5eme - Revision history

OCA at 06:34, 5 July 2023

OCA — Wed, 05 Jul 2023 06:34:06 GMT

←Older revision		Revision as of 06:34, 5 July 2023
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	<StructureSection load='5eme' size='340' side='right'caption='[[5eme]], [[Resolution\|resolution]] 1.15Å' scene=''>		<StructureSection load='5eme' size='340' side='right'caption='[[5eme]], [[Resolution\|resolution]] 1.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5eme]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EME OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5EME FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5eme]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EME FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.15Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-CYTOSINE'>CPN</scene>, <scene name='pdbligand=GPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-GUANINE'>GPN</scene>, <scene name='pdbligand=TPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-THYMINE'>TPN</scene></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-CYTOSINE'>CPN</scene>, <scene name='pdbligand=GPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-GUANINE'>GPN</scene>, <scene name='pdbligand=TPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-THYMINE'>TPN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5eme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eme OCA], [~~http~~://pdbe.org/5eme PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5eme RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5eme PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5eme ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5eme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eme OCA], [https://pdbe.org/5eme PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5eme RCSB], [https://www.ebi.ac.uk/pdbsum/5eme PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5eme ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Banaszak, K]]	+	[[Category: Synthetic construct]]
-	[[Category: Dauter, Z]]	+	[[Category: Banaszak K]]
-	[[Category: Kiliszek, A]]	+	[[Category: Dauter Z]]
-	[[Category: Rypniewski, W]]	+	[[Category: Kiliszek A]]
-	~~[[Category: Cag repeat]]~~	+	[[Category: Rypniewski W]]
-	~~[[Category: Pna antisense oligomer]]~~	+
-	~~[[Category: Poly-q diesease]]~~	+
-	~~[[Category: Rna]]~~	+
-	~~[[Category: Rna/pna~~]]	+

OCA at 07:05, 22 April 2020

OCA — Wed, 22 Apr 2020 07:05:22 GMT

←Older revision		Revision as of 07:05, 22 April 2020
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	==Complex of RNA r(GCAGCAGC) with antisense PNA p(CTGCTGC)==		==Complex of RNA r(GCAGCAGC) with antisense PNA p(CTGCTGC)==
-	<StructureSection load='5eme' size='340' side='right' caption='[[5eme]], [[Resolution\|resolution]] 1.15Å' scene=''>	+	<StructureSection load='5eme' size='340' side='right'caption='[[5eme]], [[Resolution\|resolution]] 1.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5eme]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EME OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5EME FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5eme]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EME OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5EME FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-CYTOSINE'>CPN</scene>, <scene name='pdbligand=GPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-GUANINE'>GPN</scene>, <scene name='pdbligand=TPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-THYMINE'>TPN</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-CYTOSINE'>CPN</scene>, <scene name='pdbligand=GPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-GUANINE'>GPN</scene>, <scene name='pdbligand=TPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-THYMINE'>TPN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5eme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eme OCA], [http://pdbe.org/5eme PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eme RCSB], [http://www.ebi.ac.uk/pdbsum/5eme PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eme ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5eme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eme OCA], [http://pdbe.org/5eme PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eme RCSB], [http://www.ebi.ac.uk/pdbsum/5eme PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eme ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Banaszak, K]]		[[Category: Banaszak, K]]
	[[Category: Dauter, Z]]		[[Category: Dauter, Z]]

OCA at 08:51, 17 May 2017

OCA — Wed, 17 May 2017 08:51:55 GMT

←Older revision		Revision as of 08:51, 17 May 2017
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-CYTOSINE'>CPN</scene>, <scene name='pdbligand=GPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-GUANINE'>GPN</scene>, <scene name='pdbligand=TPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-THYMINE'>TPN</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-CYTOSINE'>CPN</scene>, <scene name='pdbligand=GPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-GUANINE'>GPN</scene>, <scene name='pdbligand=TPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-THYMINE'>TPN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eme OCA], [http://pdbe.org/5eme PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eme RCSB], [http://www.ebi.ac.uk/pdbsum/5eme PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eme OCA], [http://pdbe.org/5eme PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eme RCSB], [http://www.ebi.ac.uk/pdbsum/5eme PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eme ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 19:32, 9 March 2016

OCA — Wed, 09 Mar 2016 19:32:44 GMT

←Older revision		Revision as of 19:32, 9 March 2016
Line 1:		Line 1:
		+
	==Complex of RNA r(GCAGCAGC) with antisense PNA p(CTGCTGC)==		==Complex of RNA r(GCAGCAGC) with antisense PNA p(CTGCTGC)==
	<StructureSection load='5eme' size='340' side='right' caption='[[5eme]], [[Resolution\|resolution]] 1.15Å' scene=''>		<StructureSection load='5eme' size='340' side='right' caption='[[5eme]], [[Resolution\|resolution]] 1.15Å' scene=''>

OCA at 20:02, 13 January 2016

OCA — Wed, 13 Jan 2016 20:02:09 GMT

←Older revision		Revision as of 20:02, 13 January 2016
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Complex of RNA r(GCAGCAGC) with antisense PNA p(CTGCTGC)==
		+	<StructureSection load='5eme' size='340' side='right' caption='[[5eme]], [[Resolution\|resolution]] 1.15Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5eme]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EME OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EME FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-CYTOSINE'>CPN</scene>, <scene name='pdbligand=GPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-GUANINE'>GPN</scene>, <scene name='pdbligand=TPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-THYMINE'>TPN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eme OCA], [http://pdbe.org/5eme PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eme RCSB], [http://www.ebi.ac.uk/pdbsum/5eme PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	PNA is a promising molecule for antisense therapy of trinucleotide repeat disorders. We present the first crystal structures of RNA-PNA duplexes. They contain CUG repeats, relevant to myotonic dystrophy type I, and CAG repeats associated with poly-glutamine diseases. We also report the first PNA-PNA duplex containing mismatches. A comparison of the PNA homoduplex and the PNA-RNA heteroduplexes reveals PNA's intrinsic structural properties, shedding light on its reported sequence selectivity or intolerance of mismatches when it interacts with nucleic acids. PNA has a much lower helical twist than RNA and the resulting duplex has an intermediate conformation. PNA retains its overall conformation while locally there is much disorder, especially peptide bond flipping. In addition to the Watson-Crick pairing, the structures contain interesting interactions between the RNA's phosphate groups and the Pi electrons of the peptide bonds in PNA.

-	The ~~entry 5eme is ON HOLD~~	+	The first crystal structures of RNA-PNA duplexes and a PNA-PNA duplex containing mismatches-toward anti-sense therapy against TREDs.,Kiliszek A, Banaszak K, Dauter Z, Rypniewski W Nucleic Acids Res. 2015 Dec 29. pii: gkv1513. PMID:26717983<ref>PMID:26717983</ref>

-	~~Authors: Kiliszek~~, A.~~, Banaszak, K~~.~~, Dauter, Z., Rypniewski, W~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Complex of RNA r(GCAGCAGC) with antisense PNA p(CTGCTGC)~~	+	<div class="pdbe-citations 5eme" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Unreleased Structures~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Banaszak, K]]
	[[Category: Dauter, Z]]		[[Category: Dauter, Z]]
	[[Category: Kiliszek, A]]		[[Category: Kiliszek, A]]
-	[[Category: Banaszak, K]]
	[[Category: Rypniewski, W]]		[[Category: Rypniewski, W]]
		+	[[Category: Cag repeat]]
		+	[[Category: Pna antisense oligomer]]
		+	[[Category: Poly-q diesease]]
		+	[[Category: Rna]]
		+	[[Category: Rna/pna]]

OCA: Protected "5eme" [edit=sysop:move=sysop]

OCA — Tue, 01 Dec 2015 03:02:55 GMT

Protected "5eme" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:02, 1 December 2015

OCA: New page: '''Unreleased structure''' The entry 5eme is ON HOLD Authors: Kiliszek, A., Banaszak, K., Dauter, Z., Rypniewski, W. Description: Complex of RNA r(GCAGCAGC) with antisense PNA p(CTGCTG...

OCA — Tue, 01 Dec 2015 03:02:54 GMT

New page: '''Unreleased structure''' The entry 5eme is ON HOLD Authors: Kiliszek, A., Banaszak, K., Dauter, Z., Rypniewski, W. Description: Complex of RNA r(GCAGCAGC) with antisense PNA p(CTGCTG...

New page

'''Unreleased structure'''

The entry 5eme is ON HOLD

Authors: Kiliszek, A., Banaszak, K., Dauter, Z., Rypniewski, W.

Description: Complex of RNA r(GCAGCAGC) with antisense PNA p(CTGCTGC)
[[Category: Unreleased Structures]]
[[Category: Dauter, Z]]
[[Category: Kiliszek, A]]
[[Category: Banaszak, K]]
[[Category: Rypniewski, W]]