5eqx - Revision history

OCA at 08:17, 12 July 2023

OCA — Wed, 12 Jul 2023 08:17:40 GMT

←Older revision		Revision as of 08:17, 12 July 2023
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	<StructureSection load='5eqx' size='340' side='right'caption='[[5eqx]], [[Resolution\|resolution]] 3.05Å' scene=''>		<StructureSection load='5eqx' size='340' side='right'caption='[[5eqx]], [[Resolution\|resolution]] 3.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5eqx]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EQX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5EQX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5eqx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EQX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EQX FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=CA:CALCIUM+ION'~~>~~CA</scene>, <scene name='pdbligand=MAN:ALPHA~~-~~D-MANNOSE'>MAN</scene>~~, ~~<scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.05Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5erd\|5erd]], [[5erp\|5erp]]~~<~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<~~tr id~~='~~gene~~'><~~td class="sblockLbl"~~><~~b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">DSG3, CDHF6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5eqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eqx OCA], [https://pdbe.org/5eqx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5eqx RCSB], [https://www.ebi.ac.uk/pdbsum/5eqx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5eqx ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5eqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eqx OCA], [~~http~~://pdbe.org/5eqx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5eqx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5eqx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5eqx ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DSG3_HUMAN DSG3_HUMAN]] Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	+	[https://www.uniprot.org/uniprot/DSG3_HUMAN DSG3_HUMAN] Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Brasch, J]]	+	[[Category: Brasch J]]
-	[[Category: Harrison~~, O J~~]]	+	[[Category: Harrison OJ]]
-	[[Category: Shapiro, L]]	+	[[Category: Shapiro L]]
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Cell surface]]~~	+
-	~~[[Category: Desmosome]]~~	+
-	~~[[Category: Extracellular cadherin domain~~]]	+

OCA at 11:34, 25 December 2019

OCA — Wed, 25 Dec 2019 11:34:53 GMT

←Older revision		Revision as of 11:34, 25 December 2019
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	==Crystal structure of human Desmoglein-3 ectodomain==		==Crystal structure of human Desmoglein-3 ectodomain==
-	<StructureSection load='5eqx' size='340' side='right' caption='[[5eqx]], [[Resolution\|resolution]] 3.05Å' scene=''>	+	<StructureSection load='5eqx' size='340' side='right'caption='[[5eqx]], [[Resolution\|resolution]] 3.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5eqx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EQX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EQX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5eqx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EQX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EQX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5erd\|5erd]], [[5erp\|5erp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5erd\|5erd]], [[5erp\|5erp]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DSG3, CDHF6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eqx OCA], [http://pdbe.org/5eqx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eqx RCSB], [http://www.ebi.ac.uk/pdbsum/5eqx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eqx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eqx OCA], [http://pdbe.org/5eqx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eqx RCSB], [http://www.ebi.ac.uk/pdbsum/5eqx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eqx ProSAT]</span></td></tr>
	</table>		</table>
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	</div>		</div>
	<div class="pdbe-citations 5eqx" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5eqx" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cadherin 3D structures\|Cadherin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Brasch, J]]		[[Category: Brasch, J]]
	[[Category: Harrison, O J]]		[[Category: Harrison, O J]]

OCA at 17:08, 15 November 2017

OCA — Wed, 15 Nov 2017 17:08:00 GMT

←Older revision		Revision as of 17:08, 15 November 2017
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5eqx" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5eqx" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Cadherin\|Cadherin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:46, 21 September 2017

OCA — Thu, 21 Sep 2017 04:46:38 GMT

←Older revision		Revision as of 04:46, 21 September 2017
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5eqx" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5eqx" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cadherin\|Cadherin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:40, 12 July 2016

OCA — Tue, 12 Jul 2016 18:40:48 GMT

←Older revision		Revision as of 18:40, 12 July 2016
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5erd\|5erd]], [[5erp\|5erp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5erd\|5erd]], [[5erp\|5erp]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eqx OCA], [http://pdbe.org/5eqx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eqx RCSB], [http://www.ebi.ac.uk/pdbsum/5eqx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eqx OCA], [http://pdbe.org/5eqx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eqx RCSB], [http://www.ebi.ac.uk/pdbsum/5eqx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eqx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/DSG3_HUMAN DSG3_HUMAN]] Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.		[[http://www.uniprot.org/uniprot/DSG3_HUMAN DSG3_HUMAN]] Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Desmosomes are intercellular adhesive junctions that impart strength to vertebrate tissues. Their dense, ordered intercellular attachments are formed by desmogleins (Dsgs) and desmocollins (Dscs), but the nature of trans-cellular interactions between these specialized cadherins is unclear. Here, using solution biophysics and coated-bead aggregation experiments, we demonstrate family-wise heterophilic specificity: All Dsgs form adhesive dimers with all Dscs, with affinities characteristic of each Dsg:Dsc pair. Crystal structures of ectodomains from Dsg2 and Dsg3 and from Dsc1 and Dsc2 show binding through a strand-swap mechanism similar to that of homophilic classical cadherins. However, conserved charged amino acids inhibit Dsg:Dsg and Dsc:Dsc interactions by same-charge repulsion and promote heterophilic Dsg:Dsc interactions through opposite-charge attraction. These findings show that Dsg:Dsc heterodimers represent the fundamental adhesive unit of desmosomes and provide a structural framework for understanding desmosome assembly.
		+
		+	Structural basis of adhesive binding by desmocollins and desmogleins.,Harrison OJ, Brasch J, Lasso G, Katsamba PS, Ahlsen G, Honig B, Shapiro L Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7160-5. doi:, 10.1073/pnas.1606272113. Epub 2016 Jun 13. PMID:27298358<ref>PMID:27298358</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5eqx" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 22:24, 20 June 2016

OCA — Mon, 20 Jun 2016 22:24:23 GMT

←Older revision		Revision as of 22:24, 20 June 2016
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-	'''Unreleased structure'''

-	~~The entry~~ 5eqx is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of human Desmoglein-3 ectodomain==
-		+	<StructureSection load='5eqx' size='340' side='right' caption='[[5eqx]], [[Resolution\|resolution]] 3.05Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5eqx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EQX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EQX FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5erd\|5erd]], [[5erp\|5erp]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eqx OCA], [http://pdbe.org/5eqx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eqx RCSB], [http://www.ebi.ac.uk/pdbsum/5eqx PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DSG3_HUMAN DSG3_HUMAN]] Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Brasch, J]]
		+	[[Category: Harrison, O J]]
		+	[[Category: Shapiro, L]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Cell surface]]
		+	[[Category: Desmosome]]
		+	[[Category: Extracellular cadherin domain]]

OCA at 12:32, 15 May 2016

OCA — Sun, 15 May 2016 12:32:34 GMT

←Older revision		Revision as of 12:32, 15 May 2016
Line 3:		Line 3:
	The entry 5eqx is ON HOLD until Paper Publication		The entry 5eqx is ON HOLD until Paper Publication

-	Authors: ~~Harrison, O.J., Brasch, J., Shapiro, L.~~	+	Authors:

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Shapiro, L]]
-	[[Category: Harrison, O.J]]
-	[[Category: Brasch, J]]

OCA at 13:48, 10 February 2016

OCA — Wed, 10 Feb 2016 13:48:31 GMT

←Older revision		Revision as of 13:48, 10 February 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5eqx is ON HOLD	+	The entry 5eqx is ON HOLD until Paper Publication

	Authors: Harrison, O.J., Brasch, J., Shapiro, L.		Authors: Harrison, O.J., Brasch, J., Shapiro, L.

OCA: Protected "5eqx" [edit=sysop:move=sysop]

OCA — Tue, 01 Dec 2015 03:15:02 GMT

Protected "5eqx" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:15, 1 December 2015

OCA: New page: '''Unreleased structure''' The entry 5eqx is ON HOLD Authors: Harrison, O.J., Brasch, J., Shapiro, L. Description: Category: Unreleased Structures Category: Shapiro, L [[Categ...

OCA — Tue, 01 Dec 2015 03:15:01 GMT

New page: '''Unreleased structure''' The entry 5eqx is ON HOLD Authors: Harrison, O.J., Brasch, J., Shapiro, L. Description: Category: Unreleased Structures Category: Shapiro, L [[Categ...

New page

'''Unreleased structure'''

The entry 5eqx is ON HOLD

Authors: Harrison, O.J., Brasch, J., Shapiro, L.

Description:
[[Category: Unreleased Structures]]
[[Category: Shapiro, L]]
[[Category: Harrison, O.J]]
[[Category: Brasch, J]]