1 complexed with NADPH and 6-ethyl-5-(3-(2-methoxy-5-(pyridin-4-yl)phenyl)prop-1-yn-1-yl)pyrimidine-2,4-diamine==		==Klebsiella pneumoniae DfrA1 complexed with NADPH and 6-ethyl-5-(3-(2-methoxy-5-(pyridin-4-yl)phenyl)prop-1-yn-1-yl)pyrimidine-2,4-diamine==
-	<StructureSection load='5ecc' size='340' side='right' caption='[[5ecc]], [[Resolution\|resolution]] 1.87Å' scene=''>	+	<StructureSection load='5ecc' size='340' side='right'caption='[[5ecc]], [[Resolution\|resolution]] 1.87Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5ecc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ECC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ECC FirstGlance]. <br>		<table><tr><td colspan='2'>[[5ecc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ECC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ECC FirstGlance]. <br>
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]	+	*[[Dihydrofolate reductase 3D structures\|Dihydrofolate reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Anderson, A C]]		[[Category: Anderson, A C]]
	[[Category: Lombardo, M N]]		[[Category: Lombardo, M N]]

OCA at 06:19, 18 April 2018

OCA — Wed, 18 Apr 2018 06:19:26 GMT

←Older revision		Revision as of 06:19, 18 April 2018
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ecc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ecc OCA], [http://pdbe.org/5ecc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ecc RCSB], [http://www.ebi.ac.uk/pdbsum/5ecc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ecc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ecc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ecc OCA], [http://pdbe.org/5ecc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ecc RCSB], [http://www.ebi.ac.uk/pdbsum/5ecc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ecc ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Multidrug-resistant Enterobacteriaceae, notably Escherichia coli and Klebsiella pneumoniae, have become major health concerns worldwide. Resistance to effective therapeutics is often carried by class I and II integrons that can confer insensitivity to carbapenems, extended spectrum beta-lactamases, the antifolate trimethoprim, fluoroquinolones, and aminoglycosides. Specifically of interest to the study here, a prevalent gene (dfrA1) coding for an insensitive dihydrofolate reductase (DHFR) confers 190- or 1000-fold resistance to trimethoprim for K. pneumoniae and E. coli, respectively. Attaining inhibition of both the wild-type and resistant forms of the enzyme is critical for new antifolates. For several years, we have been developing the propargyl-linked antifolates (PLAs) as effective inhibitors against trimethoprim-resistant DHFR enzymes. Here, we show that the PLAs are active against both the wild-type and DfrA1 DHFR proteins. We report two high-resolution crystal structures of DfrA1 bound to potent PLAs. The structure-activity relationships and crystal structures will be critical in driving the design of broadly active inhibitors against wild-type and resistant DHFR.
		+
		+	Crystal Structures of Trimethoprim-Resistant DfrA1 Rationalize Potent Inhibition by Propargyl-Linked Antifolates.,Lombardo MN, G-Dayanandan N, Wright DL, Anderson AC ACS Infect Dis. 2016 Feb 12;2(2):149-56. doi: 10.1021/acsinfecdis.5b00129. Epub, 2016 Jan 4. PMID:27624966<ref>PMID:27624966</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5ecc" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 12:37, 6 November 2017

OCA — Mon, 06 Nov 2017 12:37:49 GMT

←Older revision		Revision as of 12:37, 6 November 2017
Line 3:		Line 3:
	<StructureSection load='5ecc' size='340' side='right' caption='[[5ecc]], [[Resolution\|resolution]] 1.87Å' scene=''>		<StructureSection load='5ecc' size='340' side='right' caption='[[5ecc]], [[Resolution\|resolution]] 1.87Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ecc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ECC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ECC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ecc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ECC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ECC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6DR:6-ETHYL-5-{3-[2-METHOXY-5-(PYRIDIN-4-YL)PHENYL]PROP-1-YN-1-YL}PYRIMIDINE-2,4-DIAMINE'>6DR</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6DR:6-ETHYL-5-{3-[2-METHOXY-5-(PYRIDIN-4-YL)PHENYL]PROP-1-YN-1-YL}PYRIMIDINE-2,4-DIAMINE'>6DR</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ecx\|5ecx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ecx\|5ecx]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ecc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ecc OCA], [http://pdbe.org/5ecc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ecc RCSB], [http://www.ebi.ac.uk/pdbsum/5ecc PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dfrA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ecc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ecc OCA], [http://pdbe.org/5ecc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ecc RCSB], [http://www.ebi.ac.uk/pdbsum/5ecc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ecc ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 15:51, 1 June 2016

OCA — Wed, 01 Jun 2016 15:51:43 GMT

←Older revision		Revision as of 15:51, 1 June 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 5ecc is ON HOLD until Paper Publication~~	+	==Klebsiella pneumoniae DfrA1 complexed with NADPH and 6-ethyl-5-(3-(2-methoxy-5-(pyridin-4-yl)phenyl)prop-1-yn-1-yl)pyrimidine-2,4-diamine==
-		+	<StructureSection load='5ecc' size='340' side='right' caption='[[5ecc]], [[Resolution\|resolution]] 1.87Å' scene=''>
-	~~Authors: Lombardo, M.N., Anderson, A.C.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5ecc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ECC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ECC FirstGlance]. <br>
-	~~Description:~~ Klebsiella pneumoniae DfrA1 complexed with NADPH and 6-ethyl-5-(3-(2-methoxy-5-(pyridin-4-yl)phenyl)prop-1-yn-1-yl)pyrimidine-2,4-diamine	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6DR:6-ETHYL-5-{3-[2-METHOXY-5-(PYRIDIN-4-YL)PHENYL]PROP-1-YN-1-YL}PYRIMIDINE-2,4-DIAMINE'>6DR</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ecx\|5ecx]]</td></tr>
-	[[Category: Anderson, A.C]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ecc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ecc OCA], [http://pdbe.org/5ecc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ecc RCSB], [http://www.ebi.ac.uk/pdbsum/5ecc PDBsum]</span></td></tr>
-	[[Category: Lombardo, M.N]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Anderson, A C]]
		+	[[Category: Lombardo, M N]]
		+	[[Category: Antifolate]]
		+	[[Category: Dfra1]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
		+	[[Category: Plasmid borne resistance]]

OCA at 14:32, 2 December 2015

OCA — Wed, 02 Dec 2015 14:32:19 GMT

←Older revision		Revision as of 14:32, 2 December 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5ecc is ON HOLD	+	The entry 5ecc is ON HOLD until Paper Publication

	Authors: Lombardo, M.N., Anderson, A.C.		Authors: Lombardo, M.N., Anderson, A.C.

OCA: Protected "5ecc" [edit=sysop:move=sysop]

OCA — Tue, 01 Dec 2015 02:38:27 GMT

Protected "5ecc" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:38, 1 December 2015

OCA: New page: '''Unreleased structure''' The entry 5ecc is ON HOLD Authors: Lombardo, M.N., Anderson, A.C. Description: Klebsiella pneumoniae DfrA1 complexed with NADPH and 6-ethyl-5-(3-(2-methoxy-5...

OCA — Tue, 01 Dec 2015 02:38:26 GMT

New page: '''Unreleased structure''' The entry 5ecc is ON HOLD Authors: Lombardo, M.N., Anderson, A.C. Description: Klebsiella pneumoniae DfrA1 complexed with NADPH and 6-ethyl-5-(3-(2-methoxy-5...

New page

'''Unreleased structure'''

The entry 5ecc is ON HOLD

Authors: Lombardo, M.N., Anderson, A.C.

Description: Klebsiella pneumoniae DfrA1 complexed with NADPH and 6-ethyl-5-(3-(2-methoxy-5-(pyridin-4-yl)phenyl)prop-1-yn-1-yl)pyrimidine-2,4-diamine
[[Category: Unreleased Structures]]
[[Category: Anderson, A.C]]
[[Category: Lombardo, M.N]]