5erf - Revision history

OCA at 08:18, 12 July 2023

OCA — Wed, 12 Jul 2023 08:18:43 GMT

←Older revision		Revision as of 08:18, 12 July 2023
Line 3:		Line 3:
	<StructureSection load='5erf' size='340' side='right'caption='[[5erf]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='5erf' size='340' side='right'caption='[[5erf]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5erf]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Bacsu Bacsu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ERF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ERF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5erf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ERF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ERF FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5eny\|5eny]], [[5elp\|5elp]], [[5erb\|5erb]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.1Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">pksL, outG, pksA, pksX, BSU17190 ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=224308 BACSU])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5erf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5erf OCA], [https://pdbe.org/5erf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5erf RCSB], [https://www.ebi.ac.uk/pdbsum/5erf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5erf ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5erf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5erf OCA], [~~http~~://pdbe.org/5erf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5erf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5erf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5erf ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PKSL_BACSU PKSL_BACSU]] Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism.<ref>PMID:17234808</ref>	+	[https://www.uniprot.org/uniprot/PKSL_BACSU PKSL_BACSU] Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism.<ref>PMID:17234808</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacsu~~]]	+	[[Category: Bacillus subtilis subsp. subtilis str. 168]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gay~~, D C~~]]	+	[[Category: Gay DC]]
-	[[Category: Keatinge-Clay~~, A T~~]]	+	[[Category: Keatinge-Clay AT]]
-	[[Category: Wagner~~, D T]]~~	+	[[Category: Wagner DT]]
-	~~[[Category: Bacillaene]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Ketosynthase]]~~	+
-	~~[[Category: Polyketide]]~~	+
-	~~[[Category: Trans-at~~]]	+

OCA at 11:35, 25 December 2019

OCA — Wed, 25 Dec 2019 11:35:09 GMT

←Older revision		Revision as of 11:35, 25 December 2019
Line 1:		Line 1:

	==Ketosynthase from module 6 of the bacillaene synthase from Bacillus subtilis 168==		==Ketosynthase from module 6 of the bacillaene synthase from Bacillus subtilis 168==
-	<StructureSection load='5erf' size='340' side='right' caption='[[5erf]], [[Resolution\|resolution]] 3.10Å' scene=''>	+	<StructureSection load='5erf' size='340' side='right'caption='[[5erf]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5erf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacsu Bacsu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ERF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ERF FirstGlance]. <br>		<table><tr><td colspan='2'>[[5erf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacsu Bacsu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ERF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ERF FirstGlance]. <br>
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Bacsu]]		[[Category: Bacsu]]
		+	[[Category: Large Structures]]
	[[Category: Gay, D C]]		[[Category: Gay, D C]]
	[[Category: Keatinge-Clay, A T]]		[[Category: Keatinge-Clay, A T]]

OCA at 17:08, 15 November 2017

OCA — Wed, 15 Nov 2017 17:08:27 GMT

←Older revision		Revision as of 17:08, 15 November 2017
Line 3:		Line 3:
	<StructureSection load='5erf' size='340' side='right' caption='[[5erf]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='5erf' size='340' side='right' caption='[[5erf]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5erf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ERF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ERF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5erf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacsu Bacsu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ERF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ERF FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5eny\|5eny]], [[5elp\|5elp]], [[5erb\|5erb]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5eny\|5eny]], [[5elp\|5elp]], [[5erb\|5erb]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pksL, outG, pksA, pksX, BSU17190 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224308 BACSU])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5erf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5erf OCA], [http://pdbe.org/5erf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5erf RCSB], [http://www.ebi.ac.uk/pdbsum/5erf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5erf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5erf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5erf OCA], [http://pdbe.org/5erf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5erf RCSB], [http://www.ebi.ac.uk/pdbsum/5erf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5erf ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacsu]]
	[[Category: Gay, D C]]		[[Category: Gay, D C]]
	[[Category: Keatinge-Clay, A T]]		[[Category: Keatinge-Clay, A T]]

OCA at 11:11, 2 November 2016

OCA — Wed, 02 Nov 2016 11:11:10 GMT

←Older revision		Revision as of 11:11, 2 November 2016
Line 1:		Line 1:
		+
	==Ketosynthase from module 6 of the bacillaene synthase from Bacillus subtilis 168==		==Ketosynthase from module 6 of the bacillaene synthase from Bacillus subtilis 168==
	<StructureSection load='5erf' size='340' side='right' caption='[[5erf]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='5erf' size='340' side='right' caption='[[5erf]], [[Resolution\|resolution]] 3.10Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[5erf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ERF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ERF FirstGlance]. <br>		<table><tr><td colspan='2'>[[5erf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ERF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ERF FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5eny\|5eny]], [[5elp\|5elp]], [[5erb\|5erb]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5eny\|5eny]], [[5elp\|5elp]], [[5erb\|5erb]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5erf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5erf OCA], [http://pdbe.org/5erf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5erf RCSB], [http://www.ebi.ac.uk/pdbsum/5erf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5erf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5erf OCA], [http://pdbe.org/5erf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5erf RCSB], [http://www.ebi.ac.uk/pdbsum/5erf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5erf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PKSL_BACSU PKSL_BACSU]] Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism.<ref>PMID:17234808</ref>		[[http://www.uniprot.org/uniprot/PKSL_BACSU PKSL_BACSU]] Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism.<ref>PMID:17234808</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Polyketides such as the clinically-valuable antibacterial agent mupirocin are constructed by architecturally-sophisticated assembly lines known as trans-acyltransferase polyketide synthases. Organelle-sized megacomplexes composed of several copies of trans-acyltransferase polyketide synthase assembly lines have been observed by others through transmission electron microscopy to be located at the Bacillus subtilis plasma membrane, where the synthesis and export of the antibacterial polyketide bacillaene takes place. In this work we analyze ten crystal structures of trans-acyltransferase polyketide synthases ketosynthase domains, seven of which are reported here for the first time, to characterize a motif capable of zippering assembly lines into a megacomplex. While each of the three-helix LINKS (Laterally-INteracting Ketosynthase Sequence) motifs is observed to similarly dock with a spatially-reversed copy of itself through hydrophobic and ionic interactions, the amino acid sequences of this motif are not conserved. Such a code is appropriate for mediating homotypic contacts between assembly lines to ensure the ordered self-assembly of a noncovalent, yet tightly-knit, enzymatic network. LINKS-mediated lateral interactions would also have the effect of bolstering the vertical association of the polypeptides that comprise a polyketide synthase assembly line.
		+
		+	The LINKS motif zippers trans-acyltransferase polyketide synthase assembly lines into a biosynthetic megacomplex.,Gay DC, Wagner DT, Meinke JL, Zogzas CE, Gay GR, Keatinge-Clay AT J Struct Biol. 2016 Mar;193(3):196-205. doi: 10.1016/j.jsb.2015.12.011. Epub 2015, Dec 23. PMID:26724270<ref>PMID:26724270</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5erf" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:50, 23 December 2015

OCA — Wed, 23 Dec 2015 12:50:13 GMT

←Older revision		Revision as of 12:50, 23 December 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Ketosynthase from module 6 of the bacillaene synthase from Bacillus subtilis 168==
-		+	<StructureSection load='5erf' size='340' side='right' caption='[[5erf]], [[Resolution\|resolution]] 3.10Å' scene=''>
-	~~The entry~~ 5erf is ~~ON HOLD until Dec 23 2016~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5erf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ERF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ERF FirstGlance]. <br>
-	~~Authors~~: ~~Wagner~~, D.T., ~~Gay~~, D.C., ~~Keatinge-Clay, A~~.T.	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5eny\|5eny]], [[5elp\|5elp]], [[5erb\|5erb]]</td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5erf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5erf OCA], [http://pdbe.org/5erf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5erf RCSB], [http://www.ebi.ac.uk/pdbsum/5erf PDBsum]</span></td></tr>
-	~~Description: Ketosynthase from module 6 of the bacillaene synthase from Bacillus subtilis 168~~	+	</table>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	== Function ==
-	[[Category: Gay, D.C]]	+	[[http://www.uniprot.org/uniprot/PKSL_BACSU PKSL_BACSU]] Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism.<ref>PMID:17234808</ref>
-	[[Category: Keatinge-Clay, A.T]]	+	== References ==
-	[[Category: Wagner, D.T]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Gay, D C]]
		+	[[Category: Keatinge-Clay, A T]]
		+	[[Category: Wagner, D T]]
		+	[[Category: Bacillaene]]
		+	[[Category: Hydrolase]]
		+	[[Category: Ketosynthase]]
		+	[[Category: Polyketide]]
		+	[[Category: Trans-at]]

OCA at 12:11, 16 December 2015

OCA — Wed, 16 Dec 2015 12:11:37 GMT

←Older revision		Revision as of 12:11, 16 December 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5erf is ON HOLD	+	The entry 5erf is ON HOLD until Dec 23 2016

	Authors: Wagner, D.T., Gay, D.C., Keatinge-Clay, A.T.		Authors: Wagner, D.T., Gay, D.C., Keatinge-Clay, A.T.

OCA: Protected "5erf" [edit=sysop:move=sysop]

OCA — Tue, 01 Dec 2015 03:16:13 GMT

Protected "5erf" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:16, 1 December 2015

OCA: New page: '''Unreleased structure''' The entry 5erf is ON HOLD Authors: Wagner, D.T., Gay, D.C., Keatinge-Clay, A.T. Description: Ketosynthase from module 6 of the bacillaene synthase from Bacil...

OCA — Tue, 01 Dec 2015 03:16:11 GMT

New page: '''Unreleased structure''' The entry 5erf is ON HOLD Authors: Wagner, D.T., Gay, D.C., Keatinge-Clay, A.T. Description: Ketosynthase from module 6 of the bacillaene synthase from Bacil...

New page

'''Unreleased structure'''

The entry 5erf is ON HOLD

Authors: Wagner, D.T., Gay, D.C., Keatinge-Clay, A.T.

Description: Ketosynthase from module 6 of the bacillaene synthase from Bacillus subtilis 168
[[Category: Unreleased Structures]]
[[Category: Gay, D.C]]
[[Category: Keatinge-Clay, A.T]]
[[Category: Wagner, D.T]]