5epb - Revision history

OCA at 08:13, 12 July 2023

OCA — Wed, 12 Jul 2023 08:13:36 GMT

←Older revision		Revision as of 08:13, 12 July 2023
Line 3:		Line 3:
	<StructureSection load='5epb' size='340' side='right'caption='[[5epb]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='5epb' size='340' side='right'caption='[[5epb]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5epb]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EPB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5EPB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5epb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EPB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EPB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5QW:~{N}-[(2~{S})-2-MORPHOLIN-4-YLPROPYL]-4-OXIDANYLIDENE-3,5-DIHYDRO-2~{H}-1,5-BENZOTHIAZEPINE-7-CARBOXAMIDE'>5QW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATAD2, L16, PRO2000 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5QW:~{N}-[(2~{S})-2-MORPHOLIN-4-YLPROPYL]-4-OXIDANYLIDENE-3,5-DIHYDRO-2~{H}-1,5-BENZOTHIAZEPINE-7-CARBOXAMIDE'>5QW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5epb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5epb OCA], [https://pdbe.org/5epb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5epb RCSB], [https://www.ebi.ac.uk/pdbsum/5epb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5epb ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5epb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5epb OCA], [~~http~~://pdbe.org/5epb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5epb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5epb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5epb ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN]] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>	+	[https://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>

	==See Also==		==See Also==
Line 18:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Adenosinetriphosphatase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Caflisch, A]]	+	[[Category: Caflisch A]]
-	[[Category: Dong, J]]	+	[[Category: Dong J]]
-	~~[[Category: Hydrolase inhibitor complex]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 07:08, 22 April 2020

OCA — Wed, 22 Apr 2020 07:08:45 GMT

←Older revision		Revision as of 07:08, 22 April 2020
Line 1:		Line 1:

	==Crystal structure of the bromodomain of human ATAD2 in complex with Compound 49==		==Crystal structure of the bromodomain of human ATAD2 in complex with Compound 49==
-	<StructureSection load='5epb' size='340' side='right' caption='[[5epb]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='5epb' size='340' side='right'caption='[[5epb]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5epb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EPB OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5EPB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5epb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EPB OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5EPB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5QW:~{N}-[(2~{S})-2-MORPHOLIN-4-YLPROPYL]-4-OXIDANYLIDENE-3,5-DIHYDRO-2~{H}-1,5-BENZOTHIAZEPINE-7-CARBOXAMIDE'>5QW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5QW:~{N}-[(2~{S})-2-MORPHOLIN-4-YLPROPYL]-4-OXIDANYLIDENE-3,5-DIHYDRO-2~{H}-1,5-BENZOTHIAZEPINE-7-CARBOXAMIDE'>5QW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATAD2, L16, PRO2000 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5epb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5epb OCA], [http://pdbe.org/5epb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5epb RCSB], [http://www.ebi.ac.uk/pdbsum/5epb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5epb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5epb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5epb OCA], [http://pdbe.org/5epb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5epb RCSB], [http://www.ebi.ac.uk/pdbsum/5epb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5epb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN]] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>		[[http://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN]] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>
		+
		+	==See Also==
		+	*[[ATPase family AAA domain-containing protein\|ATPase family AAA domain-containing protein]]
	== References ==		== References ==
	<references/>		<references/>
Line 15:		Line 19:
	</StructureSection>		</StructureSection>
	[[Category: Adenosinetriphosphatase]]		[[Category: Adenosinetriphosphatase]]
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Caflisch, A]]		[[Category: Caflisch, A]]
	[[Category: Dong, J]]		[[Category: Dong, J]]
	[[Category: Hydrolase inhibitor complex]]		[[Category: Hydrolase inhibitor complex]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 10:48, 10 December 2016

OCA — Sat, 10 Dec 2016 10:48:21 GMT

←Older revision		Revision as of 10:48, 10 December 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5epb is ~~ON HOLD until Nov 11 2017~~	+	==Crystal structure of the bromodomain of human ATAD2 in complex with Compound 49==
-		+	<StructureSection load='5epb' size='340' side='right' caption='[[5epb]], [[Resolution\|resolution]] 1.50Å' scene=''>
-	~~Authors~~: ~~Dong~~, J., ~~Caflisch~~, A.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5epb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EPB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EPB FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure~~ of the ~~bromodomain~~ of ~~human ATAD2~~ in ~~complex with Compound 49~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5QW:~{N}-[(2~{S})-2-MORPHOLIN-4-YLPROPYL]-4-OXIDANYLIDENE-3,5-DIHYDRO-2~{H}-1,5-BENZOTHIAZEPINE-7-CARBOXAMIDE'>5QW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5epb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5epb OCA], [http://pdbe.org/5epb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5epb RCSB], [http://www.ebi.ac.uk/pdbsum/5epb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5epb ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN]] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Adenosinetriphosphatase]]
		+	[[Category: Caflisch, A]]
	[[Category: Dong, J]]		[[Category: Dong, J]]
-	[[Category: ~~Caflisch, A~~]]	+	[[Category: Hydrolase inhibitor complex]]
		+	[[Category: Transferase]]

OCA: Protected "5epb" [edit=sysop:move=sysop]

OCA — Tue, 01 Dec 2015 03:10:30 GMT

Protected "5epb" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:10, 1 December 2015

OCA: New page: '''Unreleased structure''' The entry 5epb is ON HOLD until Nov 11 2017 Authors: Dong, J., Caflisch, A. Description: Crystal structure of the bromodomain of human ATAD2 in complex with ...

OCA — Tue, 01 Dec 2015 03:10:29 GMT

New page: '''Unreleased structure''' The entry 5epb is ON HOLD until Nov 11 2017 Authors: Dong, J., Caflisch, A. Description: Crystal structure of the bromodomain of human ATAD2 in complex with ...

New page

'''Unreleased structure'''

The entry 5epb is ON HOLD until Nov 11 2017

Authors: Dong, J., Caflisch, A.

Description: Crystal structure of the bromodomain of human ATAD2 in complex with Compound 49
[[Category: Unreleased Structures]]
[[Category: Dong, J]]
[[Category: Caflisch, A]]