5ejy - Revision history

OCA at 06:31, 5 July 2023

OCA — Wed, 05 Jul 2023 06:31:19 GMT

←Older revision		Revision as of 06:31, 5 July 2023
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	<StructureSection load='5ejy' size='340' side='right'caption='[[5ejy]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='5ejy' size='340' side='right'caption='[[5ejy]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ejy]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Dicdi Dicdi~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EJY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5EJY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ejy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EJY FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=15P:POLYETHYLENE+GLYCOL+(N=34)'>15P</scene>~~, ~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~myoI, DDB_G0274455 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id~~=~~44689 DICDI]~~)</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=15P:POLYETHYLENE+GLYCOL+(N=34)'>15P</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5ejy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ejy OCA], [~~http~~://pdbe.org/5ejy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ejy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ejy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ejy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ejy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ejy OCA], [https://pdbe.org/5ejy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ejy RCSB], [https://www.ebi.ac.uk/pdbsum/5ejy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ejy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MYOI_DICDI MYOI_DICDI]] Myosins are actin-based motor molecules with ATPase activity. Involved in the early steps of phagocytosis and adhesion.<ref>PMID:10574761</ref> <ref>PMID:11267868</ref> <ref>PMID:15826949</ref>	+	[https://www.uniprot.org/uniprot/MYOI_DICDI MYOI_DICDI] Myosins are actin-based motor molecules with ATPase activity. Involved in the early steps of phagocytosis and adhesion.<ref>PMID:10574761</ref> <ref>PMID:11267868</ref> <ref>PMID:15826949</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Dicdi~~]]	+	[[Category: Dictyostelium discoideum]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Houdusse, A]]	+	[[Category: Houdusse A]]
-	[[Category: Sirigu, S]]	+	[[Category: Sirigu S]]
-	[[Category: Titus~~, M A]]~~	+	[[Category: Titus MA]]
-	~~[[Category: Molecular motor]]~~	+
-	~~[[Category: Motor protein]]~~	+
-	~~[[Category: Myosin]]~~	+
-	~~[[Category: Myosin tail]]~~	+
-	~~[[Category: Myth4-ferm~~]]	+

OCA at 07:02, 22 April 2020

OCA — Wed, 22 Apr 2020 07:02:08 GMT

←Older revision		Revision as of 07:02, 22 April 2020
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	==Structure of Dictyostelium Discoideum Myosin VII MyTH4-FERM MF1 domain==		==Structure of Dictyostelium Discoideum Myosin VII MyTH4-FERM MF1 domain==
-	<StructureSection load='5ejy' size='340' side='right' caption='[[5ejy]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='5ejy' size='340' side='right'caption='[[5ejy]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ejy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EJY OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5EJY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ejy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dicdi Dicdi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EJY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5EJY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=15P:POLYETHYLENE+GLYCOL+(N=34)'>15P</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=15P:POLYETHYLENE+GLYCOL+(N=34)'>15P</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ejy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ejy OCA], [http://pdbe.org/5ejy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ejy RCSB], [http://www.ebi.ac.uk/pdbsum/5ejy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ejy ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">myoI, DDB_G0274455 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=44689 DICDI])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ejy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ejy OCA], [http://pdbe.org/5ejy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ejy RCSB], [http://www.ebi.ac.uk/pdbsum/5ejy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ejy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5ejy" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5ejy" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Myosin 3D Structures\|Myosin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Dicdi]]
		+	[[Category: Large Structures]]
	[[Category: Houdusse, A]]		[[Category: Houdusse, A]]
	[[Category: Sirigu, S]]		[[Category: Sirigu, S]]

OCA at 02:20, 13 July 2016

OCA — Wed, 13 Jul 2016 02:20:05 GMT

←Older revision		Revision as of 02:20, 13 July 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5ejy is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Structure of Dictyostelium Discoideum Myosin VII MyTH4-FERM MF1 domain==
		+	<StructureSection load='5ejy' size='340' side='right' caption='[[5ejy]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5ejy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EJY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EJY FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=15P:POLYETHYLENE+GLYCOL+(N=34)'>15P</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ejy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ejy OCA], [http://pdbe.org/5ejy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ejy RCSB], [http://www.ebi.ac.uk/pdbsum/5ejy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ejy ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MYOI_DICDI MYOI_DICDI]] Myosins are actin-based motor molecules with ATPase activity. Involved in the early steps of phagocytosis and adhesion.<ref>PMID:10574761</ref> <ref>PMID:11267868</ref> <ref>PMID:15826949</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Myosins containing MyTH4-FERM (myosin tail homology 4-band 4.1, ezrin, radixin, moesin, or MF) domains in their tails are found in a wide range of phylogenetically divergent organisms, such as humans and the social amoeba Dictyostelium (Dd). Interestingly, evolutionarily distant MF myosins have similar roles in the extension of actin-filled membrane protrusions such as filopodia and bind to microtubules (MT), suggesting that the core functions of these MF myosins have been highly conserved over evolution. The structures of two DdMyo7 signature MF domains have been determined and comparison with mammalian MF structures reveals that characteristic features of MF domains are conserved. However, across millions of years of evolution conserved class-specific insertions are seen to alter the surfaces and the orientation of subdomains with respect to each other, likely resulting in new sites for binding partners. The MyTH4 domains of Myo10 and DdMyo7 bind to MT with micromolar affinity but, surprisingly, their MT binding sites are on opposite surfaces of the MyTH4 domain. The structural analysis in combination with comparison of diverse MF myosin sequences provides evidence that myosin tail domain features can be maintained without strict conservation of motifs. The results illustrate how tuning of existing features can give rise to new structures while preserving the general properties necessary for myosin tails. Thus, tinkering with the MF domain enables it to serve as a multifunctional platform for cooperative recruitment of various partners, allowing common properties such as autoinhibition of the motor and microtubule binding to arise through convergent evolution.

-	~~Authors: Sirigu~~, S., ~~Titus~~, M~~.A.~~, Houdusse, A.	+	Myosin MyTH4-FERM structures highlight important principles of convergent evolution.,Planelles-Herrero VJ, Blanc F, Sirigu S, Sirkia H, Clause J, Sourigues Y, Johnsrud DO, Amigues B, Cecchini M, Gilbert SP, Houdusse A, Titus MA Proc Natl Acad Sci U S A. 2016 May 24;113(21):E2906-15. doi:, 10.1073/pnas.1600736113. Epub 2016 May 10. PMID:27166421<ref>PMID:27166421</ref>

-	~~Description: Structure~~ of ~~Dictyostelium Discoideum Myosin VII MyTH4-FERM MF1 domain~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Sirigu, S]]~~	+	<div class="pdbe-citations 5ejy" style="background-color:#fffaf0;"></div>
-	~~[[Category: Titus, M.A]]~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Houdusse, A]]		[[Category: Houdusse, A]]
		+	[[Category: Sirigu, S]]
		+	[[Category: Titus, M A]]
		+	[[Category: Molecular motor]]
		+	[[Category: Motor protein]]
		+	[[Category: Myosin]]
		+	[[Category: Myosin tail]]
		+	[[Category: Myth4-ferm]]

OCA: Protected "5ejy" [edit=sysop:move=sysop]

OCA — Tue, 01 Dec 2015 02:56:47 GMT

Protected "5ejy" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:56, 1 December 2015

OCA: New page: '''Unreleased structure''' The entry 5ejy is ON HOLD until Paper Publication Authors: Sirigu, S., Titus, M.A., Houdusse, A. Description: Structure of Dictyostelium Discoideum Myosin VI...

OCA — Tue, 01 Dec 2015 02:56:46 GMT

New page: '''Unreleased structure''' The entry 5ejy is ON HOLD until Paper Publication Authors: Sirigu, S., Titus, M.A., Houdusse, A. Description: Structure of Dictyostelium Discoideum Myosin VI...

New page

'''Unreleased structure'''

The entry 5ejy is ON HOLD until Paper Publication

Authors: Sirigu, S., Titus, M.A., Houdusse, A.

Description: Structure of Dictyostelium Discoideum Myosin VII MyTH4-FERM MF1 domain
[[Category: Unreleased Structures]]
[[Category: Sirigu, S]]
[[Category: Titus, M.A]]
[[Category: Houdusse, A]]